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Analisis Pengaruh Metode Penggerusan Kaplet Paracetamol terhadap Kadar Bahan Aktif Obat Amanda Aulia; Yuyun Febriani; Tri Puspita Yuliana
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 1 (2025): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i1.29049

Abstract

One of the drugs commonly used by the general public is paracetamol. This drug has relatively mild side effects compared to other drugs, so it is common to be prescribed for compounding pulmonary drugs for patients with certain doses There are two grinding methods used, namely a mortir and a blender. The purpose of this study was determined the variation effects in the dissolution speed and particle size on decreasing levels of paracetamol potency in each grinding methods. UV-Vis Spectrofotometer was used as quantitative methode.  Based on the results, the percentage level of solubility velocity were in mortar: 70.54% aquadest, 115.49% ethanol, 96.10% acetone, 113.20% NaOH. In the blender: 65.44% aquadest, 88.14% ethanol, 48.31% acetone, 98.20% NaOH. Meanwhile, for variations in particle size, the mortar obtained: mesh20 101.82%, mesh40 117.73%, mesh80 80.91%, mesh100 113.20%. In the blender obtained: mesh20 96.98%, mesh40 88.40%, mesh80 69.06%, mesh100 99.11%. Furthermore, the statistical analysis by two-way anova obtained a significance value of 0.059 for variations in dissolution speed and 0.659 in particle size. In conclusion, there was an effect of variations in solvents but did not show an effect of variations in particle size on decreasing levels of active drug ingredients.
Efficacy of Sodium Hypochlorite (NaOCl) Against Gram Positive and Gram Negative Bacteria: A Systematic Literature Review Jeli Marlita; Yuyun Febriani; Baiq Risma Fatmayanti; Leny Ramadhan
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.12508

Abstract

Sodium hypochlorite (NaOCl) is a chemical compound that acts as a strong oxidizer commonly used as an antibacterial, antiseptic, and disinfectant in various pharmaceutical and health applications. This systematic review aims to evaluate the antibacterial activity of NaOCl against various types of bacteria based on the PICO framework. Literature searches were conducted through the PubMed, ScienceDirect, and Scopus databases for publications from 2017 to 2024. Inclusion criteria included all types of bacteria, the use of NaOCl as an antibacterial or antimicrobial agent, and articles published within that time frame. The interventions reviewed were the use of NaOCl at various concentrations, while the control group referred to conditions without treatment or a comparative antibacterial agent. The results were determined based on antimicrobial activity against the bacteria tested. Two stages of independent literature searches were conducted according to the established inclusion and exclusion criteria. This review shows that NaOCl has significant antibacterial activity against various bacteria, with effectiveness depending on the concentration and characteristics of the target microorganisms.