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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Biomolecular and Health Science Journal Cermin Dunia Kedokteran Cermin Dunia Kedokteran

Trisniartami Setyaningrum

Departemen/ SMF Ilmu Kesehatan Kulit Dan Kelamin, Fakultas Kedokteran Universitas Airlangga/ RSU Dr. Soetomo, Surabaya, Indonesia

Author-ID : 563364

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Uji Difusi Sefiksim terhadap Neisseria gonorrhoeae pada Servisitis Gonore tanpa Komplikasi Astindari Astindari; Hans Lumintang,; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Latar belakang: Gonore merupakan salah satu infeksi menular seksual yang sering ditemukan. Resistensi terhadap beberapa antibiotik banyak ditemukan dalam beberapa tahun terakhir. Sefalosporin generasi ketiga seperti sefiksim dan seftriakson merupakan pilihan terapi lini pertama di berbagai negara, namun penurunan kepekaan sefiksim sudah ditemukan dan mulai menyebar. Tujuan: Mengevaluasi kepekaan sefiksim terhadap Neisseria gonorrhoeae secara difusi. Metode: Penelitian laboratorium yang bersifat deskriptif observasional, potong lintang mulai November 2012-Januari 2013. Terdapat 12 isolat N. gonorrhoeae dari 68 sekret serviks yang dilakukan uji kepekaan sefiksim secara difusi. Hasil: Uji kepekaan sefiksim secara difusi terhadap N. gonorrhoeae didapatkan 3 dari 12 isolat (25%) resisten terhadap sefiksim dan 9 dari 12 isolat (75%) sensitif terhadap sefiksim. Empat dari 9 isolat (44,5%) yang sensitif terhadap sefiksim mempunyai zona hambat dengan diameter 31 mm yang merupakan batas kemampuan sefiksim untuk menghambat pertumbuhan N. gonorrhoeae. Simpulan: Ditemukan strain N. gonorrhoeae yang menunjukkan, sehingga perlu dilakukan penelitian lebih lanjut berupa uji kepekaan secara dilusi untuk mengetahui adanya peningkatan resistensi N. gonorrhoeae terhadap sefiksim.Kata kunci: sefiksim, uji kepekaan secara difusi, N.gonorrhoeae.

Dermoscopy Supports the Diagnose of Papulosquamous Disorders Medhi Denisa Alinda; Marsudi Hutomo; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V26.3.2014.1-7

Background: The diagnose of papulosquamous skin disorder was established by clinical symptoms. However, some of papulosquamous manifestation are alike with each other and lead to misdiagnostic. Histopathology examination usually can help to establish diagnose but this method is invasive and time consuming. Purpose: To evaluate dermoscopic features of papulosquamous disorder. Methods: Descriptive observasional cross sectional study, total sampling in ward and out patient clinic of Dermato-venereology Department Dr. Soetomo General Hospital. Twenty four samples were included in the study, followed by the procedures from anamnesis, physical examination, dermoscopy procedures, and histopathology examination. Results: From 24 samples, 19 samples showed plaque psoriasis describing 12 ring patterns, 1 cluster pattern, 2 patchy patterns, 2 reguler patterns, and 2 unspesiﬁc patterns; 3 samples showed nummular dermatitis describing 2 cluster patterns and 1 unspesiﬁc pattern; and 2 samples showed pityriasis rosea describing 2 pheripery patterns. Conclusion: Dermoscopy can support the diagnosis of papulosquamous skin disorder especially plaque psoriasis.Key words: papulosquamous disorder, dermosocopy, histopathology examination, plaque psoriasis.

Tinea Capitis Kerion Type: A Case Report Dyah Ratri Anggarini; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Tinea capitis is a superficial fungal infection. Kerion is one of its form, which is an inflammation form due to a hypersensitivity reaction to fungal infection caused by group Mycosporum and Trichophyton. Purpose: To understand the clinical manifestation, species causing agent, and management of tinea capitis. Case management: A four-year-old boy, 17 kg, came with a mass on the head, accompanied with pain, fever, and hair loss since 1 week before hospitalization, it appeared after playing with the neighbor's pets. General examination showed enlargement of the right preauricular lymph node. Dermatological examination revealed a mass in the head 7 cm in size with pus, partially covered with crust, and there were also warm and pain on palpation. Wood lamp examination was negative, but in potassium hydroxide examination showed spores outside and inside the hair shaft. Result of fungal cultures was T. mentagrophytes. Routine blood tests obtained only leukocytosis, which was 12.390/µL. The patient was treated with griseofulvin, erythromycin, wet dressing, and ketokonazole shampoo. It was shown good results after therapy for 8 weeks. Conclusions: Tinea capitis caused by T. mentagrophytes presenting an inflammatory reaction, causing a fungal infection in the hair shaft. Auxiliary examination for the diagnosis of tinea capitis can be done in various ways, the easiest one is by potassium hydroxide 20% examination, fungal culture is then performed to determine the species causing the infection. Therapeutic use of griseofulvin is still the main choice.Key words: tinea capitis kerion type, T. mentagrophytes, griseofulvin.

Retrospective Study: The Use of Chemical Peeling with A Modiﬁed Jessner's in Melasma Patients Zada Febrial Effendy; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Melasma is a hipermelanosis that lead to brownish or brownish-grey discoloration on the face. Chemical peeling is one of the additional therapy for melasma. The right indication using modiﬁed Jessner's solution give a good result for melasma. Purpose: To evaluate new patients of melasma which underwent chemical peeling therapy with Jessner's modiﬁed in Medical Cosmetics Division of Dermato-Venerology Department, Dr. Soetomo General Hospital Surabaya in 2010-2013. Methods: Retrospective study of the new medical records of melasma, including the number of patients, age distribution, gender, occupation, risk factors, history of previous treatment, duration of treatment, location of melasma, color of melasma, size of melasma, additional test results, type of melasma, melasma side effects, the use of priming, chemical peeling, post-peels, and follow up. Results: The number of new patients with melasma which underwent chemical peeling were 108 patients from 1544 (14.2%) new melasma patients visiting Cosmetics Division of Dermato-Venerology Department, Dr. Soetomo General Hospital. All patients were women with the largest age group of 40-49 years, which is 66 (61.1%) patients. Highest risk factor was a mixture of sun exposure and use of cosmetics product, which is 56 (51.8%) patients. Most melasma type was mixed melasma. Patients who used a Jessner's modiﬁed peels, mostly used alpha hydoxy acid (AHA), Kligman's formula, and tretinoin as priming as many as 28 (25.9%) patients and majority post-peels used a moisturizer, sunblock, hydrocortisone, which is 57 (52.8%) patients. Erythema after peeling were complained from 50 (46.3% ) patients. Conclusion: The use of chemical peeling is one of adjunctive therapy in melasma with a proper diagnosis.Keywords: melasma, chemical peeling, modiﬁed Jessner's, retrospective.

Retrospective Study : Rosacea Profile Shakti Indraprasta; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Rosacea is a chronic skin disorder which characterized by erythema of the central face that has persisted for months. Primary features of rosacea include flushing, papules, pustules, and telangiectatic. Although rosacea is clearly visible to all, it is largely unknown to misunderstood by the general public. Knowledge relating to the epidemiology, etiology, pathogenesis, and treatment of this facial disorder is limited. Purpose: To evaluate the management of patients with Rosacea in the cosmetic division, dermatovenereology outpatient clinic Dr. Soetomo general hospital period 2010-2012. Methods: Retrospective study of new patients with Rosacea in cosmetic division during 2010-2012. Results: During the period of three years (2010-2012), there were 49 new patients in cosmetic division, dermatovenereology outpatient clinic Dr. Soetomo general hospital. The most common patient was female, with the highest age group of 25-44 years old, and the most clinical feature found were papulopustular rosacea and erythemato-telangiectatic rosacea. The most common treatment were metronidazole for topical treatment and doxycycline for systemic treatment. Conclusions: The most clinical feature were papulopustular and erythematotelangiectatic subtype, only few cases of phymatous subtype, while the ocular subtype was not found. There were so many varieties in the management of rosacea because there was no standard therapy yet for the management of this disease.Key words: rosacea, retrospective study, rosacea subtype.

Open Oral Food Challenge in Adult with Food Allergy to Chicken Meat Yosi Charly; Cita Rosita SP; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Food allergy is a hypersensitivity of the body's response to food. Food allergies are divided into three groups: immunoglobulin E (IgE) mediated, non-IgE mediated, and mixed IgE mediated with non-IgE mediated. Food allergies can be life threatening, causing malnutrition, eating disorders, and psychosocial problems. The gold standard for the diagnosis of food allergy is double-blind placebo-controlled food challenge (DBPCFC), but time consuming, costly, and a resuming specialist to perform it. Open oral food challenge (OFC), commonly used as screening in the clinic, with food suspected of being in its true form, in particular to look for symptoms. Objective: To evaluate specific IgE and open OFC in adult patients with a history of food allergies to chicken. Methods: Descriptive cross-sectional study involving 28 adult patients with history of food allergies to chicken were diagnosed as urticaria, angioedema, and atopic dermatitis. Specific IgE chicken meat was performed and patients were asked to eliminate chicken for 1 week before open OFC. Results: Twenty eight samples, specific IgE within normal limit. Positive results of open OFC were found in 9 people and 19 negative result. Conclusion: The specific IgE chicken does not always correlate with clinical reactivity and open the OFC can be used for the diagnosis of food allergy to chicken meat. Key words: food allergies, spesific Ig E, open oral food challenge.

Increase of Serum Zinc Levels in Patients with Vitiligo Dinar Witasari; Hari Sukanto; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Vitiligo is a common acquired depigmentary disease characterized by depigmented patches of the skin, hair, and mucous membranes due to selective destruction of melanocytes. Zinc is one of the trace element that suspected to play an important role in pathogenesis of vitiligo. Previous research showed a controversial result in zinc level of vitiligo. Purpose: To compare serum zinc between vitiligo and control in Dermatology and Venereology Outpatient Clinic in Dr. Soetomo General Hospital Surabaya. Methods: Analitic observational case control research was conducted, with 19 vitiligo patients in Dermatology and Venereology Outpatient Clinic Dr. Soetomo hospital and 19 age-sex matched controls (non-vitiligo subjects) that were qualified with inclusion and exclusion criteria. Serum zinc level was measured in both groups using atomic absorbtion spectrophotometer. Results: Mean serum zinc in vitiligo groups were 254.53 µg/dL and 109.53 µg/dL in control groups. This results showed that mean serum zinc in vitiligo group significantly higher compared to control group (p<0,05). There was a statistically significant association between serum zinc level and progressivity of the lesion as patient with active vitiligo lesion showed higher values of serum zinc. Stress is the most common predisposing factors (36%), meanwhile stress can also induce the increasing of serum zinc. Conclusion: Serum zinc in vitiligo patient is higher than control and showed correlation with course of the disease. It is required further research to reveal the role of zink in vitiligo and the connection between the degree of stress and serum zinc.

The Profile of Interferon-ɣ and BCG Scar as an Immune Response Reflection in Children with Leprosy Renata Mayangsari; Iskandar Zulkarnain; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Leprosy in children are commonly found in Madura, Indonesia. Bacillus Calmette-Guerin (BCG) vaccination and interferon--γ (IFN-γ) level associated with severity of leprosy. Purpose: To evaluate IFN-γ level and BCG scar due to leprosy in child. Methods: A descriptive observational cross sectional research, with leprosy in patients in Bangkalan, Madura as subjects. Subjects has been collected through consecutive sampling, then BCG scars were observed and blood vein samples were taken to measure IFN-γ level. Results: IFN-γ level were below normal range in almost all subjects. Mean level in patients with BCG scar (10,07 pg/ml) were higher than patients with non-scar (6,9 pg/ml). Seventy percents patients without BCG scar tend to be MB type based on percentage BCG scar due to type of leprosy. Conclusion: Immunity status as a result of BCG vaccination measured from IFN-γ level has many confounding factor. BCG vaccination seems to have an important role in severity of leprosy. Patients with BCG scar tend to be PB type. BCG vaccination can be benefits to make milder symptoms of leprosy.

Significant Different Level of Malondialdehyde (MDA) as Oxydative Stress Marker in Severity Groups of Acne Vulgaris Sylvia Anggraeni; Trisniartami Setyaningrum; M Yulianto Listiawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Acne vulgaris (AV) is a common chronic inflammatory disease of sebaceous gland that may decrease patient’s quality of life. Oxidative stress is suggested to play role in the pathogenesis of AV. Purpose: To evaluate the differences of malondialdehyde (MDA) level as oxidative stress marker in AV severity. Method: This is an analytic observational cross sectional research of AV patients in Cosmetic Division of Dermatology and Venereology Outpatient Clinic of Dr. Soetomo hospital Surabaya. Subjects were collected through consecutive sampling since May-August 2015. Total samples were 42 patients, classified into 3 severity groups (mild, moderate, severe). Samples were taken from blood vein, examined with Enzyme-linked immunosorbent assay (ELISA) then analyzed statistically. Results: There were differences of MDA mean level among AV severity groups: mild 58.371 ng/ml (SD±25.2141); moderate 99.121 ng/ml (SD±8.5172); and severe 171.779 ng/ml (SD±49.9694). Post hoc analytic revealed that there were statistically differences of MDA level in all stages (mild-moderate p=0.002; mild-severe p=0.000; moderate-severe p=0.000). Conclusions: This research revealed that oxidative stress plays a role in AV pathogenesis. Lipid peroxidation process in sebum produced lipid oxidant that could induce inflammatory process in sebaseous gland via Peroxisome Proliferator-Activated Receptor (PPAR).

The Profile of Erythroderma Patients Shelma Maharani; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Erythroderma is a rare, but it is life threatening. By knowing the profile of eritroderma, can expect the management and the cure of the patient more better. Objective: To evaluate the general profile of erythrodermic patients. Methods: This study was conducted retrospectively in erythrodermic patients in Kemuning Ward dr. Soetomo General Hospital Surabaya in 2011- 2014, collecting data from medical records of patients, including the incidence, etiology, clinical features, investigations, treatment, complications, mortality, and return visit. Results: The incidence of erytroderma patient was 83 (5.3%), gender most was men (54.2%) with the highest age range > 60 years (31.3%), the etiology of most was due to drug reactions (39.7%), skin efflorescence highest number was macular erythematous and thin scale, the percentage of each 69 (83.1%) and 65 (78.3%), the majority results of histopathological examination was drug reaction 23 (43.5%) and psoriasis vulgaris 18 (33.9%), patients were receiving oral dexamethasone therapy (80.7%), mostly complications was on the skin (69.9%), mortality rate was 6.1%. Conclusion: The profile of erythroderma patient has already been described, and the management was giving a good outcome with the mortality rate 6,1%.

Co-Authors Abdul Karim Ade Fernandes Afif Nurul Hidayati, Afif Nurul Afria Arista Afria Arista Afria Arista, Afria Agatha Anindhita Ayu Ardhaninggar Alarik L., Albertus Alphania Rahniayu Amanda Gracia Manuputty Amira Suryani Rahmatika Anggraeni, Sylvia Arifa Mustika Artaria Tjempakasari, Artaria Asrianti, Nur Ilma Astindari Astindari Astindari Astindari Astindari Astindari, Astindari Aulia Rafikasari Axelia, Presstisa Gifta Bagus Haryo Kusumaputra, Bagus Haryo Budiono Budiono Christina Avanti Cita Rosita Sigit Prakoeswa Cita Rosita SP Damayanti Damayanti - Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Deasy Fetarayani Diah Mira Indramaya Dinar Witasari Dwi Murtiastutik Dyah Ratri Anggarini Dyah Ratri Anggarini, Dyah Ratri Eden Leonita Eva Lydiawati Evy Ervianti Febrina Dewi Pratiwi Gondo Mastutik Hadiwidjaja, Farsha Naufal Hans Lumintang Hans Lumintang, Hans Lumintang,, Hans Hari Sukanto Hening Laswati Indiastuti, Danti Nur Irmadita Citrashanty Irmadita Citrashanty, Irmadita Irwadi, Irfiansyah Iskandar Zulkarnain Kathrin Kezia Henry Koesandrini, Kinanthi KUSUMASTUTI, ETTY HARY Linda Astari, Linda LINGGA, FEBRINA DEWI PRATIWI Lisa Aditama, Lisa Lutfia Ariska Ramadhani M. Yulianto Listiawan Mappamasing, Hasnikmah Marsudi Hutomo Marsudi Hutomo, Marsudi Maylita Sari Maylita Sari, Maylita Medhi Denisa Alinda, Medhi Denisa Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Nabiha Missaoui Ngesti Kumalasari, Diah Pramitha, Riezky Januar Puspowati, Erindah Putri Brillian Betrista Viorizka Qurnianingsih, Ema Rahmadewi Rahmadewi Rahmadewi Ramadhina, Anasya Putri Renata Mayangsari Ridha Ramadina Widiatma Rozita Maharani, Dinda Ryski Meilia Novarina Ryski Meilia Novarina Ryski Meilia Novarina, Ryski Meilia Samsriyaningsih Handayani Sawitri Sawitri Shakti Indraprasta Shakti Indraprasta, Shakti Shelma Maharani Shinta Dewi Rahmadhani Soetojo Suhartono Taat Putra Sulaksanaswastho Suyoso Sunarto, Olivia Awwalin Susanto, Ester Chateline Tasya Wikassa Tengku Riza Zarzani N Widyantari, Septiana Willy Sandhika Yasmin Adzra Nabila Yosi Charly Yuani Setiawati Yuli Wahyu Rahmawati Yuri Widia, Yuri Zada Febrial Effendy Zada Febrial Effendy, Zada Febrial

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