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All Journal Research Journal of Life Science Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease MEDISAINS MNJ (Malang Neurology Journal) Science and Technology Indonesia Jurnal Ilmiah Kedokteran Wijaya Kusuma Majalah Kesehatan FKUB Jurnal Berkala Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Dinamisia: Jurnal Pengabdian Kepada Masyarakat ISM (Intisari Sains Medis) : Jurnal Kedokteran AKSELERASI: Jurnal Ilmiah Nasional Jurnal Klinik dan Riset Kesehatan International Journal of Science and Society (IJSOC) Asian Journal of Health Research Jurnal Ilmu Kedokteran Keluarga Journal of General Procedural Dermatology and Venereology Indonesia Journal of International Surgery and Clinical Medicine JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit)
Dhelya Widasmara
Department Of Dermatology And Venereology, Faculty Of Medicine, Brawijaya University.
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Science and Technology Indonesia

 1 
Anti-Photoaging Effects of Moisturizer and Serum Containing Andrographis paniculata, Syzygium aromaticum, and Pogostemon cablin: A Network Pharmacology, Molecular Docking, and in vivo Study Adianingsih, Oktavia Rahayu; Johan, Christopher Kuncoro; Widarson; Ravsanjani, Eurica Andriani Najwa; Sutiyono, Bershiella Amandari; Qurrotuain, Iffah; Yurina, Valentina; Puspita, Oktavia Eka; Widasmara, Dhelya; Saitama, Akbar; Hariyono, Didik
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.19-34

Abstract

Ultraviolet-B (UVB)-induced photoaging accelerates collagen degradation, disrupts dermal structure, and compromises epidermal integrity. Natural extracts, such as Andrographis paniculata, Syzygium aromaticum, and Pogostemon cablin demonstrated antioxidant and anti-aging properties to mitigate these damages. This study investigated the protective effects of serum and moisturizer containing A. paniculata extract, S. aromaticum oil, and P. cablin oil on UVB-induced photoaging rats, by integrating network pharmacology and in vivo experiment. Compounds and photoaging-associated targets were retrieved through online databases. Enrichment analyses were performed using Metascape. Protein-protein interaction (PPI) construction and herbs-compounds-targets-pathways disease network were performed using STRING and Cytoscape 3.10.0, respectively, followed by molecular docking. An in vivo study was conducted to evaluate epidermal thickness, collagen density, and dermo-epidermal junction (DEJ) structure. Eleven key phytoconstituents and twelve core targets were identified in anti-photoaging molecular mechanisms using network pharmacology. Molecular docking analysis revealed that 7-O-methylwogonin demonstrated favorable binding against ten photoaging-associated targets. KEGG enrichment analysis showed potential inflammation processes inhibition, including photocarcinogenesis, AGE-RAGE signaling pathway, and TNF-α expression. Furthermore, treatment with serum, moisturizer, or combination of both significantly reduced epidermal thickening and enhanced collagen density compared to the UVB-exposed only group. Although no significant difference was observed in DEJ interdigitation index across groups, treated groups exhibited a trend towards better preservation of DEJ structure relative to the UVB group. In summary, serum and moisturizer containing A. paniculata, S. aromaticum, and P. cablin extracts demonstrated potential anti-photoaging effects by reducing epidermal thickness and preserving collagen density in UVB-exposed rats. These findings support these botanical-based formulations potential as effective anti-aging skincare.
Co-Authors Abdul Gofur Ade Setyagraha Adya Sitaresmi Agnes Sri Siswati Agung Minto Wahyu Angela Lumaksono, Maria Anggun Putri Yuniaswan Anum, Qaira Bagus Haryo Kusumaputra Cita Rosita Sigit Prakoeswa Dani, Adinda Amalia Dea Florensia Didik Hariyono Dwi Murtiastutik Fifa Argentina Fuzianingsih, Eka Noviya Haidar Abror Firladi Hansel Hansel Hardiati, Rien Henggar Sulistiarto Herwinda Brahmanti I Wayan Agung Indrawan Ika Andrini Farida Imani, Izzah Imaroh, Rifa Jayawarsa, A.A. Ketut Johan, Christopher Kuncoro Kurnia Penta Seputra Kuswantoro Rusca Putra Lita Setyowatie, Lita Lubis, Ramona Sari Luh Made Mas Rusyati Lumaksono, Maria Angela M. Yulianto Listiawan Mamuaja, Enricco Hendra Maulidah Maulidah Medhi Denisa Alinda, Medhi Denisa Mochammad Yunus, Mochammad Mohammad Bisri Muchtar, Vitayani Mulianto, Nur Rachmat Nanik Setijowati Novita, Khuznita Dasa Nugrahanti Prasetyorini Oktavia Eka Puspita, Oktavia Eka Oktavia Rahayu Adianingsih Panji Sananta Qurrotuain, Iffah rahmah, shofi nur Rakhmaditya Dewi Noorrizki Ravsanjani, Eurica Andriani Najwa Regitta Indira Agusni Renni Yuniati Ristiawan Muji Laksono Rizka Melina Fauziyyah Saitama, Akbar Sanata, Panji Santosa Basuki Santosa Basuki Sari, Diane Tantia Sari, Diane Tantia Saviestya, Kaorie Bunga Septina Yosephine Servasius To’o Jala Mulu Shahdevi Nandar Kurniawan, Shahdevi Nandar Siti Umi Ernawati Sri L. Menaldi Sunarso Suyoso Sunarso Suyoso, Sunarso Suparno Adi Santika Sutiyono, Bershiella Amandari Tamadi, Virginia Rosa Tasya Yuni Ariskasari Titin Andri Wihastuti Tutut Chusniyah VALENTINA YURINA Widarson Widiatmoko, Arif Widodo Mardi Santoso, Widodo Mardi Wildan Faza Pratama Yuniati, Wahyu