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Journal : Medical Sains : Jurnal Ilmiah Kefarmasian

Tectona grandis Linn. : ANTIDIABETIC ACTIVITY OF THE FRACTIONS USING AN IN VIVO APPROACH Nurramadhani ASida; Rifa’atul Mahmudah; Nita Trinovitasari; Nada Shofa; Parawansah; Nuralifah; Abd Rafid; Risma
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1058

Abstract

The exploration of Tectona grandis Linn. from Indonesia, especially its use as an anti-diabetes agent is still quite limited. This study aims to determine the antidiabetic activity of the fractions from Tectona grandis Linn. leaves in male Rattus norvegicus. The animal blood glucose level was measured first as T0, then the animals were injected with streptozotocin (STZ) 40 mg/Kg BW to induce diabetes mellitus (DM), and then the blood was collected to determine the blood glucose level (T1). The animal was divided into six groups, namely normal group (NC) without treatment, positive control (K+) (DM+glibenclamide 5 mg), negative control (K-) (DM+NaCMC 0.5%), fractions group (DM+nHexane fraction (P1), DM+chloroform fraction (P2), and DM+ethyl acetate fraction (P3), each dose 300 mg/kg BW). The duration of treatment was 7 days, and at the end of treatment, the blood glucose levels were determined. The T0, T1, and T2 are analyzed using One-Way ANOVA and post-hoc LSD. The results obtained that the K+, P3, P2, and P1 groups were able to reduce the animals' blood glucose levels significantly (p<0.05), with the blood glucose levels are 97.01; 110.96; 129.38; and 111.46 mg/dL, respectively. The percentage of reduction in blood glucose level shows that the K+ group has the highest percentage at 66.8%, followed by the P3 group at 64.0%. The n-hexane, chloroform, and ethyl acetate fractions showed similar effectiveness to glibenclamide in reducing blood glucose levels statistically (p>0.05). Consequently, Tectona grandis Linn ...
Co-Authors ,, Suryani Abd Rafid Abd Rafid Adryan Fristiohady Amilia Primawanty Andi Muammar Zayed Andi Srie Muniati T Arfan Arfan Arfan Arfan Arifah Indar Cahyani Aswani Aswani Aswani Aswani Aswani Aswani Dian Munasari Solo Diana Hijrah Edy Meiyanto Fery Indradewi Fifi Nirmala Firdarini, Evi Apriyani Fitrawan, La Ode Muhammad Halik Hardianti, Nia Hasnawati Hasnawati Idin Sahidin Idrus, Loly Subhiaty Irvan Irvan Anwar Irvan Anwar Irvan Anwar Kasmawati, Henny La Ode Muh. Fitrawan La Ode Muhammad Diman Loly Subhiaty Idrus Loly Subhiaty Idrus Loly Subhiyati Idrus Malina, Rachma Muhammad Abdillah Muhammad Jefriyanto B Muhammad Syamsir Muhammad, Umi Kalsum Muthi Ikawati Nada Shofa Nasruddin Nasruddin Nita Trinovitasari Nita Trinovitasari Normaidah, Normaidah Nur Illiyyin Akib Nur Illiyyin Akib Nur Rayani Nuralifah Nuralifah Nuralifah Nuralifah Nuralifah Nuralifah, Nuralifah Nurul Hikmah Nurull Hikmah Nurull Hikmah Parawansah Parawansah Parawansah Parawansah, Parawansah Rachma Malina Rachma Malina Rahmadani, Ulfa Novianti Ramdhayani, Vinarti Ratna Asmah Susidarti Restu Nur Hasanah Rifa'atul Mahmudah Rifa’atul Mahmudah Rina Andriani Risma Risnawati Risnawati Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin, Ruslin Rusman, Arman Sabarudin Sabarudin Siti Sarmila Dewi Sitti Raodah Nurul Jannah Sitti Raodah Nurul Jannah Sitti Raodah Nurul Jannah Suryani Tahis, Ita Priati Vica Aspadiah Vica Aspadiah Wa Ode Asdia Wa Ode Asriani Wa Ode Dian Indrayanti Wa Ode Sinta Hasrawati Wa Ode Sitti Zubaydah Wahyuni Wahyuni Wiwin Putri Wulandari Yamin Yamin Yodha, Agung Wibawa Mahatva