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All Journal Folia Medica Indonesiana Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Molecular and Cellular Biomedical Sciences (MCBS) Manuju : Malahayati Nursing Journal International Journal of Applied Technology Research TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora International Journal of Economics (IJEC) Eduvest - Journal of Universal Studies Riwayat: Educational Journal of History and Humanities Jurnal Informatika: Jurnal Pengembangan IT

Yulistiani Yulistiani, Yulistiani

Mahasiswa Jurusan Perencanaan Wilayah dan Kota, Fakultas Teknik, Universitas Diponegoro

Author-ID : 575691

Aerospace Engineering Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

Published : 22 Documents Claim Missing Document

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ANALYSIS OF DL-ï¡-TOCOPHEROL AS ANTIOXIDANT ON MALONDIALDEHYDE LEVEL IN PEDIATRIC PATIENTS WITH ï¢-THALASSEMIA MAJOR Rismayanti, Levana; Yulistiani, Yulistiani; Andarsini, Mia Ratwita; Qibtiyah, Mariyatul
Folia Medica Indonesiana Vol. 53 No. 1 (2017): JANUARY - MARCH 2017
Publisher : Universitas Airlangga

Thalassemia is a hereditary form of anemia that affects the synthesis of hemoglobin. The management of therapy in patients with b-thalassemia major which patients should receive continuous blood transfusions and increased iron absorption from the digestive tract causes excess iron in the body. This will lead to an increase of free iron level that triggers Radical Oxygen Species (ROS). Increased level of ROS can initiate lipid peroxidation which used as an indicator of oxidative stress in cells and tissues and produce reactive carbonyl, mainly malondialdehyde (MDA). Thus, MDA measurement is widely used as an indicator of lipid peroxidation. On the other hand, the risk of oxidative damage can be reduced by antioxidant, one of them is Vitamin E that is a fat-soluble vitamin with high potential antioxidant. The objective of this study was to analyze the effect of the dl-a-tocopherol (Vitamin E) administration on decrease of MDA serum level on pediatric patients with b-thalassemia major. This was a longitudinal observational study design for one group without comparison was conducted to examine the use of vitamin E to decreased MDA serum level on children patients with b-thalassemia major. The inclusion criteria were patients who rely on blood transfusions, patients who received only one type of iron chelating agents during the study period, the clinical condition is stable, agrees, and has completed the informed consent. In the course of the study of 21 patients there were variations in patient compliance in taking vitamin E tablet dosage 200 IU once-daily for one month: only 11 out of 21 patients consumed 30 tablets of vitamin E 200 IU (total dose of 6000 IU) in the 1-month study, and only data from those 11 samples will be analysed further. MDA serum level was measured pre- and post-administration of vitamin E and patient's characteristics of subjects was obtained for additional information. Pre-administration of vitamin E, serum level of MDA was 1239.4 ± 502.55 ng/mL with a range of 216.95 to 2297.3 ng/mL, whereas in the group post administration of vitamin E, MDA serum level was 786.49 ± 704.88 ng/mL with a range of 6.5380 to 1958.6 ng/mL. In conclusion, there was no significant difference in MDA serum level in the group pre- and post- administration of vitamin E (p = 0.15).

ANALYSIS OF NACL-MANNITOL HYDRATION ON RENAL FUNCTION OF HEAD AND NECK CANCER PATIENTS RECEIVING HIGH-DOSE CISPLATIN CHEMOTHERAPY COMBINATION Desiani, Ekanita; Suharjono, Suharjono; Yulistiani, Yulistiani; Susilo, Dwi Hari
Folia Medica Indonesiana Vol. 53 No. 1 (2017): JANUARY - MARCH 2017
Publisher : Universitas Airlangga

Cisplatin is one of platinum cytostatic drug for the medication of solid cancers, one of which is head and neck cancer. Adverse event that resulted during drug treatment was acute or chronic nephrotoxicity. Cisplatin concentration in proximal tubular epithelial cells is about 5 times the serum concentration. Platinum exposure on renal tubular cells bonding covalent complex which stimulate production of inflammatory factors that lead to apoptosis and necrosis cell. Cisplatin nephrotoxicity can be prevented by aggressive hydration or alternate method of administration. The aim of this study was to analyze the effectiveness of NaCl-Mannitol hydration on renal function of head and neck cancer patients receiving cisplatin 100 mg/m2 chemotherapy combination with 5FU or paclitaxel. This was a cohort, prospective, and observational study to analyze renal function of head and neck cancer patients receiving cisplatin 100 mg/m2 chemotherapy combination with 5FU or paclitaxel. Inclusion criteria were BUN 7-18 mg/dl and serum creatinine < 2 mg/dl of any cycle. All patients received infuse NaCl-Mannitol hydration with term that provided in Surgeon Departement of Dr. Soetomo General Hospital. Data obtained were BUN, SCr, and eClCr Cockroft-Gault, each was measured pre- and post-hydration. In cisplatin and 5FU chemotherapy combination value BUN pre-hydration (11,99 + 4,62) mg/dl, value BUN post-hydration (12,14 + 4,74) mg/dl and value serum creatinine pre-hydration (0,97 + 0,34) mg/dl, value serum creatinine post-hydration (1,02 + 0,37) mg/dl. Meanwhile to the combination of cisplatin and paclitaxel chemotherapy, value BUN pre-hydration (10,19 + 2,58) mg/dl, value of BUN post-hydration (10,43 + 2,31) mg/dl and value of serum creatinine post- hydration (0,98 + 0,26) mg/dl. In conclusion, NaCl-Mannitol hydration administration is adequate which is shown by BUN and serum creatinine in pre- and post-hydration data within normal limits.

METHOTREXATE USE IS SAFE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA Utomo, Febriansyah Nur; Yulistiani, Yulistiani; Zairina, Nun; Permono, Bambang
Folia Medica Indonesiana Vol. 53 No. 2 (2017): JUNE 2017
Publisher : Universitas Airlangga

Monitoring level of methotrexate is not only aimed at monitoring effectiveness, but also safety aspects of the administration of high-dose methotrexate because the use of high-dose methotrexate is one of the problems associated with toxicity in various organs. In the use of high-dose methotrexate, measurement of methotrexate is important to identify patients with a high risk of toxicity, particularly nephrotoxicity as well as for dosing guidelines for leucovorin therapy. The aim of this study was to analyze the safety of high-dose methotrexate on kidney function during chemotherapy consolidation phase in children with acute lymphoblastic leukemia. This was a longitudinal, observational prospective study conducted to determine the safety profile of high-dose methotrexate on kidney function during chemotherapy consolidation phase in children with acute lymphoblastic leukemia. Patients who met the inclusion criteria were given high-dose methotrexate according to the 2013 Indonesian ALL Chemotherapy Protocol. Measurement of methotrexate level and kidney function was done 3 times on each cycle of chemotherapy consolidation phase. Measurements were made on the 0, 24 and 48 hours after the first drop of high-dose methotrexate. This study had been reviewed by Ethics Committee of Dr. Soetomo Hospital Surabaya. There were 12 patients who met inclusion criteria and 6 patients among them had finished their chemotherapy consolidation phase completely. There was no significant change in kidney function after the administration of high-dose methotrexate compared to baseline (p>0.05) and there was no significant correlation between serum level of methotrexate versus creatinine clearance. In conclusion, methotrexate was safe to use in children with acute lymphoblastic leukemia.

Analysis of ANC Levels after Filgrastim Therapy in Acute Leukemia Children with Neutropenia Widya, Reta Anggraeni; Nugroho, Susanto; Winarsih, Sri; Yulistiani, Yulistiani
Folia Medica Indonesiana Vol. 55 No. 1 (2019): March
Publisher : Universitas Airlangga

Cytotoxic chemotherapy suppresses the hematopoietic system, and the most serious hematologic toxicity is neutropenia. This can decrease a risk of infection that causes delays in treatment and reduction of dose intensity, which reduces therapeutic outcome. Filgrastim is used to increase neutrophils level whose therapeutic effect is unknown. The effectiveness of filgrastim is based on the ANC level pre- and post-therapy. This study aimed to analyze the use of filgrastim on ANC level changes in acute leukemia children with neutropenia, and to analyze the patient that achieve ANC level's targeted therapy = 1000 cell/mm3. A prospective observational study with a longitudinal design was conducted from June to October 2016. The inclusion criteria of the study were patients who diagnosed acute leukemia with neutropenia and received filgrastim 10 µg/kgBW for 3, 4, 5 days. Patients' ANC levels were measured before and after filgrastim therapy. This study has been approved its ethical clearance by Dr. Saiful Anwar Hospital, Malang. Data were obtained on the basis of neutropenic episodes, followed by 7 episodes of obtaining filgrastim for 3 days, 1 episode of obtaining filgrastim for 4 days, and 7 episodes of obtaining filgrastim for 5 days. Thus, it consists of 15 episodes. In 3 days, ANC levels increased by 9.5 fold from 381.3 ± 91.8 cell/mm3 to 3984.9 ± 426.8 cell/mm3, but in 5 days, ANC levels decreased by 0.9 fold from 200.9 cell/mm3 ± 98.2 to 189.7 ± 14.2 cell/mm3. Filgrastim was able to increased the ANC levels around nine fold for 3 days of theraphy. There were 53% neutropenia patients who achieved the goal of therapy. Filgrastim therapy with dose 10 µg/kgBW for 3 to 5 days has been able to reach the therapeutic target of 53% in acute leukemia children with neutropenia. The increased levels of ANC maximum was reached on the third day with increased levels of 9.5 fold.

Analysis of IFN-gamma and IL-10 Levels as Markers of Inflammation and Response Therapy of Anti-Tuberculosis in MDR Lung TB Patients Setyawati, Herni; Soedarsono, Soedarsono; Yulistiani, Yulistiani; Fatmawati, Umi
Folia Medica Indonesiana Vol. 55 No. 4 (2019): December
Publisher : Universitas Airlangga

Multidrug-Resistant Tuberculosis (MDR TB) is caused by an organism that is resistant to at least isoniazid and rifampisin, the two most potent TB drug. Immune response to against Mycobacterum tuberculosis infection is related to the function of immunity. The function of interferon-Î³ (pro-inflammatory) is to activate macrophages, to stimulate antimicrobial molecules (to reactive oxygen species and nitric oxide), and to inhibits interleukin-10. Interleukin-10 function is to triggers humoral immunity, to inhibit IFN- Î³. This study aimed to analyze level changes and the correlation with clinical data, also months of MDR TB patients who received standard OAT therapy. This was an observational study using cross sectional design. There were 29 patients who received standard MDR TB OAT therapy from 1-24 months, who met the inclusion criteria. Then, the patients were divided based on duration of the therapy, which are the initial/intensive and advanced phase. The initial phase divided into 2: first one is for 1-4 months therapy's time (5 patients) and the second one is for more than 4-8 months (6 patients). Then, the advanced group divided into two groups again, which are third group with more than 8-16 months (13 patients) and fouth group with more than 16-24 months (5 patients). Then, measured serum concentration IFN-Î³, IL-10 at the start of the study and 4 weeks later with the ELISA method. This research during the period July-December (6 months). IFN-Î³ post concentrations were decreased by 39.14 ± 139.12 pg/mL (p > 0.05). The concentration of IL-10 was decreased by 33.93 ± 109.20pg/mL (p>0.05). Based on the TB score bandim method during pre and posts results were 1 patient experienced severity change from severity class 1 to 2, 1 patient from severity class 2 to 1, 1 patient remained in severity 2 and 26 patient remained in severity 1. The results showed that serum IFN-Î³ and IL-10 levels in initial/intensive and advanced phase patients who received MDR TB regiment after four weeks did not changed,

Effectivity of Erythropoietin-Alpha between Fixed- and Adjusted-Dose in Chronic Kidney Disease Patients With Anemia on Hemodialysis Purwiningtyas, Mida; Yulistiani, Yulistiani; Suprapti, Budi; Santi, Bayu Dharma
Folia Medica Indonesiana Vol. 55 No. 4 (2019): December
Publisher : Universitas Airlangga

Anemia is a common complication in chronic kidney disease (CKD) patient with hemodialysis. The cause of anemia is mainly due to erythropoetin deficiency because the kidneys as a erythropoetin producer are damaged. The most appropriate management of anemia in CKD with hemodialysis is the administration of Erythropoietin Stimulating Agent (ESA) or erythropoetin (Epo). The effectiveness of Epo therapy is influenced by the type of Epo used, the dose of Epo given, the route and frequency of Epo administration, as well as several conditions that affect it such as infection or inflammation, absolute and functional iron deficiency, and malnutrition. Therapeutic targets can be achieved if the dose given is in accordance with the needs of the patient, based on the patient's weight The purpose of this study was to determine the differences in the achievement of Epo-alpha fixed-dose administration compared with adjustment-dose in patients with CKD anemia with hemodialysis after administration of Epo-alpha for 4 weeks in outpatient poly hemodialysis units at Bhayangkara H.S Hospital. Samsoeri Mertojoso Surabaya. In this study, there were 20 patients who met the inclusion criteria (15 male and 5 female) divided into 2 groups, 10 patients in the fixed-dose group and 10 patients in the adjustment-dose group. In the fixed-dose group with a adequacy level of 132.25 ± 29.17, the average Hb change achievement was 0.68 ± 0.63 g / dL (p=0.008), whereas in the adjustment-dose group the achievement of the average Hb change the mean was 1.09 ± 0.82 g / dL (p=0.002). For the Hct parameter, the average Hct change in the fixed-dose group was 2.77 ± 2.23% (p=0.004), while in the adjustment-dose group the average Hct change achievement was 4.02 ± 2.63 g / dL (p=0.001). There was no difference in the achievement of the effectiveness of Epo on the two parameters Hb (p=0.224) and Hct (p=0.256) in the fixed-dose group compared with adjustment-dose.

Syndrome Serotonin Warni, Asri Indahning; Yulistiani, Yulistiani
Eduvest - Journal of Universal Studies Vol. 5 No. 6 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i6.50097

Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are prevalent mental health conditions often treated with antidepressants, including SSRIs, SNRIs, tricyclic antidepressants, and benzodiazepines. However, abrupt discontinuation or rapid dose reduction of these medications can lead to withdrawal syndromes, ranging from somatic symptoms like dizziness and nausea to psychological effects such as mood swings and suicidal thoughts. This study examines withdrawal events associated with various antidepressants, emphasizing the need for effective health management strategies. The research aims to review withdrawal symptoms across antidepressant classes, identify high-risk medications, and explore alternative tapering methods such as hyperbolic dose reduction. A systematic literature review analyzed clinical studies, case reports, and patient surveys to evaluate withdrawal prevalence, symptom severity, and duration. Findings indicate that short half-life antidepressants (e.g., paroxetine, venlafaxine) pose elevated withdrawal risks, with symptoms persisting from weeks to years. Hyperbolic tapering demonstrated reduced severity in cases like escitalopram withdrawal. Persistent post-withdrawal disorders, including post-SSRI sexual dysfunction (PSSD), were documented. The research underscores the importance of structured discontinuation protocols and clinician awareness in mitigating withdrawal effects within healthcare systems. Implications highlight the necessity for evidence-based clinical guidelines on antidepressant tapering and enhanced patient education initiatives to prevent non-compliance and abrupt cessation. Future research should investigate long-term outcomes of withdrawal management strategies in diverse care settings.

Implementasi Pembelajaran Islam Moderat Berbasis Kearifan Lokal di SMK Madura Yulistiani, Yulistiani; Shohib, Muhammad
TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora Vol 6, No 2 (2025)
Publisher : Universitas Nurul Jadid

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33650/trilogi.v6i2.11322

This study investigates how moderate Islamic education is implemented through local wisdom at SMK Az-Harul Ulum at SMK Az-Harul Ulum Gunung Rancak. The significance of this research is grounded in The urgency of promoting moderate Islamic education in Madura stems from the need to counter rising ideological rigidity and preserve the region’s strong tradition of tolerance and local wisdom and intolerance, as well as the role of local wisdom in strengthening students’ cultural identity and character. This study employs a qualitative approach with a case study design. with 10 teachers and 25 students from March to June 2024 with teachers, students, and school administrators, as well as through analysis of curriculum documents and learning materials. The data analysis technique used is thematic analysis to identify patterns and meanings within the collected data. The results of this research are expected to provide a comprehensive understanding of the implementation of the learning model, its challenges and supporting factors, as well as its impact on students’ understanding and internalization of moderate Islamic values and local wisdom at SMK Az-Harul Ulum Gunung Rancak. This research has the potential to contribute to the development of a model of moderate Islamic education that is relevant to the local cultural context.

An Updated Review of Goserelin as Ovarian Protection in Premenopausal Breast Cancer Berliana, Dini; Yulistiani, Yulistiani
Riwayat: Educational Journal of History and Humanities Vol 6, No 4 (2023): Educational, Historical Studies and Humanities
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jr.v6i4.36208

Premenopausal breast cancer is a serious medical challenge, with treatment focusing on inhibiting estrogen production to stop the growth of cancer cells. Goserelin, a gonadotropin hormone (GnRH) agonist, has been used to protect the ovaries and reduce estrogen levels in premenopausal women undergoing breast cancer therapy. Previous studies have provided evidence of Goserelin's efficacy and safety, but understanding continues to evolve. Therefore, we conducted this study to provide a recent update on the role of Goserelin in ovarian protection in premenopausal breast cancer. This study is an updated review that summarizes the relevant scientific literature on the use of Goserelin in ovarian protection in premenopausal breast cancer. We examined clinical research, randomized trials, and observational studies published in several leading academic databases. The results of these studies were analyzed and organized in the context of ovarian protection and therapeutic effects on patients. A review of the literature indicates that Goserelin remains an effective option in reducing estrogen levels in premenopausal women with breast cancer. Recent studies show continuity in Goserelin's role in reducing the risk of ovarian failure and side effects associated with estrogen inhibition, such as premature menopause. Apart from that, giving Goserelin in the form of monthly and 3-monthly implants is equally effective in controlling estrogen levels.

Analysis of Short Term Funding with Mudharabah Agreements in Bank Syariah Indonesia (Study on Indonesian Sharia Bank KC Jambi Gatot Subroto) Anggraini, Dian Septi; Siregar, Erwin Saputra; Yulistiani, Yulistiani; Mellyani, Netty Purnama Sari; Rusmiyati, Melly; Assaidiqi, M. Irfan; Nazori, Nazori
International Journal of Economics (IJEC) Vol. 3 No. 2 (2024): July-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijec.v3i2.691

This research discusses the Analysis of Short-Term Funding with Mudharabah Agreements at Indonesian Sharia Banks (Study at the Jambi Gatot Subroto Branch Office Sharia Bank). The aim of this research is to describe the causes of the decline in the level of mudharabah financing in 2020 and the reasons why short-term funding in mudharbah contracts is less banking friendly due to the complexity and many requirements for MSMEs. This research is field research using descriptive qualitative methods. Data collection involves observation, interviews and documentation. Test the validity of this research using triangulation techniques. The subjects in this research were Bank Syariah Indonesia Jambi Gatot Subroto Branch Office. The results of this research show that there are two factors causing the decline in mudharabah financing in 2020, namely internal and external factors, internal factors include ineffective risk management, inefficient operational management, and declining service quality. External factors include the COVID-19 pandemic and the unreliability of customers in mudhrabah financing. The factors that cause short-term funding at Bank Syariah Indonesia Jambi Gatot Subroto Branch Office to be less banking friendly towards MSMEs are internal factors including fairly strict risk policies, complicated requirements, and a lack of understanding about MSMEs. External factors include a lack of support infrastructure such as providing business training with short-term funding.

Co-Authors A.A. Ketut Agung Cahyawan W Agus Sulistyono Amir, Nur Rezky Rutami Anggraini, Dian Septi Assaidiqi, M. Irfan Bagus PP Suryana, Bagus PP Bambang Permono Berliana, Dini Budi Suprapti Darto Saharso Desantika Wuryana, Desantika Desiani, Ekanita Dwiyatna, Surya Erwin Saputra Siregar Gustaji, F Herni Setyawati Karisma, R F Mariyatul Qibtiyah Melawati Olevianingrum, Melawati Mellyani, Netty Purnama Sari Mia Ratwita Andarsini Muhammad Shohib, Muhammad Muhammad Yahya Nazori, Nazori Nisriyati Fiddina Nun Zairina, Nun Permanasari, Ayu Ratna Purwiningtyas, Mida Rahmadani, Rizal Umar Rana, Rana Rismayanti, Levana Rusmiyati, Melly Santi, Bayu Dharma Simbolon, Octaviana Soedarsono Soedarsono Sri Winarsih Styawati, Styawati Suharjono, Suharjono Susanto Nugroho Susilo, Dwi Hari Ugrasena, I DG UMI FATMAWATI Utomo, Febriansyah Nur WAHYU WIBISONO Warni, Asri Indahning Widya, Reta Anggraeni Widya, Reta Anggraeni

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