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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Molecular and Cellular Biomedical Sciences (MCBS) Smart Medical Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Mandala Pharmacon Indonesia BERDAYA: Jurnal Pendidikan dan Pengabdian Kepada Masyarakat International Journal of Applied Technology Research Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora International Journal of Economics (IJEC) Sciences of Pharmacy Eduvest - Journal of Universal Studies Riwayat: Educational Journal of History and Humanities Jurnal Informatika: Jurnal Pengembangan IT Folia Medica Indonesiana
Yulistiani Yulistiani, Yulistiani
Mahasiswa Jurusan Perencanaan Wilayah dan Kota, Fakultas Teknik, Universitas Diponegoro
Aerospace Engineering Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Genetic Polymorphism of N-acetyltransferase 2 (NAT2) among Patients with Tuberculosis: A Scoping Review of the Indonesian Studies Putra, Oki Nugraha; Ramadhani, Sylvia Rizki; Yulistiani, Yulistiani; Julaeha, Julaeha; Hidayatullah, Affan Yuniar Nur
Sciences of Pharmacy Volume 5 Issue 2
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501599

Abstract

The distribution of N-acetyltransferase-2 (NAT2) genetic polymorphisms varies across ethnic groups among Indonesian TB patients. This review aimed to provide a comprehensive understanding of the prevalence of NAT2 genetic polymorphisms and their association with DILI and isoniazid pharmacokinetics in Indonesian TB patients. A scoping review was conducted by searching Google Scholar, Scopus, and PubMed in accordance with PRISMA guidelines for scoping review (PRISMA-ScR). We retrieved 668 studies from three databases and we enrolled 12 studies for final analysis. Eleven studies reported on adult TB patients and one study on pediatric TB patients. Overall, the available evidence suggests that the slow acetylator phenotype is relatively common among TB patients in Indonesia, although its distribution varies across regions and ethnic groups. The NAT2*6 polymorphism was frequently observed among TB patients with a slow acetylator phenotype. TB patients with slow acetylation exhibited higher serum concentrations of isoniazid, which were significantly associated with an increased risk of DILI. No studies reported an association between NAT2 genetic polymorphisms or acetylation status and treatment outcomes among TB patients. This review confirms substantial variation in NAT2 genetic polymorphisms across studies in Indonesia. TB patients with a slow acetylator phenotype appear to have a greater risk of developing DILI compared with those with intermediate or fast acetylator phenotypes. Information on acetylator status may identify patients at higher risk of hepatotoxicity, particularly those with the slow acetylator phenotype. Therefore, integrating NAT2 pharmacogenetics into clinical practice may predict hepatotoxicity and optimize tuberculosis therapy.
Prescribing Patterns of Antipsychotics in Schizophrenia Patients: A Study at Sikumana and Oesapa Primary Health Centers Nesimnasi, Reinaldo Erasmus; Puspitasari, Hanni Prihhastuti; Yulistiani, Yulistiani
Smart Medical Journal Vol 8, No 3 (2025): December
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v8i3.109562

Abstract

Introduction: Schizophrenia is a chronic mental disorder with a rising prevalence, including in East Nusa Tenggara. Antipsychotics are the mainstay therapy, but prescribing patterns in primary care vary depending on patient condition and drug response. This study aimed to describe the prescribing patterns of antipsychotics among schizophrenia patients at Sikumana and Oesapa Primary Health Centers, Kupang City.Methods: A non-experimental descriptive design was applied using retrospective data from medical records of schizophrenia patients (ICD-X F20) during February–July 2025. Inclusion criteria consisted of patients who received antipsychotic therapy at both of two Primary Health Centers. Exclusion criteria included patients referred to higher-level facilities before receiving antipsychotic treatment.Results: A total of 42 patients with 129 visits were analyzed, dominated by males (52.4%) and the 25–44 age group (59.5%). Most were chronic patients (88.1%). Of 129 prescriptions, monotherapy predominated (57.4%), dominated by haloperidol (45 times) and risperidone (21 times). Combination therapy was also common (42.6%), particularly chlorpromazine + risperidone (29 times) and chlorpromazine + haloperidol (24 times). Trihexyphenidyl (103 times) was frequently prescribed as prophylaxis against extrapyramidal side effects, while diazepam (17 times) was used for anxiety or sleep disturbances. Several drugs were prescribed at lower doses than national and international guidelines, reflecting stable patient conditions in primary care, where lower doses remained effective while minimizing adverse effects.Conclusion: These findings highlight the dominance of typical antipsychotics and the limited variety of available drugs in primary care, underscoring the need for broader drug availability and more systematic monitoring of side effects.
Co-Authors A.A. Ketut Agung Cahyawan W Aghnia Fuadatul Inayah Agus Sulistyono Alfatihah, Humaira Izka Amarullah, Adinugraha Anggraini, Dian Septi Anisa Anisa Asmaningsih, Ninik Assaidiqi, M. Irfan Aulia, Natasya Budi AYU RATNASARI Ayuningsih, Nenden Maida Bagus PP Suryana, Bagus PP Bambang Permono Berliana, Dini Budi Suprapti Darto Saharso Desantika Wuryana, Desantika Didik Hasmono Dwiyatna, Surya Ekanita Desiani Erwin Saputra Siregar Fadhillah, Jenisa Nadhia Gustaji, F Herni Setyawati Herwati, Teri Wina Hidayatullah, Affan Yuniar Nur Julaeha, Julaeha Juwita, Dina Ratna Karisma, R F M, Eddy Zarkaty Mamo, Hendriette Irene Mariyatul Qibtiyah Markus, Unedo H Marpatmawati, Idhfi Melawati Olevianingrum, Melawati Mellyani, Netty Purnama Sari Meti Kusmiati, Meti Mia Ratwita Andarsini Muhammad Shohib, Muhammad Muhammad Yahya Muzayyanah, Binti Nazori, Nazori Nesimnasi, Reinaldo Erasmus Ningsih, Ernawati Nisriyati Fiddina Nun Zairina, Nun Nur ‘Azah Oktavia, Nur Permanasari, Ayu Ratna Pratama, Muhammad Diva Purwiningtyas, Mida Puspitasari, Hanni Prihhastuti Putra, Oki Nugraha Rahmadani, Rizal Umar Ramadhani, Sylvia Rizki Rana, Rana Rismayanti, Levana Robbany, Gianova Akhsan Rusmiyati, Melly Santi, Bayu Dharma Setyani, Dessy Surya Simbolon, Octaviana Soedarsono Soedarsono Sri Winarsih Styawati, Styawati Suharjono Susanto Nugroho Susilo, Dwi Hari Tyas Angganawati, Rahmadhani Ugrasena, I DG Ugrasena, IGD UMI FATMAWATI Utomo, Febriansyah Nur WAHYU WIBISONO Warni, Asri Indahning Widya, Reta Anggraeni Widya, Reta Anggraeni Wisudani, Nuraida Yuniartina, Gina