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Fahrudin Arif
Universitas Muhammadiyah Kudus
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HUBUNGAN FAKTOR PENDIDIKAN TERHADAP PENGETAHUAN DAN PERILAKU PENGOBATAN SWAMEDIKASI DISMENORE Bita Yulia Maharani; Etikasari, Ria; Arif, Fahrudin
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.48694

Abstract

Dismenore merupakan salah satu masalah yang umum dialami oleh gadis remaja, gejala yang sering terjadi pada saat dismenore kram di perut bagian bawah yang disertai gejala seperti mual, muntah, pusing, dan sakit kepala. Faktor pendidikan berperan penting dalam menentukan tingkat pengetahuan dan perilaku swamedikasi dismenore tersebut. Penelitian ini bertujuan untuk mengetahui hubungan faktor pendidikan terhadap pengetahuan dan perilaku swamedikasi pada wanita yang mengalami dismenore.. Metode penelitian bersifat observasional kuantitatif dengan pendekatan cross sectional yang dilaksanakan pada bulan Mei 2025. Jumlah subjek penelitian sebanyak 325 responden yang didapat melalui teknik purposive sampling. Kriteria inklusi mencankup : berusia 16 – 27 tahun, menempuh pendidikan SMP, SMA dan tamat SMA, mempunyai pengalaman dismenore, pernah melakukan swamedikasi, dan bersedia menjadi responden telah mengisi kuesioner dan menandatangani lembar informed consent hingga selesai. Hasil responden memiliki pengetahuan dalam kategori cukup sebanyak 70,8 %. Responden yang memiliki perilaku swamedikasi pengobatan dismenore juga dalam kategori cukup 73,5 %. Hasil uji chi-square menunjukkan adanya hubungan yang signifikan antara pendidikan terhadap pengetahuan serta perilaku (p = 0,000) dan hasil uji ANOVA dua jalan juga menunjukan bahwa terdapat hubungan yang signifikan pendidikan terhadap pengetahuan dan perilaku swamedikasi dismenore (p = 0,000). Kesimpulan terdapat hubungan yang signifikan antara faktor pendidikan terhadap pengetahuan serta perilaku swamedikasi dismenore.
PENGARUH KONSENTRASI EKSTRAK KOMBINASI DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DAN BERAS (Oryza sativa) PADA SEDIAAN KRIM TERHADAP SIFAT FISIK DAN AKTIVITAS ANTIBAKTERI Staphylococcus aureus Rahma, Siti Sofia; Fadel, Muhammad Nurul; Arif, Fahrudin
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.49439

Abstract

Diabetes melitus (DM) disebabkan oleh hiperglikemia, metabolisme protein, karbohidrat dan lemak yang tidak normal, sekresi insulin dan juga dapat diakibatkan oleh keturunan atau genetik. Penderita diabetes bila dibiarkan tanpa pengobatan yang tepat dapat memicu berbagai macam komplikasi, diantaranya ulkus diabetikum yang di akibatkan oleh bakteri Staphylococcus aureus. Keparahan pada ulkus diabetikum dapat menyebabkan amputasi. Penelitian ini bertujuan untuk mengevaluasi efektivitas sediaan krim kombinasi daun binahong dan beras dengan konsentrasi ekstrak 5%:15%, 10%:10%, 15%:5% dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Metode penelitian yang digunakan yaitu metode eksperimental dengan pengujian pH, homogenitas, daya sebar, daya lekat dan uji antibakteri dengan difusi cakram. Hasil menunjukkan bahwa formula F3 (15% binahong : 5% beras) memiliki zona hambat antibakteri paling luas (8,9 mm), termasuk kategori sedang, dan nilai pH dalam rentang aman untuk kulit. Formula ini juga memenuhi kriteria fisik sediaan krim topikal. Dengan demikian, kombinasi ekstrak daun binahong dan beras berpotensi sebagai alternatif pengobatan topikal luka infeksi diabetes.
FORMULASI SEDIAAN LIP BALM KULIT MANGGIS (Garcinia mangostana L.) SEBAGAI ANTIOKSIDAN Sakna Binta Munaya; Endang Setyowati; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1624

Abstract

Lip balm is a cosmetic preparation designed to help protect, nourish, and moisturize the lips. This study utilizes mangosteen peel extract (Garcinia mangostana L.), which is rich in antioxidants, as the active ingredient in lip balm formulations. The aim of the study is to evaluate the physical quality and antioxidant activity of five lip balm formulas containing varying concentrations of mangosteen peel extract (10%, 15%, 20%, 25%) and one comparison formula containing 10% vitamin C. Physical quality tests included organoleptic evaluation, homogeneity test, and pH measurement. In addition, antioxidant activity was assessed using the DPPH method, along with skin irritation and user preference tests. The results showed that all lip balm formulas exhibited good organoleptic characteristics and homogeneity, with pH values ranging from (4.5 to 6.5). Irritation tests revealed no negative skin reactions. User preference tests indicated that Formulas F3 and F4 were the most favored in terms of texture, aroma, and comfort of use. The highest antioxidant activity was observed in Formula F5 (IC₅₀ = 46.6 µg/mL), followed by F4 (64.3 µg/mL), F3 (101 µg/mL), F2 (112 µg/mL), and F1 (113 µg/mL). These findings demonstrate that mangosteen peel extract can be successfully formulated into lip balm products that meet physical quality standards and exhibit significant antioxidant activity. The formula containing 25% extract (F4) showed the most optimal overall performance among the tested formulations.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK BIJI KAPUK RANDU (Ceiba pentandra (L) Gaertn) DENGAN METODE DPPH Ariyanis Salma; Endang Setyowati; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1626

Abstract

Kapuk randu (Ceiba pentandra (L). Gaertn) is a plant that is widely found in Indonesia and has long been used in traditional medicine. The seeds of this plant are known to contain various secondary metabolite compounds such as alkaloids, flavonoids, saponins, tannins and phenolics that have the potential to be antioxidants. This study aims to identify the compounds contained in randu kapok seeds and evaluate their potential antioxidant activity. The research method involves the extraction of kapuk seeds using maceration with 70% ethanol solvent. Furthermore, qualitative phytochemical screening is carried out to identify groups of compounds such as alkaloids, saponins, flavonoids, tannins, and phenolics. The antioxidant activity test was carried out using the DPPH method with concentration variations of 40, 80, 120, 160, and 200 ppm. The results of phytochemical screening showed that randu kapok seed extract was positive for alkaloid and flavonoid compounds. Antioxidant activity testing yielded an average IC50 value of 276.5 μg/mL. Based on categorization, the IC50 value indicates that randu kapuk seed extract has very weak antioxidant activity.
TINGKAT KEPATUHAN PENGGUNAAN ALLOPURINOL 100 MG TERHADAP KUALITAS HIDUP PASIEN GOUT DI DESA DONOREJO, KARANG TENGAH, DEMAK, JAWA TENGAH Ayu Aprilia Atika Sari; Eko Retnowati; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1639

Abstract

Gout is a metabolic disorder that results in chronic accumulation of excess uric acid in the blood/hyperuricemia, resulting in the accumulation and formation of uric acid crystals abnormally in the intra-articular space. One of the risk factors that can cause an increase in the incidence of morbidity and mortality of gout sufferers is patient non-compliance in taking anti-gout medication. Anti-gout treatment must be carried out routinely to improve the patient's quality of life. This research to analyze the level of compliance with the use of allopurinol 100 mg on the quality of life of gout patients in Donorejo Village, Karang Tengah, Demak, Central Java. This study is a non-experimental observational study with a cross-sectional research approach. The sample in this study were gout sufferers in the last 3 months, namely June - August 2025 in Donorejo Village, Karang Tengah, Demak, Central Java, namely 105 respondent samples. The sampling technique in this study used a total sampling approach. The data used in the study were primary data in the form of MMAS-8 and WHOQOL-BREF questionnaires, as well as secondary data in the form of medical records of gout patients. Bivariate analysis was performed using the Chi-square (x2) test. Post-test medication adherence showed that the majority of respondents had a high level of medication adherence, with 77 respondents (73.3%). The post-test Chi-square test obtained a P-value of 0.000, indicating that Ho was rejected and Ha was accepted. This indicates a relationship between adherence to 100 mg allopurinol and the quality of life of gout patients in Donorejo Village, Karang Tengah, Demak, Central Java. The Odd Ratio value obtained was 57.061, indicating that adherence to 100 mg allopurinol in compliant gout patients had a 57.061 times better quality of life than non-compliant gout patients.
FORMULASI DAN UJI STABILITAS FISIK DEODORAN SPRAY KOMBINASI EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) DAN DAUN BELIMBING WULUH (Averrhoa bilimbi L) SEBAGAI ANTIBAKTERI TERHADAP Staphylococcus aureus Anisa Nurjanah; Zaenal Fanani; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 4 (2025): Nusantara Hasana Journal, September 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i4.1688

Abstract

Body odor problems triggered by the activity of bacteria such as Staphylococcus aureus are a concern in tropical regions such as Indonesia, which have high temperatures and humidity. Long-term use of synthetic chemical deodorants carries the risk of side effects, so safe and effective natural alternatives are needed. This study aims to formulate and evaluate the physical stability and antibacterial effectiveness of a spray deodorant preparation made from a combination of red betel leaf extract (Piper crocatum Ruiz and Pav.) and starfruit leaf extract (Averrhoa bilimbi L.). The extract was obtained through a maceration method with 70% ethanol as a solvent. This study used a laboratory experimental design with a quantitative approach. The study population was a spray deodorant preparation formulated in four variations: F0 (Negative control), F1 (7.5% red betel leaf + 2.5% starfruit leaf), F2 (5% + 5%), and F3 (2.5% + 7.5%). Physical stability tests included organoleptic tests, pH, displaced volume, and homogeneity. Antibacterial activity test was carried out using the well diffusion method against Staphylococcus aureus ATCC 25923. Data analysis was performed using normality test, homogeneity test, and one-way ANOVA test, and Tukey HSD post-hoc test. The results showed significant differences between treatment groups, but no significant differences between test formulas. All formulas met physical stability standards and showed strong antibacterial activity (inhibition zone 12.1 -14.37 mm). Formula F2 showed the highest inhibition, indicating a synergistic effect of a balanced extract ratio. This study contributes to the development of natural spray deodorant products that are safe, effective, and have the potential to replace synthetic ingredients in pharmaceutical formulations.
Formulation and Physical Evaluation of Liquid Shampoo Combining Patchouli Leaf Extract and Coconut Oil as an Antidandruff Shampoo Wahyuni, Risma Sri; Hasriyani, Hasriyani; Arif, Fahrudin
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.516

Abstract

Purpose: Dandruff is a scalp condition that affects approximately 50% of the global population and 26% of the population in Indonesia. This study aims to formulate and evaluate various formulations of liquid shampoo containing a combination of patchouli leaf extract (Pogostemon cablin Benth.) and coconut oil as an alternative natural-based anti-dandruff shampoo. Research Method: This study used a quantitative approach with an experimental design. The formulation consisted of a combination of patchouli leaf extract at concentrations of 0.5%, 0.75%, and 1% and coconut oil at concentrations of 2%, 3%, and 4%. Quality evaluation was conducted through organoleptic testing, homogeneity testing, pH measurement, foam height measurement, viscosity measurement, and skin irritation testing on 15 respondents. Results and Discussion: All formulas (F0, F1, F2, F3) meet the physical quality criteria for shampoo. Organoleptic testing indicates that the formula has a thick liquid consistency, is homogeneous, and ranges in color from clear to dark green, with a green tea aroma. The average pH is within the safe range (6.75–5.31). Foam height and viscosity are within normal limits, and no respondents reported any irritation complaints. Implications: The formulation of liquid shampoo combining patchouli leaves and coconut oil can be a potential solution in the development of safe, natural-based anti-dandruff products. This study provides scientific contributions to the herbal cosmetics industry in Indonesia.
Formulation and Efficacy Test of Antistress Aromatherapy Candle with Jasmine Essential Oil (Jasminum sambac L) on Mice (Mus musculus) Febrianti, Noor Alfina; Rahmawati, Riana Putri; Arif, Fahrudin
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.521

Abstract

Purpose: Aromatherapy is a non-pharmacological healing method that uses essential oils as therapeutic agents. Jasmine flowers (Jasminum sambac L.) contain active compounds such as linalool, benzyl acetate, methyl salicylate, cis-jasmone, nerolidol, and indole that have potential applications in stress management. This study aims to investigate the antistress efficacy of aromatherapy candles made from jasmine essential oil on mice (Mus musculus). Research Method: This study employed a laboratory experiment with a post-test-only control group design. A total of 25 male mice were divided into five groups, each consisting of five mice. The treatment groups were exposed to aromatherapy candles with essential oil concentrations of 2%, 4%, and 6%, while the control groups included a negative control and a positive control. Stress induction was performed using the Tail Suspension Test (TST), and effectiveness was assessed through immobility time parameters. Data analysis was conducted using a One-Way ANOVA test. Results and Discussion: The results indicate that the wax formula with a concentration of 6% has the best physical characteristics and provides the fastest relaxation effect. The ANOVA test reveals a significant difference between groups (p < 0.05), indicating a significant effect of aromatherapy wax on stress reduction in mice. Implications: This study reinforces the potential of jasmine essential oil-based aromatherapy candles as an alternative therapy for stress management, while also supporting the development of safe and effective, naturally based health products.
Analisis Kemometrika Kandungan Fitokimia dan Uji Anti Acne Ekstrak Etanol 70% dan Etil Asetat Daun Alpukat : (Persea Americana Mill) Pramesti Anggun Asyifa; Endang Setyowati; Fahrudin Arif
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7566

Abstract

Human skin requires care to prevent and treat acne caused by Propinobacterium acnes bacteria. Researchers are exploring the use of avocado leaves as a natural therapy to treat acne. Avocado leaves contain antibacterial and anti-inflammatory compounds such as flavonoids, saponins, and alkaloids. This study aims to measure the total flavonoid and phenolic content in extracts obtained with 70% ethanol and avocado ethyl acetate and analyze their anti-acne activity. Total flavonoids were determined using a reagent consisting of 10% AlCl3 and 5% acetic acid. Total phenolic determination was carried out using the Folin-Ciocalteu reagent with gallic acid as a reference standard. Measurement of phytochemical levels used the UV-Vis spectrophotometry method. Antibacterial testing was carried out using Staphylococcus aureus bacteria with concentrations of 12%, 14%, and 16%. The positive control used clindamycin. The negative control used 10% DMSO. The disc diffusion method was used to observe the inhibition zone in this study. The results of this study will be processed using chemometrics to analyze complex chemical data. The data results showed that 70% ethanol extract produced total flavonoid levels of 8.6954% mgEK/mL and total phenolics of 15.4385% mgEAG/mL, higher than ethyl acetate extract with total flavonoid results of 3.418% mgEK/mL and total phenolics of 4.6052% mgEAG/mL. The results of antibacterial activity at concentrations of 12%, 14%, 16%, 70% ethanol extract were 10.5±0.70 mm; 12.1±0.28 mm; 14.3±0.57 mm, respectively, which had higher activity than ethyl acetate extract with results of 9.1±0.28 mm; 10.5±0.5 mm; 12.3±0.57 mm, the highest antibacterial activity at a concentration of 16%. Chemometric analysis using Principal Component Analysis (PCA) showed a strong positive correlation between phytochemical content and antibacterial activity. The highest antibacterial activity was found in the 70% ethanol extract at a concentration of 16%.
Uji Aktivitas Lilin Aromaterapi Daun Sereh (Cymbopogon Citratus) terhadap Tingkat Stres Mencit (Mus Musculus) Rahmawati, Riana Putri; Murharyanti, Rika; Arif, Fahrudin; Isnaini, Ratna Dewi; Hardiani, Elia
Prosiding University Research Colloquium Proceeding of The 16th University Research Colloquium 2022: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Stres adalah respon tubuh yang tidak spesifik terhadap setiap kebutuhan tubuh yang terganggu, yang terjadi dalam kehidupan sehari-hari dan tidak dapat dihindari, setiap orangmengalaminya, stres memberi dampak secara total pada individu yaitu terhadap fisik,psikologis, intelektual, sosial dan spiritual, Tanaman sereh (Cymbopogon citrus) terutama batang dan daun bisa dimanfaatkan aromaterapi karena mengandung zat-zat seperti geraniol, sitronelal, sitronelol yang merupakan komponen dari minyak atsiri. Proses relaksasi akan berefek pada jalur neural dan neuroendokrin dibawah kontrol hipotalamus akan lebih cepat diaktifkan. Tujuan dalam penelitian ini yaitu untuk mengetahui aktivitas lilin aromaterapi daun sereh (Cymbopogon citratus) terhadap stress mencit (Mus musculus) pada masing-masing konsentrasi. Penelitian ini menggunakan metode eksperimental laboratorium dengan metode post-test only with control group design. Analisis statistik dilakukan dengan menggunakan perangkat lunak (SPSS) dengan uji statistik (ANOVA) dilanjutkan dengan uji post hoc. Hasil uji pemberian lilin aromaterapi daun sereh (Cymbopogon citratus) terhadap mencit (Mus musculus) yang telah di streskan pada konsentrasi 3% didapatkan hasil rata-rata 17,4 menit. Konsentrasi 5% didapatkan hasil rata-rata 12,4 menit. Konsentrasi 7% didapatkan hasil rata-rata 7 ,4 menit. Kontrol positif menggunakan lorazepam 2mg hasil yang didapat setelah mencit (Mus musculus) di streskan dengan hasil rata-rata 5,2 menit. Semakin tinggi konsentrasi lilin aromaterapi daun sereh (Cymbopogon citratus) maka semakin cepat efek relaksasi yang didapatkan dan konsentrasi yang paling optimal yaitu konsentrasi 7%.
Co-Authors AHMAD ROYKHAN Akhyasin Akhyasin Alviona, Juana Della Anisa Nurjanah Ardiansyah, M. Yusuf Ari Simbara, Ari Ariyanis Salma Ayu Aprilia Atika Sari Bita Yulia Maharani Chabibah, Chabibah Dwi Shara, Wahyu Mega Eka Putri, Radya Rahma Desy Eko Retnowati Elia Hardiani Endang Setyowati Etikasari, Ria Febrianti, Noor Alfina Ferliano Miko Fachriansyah Firdiansyah, Moh. Rofiqi Fitri Apriliyani GALIH KURNIAWAN Hardiani, Elia Hasriyani Hasriyani, Hasriyani Isnaini, Ratna Dewi Joko Pramono Lestari, Leni Angga Mafitri, Hanifah Miftah Muhamad Khudzaifi Muhammad Nurul Fadel Murharyanti, Rika Mustofa, Mochamad Charis Pramesti Anggun Asyifa Purwantoro, Guntur Rahma, Siti Sofia Rahmawati, Riana Putri Ratna Dewi Isnaini Riana Putri Rahmawati Riana Putri Rahmawati Rika Murharyanti Sakna Binta Munaya Salsabila Khairunnisa Santi Dwi Rahayu Setyaningrum, Intansari Wahyuni, Risma Sri Wibowo, Teguh Setiawan Wijaya, Nadela Wahyu Zaenal Fanani