Background: Postpartum is a critical period in a woman's life where several problems can occur. One of them is related to the postpartum sexual function index, which can have a negative impact resulting in sexual dysfunction for women. Sexual function is multifactorial, meaning biological, psychological, and social factors can affect a woman's sexual performance. Postpartum low sexual function index has been associated with several risk factors, namely type of delivery, parity, breastfeeding, postpartum depression, family income, and length of the marriage. This study analyzed the risk factors affecting the postpartum sexual function index. Methods: The Analytical survey method with a Cross-sectional study design was used in this study. The research sample consisted of 134 postpartum women at the Andalas Community Health Center in Padang selected by Proportional random sampling. Statistical analysis Chi-square test determines the relationship between the two research variables. Results: Postpartum depression is reported that there was a significant relationship with the postpartum sexual function index. Women with depressive symptoms had a risk of 4.144 times having a low sexual function index after delivery (p=0.002; OR=4.144; CI 95%=1.736-9.889). Statistical analysis showed that there was no significant relationship between the type of delivery (p=0.731), parity (p=0.549), breastfeeding (p=0.847), family income (p=0.688), and length of the marriage (p=0.864) with the postpartum sexual function index. Conclusion: According to the study's findings, postpartum depression is a risk factor that may impact the postpartum sexual function index. Through this study, it is expected to increase the insight and information about sexual health for the family sector in the work area of Andalas Community Health Center and to educate the wider community. This study is also expected to be an input in providing health services by carrying out early detection and prevention of sexual health problems.