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All Journal E-Jurnal Medika Udayana Indonesian Journal of Biotechnology WMJ (Warmadewa Medical Journal) International Journal of Community Service Learning Journal of Health Sciences Jurnal Peduli Masyarakat Indonesian Journal of Multidisciplinary Science Aesculapius Medical Journal Warmadewa Minesterium Medical Journal Abdi Widya: Jurnal Pengabdian Masyarakat INCOME: Indonesian Journal of Community Service and Engagement Physical Therapy Journal of Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Fransiscus Fiano Anthony Kerans
Universitas Warmadewa
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THE EFFECT OF NOISE EXPOSURE ON THE AVERAGE NUMBER OF TEMPORAL LOBUS NEURONS IN ADULT WISTAR RATS Suka Astini, Dewa Ayu Agung Alit; Evayanti, Luh Gde; Witari, Ni Putu Diah; Sumadewi, Komang Trisna; Prima Dewi, A.A.A Asri; Anthony Kerans, Fransiscus Fiano; Kurniawati, Ida
E-Jurnal Medika Udayana Vol 13 No 07 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i07.P09

Abstract

Noise is defined as unwanted and disruptive sound, considered an environmental stressor and disturbance. Noise encompasses many aspects of modern communities, including work environments. The damaging effects of noise primarily result from the unrestricted production of free radicals into the auditory organs. Exposure to noise causes various health problems, such as hearing impairment, sleep disturbances, and interference with individual performance. Reactive oxygen species (ROS), also known as free oxygen radicals, are normal by-products of cellular aerobic metabolism. These unstable molecules can damage cellular lipids, proteins, and nucleic acids in DNA if the antioxidant balance is disrupted. Acute and chronic exposure to loud noise generates excessive free radicals and disrupts extra-auditory organs such as the nervous, endocrine, and cardiovascular systems. The purpose of this study is to analyze the relationship between noise exposure and the number of neurons in the temporal lobes of Wistar rats. The research design used is a laboratory experimental design, specifically a pure experimental design, implemented with the randomized posttest-only control group design. The research sample consists of 30 male Wistar rats randomized into 2 groups, control and treatment. The treatment group is exposed to 95dB noise for 4 hours per day for 14 days. The rats are then euthanized, and their brain tissue is fixed with 10% neutral buffered formalin. Assessment is performed using Hematoxylin Eosin staining, and analysis is conducted blindly on the average number of neurons in the rat's temporal lobes. Data is subjected to normality testing using the Shapiro-Wilk test and analyzed using independent t-tests for parametric comparison. The results show a significant difference in the mean number of neurons in the temporal lobes between rats exposed to noise and the control group (p <0.005). The conclusion of this study is that noise affects neuron cells in the temporal lobes. Keywords : noise, temporal lobe, neurons.
EVALUATING THE EFFECTIVENESS OF ANATOMY AND HISTOLOGY PRACTICUM DURING COVID-19 PANDEMIC AT FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS WARMADEWA Evayanti, Luh Gde; Sumadewi, Komang Trisna; Witari, Ni Putu Diah; Suka Astini, Dewa Ayu Agung Alit; Kerans, Fransiscus Fiano Anthony; Dewi, A.A.Ayu Asri Prima; Ekayani, Ni Wayan Diana
E-Jurnal Medika Udayana Vol 13 No 6 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i06.P11

Abstract

The implementation of anatomy and histology practical sessions at Fakultas Kedokteran dan Ilmu Kesehatan (FKIK) Universitas Warmadewa during the Covid-19 pandemic still has many variations. This difference in implementation will have an influence on the achievement of student learning. This research aims to evaluate the knowledge of anatomy and histology among students by giving asynchronous learning, pre-test, post-test and practicum exam. This study using cross-sectional approach. 124 participants are 3th semester students whose active status at FKIK Universitas Warmadewa. The primary data were collected directly from practical sessions and practicum exam. The pre-test and post-test data were analyzed using paired-T test (p<0.05). The post-test and practicum exam were analyzed using Spearman rho (p<0.05). In anatomical practicum, there is an increase in post-test scores when compared to pre-test although not significant (p = 0.119). Anatomical practicum exam results have a meaningful positive correlation with post-tests (p = 0.013, r = 0.22). In histological practicum there was a significant increase in post-test scores when compared to pre-tests (p = 0.013), although practicum exam results were not significantly correlated with post-test (p = 0.410). Based on this study, improvements are needed related to technical of anatomical and histological practicums, as well as provisions related to practicums so that activities are structured
The Differences of 10% Neutral Buffered Formalin, 4% Paraformaldehyde, and Bouin Solution in Newborn Rat Brain Luh Gde Evayanti; Ni Putu Diah Witari; Komang Trisna Sumadewi; A.A.Ayu Asri Prima Dewi; Fransiscus Fiano Anthony Kerans; Dewa Ayu Agung Alit Suka Astini
WMJ (Warmadewa Medical Journal) Vol 9 No 1 (2024): May 2024
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.9.1.9180.1-4

Abstract

Rats are widely used in the study of embryological development of the central nervous system and its congenital disorders. Therefore, tissue fixation is very important in obtaining a good picture of the central nervous system, especially in newborn rats. This study aims to determine the difference in fixation using a solution of 10% neutral buffered formalin, 4% paraformaldehyde, and Bouin solution in the brain tissue of newborn rats. This experimental study used a post-test only controlled-group design with 18 newborn rats aged zero day. After randomization, the pups were grouped into 3 treatment groups, namely: fixation with 10% neutral buffered formalin solution (P1, n = 6), and fixation with 4% paraformaldehyde solution (P2, n = 6), and fixation with Bouin solution (P3, n = 6). Assessment using Hematoxylin Eosin staining, and analyzed by blinding based on the histology of the cerebral tissue (cell nucleus staining, cytoplasmic staining, staining clarity, uniformity of staining). Five cerebrum fields were examined. Data analysis used Kruskall Wallis test and post hoc Mann Whitney test using SPSS. The result was a significant difference in the histology of the brain tissue of newborn rats with the fixation of a solution of 10% neutral buffered formalin, 4% paraformaldehyde and Bouin solution (p = 0.001). Brain tissue fixation using 10% neutral buffered formalin solution showed better quality of histological pictures compared to 4% solution of paraformaldehyde solution and Bouin solution (p <0.05).
Pelatihan Pembuatan Mainan Edukasi Terhadap Peningkatan Pengetahuan Kader Posyandu dalam Stimulasi Perkembangan Balita Kurniawati, Ida; Witari, Ni Putu Diah; Dewi, A.A. Ayu Asri Prima; Kerans, Fransiscus Fiano Anthony; Wangsa, Putu Gde Hari; Adhitya, I Putu Gde Surya
International Journal of Community Service Learning Vol. 8 No. 2 (2024): May
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/ijcsl.v8i2.76911

Abstract

Proses tumbuh kembang anak pada periode emas akan sangat menentukan fase tumbuh kembang anak selanjutnya. Deteksi dini dan stimulasi perkembangan anak perlu dilakukan secara berkala sebagai upaya untuk mengoptimalkan perkembangan dan mencegah masalah terkait yang dapat muncul pada anak. Penelitian ini bertujuan untuk memberikan pendampingan kepada mitra untuk meningkatkan keterampilan pembuatan mainan edukasi anak berbahan sederhana dan memberikan pengetahuan mengenai peranan mainan edukasi dalam stimulasi perkembangan anak. Penelitian ini merupakan penelitian deskriptif dengan menggunakan teknik pendekatan survey kepada masyarakat. Penelitian ini melibatkan subjek sebanyak 15 orang anak. Metode pelaksanaan PKM meliputi sosialisasi dan diskusi menggunakan Focus Group Discussion (FGD) untuk menentukan permasalahan di masyarakat.  Adapun instrumen yang digunakan adalah panduang FGD.  Setelah data dikumpulkan kemudian dianalisis menggunakan metode analisis deskriptif.  Hasil penelitian ini yaitu terdapat peningkatan keterampilan mitra dalam pembuatan mainan edukasi untuk stimulasi perkembangan anak. Sehingga dapat disimpulkan bahwa, pelatihan pembuatan mainan edukasi anak dapat meningkatkan kemampuan peserta untuk berkreasi dalam membuat mainan edukasi anak berbahan sederhana Penelitian ini memiliki dampak positif terhadap peningkatan pengetahuan bagi kader posyandu terkait pembuatan mainan edukatif untuk stimulasi tumbuh kembang balita. Permainan edukatif sangat bermanfaat dalam proses perkembangan anak.
Pemberdayaan Kader Posyandu Dalam Stimulasi Perkembangan Bayi Melalui Baby Gym di Banjar Tandang Tri Buana, Desa Batur Tengah, Kintamani Sumadewi, Komang Trisna; Asri Prima Dewi, Anak Agung Ayu; Anthony Kerans, Fransiscus Fiano; Diah Witari, Ni Putu; Suka Astini, Dewa Ayu Agung Alit; Evayanti, Luh Gede; Kurniawati, Ida
Warmadewa Minesterium Medical Journal Vol. 3 No. 3 (2024): September 2024
Publisher : Warmadewa University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Gangguan perkembangan pada bayi dan anak menjadi perhatian pemerintah karena dampak yang dapat ditimbulkan. Gangguan perkembangan motorik banyak ditemukan pada bayi usia 3-5 bulan. Gangguan ini berupa keterlambatan perkembangan yang tidak sesuai dengan usianya. Kondisi ini terjadinya karena dipengaruhi oleh berbagai faktor, salah satunya rendahnya stimulus yang diberikan. Berdasarkan wawancara bersama kader Posyandu di Banjar Tandang Tribuana, Desa Batur Tengah, Kecamatan Kintamani, Kabupaten Bangli, didapatkan bahwa pemberian informasi mengenai perkembangan anak masih rendah, pelatihan mengenai pemberian stimulasi bayi dan anak juga masih jarang dilakukan, serta belum pernah dilakukan pelatihan mengenai baby gym. Melihat permasalahan tersebut, maka solusi yang dapat dilakukan antara lain memberikan edukasi mengenai tumbuh kembang serta stimulasi anak berdasarkan usia, dan pelatihan mengenai baby gym yang dapat membantu perkembangan bayi dan anak. Program ini bertujuan untuk meningkatkan pengetahuan mitra mengenai tumbuh kembang anak, stimulasi perkembangan sesuai usia, mengenali keterlambatan perkembangan serta meingkatkan keterampilan mitra dalam melakukan baby gym. Mellalui kegiatan ini didapatkan hasil berupa peningkatan pengetahuan mitra mengenai tumbuh kembang dan stimulasi anak sebesar 51.17%, peningkatan keterampilan mitra dalam memberikan stimulasi serta melalukan baby gym. Kehadiran peserta 100% dengan pastisipasi aktif melalui respon yang diberikan oleh peserta. Kesimpulannya, program ini terlaksana dengan lancar dan dapat memenuhi indikator keberhasilan program yang sudah ditetapkan oleh tim pengabdian.
Hematology Profiles in Colorectal Cancer Patients in Bali Kurniawati, Ida; Dewi, Anak Agung Ayu Asri Prima; Kerans, Fransiscus Fiano Anthony; Witari, Ni Putu Diah; Adyasputri, A A I Ayesa Febrinia; Sueta, Made Agus Dwianthara; Sumadewi, Komang Trisna; Evayanti, Luh Gde; Astini, Dewa Ayu Agung Alit Suka
Jurnal Ilmiah Kesehatan Vol 18 No 01 (2025): Jurnal Ilmiah Kesehatan (Journal of Health Science) 
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/jhs.v18i01.6936

Abstract

Colorectal cancer is a leading cause of cancer-related deaths worldwide. This study explores blood profile and cancer staging in colorectal cancer patients in Bali. It was a descriptive-analytical study that collected demographic and clinical data from medical records of colorectal cancer patients at Prof. Dr. I.G.N.G. Ngoerah Hospital. The results of the study showed the basic characteristics and hematology profiles of 100 colorectal cancer patients. The average age of patients was 55.6 ± 11.4 years, with 54% of the total sample being male. The average body mass index (BMI) was 21.1 ± 3.6 kg/m², with an average height of 161.9 ± 6.1 cm and an average weight of 55.3 ± 10.0 kg. Laboratory tests revealed an average hemoglobin (Hb) level of 11.0 ± 3.6 g/dL, red blood cell count of 4.0 ± 0.9 million/μL, white blood cell count of 11.2 ± 7.3 thousand/μL, and platelet count of 302.8 ± 154.8 thousand/μL. The average hematocrit (HCT) level was 33.7 ± 6.6 L/L. Liver function parameters indicated average aspartate aminotransferase (AST/SGOT) levels of 45.6 ± 63.6 U/L and alanine aminotransferase (ALT/SGPT) levels of 24.6 ± 29.4 U/L. Renal function was described by an average blood urea nitrogen (BUN) level of 21.8 ± 21.0 mg/dL, urea levels of 21.9 ± 21.2 mg/dL, and creatinine levels of 2.3 ± 11.5 mg/dL. Our study highlights the importance of hematology profiles in colorectal cancer patients as part of cancer screening examination. Further study with a larger number of samples and more diverse populations is needed to analyze the relation between variables.
Female gender and time from injury to surgery as risk factors for decreased knee functions in ACL injury survivors Kurniawati, Ida; Witari, Ni Putu Diah; Dewi, Anak Agung Ayu Asri Prima; Kerans, Fransiscus Fiano Anthony; Sumadewi, Komang Trisna; Astini, Dewa Ayu Agung Alit Suka; Evayanti, Luh Gde
Physical Therapy Journal of Indonesia Vol. 6 No. 1 (2025): January-June 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i1.247

Abstract

Background: Anterior cruciate ligament (ACL) injuries are serious orthopedic conditions that require long-term recovery and significant costs. This study aimed to assess the risk of decreased knee function among ACL injury survivors in the Indonesian ACL community. Methods: This study used a prospective observational cohort design with a population of all members of the Indonesian ACL community who experienced ACL injury. The primary outcome of this study was a decrease in knee function was measured using the Lysholm knee score. We calculated univariate and multivariate analyses using logistic regression for each variable. Results: The results showed that female gender and time from injury to surgery were significant factors that influenced poor knee function after ACL reconstruction. Women had a significantly higher risk (odd ratio (OR) = 15.28; adjusted OR (AOR) = 23.47; p-value < 0.010). In addition, the time between injury and surgery significantly affected postoperative knee function (AOR = 1.05; p-value = 0.049). Other factors such as age and body mass index did not show significant associations in either univariate or multivariate analyses. Conclusion: This study confirmed that female gender and time from injury to surgery were important factors influencing poor knee function after ACL reconstruction. Timely intervention and focused rehabilitation programs are key steps to improve patient functional outcomes.
Peningkatan Peran OSIS Dalam Pencegahan Kanker Serviks Dan Vaksinasi HPV Pada Siswi SMP di Bali Lestari, Desak Putu Oki; Analysa, Analysa; Kerans, Fransiscus Anthony; Winata, I Gde Sastra; Riasa, I Nyoman Putu
INCOME: Indonesian Journal of Community Service and Engagement Vol 4 No 3 (2025)
Publisher : EDUPEDIA Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56855/income.v4i3.1496

Abstract

Kanker serviks merupakan jenis kanker tertinggi ke-2 di Bali dan Indonesia, dengan infeksi virus HPV high risk sebagai faktor risiko utama. Meskipun vaksinasi HPV efektif menurunkan insiden kanker serviks, implementasinya di Indonesia, khususnya Bali masih baru dimulai dan tingkat pengetahuan remaja tentang kanker serviks masih rendah. Kegiatan pengabdian kepada masyarakat (PKM) ini bertujuan untuk meningkatkan pengetahuan, sikap, dan perilaku siswi SMP, khususnya pengurus OSIS terkait pencegahan kanker serviks dan vaksinasi HPV, serta mendorong peran aktif OSIS sebagai agen edukasi di lingkungan sekolah. Program dilakukan melalui penyuluhan aktif, pelatihan, dan pendampingan kepada pengurus OSIS di tiga SMP di Bali. Evaluasi dilakukan menggunakan pre-test dan post-test untuk mengukur perubahan pengetahuan, sikap, dan perilaku, serta pemantauan capaian vaksinasi HPV. Terdapat peningkatan signifikan pada nilai pengetahuan (dari rata-rata 3,47 menjadi 8,74), sikap (4,12 menjadi 9,32), dan perilaku (3,54 menjadi 9,01) setelah intervensi (p < 0,05). Cakupan vaksinasi HPV mencapai lebih dari 95%. Sebanyak 75% siswa mampu melakukan edukasi di kelompok kecil, dan 25% mampu melakukan penyuluhan di kelas besar. Intervensi berbasis OSIS efektif meningkatkan pengetahuan, sikap, perilaku, dan cakupan vaksinasi HPV pada siswa SMP. Peran OSIS sebagai duta kesehatan perlu terus didukung untuk memperluas dampak edukasi pencegahan kanker serviks di lingkungan sekolah.
Prevalensi Kejadian Anemia pada Siswi SMP Negeri 1 Kintamani Ni Putu Diah Witari; Sri Ratna Dewi; Fransiscus Fiano Anthony Kerans; Aanak Agung Ayu Asri Prima Dewi; Ida Kurniawati; Komang Trisna Sumadewi; Luh Gde Evayanti; Dewa Ayu Agung Alit Suka Astini
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.7411

Abstract

Anemia is a condition characterized by low levels of hemoglobin or red blood cell counts in the bloodstream, resulting in a decreased ability of the blood to transport oxygen throughout the body. The prevalence of anemia is relatively high, especially in developing countries. In Indonesia, there has been an increase in the prevalence of anemia among adolescents aged 15-24 years, reaching 13.6%. In Bali, the recorded prevalence of anemia is 21.9%, with Bangli Regency ranking second. Kintamani is one of the sub-districts located in Bangli Regency, and SMP Negeri 1 Kintamani is one of the middle schools in the area. This study aims to identify the prevalence of anemia among female students of SMP Negeri 1 Kintamani. The method used is a cross-sectional study involving 147 respondents. Hemoglobin levels were measured using the Easy Touch GCHb device. The results indicate that the prevalence of anemia among female students at SMP Negeri 1 Kintamani is 18.37%, with mild anemia at 12.24% and moderate anemia at 6.12%. The majority of respondents are 12 years old.
Molecular and Histological Changes in Airway Basal Stem Cells on Chronic Obstructive Pulmonary Disease Dewi, A. A. Ayu Asri Prima; Inayati, Rizqa; Sumadewi, Komang Trisna; Kerans, Fransiscus Fiano Anthony
Indonesian Journal of Multidisciplinary Science Vol. 2 No. 10 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v2i10.586

Abstract

Airway basal stem cell changes in COPD including hyperplasia, squamous cell metaplasia, epithel-mesenchymal transision, impairment of cillia and secretoric non mucosal cell differentiation, and junctional barrier integrity disturbances that lead to histological changes. There are also molecular changes such as disturbances in gene expresion, cytokines, inflamation factor and dysregulation of basal cell transcriptome in locus 19q13.2. This article is aimed to review airway basal cell changes in COPD. By understanding initial changes of airway basal stem cell in COPD, hopefully can help to develop stem cell therapy in COPD treatment. The research aims to explore molecular and histological changes in airway basal stem cells on chronic obstructive pulmonary disease. The researchers used literature review as the way to verify their arguments on the issue discussed by analyzing the results of scientific sources, especially from trusted sources such as Google Scholar and Science Direct. The study continues by stating that regenerative therapy using stem cells has started to evolve with the advancement of stem cell technology and is anticipated to improve and treat this illness. Only preclinical and phase 2 clinical trials have seen recent advancements in the use of stem cells for treating COPD.
Co-Authors A A I Ayesa Febrinia Adyasputri A. A. Ayu Asri Prima Dewi A.A.Ayu Asri Prima Dewi Aanak Agung Ayu Asri Prima Dewi Adhitya, I Putu Gde Surya Agus Pramana Shakti Manik Artha Anak Agung Ayu Asri Prima Dewi Anak Agung Ayu Istri Prima Dewi Analysa, Analysa Asri Prima Dewi AA Ayu Asri Prima Dewi, Anak Agung Ayu Astini, Dewa Ayu Agung Alit Suka Desak Putu Oki Lestari Dewa Ayu Agung Alit Suka Astini Dewa Ayu Ratna Juwita Dewi, A. A. Ayu Asri Prima Dewi, A.A. Ayu Asri Prima Dewi, A.A.Ayu Asri Prima Dewi, Anak Agung Ayu Asri Prima E. Henny Herningtyas Ekayani, Ni Wayan Diana Evayanti, Luh Gede I Ketut Suwiyoga I Wayan Sudiarta Ida Kurniawati Ida Kurniawati Ida Kurniawati, Ida Inayati, Rizqa Komang Trisna Sumadewi Luh Gde Evayanti Luh Gde Evayanti Luh Gede Evayanti Luh Gede Evayanti Lutfan Lazuardi Ni Luh Putu Putri Ni Putu Diah Witari Ni Putu Diah Witari, Ni Putu Prima Dewi, A.A.A Asri Riasa, I Nyoman Putu Rio Hermantara Rizal R Sri Ratna Dewi Sri Ratna Dewi Sueta, Made Agus Dwianthara Suka Astini, Dewa Ayu Agung Alit Sumadewi, Komang Trisna Tanjung Subrata Wangsa, Putu Gde Hari