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All Journal UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kimia Riset Dental Journal (Majalah Kedokteran Gigi) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Canrea Journal: Food Technology, Nutritions, and Culinary Journal Jurnal Ilmiah Medicamento Riset Informasi Kesehatan
Mochammad Yuwono
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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INFLUENCE OF OLEIC ACID ON THE IN VITRO PENETRATION OF DICLOFENAC SODIUM GEL Lidya Ameliana; Esti Hendradi; Mochammad Yuwono
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Diclofenac sodium (DS) is a nonsteroidalantiinflammatory drugs (NSAIDs), that inhibitscyclooxygenase-2 enzyme (COX-2). It has first passmetabolism by 40-50%, because of its shortbiological half-life, the drug has to be givenfrequently (Ganiswara, 2005). Dose of DS in gel is 1%(Sweetman, 2007). In peroral use, it may cause therisk of gastrointestinal bleeding, cardiovascular,hypersensitivity reactions and disorders of thecentral nervous (Katzung, 2002, Chuasuwan, et al.,2008).DS does not penetrate well through skin and cannotreach the effective concentration at the site ofaction after transdermal application (Mohammed,2001; Ozguney, et al., 2006). DS partition coefficientin n-octanol-buffer aqua (log P) was 1.1 (Chuasuwan,2008). Lipophilic nature of the stratum corneum andthe hydrophilic nature of the underlying tissuesshowed that the drug will penetrate the skin shouldhave an optimal balance between the lipophilic andhydrophilic properties. In general, the skin is morepermeable to the material which has a partitioncoefficient (P) in octanol-water between 10-1000(Michniac-Kohn et al., 2005).Oleic acid enhances the penetration of drugs intothe skin by increasing the fluidity of the stratumcorneum lipids through the establishment ofchannels (water channels) (Fang , et al , 2003)This study aimed to know the influence of OleicAcid (OA) in several concentrations (1%, 3% and5%) as penetration enhancer on the in vitropenetration of topical DS gel. Furthermore, thephysical properties of the topical preparation(organoleptic, pH and viscosity), and DS penetrationpercutaneously through rat skin . Then observedthat in spite of DS assay and penetrate through therat skin at certain intervals and observed by meansof HPLC.
Co-Authors Ahmad Yudianto Albertus Aditya Setiawan Ameliana, Lidya Angkasa Megistra Ulvan Asih Imulda Hari Purwani Asmi Citra Malina Asri Darmawati Bambang Tri Purwanto Bastiana Bermawi Bermawi, Bastiana Dian Ratna Rianti Eko Agus Suyono Eko Nurcahya Dewi Esti Hendradi Etik Wahyuningsih Farida Ifadotunnikmah Fawaz Shihab Febrianti, Winanda Rizki Ichsanto, Farhan Hanang Isnalita Isnalita, Isnalita Jamaluddin Fitrah Alam Julian Dwi Susanto Juni Ekowati Kholis Amalia Nofianti Laili Irfanah Lukita Purnamayati Luqmanul Hakim Megawati - Melanny Ika Sulistyowaty Mochammad Taha Ma’ruf Muhammad Agus Syamsur Rijal Muhammad Faris Adrianto Muhammad Faris Adrianto, Muhammad Faris Muhammad Hidyatullah Nabila, Aghnia Nazaratun Thaiyibah, Nazaratun Neny Prawitasari Noorma Rosita Paramita, Diajeng Putri Pratama, Adam Prayoga, Adistiar Purwitasari, Neny Rachma Ayuningtyas Rara Dyah Chrissanti Rianti, Dian Ratna Riesta Primaharinastiti Riesta Primaharinastiti, Riesta Ryan Afandi Setiawan, Albertus Aditya Suciati Suciati Suzana Thalia Vanessa Hartono Winanda Rizki Febrianti Zulni, Shalsa Septia