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Potential of Quercetin in Bitter Melon (Momordica charantia L) as an Antidiabetic: In Silico Study Roni Yuliwar; I Ketut Sudiana; Kusnanto Kusnanto; Dwi Krihariyanie; Hidayat Arifin
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

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Purpose: The purpose of this study is to predict the in silico molecular interactions of bitter melon quercetin with GLP-1 receptors using the comparable compounds of myricetin and allosteric modulators. Methods: The in silico test was used to predict the quercetin molecular interactions by docking using the Molegro Virtual Docker computer program. The receptor used was human GLP-1, code PDB: 5VEX with allosteric modulators ligand (97V_1201 [A]). As part from predicting molecular interactions, this study also carried out the prediction of its pharmacokinetic properties (ADME) and the toxicity of quercetin and myricetin using the pkCSM online tool program. The data analysis was performed by comparing the docking bond energies between quercetin, the allosteric modulator ligands and the myricetin comparators at the target receptor. The lower the bond energy of the ligands to the target receptor, the more stable the bonds are. This can be used to predict the biological activity of the compound. Results: The in silico test results showed that the bond energy of quercetin = -70.2678 kcal/mol, myricetin = -105,298 kcal/mol and allosteric modulators = -126,992 kcal/mol. Conclusions: The above test results indicate that quercetin has antidiabetic potential by activating the GLP-1 receptor although it is lower than the myricetin and allosteric modulators. The results of the in silico test using the pkCSM online tool program showed that the quercetin compound had good pharmacokinetic properties and a low toxicity level.

Hubungan Tingkat Pengetahuan dan Diabetes Self-Management dengan Tingkat Stres Pasien Diabetes Melitus yang Menjalani Diet Kusnanto Kusnanto; Putri Mei Sundari; Candra Panji Asmoro; Hidayat Arifin
Jurnal Keperawatan Indonesia Vol 22 No 1 (2019): March
Publisher : Fakultas Ilmu Keperawatan Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.7454/jki.v22i1.780

Pengetahuan sangat penting dalam mengembangkan diabetes self-management untuk mencegah resiko komplikasi jangka panjang dengan diet yang ketat. Tujuan penelitian ini untuk mengetahui hubungan antara pengetahuan dan diabetes self-management dengan tingkat stres pasien diabetes melitus yang menjalani diet. Penelitian ini menggunakan desain cross-sectional. Jumlah total sampel didapatkan sebesar 106 responden dengan multistage sampling, Kriteria inklusi meliputi pasien DM <5 tahun dengan rentang usia 35-55 tahun, tidak menggunakan insulin injeksi, Pasien DM masih berkeluarga dan tinggal dengan keluarganya. Data didapatkan dengan kuesioner Knowledge of Diabetic Diet Questionnaire, Self-Management Dietary Behaviors Questionnaire, dan tingkat stres menjalani diet. Kemudian dianalisis dengan uji Spearman test. Hasil penelitian menunjukkan bahwa tingkat pengetahuan (p=0,049; r=-0,192) dan diabetes self-management (p= 0,000; r= -0,341) memiliki hubungan terhadap tingkat stres saat menjalani diet. Diabetes self-management memiliki hubungan yang sangat kuat dari pada tingkat pengetahuan terhadap tingkat stres pasien diabetes yang menjalani diet. Penelitian selanjutnya diharapkan bisa menggunakan responden dengan wilayah yang lebih luas dan serta mengembangkan intervensi yang lebih baik untuk meningkatkan pengetahuan tentang diet pada pasien diabetes melitus. Abstract The correlation between knowledge level and diabetes self-management towards stress level of patients DM with diet. Knowledge is very important in developing diabetes self-management to prevent the risk of long-term complications with a strict diet. The purpose of this study was to determine the relationship between knowledge and diabetes self-management with stress levels of people with diabetes mellitus who went on a diet. This study uses a cross-sectional design. The total samples obtained were 106 respondents with multistage sampling, inclusion criteria included patients with DM <5 years with a range of ages 35-55 years, did not use insulin injection, DM patients were still married and lived with their families. Data are obtained with questionnaire of Knowledge of Diabetic Diet Questionnaire (KDDQ), a Self-Management Dietary Behaviors Questionnaire (SMDBQ), and a stress level on a diet. Data analyzed by the Spearman Rho. The results showed that the level of knowledge (p=0.049; r=-0.192) and diabetes self-management (p= 0.000; r=-0.341) had a relationship to stress levels while on a diet. Diabetes self-management has a very strong relationship to the level of knowledge of the stress level of diabetics with diet. Future studies are expected to be able to use respondents with a wider area and develop better interventions to increase knowledge about diets in people with diabetes mellitus. Keywords: diabetes mellitus, diet, self-management, stress level

Determinant of stunting among children under-five years: A nationwide study in Zambia Muhammad Abi Zakaria; Kusnanto Kusnanto; Ika Nur Pratiwi; Hidayat Arifin; Doreen Phiri; Agostinha Soares; Kittisak Kumpeera
The Journal of Palembang Nursing Studies Vol. 3 No. 1 (2024): January 2024
Publisher : Palembang MediRose Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55048/jpns109

Background: Stunting cases among children represent one of the most serious issues in human development. Zambia, in particular, has a higher number of stunting cases in Africa.Objective: The purpose of this research was to analyze the prevalence and determinant of stunting among children under-five years in Zambia. Methods: This study utilized data from the 2018 Zambia Demographic Health Survey (ZDHS), with a total of 1,710 surveys selected. We observed variables related to mothers, children, and the environment to assess stunting. Chi-Square and Binary Logistic Regression were used for data analysis.Results: A total of 22,16% children under five years in Zambia had a stunting. We found that factors such as low birth weight (<2500 grams) (OR = 3.24; 95% CI = 2.163-4.869), mothers with no education (OR = 1.80; 95% CI = 0.681-4.760), those with the poorest wealth index (OR = 2.30; 95% CI = 1.341-3.943), intervals between previous children less than 24 months (OR = 1.58; 95% CI = 1.107-2.270), and breastfeeding for more than 6 months (OR = 4.499; 95% CI = 3.179-6.67) were associated with a higher likelihood of stunting in Zambia.Conclusions: Our study demonstrates that stunting is associated with family and household factors, as well as breastfeeding practices. Policymakers should consider implementing structured policies to address stunting, particularly for expectant mothers, as a long-term solution.

Scoping review of grief studies in Indonesia Christina Yeni Kustanti; Nurlia Ikaningtyas; Ninik Yunitri; Hidayat Arifin; Mei Rianita Elfrida Sinaga; Eka Kristina Asi; Nimsi Melati; Henny Dwi Susanti
Jurnal Keperawatan Padjadjaran Vol. 11 No. 3 (2023): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v11i3.2318

Background: One death can cause nine bereavements. Considering the impact of human loss, studies on grief are crucial for better bereavement care services. Purpose: This study examined studies on grief conducted in Indonesia. Indonesian grief research mapping will identify study gaps and suggest further research. Methods: The reporting for a scoping review adhered to the PRISMA (preferred reporting elements for systematic review and meta-analysis) statement for a scoping review. A systematic screening was performed in MedLine, Embase, CINAHL, Web of Science, Scopus, and PubMed, as well as manual searches via Google Scholar, Portal Garuda, and relevant studies without language and date restrictions. The data retrieved in the literature were analyzed descriptively, and the themes were developed using NVivo software. Results: Based on the 18 included studies, the types of grief studies in Indonesia can be divided into pre- and after-loss grief areas. Regarding the themes of the studies that have been conducted in Indonesia, five themes can be derived, related to (1) study purposes, (2) cause of grief, (3) population, (4) concept being studied, and (5) outcomes being studied. Conclusion: There is significant room for growth in the grief research field in Indonesia. It will be vital for researchers in Indonesia to perform additional studies on pre-loss grief, other studies connected to interventional trials, and further studies examining variation in the outcomes.

The development of the health promotion program on maternal anemia: Qualitative study Sirikanok Klankhajhon; Kornkarn Pansuwan; Pratuma Rithpho; Hidayat Arifin
Jurnal Keperawatan Padjadjaran Vol. 11 No. 3 (2023): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v11i3.2360

Background: Iron deficiency anemia in pregnant women is a crucial global health problem. Iron deficiency anemia is impacted on health during antenatal, labor and postpartum period. Although the national policy provides the preventive and solving the maternal anemia, the statistics of maternal anemia are still high. Purpose: The aim of the study is to develop a health promotion program that is suitable for maternal anemia. Methods: Qualitative research was used to develop the health promotion program on maternal anemia through in-depth interviews. Ten pregnant women who had hematocrit less than 33 volume percentages or hemoglobin less than 11 g/dl and five healthcare professionals were selected by purposive sampling. A total of fifteen participants were interviewed based on the semi-structured questionnaire for 30-45 minutes per case at the antenatal care clinic, Watbot hospital, Phitsanulok, Thailand. The period of the study was six months from the first of August 2022 until the end of January 2023. Results: Thematic analysis was used to analyze the data and identified three main themes: 1) encouragement the attitude of self-care during pregnancy; 2) accessibility of the program ; and 3) practical use of the program and integrating the program based on the context of pregnant women and healthcare professionals. Conclusion: The health promotion program was developed suitable for maternal anemia. The tailored program should be tested in terms of feasibility, accessibility, and practical use. It will support pregnant women with anemia, develop a key performance index of maternal and child health, decrease risks and complications, and promote maternal and child health based on the various contexts.

Supportive-educative needs of patients with coronary heart disease: An investigation of clinical nurses Aguscik Aguscik; Rahmad Aswin Juliansyah; Rosnani Rosnani; Devi Mediarti; Christina Yeni Kustanti; Bangun Mukti Ardi; Muhammad Kamil Che Hasan; Inbar Levkovich; Agus Setiawan; Hidayat Arifin
Jurnal Keperawatan Padjadjaran Vol. 12 No. 1 (2024): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v12i1.2377

Background: The rising prevalence of coronary heart disease (CHD) has highlighted the need for supportive-educative efforts, particularly in nursing. These initiatives are crucial for improving self-care management in CHD patients, enhancing their quality of life. Clinical nurses are key in this role, leveraging their direct patient interaction and expertise to provide tailored education and support. Purpose: This study aimed to investigate the supportive-educative needs of CHD patients from the perspective of clinical nurses. Methods: A descriptive qualitative study was conducted for this research. Participants included 30 clinical nurses responsible for caring for CHD patients in both inpatient wards and outpatient polyclinics. Interview guidelines were utilized to collect data through in-depth interviews, triangulation, and the obtained interview data were analyzed using the thematic analysis approach. Results: We identified four themes related to the supportive-educative needs of CHD patients: 1) engaging and informative media; 2) culturally sensitive approaches; 3) nurses’ attitudes; and 4) family empowerment. Conclusion: Supportive education, tailored to the needs of CHD patients, is vital for effective disease management. This study's findings highlight the importance of incorporating four key elements into supportive education: engaging and informative media to enhance learning, culturally sensitive approaches to address diverse patient needs, the positive impact of nurses’ empathetic attitudes, and the empowerment of families in the care process. Integrating these aspects can significantly aid CHD patients in developing self-care skills that positively influence their quality of life.

Risk Factors for Hypertension in the Coastal Area of Tarakan City Najihah; Dewi Wijayanti; Tukan, Ramdya Akbar; Arifin, Hidayat; Suhermi
Window of Health : Jurnal Kesehatan Vol 7 No 3 (July 2024)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.v7i2.1295

Hypertension is a severe medical condition and is the leading cause of premature death worldwide, significantly increasing the risk of heart, brain, kidney, and other diseases. However, not all people with hypertension are aware of their disease, and it is only discovered after complications occur. Therefore, hypertension must be prevented and controlled. Prevention and control of hypertension aims to prevent and reduce the probability of morbidity, complications, and death. Hypertension can be prevented by controlling risky behaviors. This study aims to analyze the risk factors for hypertension in coastal communities in Tarakan City. This research is quantitative research with a cross-sectional study design. The study sampled people in the working area of the Amal Beach Health Centre, Tarakan City, and met the sample criteria obtained using a purposive sampling technique. The data obtained will be processed univariate and bivariate. The results showed that there was a significant relationship between obesity (p-value 0.001), family history (p-value 0.013), and sports activity (p-value 0.009) with the incidence of hypertension. Smoking habits did not show a significant relationship (p-value 0.230) with the incidence of hypertension. This study concludes that obesity, family history, and exercise activity are risk factors for the incidence of hypertension in coastal areas of Tarakan City. Therefore, it is hoped that health promotion efforts in the form of scheduled counseling on risk factors for hypertension and preventive efforts in the form of early detection so that people can prevent or control hypertension to avoid complications.

Family caregiver burden in schizophrenia: A structural equation model of caregiver, patient, environmental, and family function factors Sustrami, Dya; Suhardiningsih, AV Sri; Setyowati, Anggi; Fauk, Nelsensius Klau; Arifin, Hidayat
Jurnal Keperawatan Padjadjaran Vol. 12 No. 3 (2024): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v12i3.2599

Introduction: Families play a critical role in the care and support of individuals with schizophrenia. However, this responsibility often leaves caregivers with significant physical and psychological burdens. Objective: The study aimed to evaluate the family caregiver, patient, environmental factors, and family function as predictors of family caregiver burden in schizophrenia patients. Methods: This study used a cross-sectional design. The population consisted of family caregivers of schizophrenia patients who had experienced at least one episode in the past year, lived in the same house, and had been caregivers for at least one year. We recruited 220 family caregivers of schizophrenia patients. The variables in this study were family caregiver, patient, environmental factors, family function, and caregiver burden. The data was collected using a self-report questionnaire and analyzed using partial least squares. Results: Most respondents were predominantly between the ages of 46 and 65. The model showed that caregiver burden was influenced by the patient factor (t= 4.259, path coefficient: 0.088), environment factor (t= 6.540, path coefficient: 0.288), and family function (t= 10.977, path coefficient: 0.497). These findings showed that family function was the dominant factor in caregiver burden. Conclusion: Patient factors, environmental factors, and family function significantly affected the family caregiver burden, except for the family caregiver factor. This model can help family caregivers decrease their burden by managing family functioning.

Simple Coaching Clinic to Improve Nurse's Knowledge of Genetic Counseling among Thalassemia Patients Firmansyah, Andan; Yuda, Hendri Tamara; Putri, Tri Antika Rizki Kusuma; Hidayat, Nur; Richard, Selvia David; Arifin, Hidayat; Setiawan, Henri
Genius Journal Vol. 5 No. 2 (2024): GENIUS JOURNAL
Publisher : Inspirasi Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/gj.v5i2.281

Introduction: The coaching clinic is one of the strategies designed to increase nurses' knowledge in conducting genetic counseling for patients and families of thalassemia patients. Nurses will not only be given information, but they will also be taught how to communicate and how to use genetic counseling to make sure the coaching clinic's goals are met. Objective: This study aims to describes the effect of a simple coaching clinic on nurses' knowledge of genetic counseling implementation in thalassemia care. Methods: This research used a quantitative approach and was conducted on August 20th–21st , 2022. The design of this study was quasi-experimental without a control group. This study obtained a total sample of 29 nurses using a proportional sampling technique and inclusion criteria. The inclusion criteria in this study were nurses with a diploma degree, an undergraduate education background, and registered nurses. The data collection instrument was a 30-questions genetic counseling questionnaire. IBM SPSS version 25.0 was used to analyze the data using the Wilcoxon test. Results: Simple coaching clinic proved to have a significant effect in improving the knowledge level of nurses in general with p-value = 0.004. Knowledge level improvement can be seen from Mean (+SD) 53.67 (+13.64) to 69.67 (+8.26). Likewise with nurses' knowledge about thalassemia, genetic counseling and bio-informatics, the majority of respondents experienced positive changes. In contrast to the genetic topic, the majority of respondents did not experience a change in their level of knowledge so that a p-value >0.05 was obtained. Conclusions: Changes in level of knowledge indicated that the coaching clinic's effects on level of knowledge are significant and have an impact on health services across a variety of health institutions, including clinics and hospitals. As a result, it is critical to have a health strategy that promotes the accessibility of genetic counseling services for patients with thalassemia and other genetic illnesses.

Simple Coaching Clinic to Improve Nurse's Knowledge of Genetic Counseling among Thalassemia Patients Firmansyah, Andan; Yuda, Hendri Tamara; Putri, Tri Antika Rizki Kusuma; Hidayat, Nur; Richard, Selvia David; Arifin, Hidayat; Setiawan, Henri
Genius Journal Vol. 5 No. 2 (2024): GENIUS JOURNAL
Publisher : Inspirasi Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/gj.v5i2.281

Introduction: The coaching clinic is one of the strategies designed to increase nurses' knowledge in conducting genetic counseling for patients and families of thalassemia patients. Nurses will not only be given information, but they will also be taught how to communicate and how to use genetic counseling to make sure the coaching clinic's goals are met. Objective: This study aims to describes the effect of a simple coaching clinic on nurses' knowledge of genetic counseling implementation in thalassemia care. Methods: This research used a quantitative approach and was conducted on August 20th–21st , 2022. The design of this study was quasi-experimental without a control group. This study obtained a total sample of 29 nurses using a proportional sampling technique and inclusion criteria. The inclusion criteria in this study were nurses with a diploma degree, an undergraduate education background, and registered nurses. The data collection instrument was a 30-questions genetic counseling questionnaire. IBM SPSS version 25.0 was used to analyze the data using the Wilcoxon test. Results: Simple coaching clinic proved to have a significant effect in improving the knowledge level of nurses in general with p-value = 0.004. Knowledge level improvement can be seen from Mean (+SD) 53.67 (+13.64) to 69.67 (+8.26). Likewise with nurses' knowledge about thalassemia, genetic counseling and bio-informatics, the majority of respondents experienced positive changes. In contrast to the genetic topic, the majority of respondents did not experience a change in their level of knowledge so that a p-value >0.05 was obtained. Conclusions: Changes in level of knowledge indicated that the coaching clinic's effects on level of knowledge are significant and have an impact on health services across a variety of health institutions, including clinics and hospitals. As a result, it is critical to have a health strategy that promotes the accessibility of genetic counseling services for patients with thalassemia and other genetic illnesses.

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