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All Journal Current Biochemistry Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Pendidikan IPA (JPPIPA) AcTion: Aceh Nutrition Journal Meditory : The Journal of Medical Laboratory GANEC SWARA Jurnal Keperawatan Terpadu (Integrated Nursing Journal) Poltekita : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Indian Journal of Forensic Medicine & Toxicology Buletin Poltanesa Bioscientist : Jurnal Ilmiah Biologi MAHESA : Malahayati Health Student Journal Jurnal Kolaboratif Sains Bakti Sekawan : Jurnal Pengabdian Masyarakat Jurnal Ilmiah Pengabdian dan Inovasi Biomedika Jurnal Info Kesehatan
I Putu Bayu Agus Saputra
Fakultas Kedokteran, Universitas Islam Al-Azhar, Kota Mataram
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Immunological Profile of Patients with Controlled and Uncontrolled Type 2 Diabetes Melitus in Mataram City, West Nusa Tenggara Arjita, I Putu Dedy; Adnyana , I Gede Angga; Anulus, Ayu; Saputra, I Putu Bayu Agus; Diarti, Maruni Wiwin
JURNAL INFO KESEHATAN Vol 21 No 2 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss2.933

Abstract

The prevalence of DM disease in West Nusa Tenggara Province is not much different from that in Indonesia. DM cases in NTB are included in the ten most non-communicable illnesses suffered by the community and the incidence continues to increase from year to year. An increase in the levels of pro-inflammatory cytokines in the body is one of the causes of insulin resistance in cells which can further develop into type 2 diabetes. This study involved diabetic patients at the Mataram Community Health Center, who were assigned into 2 groups, namely the controlled diabetes group and the uncontrolled diabetes group and involved a standard group which was a group consisted of healthy people. Each group was examined for Fasting Blood Glucose (FBG) and HbA1c levels. The results of the examination in the standard group, controlled diabetes group and uncontrolled diabetes group obtained the FBG levels of 89.22 mg/dl, 110.0 mg/dl, and 245.80 mg/dl, respectively. Furthermore, the results of the HbA1c test in the standard group, controlled diabetes group and uncontrolled diabetes group were 5.44%, 6.03%, and 10.49%, respectively. The results of the examination of IL-6 levels in the standard group, controlled diabetes group and uncontrolled diabetes were 329.36 pg/ml, 331.52 pg/ml, and 320.33 pg/ml, respectively. The results of the IL-10 test in the standard group, controlled diabetes group and uncontrolled diabetes were 71.80 pg/ml, 116.60 pg/ml, and 128.10 pg/ml, respectively. Based on the results of the study, there was no significant difference in the levels of interleukin 6 and interleukin 10 between respondents with diabetes mellitus and healthy respondents (p>0.05). It can be concluded that there were no differences in interleukin 6 and 10 levels between healthy people with patients with controlled and uncontrolled diabetes.
Hubungan Lama Sakit, Tingkat Pendidikan, Motivasi Pasien, dan Dukungan Keluarga dengan Kepatuhan Diet Pasien Diabetes Melitus Tipe II di Rumah Sakit Daerah (RSD) Mangusada Kabupaten Badung Bali Manutama, Putu Agi Abhimana; Arjita, I Putu Dedy; Saputra, I Putu Bayu Agus; Bagiansah, Mamang
MAHESA : Malahayati Health Student Journal Vol 4, No 6 (2024): Volume 4 Nomor 6 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i6.14470

Abstract

ABSTRACT Diabetes mellitus is a non-infectious disease that has become one of the health threats worldwide. Dietary adherence has a very important function in the management of DM. factors that can affect the dietary adherence of DM patients, namely education, knowledge, motivation, family support, and length of suffering. To analyze the relationship of length of illness, education level, patient motivation, and family support with dietary compliance of Type II DM patients at RSD Mangusada Badung Regency Bali. Observational analytic quantitative research with simple random sampling research design with a sample size of 92 respondents. Data were analyzed by Chi-Square test and Spearman Rank test with a significance value limit (p-value) <0.05. The results showed that the majority of respondents were 51-60 years old 44 (47.8%), the majority of respondents were male 48 (52.2%), 78 (84.8%) complied with the diet, the length of illness without complications 42 (45.7%), higher education 35 (38%), good patient motivation 75 (81.5%), good family support 71 (77.2%). Bivariate analysis showed that there was a significant relationship between length of illness with dietary compliance (p=0.048), education level with dietary compliance (p=0.015), patient motivation with dietary compliance (p=0.001), and family support with dietary compliance (p=0.009). Length of illness, education level, patient motivation, and family support are associated with dietary adherence of Type II DM patients at Mangusada Hospital, Badung Regency, Bali. Keywords: Diabetes Melitus, Dietary Compliance, Long Illness, Level Of Education, Patient Motivation, Family Support  ABSTRAK Diabetes melitus merupakan penyakit non-infeksi yang menjadi salah satu ancaman kesehatan di seluruh dunia. Kepatuhan diet memiliki fungsi yang sangat penting dalam pengelolaan DM. faktor-faktor yang dapat mempengaruhi kepatuhan diet pasien DM, yaitu pendidikan, pengetahuan, motivasi, dukungan keluarga, dan lama menderita. Menganalisis hubungan lama sakit, tingkat pendidikan, motivasi pasien, dan dukungan keluarga dengan kepatuhan diet pasien DM Tipe II di RSD Mangusada Kabupaten Badung Bali. Penelitian kuantitatif analitik observasional dengan desain penelitian simple random sampling dengan besar sampel 92 responden. Data di analisis dengan uji Chi-Square dan uji Rank Spearman dengan batas nilai signifikansi (p-value) <0,05. Hasil penelitian menunjukkan mayoritas responden berusia 51-60 tahun 44 (47,8%), responden mayoritas berjenis kelamin laki-laki 48 (52,2%), patuh menjalani diet 78 (84,8%), lama sakit tanpa komplikasi 42 (45,7%), pendidikan tinggi 35 (38%), motivasi pasien baik 75 (81,5%), dukungan keluarga baik 71 (77,2%). Analisis bivariat menunjukkan terdapat hubungan yang signifikan antara lama sakit dengan kepatuhan diet (p=0,048), tingkat pendidikan dengan kepatuhan diet (p=0,015), motivasi pasien dengan kepatuhan diet (p=0,001), dan dukungan keluarga dengan kepatuhan diet (p=0,009). Lama sakit, tingkat pendidikan, motivasi pasien, dan dukungan keluarga berhubungan dengan kepatuhan diet pasien DM Tipe II di RSD Mangusada Kabupaten Badung Bali. Kata Kunci: Diabetes Melitus, Kepatuhan Diet, Lama Sakit, Tingkat Pendidikan, Motivasi Pasien, Dukungan Keluarga
Hubungan Anemia, Usia Ibu dan Paritas dengan Kejadian Berat Badan Lahir Rendah di RSUD Patut Patuh Patju Musviratunnisah, Bintang Yuniar; Benvenuto, Ananta Fittonia; Saputra, I Putu Bayu Agus; Hanafi, Fachrudi
MAHESA : Malahayati Health Student Journal Vol 4, No 6 (2024): Volume 4 Nomor 6 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i6.14437

Abstract

ABSTRACT Low Birth Weight (LBW) are all newborns with a birth weight of less than 2,500 grams regardless of gestational age. Causes of LBW are multifactorial, such as maternal factors, fetal factors, environmental factors and socio-economic factors. This study aims to determine the relationship between anemia, age and parity with the incidence of LBW at Patut Patuh Patju Hospital. This research is an analytical observational research with a case-control design. The sample population in this study was all newborn babies at the Patut Patuh Patju Regional Hospital for the period January-December 2022, totaling 1.297 with 230 samples taken by purposive sampling with a 1:1 ratio of which 115 were cases and 115 controls. Data analysis for this research is univariate analysis and bivariate analysis with the chi-square statistical test. The results of this research showed that there was a significant relationship between anemia and the incidence of LBW (p-value of 0.000 and an OR of 17.5). There was a significant relationship between maternal age and the incidence of LBW (p-value of 0.000 and OR 6.1). There was a significant relationship between maternal parity and the incidence of LBW (p-value of 0.017 and OR 1.9). There was a significant relationship between anemia, age and parity with the incidence of low birth weight (LBW) at Patut Patuh Patju Hospital. Keywords: LBW, Anemia, Age, Parity, Infants  ABSTRAK Berat Badan Lahir Rendah (BBLR) merupakan salah satu penyumbang Angka Kematian Bayi (AKB) tertinggi didunia. BBLR adalah semua bayi baru lahir dengan berat saat lahir kurang dari 2.500 gram tanpa memandang usia gestasi. Penyebab terjadinya BBLR bersifat multifaktorial, seperti faktor ibu, faktor janin, faktor lingkungan serta faktor sosial ekonomi. Penelitian ini bertujuan untuk mengetahui hubungan anemia, usia ibu dan paritas dengan kejadian BBLR di RSUD Patut Patuh Patju Kabupaten Lombok Barat. Jenis penelitian observasional analitik dengan pendekatan case-control. Populasi pada penelitian ini adalah seluruh bayi baru lahir di RSUD Patut Patuh Patju periode Januari-Desember tahun 2022 yang berjumlah 1.297 dengan 230 sampel yang diambil dengan  purposive sampling dengan perbandingan 1:1 dimana 115 sampel sebagai kasus dan 115 kontrol. Analisis data penelitian ini adalah analisis univariat dan analisis bivariat dengan uji statistik chi-square. Hasil penelitian ini menunjukan bahwa terdapat hubungan yang signifikan antara anemia dengan kejadian BBLR (p-value=0,000 dan OR 17,5). Terdapat hubungan yang signifikan antara usia ibu dengan kejadian BBLR (p-value 0,000 dan OR 6,1). Terdapat hubungan yang signifikan antara paritas ibu dengan kejadian BBLR (p-value 0,017 dan OR 1,9). Terdapat hubungan yang signifikan antara anemia, usia ibu dan paritas dengan kejadian BBLR di RSUD Patut Patuh Patju. Kata Kunci: BBLR, Anemia, Usia Ibu, Paritas, Bayi
The Correlation Between Smoking Behavior and The Use of “Used Cooking Oil” with Hypertension Incidences at Malimbu Coastal Area Adnyana, I Gede Angga; Kresnapati, I Nyoman Bagus Aji; Saputra, I Putu Bayu Agus; Diarti, Maruni Wiwin; Jiwintarum, Yunan
Jurnal Keperawatan Terpadu (Integrated Nursing Journal) Vol. 5 No. 2 (2023): OKTOBER
Publisher : Jurusan Keperawatan, Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jkt.v5i2.518

Abstract

Hypertension is the main risk factor that leads to cardiovascular disease such as heart attack, heart failure and stroke, which is the highest cause of death in the world. One area with high risk of hypertension is the coastal area. The famous coastal area in the Lombok is Malimbu, located in North Lombok, West Nusa Tenggara Province. This research is an analytical observational study with a cross sectional design. This study aims to determine the correlation between smoking behavior and use of “used cooking oil” and the incidence of hypertension. Samples in this study were 70 people (n=70), and was taken using accidental sampling technique. Data were analyzed using chi-square. The results showed that the incidence of hypertension was 48% of the 70 respondents. Most of the respondents (70%), had no history of hypertension in their family. This research shows that there is no correlation between smoking behavior and the incidence of hypertension (p=0.807) with PR=1.156 (0.354 - 3.797). The use of “used cooking oil” was also found to be not correlated with the incidence of hypertension (p=0.632) with PR=1.275 (0.486 - 3.345). Although several previous studies showed that the smoking behavior and the use of used cooking oil correlate to hypertension, but this study result shows different data. This can be caused by other factors. Future research needs to examine the characteristics of smokers that may be related to the incidence of hypertension
Noni (Morinda Citrifolia) Ethanol Extract Lowered Blood Glucose Levels, Increased Glutathione Peroxidase Activity, And Decreased Malondialdehyde in White Rats Model of Diabetes Arjita, I Putu Dedy; Saputra, I Putu Bayu Agus; Sukmana, Dhika Juliana
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6076

Abstract

Diabetes mellitus can increase oxidative stress and damage cells. Noni fruit has antibacterial, antifungal, antitumor, analgesic, hypotensive, and anti-inflammatory benefits, can boost immunity, and has antioxidant content. Noni contains phenolic compounds (anthraquinones, acuities, asperulosides, and scopoletin), organic acids (capric and caprylic acids), and alkaloids (xeronine). The effect of noni ethanol extract can significantly reduce blood glucose (P<0.05) of the T2 group (177.00±137.78) and T3 (159.40±86.53) when compared to the C+ group (511.00±131.45). The T1 group (387.40±170.06) had no significant difference (P>0.05) when compared to the C+ group (511.00±131.45), but there was a decrease in the average yield at T1 (387.40±170.06). Serum malondialdehyde (MDA) examination showed a significant decrease (p<0.05) in T1 (1188.32±93.41), while in T2 (1385.35±38.65) and T3 (1460.32±42.51) was not significant (p<0.05). Examination of serum glutathione peroxidase (GPX) showed a significant decrease in T1 (119.97±37.45), there was a decrease in GPX levels, while in the T2 group (236.14±6.05) and T3 (185.24±43.07), there was no decrease. Noni ethanol extract can lower blood glucose levels, reduce Malondialdehyde levels, and prevent increased activity of the enzyme glutathione peroxidase. Flavonoid compounds in noni ethanol extract can avoid increased blood glucose and reduce free radicals formed due to hyperglycemia conditions.  
Potensi senyawa turunan flavonoid dalam menjadi inhibitor enzim HMG-Coa reductase kandidat obat h Saputra, I Putu Bayu Agus; Arjita, I Putu Dedy
Jurnal Penelitian Pendidikan IPA Vol 10 No 5 (2024): May
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i5.6237

Abstract

Cardiovascular disease (CVD) is a disease that causes death in the world. Behavioral risk factors are crucial in dealing with CVD disease. High levels of cholesterol in the blood are associated with hypercholesterolemia. It can increase the risk of CVD disease. The HMG-CoA reductase enzyme is an enzyme that plays a role in cholesterol synthesis. It will convert the HMG-CoA compound into the mevalonate. Inhibition of this enzyme can reduce cholesterol synthesis because it inhibits the formation of mevalonate, which is the initial stage of cholesterol synthesis. Herbal compounds are compounds produced by plants. It has good benefits for the body. Flavonoid compounds can be beneficial for health. Molecular docking is a method used to determine the binding affinity and interaction values ​​of the enzyme protein interaction with the ligand to be bound. The results of Apigenin binding affinity values is -7.7 kcal/mol, Luteolin is -8 kcal/mol, Quercetin is -8.2 kcal/mol, Kaempferol is -7.4 kcal/mol, Phloretin is -6.8 kcal/mol, Chalconaringenin is -6.9 kcal/mol, Cyanidin is -7.9 kcal/mol, Delphinidin is -7.8 kcal/mol, Hesperetin is -7.7 kcal/mol, Narigenin is -7.8 kcal/mol, Daidzein is -6.8 kcal/mol, Genistein is -7 kcal/mol, Rutin is -9.2 kcal/mol, Taxifolin is -8 kcal /mol, Diosmetin is -7.6 kcal/mol, and its native ligand Rosuvastatin is -8.5 kcal/mol. Flavonoid derivative compounds can bind to the HMG-CoA reductase enzyme. They can be candidates for antihyperlipidemia drugs.
Fragrant Pandan (Pandanus ammaryllifolius) Leaves Ethanol Extract as an Enhancer of Endogenous Antioxidant Defence under High-Fat Diet Conditions Sukanty, Ni Made Wiasty; Fajriani, Laksmi Nur; Saputra, I Putu Bayu Agus; Ariki, Iptan; Aditya, I Ketut Agus Yura
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1171-1176

Abstract

Excessive fat consumption, especially saturated and trans fatty acids, plays a significant role in metabolic disorders such as obesity, dyslipidemia, and cardiovascular disease through increased oxidative stress. Malondialdehyde (MDA), the end product of lipid peroxidation, serves as a biomarker of oxidative damage, whereas indirect bilirubin acts as an endogenous antioxidant. This study aimed to evaluate the effect of fragrant pandan leaves ethanol extract (FPLEE) in reducing MDA levels and modulating indirect bilirubin activity in rats fed a high-fat diet (HFD). The experimental method used 24 male Rattus norvegicus divided into six treatment groups: normal control (NC), positive control (C+), negative control (C-), and three FPLEE treatment groups with different doses (8, 16, and 32 mg/200 g BW/day). Administration was carried out for 14 days after 14 days of HFD induction. MDA levels were measured using the ELISA method, while total bilirubin and direct bilirubin were measured using spectrophotometry to determine indirect bilirubin levels. Statistical analysis was performed using one-way ANOVA and the post hoc Bonferroni test. The results showed that there were no significant differences in MDA levels between groups, although the C+ group fed a HFD showed a tendency toward increased MDA. Indirect bilirubin levels increased significantly in the low-dose FPLEE group (8 mg/200 g BW/day), indicating increased endogenous antioxidant activity, while higher doses did not. Thus, FPLEE has the potential to be an effective natural phytopharmaceutical agent in enhancing the body's antioxidant defence against oxidative stress caused by excessive fat consumption, especially at low doses.
Aktivitas Fisik Sebagai Faktor Risiko Hipertensi Pada Masyarakat Desa Batu Layar, Kabupaten Lombok Barat: Physical Activity as a Risk Factor for Hypertension among the Community of Batu Layar Village, West Lombok Regency Saputra, I Putu Bayu Agus; Ni Made Wiasty Sukanty; Anisah; Laksmi Nur Fajrini; I Gede Angga Adnyana
Jurnal Kolaboratif Sains Vol. 8 No. 12: Desember 2025
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v8i12.9028

Abstract

Hipertensi merupakan kondisi peningkatan tekanan darah sistolik lebih dari 140 mmHg dan tekanan darah diastolik lebih dari 90 mmHg pada dua kali pengukuran dengan selang waktu lima menit dalam keadaan istirahat. Tujuan dari kegiatan ini untuk mengidentifikasi masalah kesehatan, menentukan prioritas masalah, merencanakan intervensi pemecahan masalah khususnya terkait masyarakat desa Batu Layar, Kabupaten Lombok Barat. Metode yang digunakan untuk menentukan prioritas masalah dari komunitas masyarakat desa Batu Layar yakni menggunakan metode delphi, prioritas masalah yang didapatkan pada komunitas masyarakat desa Batu Layar yaitu Hipertensi. Hasil penelitian dengan jumlah sampel 136 orang. Hasil dari penelitian ini didapatkan 61 orang. dapat disimpulkan bahwa terdapat hubungan yang signifikan (p<0,05) antara tingkat aktivitas fisik dengan kejadian hipertensi. Analisis data statistik menunjukkan bahwa individu dengan aktivitas fisik rendah memiliki risiko lebih tinggi mengalami peningkatan tekanan darah dibandingkan dengan individu yang melakukan aktivitas fisik sedang hingga tinggi
Kesehatan Fisik dan Mental Remaja: Hubungan Status Gizi dan Tingkat Stres Di Sekolah Menengah Kejuruan Anggriany, Nissa; Fajriani, Laksmi Nur; Sukanty, Ni Made Wiasty; Anisah, Anisah; Isasih, Widani Darma; Ardian, Junendri; Saputra, I Putu Bayu Agus
Bakti Sekawan : Jurnal Pengabdian Masyarakat Vol. 6 No. 1 (2026): Juni
Publisher : Puslitbang Sekawan Institute Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35746/bakwan.v6i1.931

Abstract

Adolescents are an age group vulnerable to various health problems, both physical and mental, along with the biological and psychosocial changes that occur during their developmental phase. Nutritional status and stress levels are two important aspects that play a role in determining adolescent well-being, however existing evidence regarding the relationship between these two variables remains inconsistent. This community service activity aims to describe the nutritional status and stress levels of adolescents and analyze the relationship between nutritional status and stress levels in adolescents in the school environment. The activity was carried out at SMKN 2 Lembar involving 21 adolescents aged 15–17 years using an observational analytical approach with a cross-sectional design. Data collection was carried out by filling out questionnaires on respondent characteristics and stress levels, as well as anthropometric measurements to determine nutritional status. Data were analyzed univariately and bivariately using the Fisher Exact test as an alternative. The results showed that most respondents were 16 years old (42.8%), had good nutritional status (90.5%), and experienced moderate stress (90.5%). The results of the bivariate analysis showed no significant relationship between nutritional status and stress levels in adolescents (p = 0.890). The conclusions of this activity indicate that stress levels in adolescents are not directly related to nutritional status but are likely more influenced by psychosocial factors. Therefore, community service programs in schools need to be implemented holistically, integrating nutrition education and mental health promotion to improve adolescent well-being.
Co-Authors Aditya, I Ketut Agus Yura Aji Kresnapati, I Nyoman Bagus Anggriany, Nissa Anisah ANISAH Ariki, Iptan Arjita, I Putu Dedy Ayu Anulus Benvenuto, Ananta Fittonia Deny Sutrisna Wiatma Dewi, Novianti Tysmala Dhika Juliana Sukmana Diani Sri Hidayati Dwik Putra Nickontara Fachrudi Hanafi Farida Ariani Hardani, H Hermawati, Resna I Gede Angga Adnyana I Putu Deddy Arjita Keninten, Ida Surya Prabawa Satya Kresnapati, I Nyoman Bagus Aji Kurniawan, Nadi Laksmi Nur Fajriani Laksmi Nur Fajrini Lina Yunita Lukitasari, Lina Mamang Bagiansah Manutama, Putu Agi Abhimana Maruni Wiwin Diarti Maruni Wiwin Diarti Maruni Wiwin Diarti Muhamad Wahyu Rizal Musviratunnisah, Bintang Yuniar Ni Made Wiasty Sukanty Ni Made Wiasty Sukanty Purnawan, Desak Putu Diva Mayra Putri Putu Sudiasa Rozikin RR. Ella Evrita Hestiandari Ruqayyah, Siti Sabariah Sabariah Sabariah Samoedra, Reksa Setia, Bayu Siti Khaerunnisa M.Si Sukanty, Ni Made Wiasty Sukmana, Dhika Juliana Syuhada, Irwan Wiasty Sukanty, Ni Made Widani Darma Isasih Yunan Jiwintarum Yunan Jiwintarum Yunita, Lina Zhalifunnafsi, Baiq Nabila