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All Journal HAYATI Journal of Biosciences Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan The Indonesian Biomedical Journal Medical Laboratory Technology Journal Molecular and Cellular Biomedical Sciences (MCBS) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JMM (Jurnal Masyarakat Mandiri) Jurnal Kreativitas PKM FITOFARMAKA: Jurnal Ilmiah Farmasi Current Research on Biosciences and Biotechnology Indonesian Journal of Biological Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kesehatan Sciences of Pharmacy Public Health Risk Assesment Journal Medical Sains : Jurnal Ilmiah Kefarmasian
Melisa Intan Barliana
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : The Indonesian Biomedical Journal

 1 
Stevia rebaudiana Bertoni Leaves Extract as a Nutraceutical with Hypoglycemic Activity in Diabetic Rats Keri Lestari; Abdurahman Ridho; Nuning Nurcayani; Zelika Mega Ramadhania; Melisa Intan Barliana
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.686

Abstract

BACKGROUND: The prevalence of diabetes mellitus is growing every year, including in Indonesia. Medicinal herbs were used empirically for lowering blood glucose. One of potential herb to have hypoglycemic activity is Stevia. Stevia rebaudiana Bertoni leaves contain stevoside, a natural, low-calorie sweetener that is 300 times sweeter than saccharose. In this study, we aimed to explore the hypoglycemic activity of S. rebaudiana Bertoni leaves extract in a rat model of type 2 diabetes mellitus (T2DM). METHODS: Male Wistar rats were feed high-fat, high-carbohydrate feed and sugar solution for 74 days to induce a diabetic rat model. The animals were then divided into five groups consisting of a negative control group treated with 2% Pulvis Gom Arabicum; a positive control group treated with Metformin 45 mg/kg body weight (BW); and three test groups treated with aqueous extract of S. rebaudiana Bertoni leaves at doses of 3.125, 6.25 and 12.5 mg/kg BW for 36 days. Blood glucose was measured on days 14, 28 and 36.RESULTS: The results showed that blood glucose levels over 36 days were significantly (p=0.043) lower in the group treated with S. rebaudiana Bertoni leaves extract. Further Newman-Keuls analysis suggested that the hypoglycemic activity of S. rebaudiana Bertoni leaves extract was dose-dependent. CONCLUSION: Our results indicate that S. rebaudiana Bertoni leaves extract has a potential role as a hypoglycemic agent in the treatment of T2DM.KEYWORDS: Stevia rebaudiana Bertoni, nutraceuticals, hypoglycemic, diabetic rats
Correlation of Moderate-Intensity Physical Exercise on Irisin, Oxidized-LDL and HDL Level in ≥50 Years Old Obese Men Made Putra Semadhi; Melisa Intan Barliana; Dewi Muliaty; Andi Wijaya
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.619

Abstract

BACKGROUND: Irisin is secreted by our muscle during physical exercise, which has been recently studied to be linked with lipid metabolism. The aim of this study was to investigate the role of irisin that interact with the oxidized-low density lipoprotein (ox-LDL) and high density lipoprotein cholesterol (HDL-C) levels that are affected by moderate intensity exercise in obese men aged ≥50 years.METHODS: This was a cross-sectional study with 70 obese men whose age ≥50 years old as participants. Participants were classified into two groups of men with and without physical exercised, based on American College of Sports Medicine (ACSM). Irisin and ox-LDL plasma levels were analyzed using enzyme-linked immunosorbent assay (ELISA), meanwhile the HDL-C serum level was analyzed using homogenous enzymatic methods.RESULTS: The result showed an association between the duration of physical exercise per week and irisin level (R=0.584, p<0.01), also between the duration of physical excercise per week and ox-LDL level (R=-0.274, p<0.05). Meanwhile, there was a negative association between irisin levels and ox-LDL (R=-0.294, p<0.05). Irisin indicated to be correlated with HDL-C (R=0.215, p>0.05).CONCLUSION: Moderate-intensity physical exercise may decrease cardiovascular risk and improve the quality of life among obese subjects aged ≥50 years old, which was indicated by the decrease of ox-LDL and the increase of irisin level. In addition, it can be concluded that the higher the irisin level showed the lower levels of ox-LDL and higher level of HDL-C.KEYWORDS: obesity, elderly, irisin, ox-LDL, HDL-C, physical exercise
Nutritional Biomarkers for Predicting Pancreatic Beta Cell Failure in Central Obesity Miftakh Nur Rahman; Ajeng Diantini; Miswar Fattah; Melisa Intan Barliana
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1440

Abstract

BACKGROUND: There is a continuous rise in the prevalence of central obesity and become a pressing health problem in the world. Central obesity followed by many metabolic disorders especially Type 2 Diabetes Mellitus (T2DM). The pathogenesis started from overnutrition signal that force pancreatic beta cells to produce a large number of insulin. Low-grade chronic inflammation that occurred also affects the organs sensitivity against insulin and caused beta cells to compensated this situation and at the end become exhausted and loss its function.CONTENT: Along compensation mechanism, certain nutrients were support the beta cells to maintain their mass and function to produce insulin. Short chain fatty acids (SCFAs) are gut microbiota fermentation product that act as nutrient and give an advantage to the proliferation and survivability of the beta cells. Zinc (Zn) also plays an important role in every step of insulin production. Moreover, these nutrients protecting pancreas against inflammation and oxidative stress through certain mechanism. Most of patients with central obesity are unaware of the presence of this disturbance at early stage. Whereas, at molecular level there is a magnitude of SCFAs and Zn level in the blood that would become an early signal and predict the damage of beta cells.SUMMARY: Quantification of these two nutrients in the blood expected to provide an early warning tool to maintain insulin adequacy and predict the possibility of beta cell failure in central obesity with promising performance.KEYWORDS: central obesity, T2DM, SCFAs, Zinc, beta cell failure 
Apoptosis and Efferocytosis in Inflammatory Diseases Chandra Agung Purnama; Anna Meiliana; Melisa Intan Barliana; Keri Lestari Dandan; Andi Wijaya
The Indonesian Biomedical Journal Vol 13, No 3 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i3.1608

Abstract

BACKGROUND: Millions of cells in multicellular organisms regenerate every day to replace aged and died cells. Effective cell clearance (efferocytosis) is critical for tissue homeostasis, as the human body recycles its cellular components. We summarize what is known about the mechanisms of efferocytosis and how it impacts the physiology of the organism, effects on inflammation and the adaptive immune response, as well as the consequences of defects in this critical homeostatic mechanism in this review.CONTENT: Cell death is the process by which the human body replaces aged or damaged cells with new ones. It can be triggered by genetically encoded machinery or regulated cell death, or by specific pharmacologic or genetic interventions, resulting in accidental cell death. Dying cells release signals that entice phagocytes to engulf them in a process known as efferocytosis. Efferocytosis is a multistep process involving the release of “find me” and “eat me” signals and destruction of death cells by phagocytes. Different types of cell death including apoptosis and necroptosis can express pro- or anti-inflammatory signals via macrophage activity modulation.SUMMARY: Failed or ineffective efferocytosis can result in disruption of tissue homeostasis, which can contribute to the development of chronic inflammatory diseases such as atherosclerosis, obesity, diabetes, and heart failure. Therefore, any therapeutic strategy that enhances efferocytosis will have a beneficial effect on the treatment of these metabolic disorders.KEYWORDS: apoptosis, necroptosis, phagocytosis, efferocytosis, macrophage.
Efficacy of Quinine Sulfate in Patients with Mild-To-Moderate COVID-19: A Randomized Controlled Trial Irma Rahayu Latarissa; Melisa Intan Barliana; Anna Meiliana; Ida Paulina Sormin; Erizal Sugiono; Cissy Bana Kartasasmita; Irmansyah Irmansyah; Keri Lestari
The Indonesian Biomedical Journal Vol 15, No 6 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i6.2543

Abstract

BACKGROUND: Before WHO revoked the emergency use authorization for Chloroquine (CQ) and Hydroxychloroquine (HCQ) because of their side effects, it was suggested to use these two drugs for COVID-19 therapy. In addition, another derivate of quinine, namely Quinine Sulfate (QS), showed good in silico and in vitro antiviral activity against SARS-CoV-2. Prior the WHO revocation, this study was conducted to evaluate the efficacy of QS in mild-to-moderate COVID-19 patients.METHODS: This was an adaptive, controlled, multicenter, randomized, double-blind clinical trial involving mild-to-moderate COVID-19 patients in Indonesia. The participants were divided into 2 groups: the control group (standard COVID-19 treatment + placebo) and the treatment group (standard COVID-19 treatment + QS). The primary outcome was the efficacy of QS based on clinical status using a 7-point ordinal scale. The secondary outcomes were the efficacy of QS in terms of the incidence and duration of oxygen supplementation, incidence of mechanical ventilation, and length of stay.RESULTS: No significant difference in the efficacy parameters studied was found between the control group and the treatment group. The difference in the mean oxygen saturation was also measured and the results showed a significant difference where the treatment group had higher mean oxygen saturation than the control group (p=0.001).CONCLUSION: Although not significant, the treatment group showed better therapy outcomes compared to the control group.KEYWORDS: clinical trials, efficacy, quinine, chloroquine, hydroxychloroquine
B Cell-Activating Factor (BAFF) and Ubiquitin Enzyme A20 as Functional Proteins in Targeted Therapy on Patients with Systemic Lupus Erythematosus Fajar, Desi Reski; Rostinawati, Tina; Hamijoyo, Laniyati; Barliana, Melisa Intan
The Indonesian Biomedical Journal Vol 16, No 5 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i5.3161

Abstract

BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by inflammation. The pathogenesis of SLE involves key proteins, including B cell-activating factor (BAFF) and the ubiquitin enzyme A20, both serving as negative regulators of inflammation and contributing to B cell homeostasis. In this review, focused on interventions directed at BAFF and the A20 enzyme, utilizing monoclonal antibodies either independently or in conjunction with conventional therapy for SLE patients.METHODS: A literature search was conducted on the PubMed platform by combining various terms, including "B-cells activating factor", "TNFAIP3 protein (human)", "therapeutics" or "drug therapy", and "lupus erythematosus, systemic" (limited to the last 10 years). From total of 104 articles discovered in thr search, the total number of articles collected after being filtered was 27 articles.RESULTS: Clinical development and evaluation have been conducted regarding the use of appropriate therapy for SLE patients. Selective BAFF inhibitor has been tested in clinical trials as a blocking agent in BAFF receptor (BAFF-R) and signaling nuclear factor-kappaB (NF-κB) by A20 bindings to inhibit the activation of autoreactive B cells. Just like other antimonoclonal therapies, BAFF and the A20 enzyme can be used as therapeutic targets with a single use or combined with the standard therapy in patients with SLE. In addition, the use of BAFF and A20 also shown to have safe side effects in patients with SLE. CONCLUSION: BAFF protein and A20 enzyme present promising therapeutic targets for managing autoimmune diseases like SLE. Therapeutic interventions can be administered individually or in conjunction with standard treatments.  KEYWORDS: systemic lupus erythematosus, therapeutic targets, BAFF, A20
Co-Authors Abdurahman Ridho Afifah, Nadya Nurul AGATHA VIKA PURWANINGTYAS Ahmad Faried Ahmad Muhtadi Ajeng Diantini, Ajeng Aliya Nur Hasanah Among, Sayyid Andi Wijaya Andi Wijaya ANDI WIJAYA Angliana Chouw, Angliana Anna Meiliana Anna Meiliana ARNANDA, QUINZHEILLA PUTRI Balqist, Syara Nur Fitri Bonor, Toga Chandra Agung Purnama Cissy Bana Kartasasmita Cynthia Retna Sartika, Cynthia Retna Dedi Suyatno Dewi Muliaty Didi Susanto Driyanti Rahayu Edhyana Sahiratmadja Effendi, M. Fariz ELLENA MAGGYVIN Erizal Sugiono Eva Feriadi Fajar, Desi Reski Febio Gutama Febriyanti, Maya Haifa, Rima HISBAN HAMID ARIFKI Ida Paulina Sormin Imas Maesaroh Indradi, Raden Bayu Intania, Ruri Irma Melyani Puspitasari Irma Rahayu Latarissa Irmansyah Irmansyah Ivan Pradipta Ivan Surya Pradipta Karina Erlianti Kennardi, Gabriel Bagus Keri Lestari Khaira, Syifa Komang Suma Triyasa Laniyati Hamijoyo, Laniyati LILY CYNTIA FAUZI Luki Yogaswara Yusuf Made Putra Semadhi Maisyarah, Intan Timur Maya Febriyanti Miftakh Nur Rahman Miswar Fattah Moses Prasetio Muhaimin Muhaimin Muhammad Fauzi Munir Alinu Mulki Mustikawati, Bunga Nadiya Nurul Afifah Nuning Nurcayani Peratiwi, Shafira Galuh Permatasari, Lany Indah Pratama, Muhammad Syawal Prayudi Santoso Putri Maharani Putri, Nazwa Septiriana Qolbina, Shofura Marsa Raden Maya Febriyanti Rendrayani, Farida Rimadani Pratiwi Rizki Rahmadi Pratama Rizky Abdulah Sahila, Elma N. M. R. Sartika Aprianti Shelly Iskandar Soemarie, Yulistia Budianti Syahrina, Nadira Alvi Tahara, Nabila Theresia Ratnadevi TIANA MILANDA Tina Rostinawati Widya Naftalia Wijasa Yudisia Ausi Yulistia Budianti Soemarie Yulistia Budianti Soemarie Yuni Elsa Hadisaputri Zakiyah, Neily Zelika Mega Ramadhania