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All Journal Farmaka Majalah Obat Tradisional The Indonesian Biomedical Journal Pharmacology and Clinical Pharmacy Research Majalah Farmasetika Indonesian Journal of Biological Pharmacy The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Sains dan Teknologi Farmasi Indonesia Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran FASKES : Jurnal Farmasi, Kesehatan, dan Sains International Journal of Health and Medicine ETHOS: Jurnal Penelitian dan Pengabdian kepada Masyarakat
Rini Hendriani
Departemen Farmakologi Dan Farmasi Klinik, Fakultas Farmasi, Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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REVIEW ARTICLE: PERAN OBAT HERBAL SEBAGAI TERAPI SUPORTIF COVID-19 Kiki Ikrima; Rini Hendriani
Farmaka Vol 20, No 1 (2022): Farmaka (Maret)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i1.34769

Abstract

ABSTRAKCorona virus disease 2019 (COVID-19) adalah infeksi virus yang muncul dengan prevalensi yang terus meningkat di seluruh dunia. Manajemen pengobatan pada COVID-19 difokuskan kepada diagnosa dini, isolasi mandiri, dan perawatan umum dan suportif. Tujuan penulisan review article ini adalah untuk mengetahui peran obat herbal sebagai terapi suportif untuk pasien dengan COVID-19. Metode yang dilakukan dalam penyusunan review article yaitu dengan studi pustaka primer dengan publikasi dari database online maksimal 10 tahun terakhir. Hal ini dilakukan sesuai dengan bukti klinis yang menunjukkan bahwa pemanfaatan obat herbal dalam perawatan COVID-19 dapat mempercepat proses penyembuhan dibandingkan dengan perawatan yang hanya menggunakan obat modern. Beberapa tanaman herbal juga berpotensi sebagai antiviral yang dapat menghambat virus corona, diantaranya yaitu meniran (Phyllantus niruri L.), cengkeh (Syzygium aromaticum), teh hijau (Camelia sinensis), jahe merah (Zingiber Officinale), kunyit (Curcuma longa L.) dan bawang putih (Allium sativum), dimana senyawa fitokimia yang terkandung dalam tanaman herbal tersebut dapat mengikat situs receptor-binding domain(RBD) protein S virus dan juga ke situs perlekatan virus di reseptor ACE2.ABSTRACTCorona virus disease 2019 (COVID-19) is an emerging viral infection with increasing prevalence worldwide.  Treatment management for COVID-19 is focused on early diagnosis, self-isolation, and general and supportive care.  The purpose of writing this review article is to explore the role of herbal medicine as supportive therapy for patients with COVID-19.  The method used in preparing the review article is by studying primary literature with publications from online databases for the last 10 years.  This is done in accordance with clinical evidence showing that the use of herbal medicines in the treatment of COVID-19 can speed up the healing process compared to treatments that only use modern medicine.  Some herbal plants also have the potential as antivirals that can inhibit the corona virus including meniran (Phyllantus niruri L.), cloves (Syzygium aromaticum), green tea (Camelia sinensis), red ginger (Zingiber Officinale), turmeric (Curcuma longa L.) and garlic (Allium sativum), where the phytochemical compounds contained  in herbal plants can bind to the viral S protein receptor-binding domain (RBD) site and also to the viral attachment site at the ACE2 receptor.
TINJAUAN AKTIVITAS ANTIBAKTERI EKSTRAK Cassia Fistula TERHADAP Staphylococcus aureus dan Escherichia coli: ARTIKEL REVIEW AI SITI RIKA FAUZIAH; Rini Hendriani
Farmaka Vol 15, No 2 (2017): Suplemen
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2862.587 KB) | DOI: 10.24198/jf.v15i2.13175

Abstract

Terdapat banyak mikroorganisme yang dapat menyebabkan masalah kesehatan (infeksi). Salah satunya yaitu S. aureus dan E.coli yang sebenarnya merupakan flora normal tubuh namun dapat menjadi patogen ketika terdapat suatu gangguan pada tubuh. Telah dikembangkan banyak obat-obatan untuk melawan infeksi terhadap mikroorganisme, namun kadang terjadi resistensi bakteri akibat tidak sensitifnya suatu bakteri terhadap obat tertentu yang sudah ada. Oleh karena itu, perlu dikembangkan suatu obat baru untuk melawan bakteri tersebut salah satunya dari tanaman. Salah satu tanaman yang sudah terbukti memiliki aktivitas antibakteri adalah Cassia fistula. Metode yang digunakan dalam pengujian aktivitas antibakteri adalah metode difusi paper disc. Dari beberapa jurnal yang telah ditelaah, didapat data-data mengenai aktivitas antibakteri dari berbagai bagian tumbuhan dengan berbagai pelarut. Dari data tersebut, aktivitas antibakteri terbaik ditunjukan oleh ekstrak biji dengan pelarut metanol pada konsentrasi 400 mg/ml dengan zona hambat 18 mm pada S. aureus dan 16 mm pada E. coli. Hal ini menunjukan bahwa aktivitas antibakteri tersebut berada pada tingkat sedang.Kata kunci: infeksi, resistensi, Cassia fistula, aktivitas antibakteri
REVIEW ARTIKEL: DIAGNOSIS DAN MANAJEMEN TERAPI ASMA AINI QOLBIYAH AFGANI; RINI HENDRIANI
Farmaka Vol 18, No 2 (2020): Farmaka (September)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v18i2.26222

Abstract

Asma merupakan penyakit heterogen, biasanya dikarakterisasi dengan adanya inflamasi kronis pada jalur pernafasan. Dapat ditandai dengan adanya mengi, nafas yang pendek, batuk dan rasa sesak di dada yang berulang dan intensif. Menurut hasil Riskesdas pada tahun 2018, prevelensi asma pada penduduk di Indonesia untuk semua umur mencapai angka 2,4%, dengan prevalensi terbanyak ada pada usia 75 tahun lebih. Oleh karena itu, artikel ini dibuat dengan tujuan untuk memberikan informasi mengenai penyakit asma, agar masyarakat mengetahui penyakit asma dan dapat lebih waspada dalam menangani penyakit asma. Metode yang dilakukan adalah dengan menggunakan pengumpulan data yang diperoleh dari berbagai sumber jurnal penelitian dari Elsevier, ResearchGate, Sciencedirect, dan situs jurnal lain pada tahun 2010-2019. Dari penulusuran pustaka didapatkan bahwa asma dapat didiagnosa dengan melihat riwayat medis, pemeriksaan fisik dan pengukuran objektif, serta pertanyaan kunci yang ditanyakan kepada pasien. Manajemen terapi yang digunakan pada pasien asma terdiri dari obat pereda dan obat pengontrol.
Review : Teknik Peningkatan Kelarutan Obat WILLYBRORDUS YOGA PERDANA ADHITYA PRAMUDHITA; Rini Hendriani
Farmaka Vol 14, No 2 (2016): Suplemen
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (354.583 KB) | DOI: 10.24198/jf.v14i2.10866

Abstract

Kelarutan merupakan parameter penting bagi suatu obat dalam mencapai konsentrasi yang dibutuhkan untuk menghasilkan respon farmakologi. Banyak obat memiliki kelarutan yang buruk di dalam air, padahal obat harus berada dalam bentuk terlarut ketika akan diabsorpsi. Banyak teknik yang telah dikembangkan untuk peningkatan kelarutan obat meliputi modifikasi fisik, modifikasi kimia, ataupun teknik lain.Kata kunci: Kelarutan, Peningkatan, Obat
TANAMAN HERBAL YANG MEMILIKI AKTIVITAS HEPATOPROTEKTOR Desi Dina Hanifa; Rini Hendriani
Farmaka Vol 14, No 4 (2016): Farmaka
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.389 KB) | DOI: 10.24198/jf.v14i4.11131

Abstract

Hati merupakan organ yang memiliki fungsi penting untuk metabolisme dalam tubuh. Kerusakan yang terjadi pada hati dapat disebabkan senyawa yang bersifat hepatotoksik. Untuk memperbaiki dan mengobati kerusakan hati, dapat menggunakan hepatoprotektor. Banyak tanaman herbal telah dilaporkan memiliki aktivitas sebagai hepatoprotektor. Mekanismenya diduga karena adanya antioksidan yang dapat mencegah terbentuknya radikal bebas yang dihasilkan oleh hepatotoksin. Dari 20 tanaman yang ditelaah dari sumber data review berupa jurnal dan internet, kayu manis memiliki efek hepatoprotektor terbesar dengan dosis 10 mg/Kg BB, diikuti dengan daun legundi dan gambir dengan dosis 30 mg/Kg BB.Kata kunci     : Tanaman herbal, Hepatoprotektor, Antioksidan
ANALISIS ABC DALAM PERENCANAAN OBAT ANTIBIOTIK DI APOTEK Luthfiah Pertiwi; Eky Septian Pradana; Rini Hendriani
Farmaka Vol 20, No 1 (2022): Farmaka (Maret)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i1.32643

Abstract

Perencanaan obat merupakan tahap awal untuk menetapkan jenis dan jumlah yang sesuai dengan kebutuhan. Antibiotik adalah terapi utama dalam mengobati penyakit infeksi bakteri sehingga harus dilakukan pengendalian obat yang baik untuk menghindari terhambatnya proses pelayanan obat kepada pasien. Penelitian ini bertujuan untuk mengelompokkan obat antibiotik berdasarkan analisis ABC untuk mempermudah perencanaan obat antibiotik di Apotek. Metode penelitian menggunakan metode deskriptif dengan pengambilan data secara retrospektif yang didasarkan pada dokumen penggunaan obat Antibiotik periode Agustus-Oktober tahun 2020 di salah satu apotek di Kota Bandung. Hasil penelitian menunjukkan bahwa 122 item obat Antibiotik dikelompokkan berdasarkan analisis ABC, didapatkan kelompok A nilai pemakaiannya 41,50% dengan nilai investasi 69.51%. Kelompok B memiliki nilai pemakaian 45,00% dan nilai investasi 20,15%. Kelompok C nilai pemakaiannya 13,50% dengan nilai investasi 10,33%. Kelompok A terdiri dari 24 item, menyerap anggaran sebesar Rp.67.331.434,00. Kelompok B terdapat 26 item, menyerap anggaran sebesar Rp.19.518.487,00. Kelompok C terdiri dari 72 item, menyerap anggaran sebesar Rp.10.010.281,00. Total anggaran antibiotik secara keseluruhan sebesar Rp.96.860.202,00. Drug’s planning is the initial stage to determine the type and amount that suits your needs. Antibiotics are the main therapy used to treat bacterial infections, so good drug control must be carried out to avoid drug vacancies that can hinder the process of drug service to patients. This study aims to classify antibiotic drugs based on ABC analysis to facilitate the planning of antibiotic drugs in pharmacies. The method used is descriptive research with retrospective data collection based on documents of antibiotics uses from August - October 2020 at a pharmacy in Bandung. The results showed that 122 items of antibiotic drugs grouped based on ABC analysis, it was found that group A had usage value of 41.50% and investment value of 69.51%. Group B has usage value of 45.00% and investment value of 20.15%. Group C has usage value of 13.50% and investment value of 10.33%. Group A consists 24 items with budget of Rp. 67,331,434.00. Group B contained 26 items with budget of Rp. 19,518,487.00. Group C consists 72 items with budget of Rp. 10,010,281.00. The total budget for antibiotics as a whole is Rp. 96,860,202.00.
Anticancer Activity Of Plant Genus Clerodendrum (Lamiaceae): A Review Donald Emilio Kalonio; Rini Hendriani; Elisabeth N. Barung
Majalah Obat Tradisional Vol 22, No 3 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (813.123 KB) | DOI: 10.22146/mot.31554

Abstract

Plants of the genus Clerodendrum (Lamiaceae) is widespread in tropical and subtropical regions. Plants of this genus are used both empirically and scientifically as anti-inflammatory, antidiabetic, antimalarial, antiviral, antihypertensive, hypolipidemic, antioxidant, and antitumor. Results of the molecular docking simulation of chemical content of these plants could potentially provide an anticancer effect. This paper aims to review the anticancer activity of plant genus Clerodendrum based on scientific data. The method used in this study is the literature study. Searches were conducted online (in the database PubMed, Science Direct and Google Scholar) and on various books (Farmakope Herbal Indonesia and PROSEA). A total 12 plants of the genus Clerodendrum have anticancer activity in vitro and in vivo, thus potentially to be developed as a source of new active compounds with anticancer activity.
The Number and Potency of Endothelial Progenitor Cells in Type 2 Diabetes Mellitus Patients Siska Darmayanti; Rini Hendriani; Cynthia Retna Sartika
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.576

Abstract

BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a metabolic disease, due to the disorder of insulin function, insulin secretion, or both. Long-term hyperglycemia conditions promote endothelial dysfunction precedes to the development of multiple organ dysfunctions. Endothelial progenitor cells (EPCs) and hematopoietic stem cell (HSCs) are the key cellular effectors of postnatal neovascularization and play central role in endothelial dysfunction. However, in T2DM condition, the number of apoptotic HSCs increase, it may cause the reduction in potency and number of EPCs. In diabetes, the circulating EPCs number decrease and their functionality is impaired,  but mechanism underlie of this impairement is unknown. The purpose of this study was to examine the relationship duration diabetes with  the number and potency of EPC cells in T2DM patients controlled and poorly controlled.METHODS: Thirty-eight T2DM male patients were classified into two group based on Indonesian Society of Endocrinology/Perkumpulan Endokrinologi Indonesia (PERKENI) criteria   on T2DM.  The   first   group   was a controlled glycemic condition group (hemoglobin A1c (HbA1C) <7.0%) and the second group was a poorly controlled glycemic condition group (HbA1C >7.0%). Cluster of differentiation (CD)34+ and CD133+ expressions were used as specific marker for EPC, while quantified bright aldehyde dehydrogenase (ALDHbr) assay was used to represented the potency of EPCs.RESULTS: This study showed that in poorly controlled T2DM group the number of EPCs was lower by 24.80% (p<0.05) compared to the T2DM controlled group. Similarly, the expression of ALDHbr was lower by 43.07% (p<0.05) in poorly controlled group.CONCLUSION: There was a decrease in the number and potency of EPCs in poorly controlled T2DM patients compared to the controlled T2DM patients. There was also a strong negative correlation between the duration of diabetes and number of EPCs.KEYWORDS: ALDHbr, endothelial progenitor cells, type 2 diabetes mellitus
Subchronic Toxicity of Ethanol Extract of Syzygium polyanthum (Wight) Walp. Leaves on Wistar Rat Sri Adi Sumiwi; Ade Zuhrotun; Rini Hendriani; Mochamad Rizal; Jutti Levita; Sandra Megantara
The Indonesian Biomedical Journal Vol 11, No 1 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i1.458

Abstract

BACKGROUND: Previous works indicated various pharmacology activities of bay plant (Syzygium polyanthum (Wight) Walp.), however only few studies investigated its toxicity. This work was aimed to study the subchronic toxicity of ethanol extract of this plant.METHODS: White Wistar rats were divided into 4 groups and were treated with 2% of Arabic gum (PGA) suspension, 1000 mg/kg of body weight (BW), 400 mg/kg of BW and 100 mg/kg of BW, respectively. The animals were observed on their body weight, hematology, clinical biochemistry parameters, organ index and histopathology.RESULTS: Flavonoids, tannins, polyphenols, saponins, quinones, monoterpenes and sesquiterpenes were detected in dried leaves and ethanol extract of bay plant. An increase of body weight in male and female groups treated with dose 100 and 400 mg/kg BW compared to controls, was observed. Moreover, there was an increase of white blood cell (WBC) in male and female groups treated with S. polyanthum extracts compared to controls, whereas a decrease of red blood cell (RBC) was observed in male groups treated with S. polyanthum extracts in dose-dependent manner compared to control. No significant changes of RBC were seen in female groups, haemoglobin values were not altered by extract treatment. Photomicrographs of liver, kidney, lungs, heart and spleen histopathology of male and female S. polyanthum extract-treated groups showed no significant alteration compared to controls.CONCLUSION: Our study revealed that S. polyanthum extracts does not show toxicity on the body weight, hematology, creatinine and serum glutamic pyruvic transaminase (SGPT), but fatty liver and necrosis are observed in female rats. This result can be beneficial for plant-based drug discovery, particularly this study provides information about the safety of S. polyanthum to be further developed as candidate of phytopharmaceutics.KEYWORDS: bay plants, salam leaves, hepatotoxicity, necrosis, SGOT, SGPT
In-Vivo Effectiveness of 5% Azadirachta indica Oil Cream as Anti-Scabies Patihul Husni; Mayang K. Dewi; Norisca A. Putriana; Rini Hendriani
Pharmacology and Clinical Pharmacy Research Vol 4, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.947 KB) | DOI: 10.15416/pcpr.v4i1.21388

Abstract

Scabies is an infectious skin disease caused by mite Sarcoptes scabiei. Neem tree (Azadirachta indica) has the potential to be used as an anti-parasite due to the presence of azadirachtin compound that is commonly found in the seeds. The aim of this study was to evaluate in-vivo effectiveness of neem oil as an anti-scabies. This study used an experimental method.  The effectiveness of the cream as an anti-scabies was tested on New Zealand white rabbits which were infected with scabies. Permethrin cream was used as a positive control and cream base was used as a negative control.  Cream was applied once daily and left for 8 hours. The data were analyzed using Kruskal Wallis and Mann Whitney. Dermal acute irritation test was performed by applying  0.5 g cream on the rabbit dorsal. We found that 5% neem oil cream was effective as an anti-scabies with 20-21 days recovery time. The recovery time is longer than permethrin cream (7-8 days), but shorter compared to negative control with recovery time over 30 days. Primary irritation index for 5% neem oil creams was 0, indicating negligible irritation category. In conclusion, A. indica cream was effective for the treatment of scabies although its recovery time is shorter than permethrin cream.  Keywords: effectiveness test, irritation test, neem oil cream, scabies
Co-Authors Ade Zuhrotun AI SITI RIKA FAUZIAH AINI QOLBIYAH AFGANI Anis Yohana Chaerunisaa ANNISA LAZUARDI LARASATI ASLAMNUR FIKRI RAMADHANA Aslamnur Fikri Ramadhana Asti Widiani Astiningsih Diah Pravitasari Atikah Khairunnisa Auliya A. Suwantika Cynthia Retna Sartika Desi Dina Hanifa Dewi, Sumartini Diah Lia Aulifa DILA TRIARINI Djamaluddin, Muhammad Ilham DOLIH GOZALI Donald Emilio Kalonio Eli Halimah, Eli Elisabeth N. Barung Ellin Febrina Enny Rohmawaty Fathurrahman, Muhammad Hilmi Herawati, Irma E. Hesti Lina Wiraswati Irma M. Puspitasari, Irma M. Jutti Levita Karim, Bilqisti Kanzabila Kiki Ikrima Luthfiah Pertiwi Mayang K. Dewi MEGANTARA, SANDRA Mochamad Rizal Muhammad Begawan Bestari MUHAMMAD IKHWAN Mutakin Mutakin Nenny Agustanti Norisca A. Putriana Nurul Fauziah Rosandi Nyi Mekar Saptarini Patihul Husni Pradana, Eky Septian Rahman, Nazhmi Fauzan Fadhl Ramadhiany, Ziyan Zulfah Rendy Septyadi Resmi Mustarichie RIFA NURFAUZIAH Riska Nurul Hidayah Rosdianto, Aziiz Mardanarian Rusdianto, Aziiz M. Saragih, Winda A. M. SASQIA FATURACHMAN Savira Ekawardhani Siska Darmayanti Sistha Anindita Pinastika Heningtyas Sri Adi Sumiwi Sumiwi, Sri A. Sunani, Sunani Syauqi Nawwar Rafif Usman, Hermin A. Wahyuni, Indah S. Wijaya, Muhammad Palar WILLYBRORDUS YOGA PERDANA ADHITYA PRAMUDHITA Yoga Windhu Wardhana