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All Journal Universa Medicina Jurnal Biomedika dan Kesehatan Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti JUARA: JURNAL WAHANA ABDIMAS SEJAHTERA JURNAL ABDI MASYARAKAT INDONESIA (JAMIN) Jurnal Abdimas Kesehatan Terpadu Jurnal Pengabdian Masyarakat Trimedika
Husnun Amalia, Husnun
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Journal : Jurnal Biomedika dan Kesehatan

 1 
Survei Pola Kuantitas Peresepan Antibiotik di Tiga Rumah Sakit di Indonesia dengan Penatagunaan Antimikroba Digital Natadidjaja, Ronald Irwanto; Lekok, Widyawati; Ariyani, Aziza; Adlani, Hadianti; Adianto, Raymond; Maharani, Ronaningtyas; Sumarsono, Hadi; Yenny, Yenny; Samira, Jihan; Hairunisa, Nany; Amalia, Husnun; Faradila, Meutia Atika; Fadilah, Tubagus Ferdi; Kalumpiu, Joice Viladelvia; Yuliana, Yuliana; Mulyani, Sri; Anggiat, Desi; Marja, Triyoko Septio; Pertiwi, Iin Indra; Dianawati, Dianawati; Legoh, Grace Nerry; Rantung, Alvin Lekonardo
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Background Antimicrobial Stewardship Program (ASP) is very essential. There are three categories of antimicrobial agents as recommended by WHO: Access, Watch and Reserve. e-RASPRO, a digital ASP model, may alter antibiotic prescribing patterns by prioritizing Access category antibiotic prescribing. Methods Our manuscript presented a quantitative survey on antibiotic prescribing patterns within 3 months and 9 months before and after implementing digital electronic-RASPRO (e-RASPRO) in three Indonesian hospitals, utilizing retrospective inpatient data. This analysis included the appropriateness of empirical antibiotic prescribing and the quantity of antibiotic prescribing based on each category. Results In the first 3 months, we found that 90.16%, 83.98%, and 81.15% of patients were included in Type 1 Risk Stratification. The appropriateness of initial empirical antibiotic prescribing with the digital guideline on antimicrobial use of e-RASPRO in three hospitals was 81.59%, 76.09% and 24.48%, respectively. Within 9 months after implementing e-RASPRO in Hospital A and B and within 3 months in Hospital C, there was a trend of reduced quantity of Watch category antibiotic prescribing of 54.93% (-58.86% per inpatient), 21.11% (-9.97% per inpatient), and 8.59% (-4.15% per inpatient), respectively. There was a 12.42% (+2.61 % per inpatient) and 223.17% (+268.83% per inpatient) increase in the quantity of Access category antibiotic prescribing in Hospitals A and B, while in Hospital C, the quantity decreased by 6.81% (-2.29% per inpatient).   Conclusions There are changes in antibiotic prescribing patterns, particularly in the antibiotics included in the Watch and Access categories following the implementation of e-RASPRO. The relationship between digital antimicrobial stewardship use and the results still needs further research.
Deteksi gen secara Epidemiologi Molekuler pada Isolat Klinik Klebsiella pneumoniae dari Pasien Dewasa dengan komorbid di Rumah Sakit Baghdad Kudaer, Nuha B; Risan, Mohsen Hashim; Raheem, Rasha; Zainulabdeen, Khalid; Salman, Israa; Hairunisa, Nany; Amalia, Husnun; Hameed, Seenar; Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.196-215

Abstract

Background Klebsiella species is one of the most worldwide opportunistic pathogens in the world that cause infections at multiple sites like lung, urinary tract, bloodstream, wound or surgical site, and brain. Klebsiella pneumoniae has many types of virulence factors that give the bacteria the ability to invade the host and cause infections. Methods A total of (105) human clinical samples were collected from different patients with different cases. Klebsiella pneumonia were isolated from 30 samples. The bacteria were identified by biochemical tests and certified by using VITEK 2 system and genetically by amplify using PCR for 16 rRNA gene. One of the Klebsiella pneumoniae virulence factors is the capsule that is responsible for the macrophage resistance and its also responsible for serotype. So to confirm the strains isolated, PCR Gene detection of, MagA, K2A, RmpA, and Kfu, where (magA, k2A, rmpA, kfu) gens are responsible for capsule synthesis of Klebsiella pneumonia have been done. Results There were 30 strains of Klebsiella pneumoniae were identified. Epidemiological studies show that infections are preceded by gastrointestinal colonization, with the gastrointestinal tract being the most important reservoir for transmission. The primary bacterial isolates were identified based on their cultural, microscopic, and biochemical traits. The API system (API 20E) and VITEK 2 systems were used to confirm the identity of the bacterial isolates. Colony morphology revealed that Klebsiella pneumonia was Gram-negative, non-motile, microscopic straight rods grouped singly or in pairs. Biochemical tests showed that neutral end products prevailed over acidic end products, with Klebsiella producing negative results for indole. The Kligler Iron Agar (KIA) test showed that Klebsiella isolates changed the color of the slant and butt, producing an acidic slant and acid butt, along with gas production. The urease test for Klebsiella distinguishes between Enterobacter and Klebsiella isolates, as Klebsiella can manufacture the urease enzyme. The indole test distinguishes K. pneumonia from K. pneumonia from K. mobiliz. The API 20E system was used for biochemical testing, and the VITEK 2 system was used for identification. The VITEK 2 system was used to test for biochemical and antibiotic susceptibility, and the results supported the findings from morphological and biochemical analyses. PCR amplification was used for molecular detection, and all nine isolates tested positive for the magA and k2A genes. The ferric iron uptake system gene (kfu) and the extracapsular polysaccharide synthesis regulator gene (rmpA) were amplified using specific primer pairs. The VITEK 2 system demonstrated promising outcomes for K. pneumoniae identification. However, standard diagnostic methods are costly and time-consuming. Conclusions Navigating the complex landscape of infectious diseases, collaborative research projects have become indispensable in unraveling the mysteries surrounding pathogens. The project in Baghdad, having stood as a shining example of such collaboration, provided valuable insights into the identification, characterization, and molecular aspects of Klebsiella pneumoniae strains. The findings, have not only contributed to the scientific community's understanding of bacterial infections but also paved the way for enhanced strategies in diagnosis and treatment.
Studi Faktor-Faktor yang Berhubungan dengan HIV pada Perempuan di Kalimantan Barat, Indonesia Hairunisa, Nany; Sabrina, Isra; Amalia, Husnun; Mashabi, Yasmine; Zaina, Nashita Amira; Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 6 No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.89-107

Abstract

Background According to national data, West Kalimantan is one of the ten top provinces that reported AIDS cases, ranked eighth. Until December 2019, based on data recorded in the Provincial Health Office that reported to the Indonesia Ministry of Health, the AIDS case rate in West Kalimantan was 49.35, showing over the national AIDS case rate (38.93). In this study, an unmatched case-control determines the factors associated with HIV/AIDS among women in West Kalimantan, Indonesia. Methods The study was conducted among 90 women who tested positive for HIV/AIDS (cases) and 90 who tested negative for HIV/AIDS (controls). Data were collected using questionnaires from June 2019 to August 2019 at three community health centres in West Kalimantan. Data were analyzed using IBM Statistical Package Social Science (SPSS) 19. Descriptive analyses and Multivariate logistic regression analysis were used to examine the factors associated with HIV/AIDS. Results: This study has found a significant association between crucial aspects such as marital status, occupation, knowledge about HIV/AIDS, HIV treatment, and VCT (Voluntary Counseling and Testing) service program with cases of HIV/AIDS. A significant association between marital statuses with HIV/AIDS suggests that divorced/widowed have a higher risk of having HIV/AIDS, followed by the married group. Women with good educational backgrounds will likely know how to prevent HIV infection and take preventive measures to protect themselves. Results This study found a significant relationship between several important aspects such as marital status, occupation, knowledge of HIV/AIDS, HIV treatment, and the VCT (Voluntary Counseling and Testing) service program with HIV/AIDS cases. The significant relationship between marital status and HIV/AIDS shows that divorced/widows have a higher risk of contracting HIV/AIDS, followed by the married group. Women with a good educational background tend to know about HIV infection prevention measures and take precautions to protect themselves. Conclusions Some factors are significantly related to HIV/AIDS. Thus, educating women about sex could potentially decrease the number of HIV/AIDS cases.
Studi Banding tentang pengembangan vaksin untuk COVID-19 Alsayed, Raghda; Zainulabdeen, Khalid; Salman, Israa; Hairunisa, Nany; Amalia, Husnun; Yusop, Rahimi M; Redwan, Amamer M; Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 6 No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.127-132

Abstract

The human respiratory system can be infected with coronaviruses (CoVs), one of the families of viruses that can lead to symptoms ranging from mild to fatal. Seven genera of CVS have been identified as having human infection to date. The virus can spread as fine, liquid particles from the mouth or nose of an infected person when coughing, sneezing, speaking, or breathing. The diameter of droplet particles ranges from large to small. In this review, we summarize vaccine development for COVID-19. We anticipate this study will be a valuable resource for any researcher interested in creating a COVID-19 vaccine.
Pterigium berhubungan dengan Sindroma Mata Kering pada Pengemudi Ojek Online Kartadinata, Erlani; Amalia, Husnun; Adiwardhani, Anggraeni; Witjaksana, Riani; Prasetyaningsih, Noviani; Margo, Eveline; Yohana, Yohana
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.71-81

Abstract

Background Dry eye syndrome (DES) is an eye disease caused by many factors involving the ocular surface, with characteristic damage to tear layer homeostasis accompanied by ocular symptoms due to tear layer instability, hyperosmolarity, damage and inflammation of the ocular surface, and neurosensory abnormalities. Delivery motorbike drivers are often on the streets where the role of environmental factors will be able to pose a risk of experiencing DES. This study aims to assess risk factors associated with the incidence of dry eye syndrome in delivery motorbike drivers.  The benefit of this research is to improve public health, especially in preventive behavior against factors associated with dry eye syndrome. Methods This study used observational analytical methods with a cross-sectional research design.  The selection of samples by consequential non-random sampling amounted to 124 with the criteria of inclusion of delivery motorbike drivers, exclusion of not using artificial tears eye drops, and not use of contact lenses.  Data were collected by filling out a DES risk factor questionnaire and a Tear Break Up Time (TBUT) examination to assess DES. The research data were analyzed using the Chi-Square test. Results This study's results show that subjects with dry eye syndrome are dominated by adults aged 19–44 and male sex. Subjects who experienced DES 76.6%, adult age 78.2%, male 80.6%, no pterygium 66.1%, working period 2-5 years 62.9%, length of work ≥8 hours 94.4%, always using a closed helmet 83.9%, not using protective glasses 39.5%, coffee consumption 71.8%, active smokers 66.1%, using gadgets >6 hours 91.9%.  There is no significant relationship between subjects' characteristics and DES (p>0.05). The incidence of DES in pterygium showed significant results (p= 0.001). Conclusions There is a significant relationship between the incidence of pterygium and DES.
Emerging Threats in the Age of Pandemics: A Focus on COVID-19 and the Novel Sub-Variant EG 5 ("Eris"): Review Article Alsayed, Raghda; Thamer, Hamsa; Hameed, Seenar; Kadhom, Mohammed; Hairunisa, Nany; Amalia, Husnun; Mashabi, Yasmine; Ahmed, Dina; Mahdi, Sarah; Husain, Amani; Salman, Israa; Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.262-267

Abstract

This paper draws attention to a recently identified sub-variant of SARS-CoV-2 known as EG 5, colloquially named "Eris," designated by the World Health Organization (WHO) as a variant of interest. The organization has urged nations to monitor and respond to the spread of this sub-variant since its identification on February 17, 2023. The discovery of the EG 5 variant, a sublineage of the Omicron variant, has introduced new challenges. Designated a "variant of interest" by the WHO, EG 5 carries distinctive genetic mutations, including an additional F456L amino acid mutation in the spike protein. Global prevalence has doubled, raising concerns about increased transmissibility. Although specific symptoms of EG 5 are not yet fully characterized, the variant has spread to 51 countries, with over 7,000 reported cases by August 15, 2023. The manuscript also explores the unique situation in Iraq, where, as of August 17, 2023, no EG 5 cases have been officially recorded. However, challenges such as self-treatment at. As the world grapples with the ongoing challenges of the COVID-19 pandemic, understanding the dynamics of emerging variants is crucial for effective public health responses and the development of targeted interventions.
JN.1 COVID-19: Variant of interest Amalia, Husnun; Mashabi, Yasmine
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.261-263

Abstract

Corona Virus Disease-19 (COVID-19) is an acute respiratory syndrome caused by the Coronavirus 2 (SARS-CoV-2) virus. WHO groups the SARS-CoV-2 virus into two categories, namely a variant of interest (VOI) and a variant of concern (VOC). The VOI category is given if there is a new mutation with predictable phenotypic implications and must be fulfilled by one mutation that causes local transmission or causes multiple clusters or is detected in several countries. In September 2023, a new variant of COVID-19 was detected in the United States, namely JN.1 as VOI. This variant is a variation of the BA.2.86 variant with the only difference being the mutation of 1 spike protein, namely the addition of the L455S protein in the JN.1 variant. This variant has the potential to evade the immune system. Globally, there has been a rapid increase in the number of sufferers, especially in 3 WHO regions, namely America (AMR), West Pacific (WPR) and Europe (EUR). However, the effectiveness of the monovalent vaccine against this variant can still protect sufferers. Several studies show that the risk of hospitalization is low in the case of elderly and young patients.
Palpebral Kista Dermoid Witjaksana, Riani; Amalia, Husnun; Hairunisa, Nany; Kartadinata, Erlani; Adhiwardan, Anggraeni; Prasetyaningsih, Noviani
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.245-250

Abstract

Dermoid and epidermoid cysts are prevalent benign orbital tumors in childhood, representing 3-9% of pediatric ocular tumors. Occasionally, dermoid cysts can attain significant size, leading to cosmetic deformities. A precise surgical approach to dermoid cysts can lead to considerable cosmetic improvement for the patient. A 19-year-old female presented with swelling in the outer corner of her left eye, accompanied by minor discomfort in the affected area. Upon ophthalmologic examination 1.5x1 cm masses were detected in the upper left eyelid near the lateral canthus Clinical diagnosis of Dermoid cyst left eye upper eyelid made. Subsequently, a surgical excision under general anesthesia was scheduled. During the procedure, the cyst was successfully excised while preserving the cyst wall integrity. The conclusion is imperative for ophthalmologists to recognize the necessity of precisely performing surgical excision of these cysts to achieve favorable functional and aesthetic outcomes.
Masalah infeksi Palpebra pada Lanjut Usia Amalia, Husnun; Pratiwi, Megawati Yulia Wina; Mustopa, Ita Tazkiatul Izzati
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.133-137

Abstract

Blepharitis is an eyelid infection that increases in incidence with age. This infection can cause anterior and posterior blepharitis and is caused by bacteria, viruses, fungi, and parasites. The most common bacteria that cause blepharitis is Staphylococcus. Blepharitis that is not caused by infection is allergic blepharitis. The pathophysiology of anterior blepharitis is the occurrence of bacterial colonization that triggers an excessive inflammatory response, while in posterior blepharitis it is mainly due to a decrease in the quality of the meibomian glands which causes dry eye and causes friction on the conjunctiva and cornea, causing inflammation. Symptoms of blepharitis are discomfort on the eyelid's surface such as itching, burning, stinging, watery eyes, and others. Risk factors for this infection include seborrheic dermatitis, acne rosacea, contact allergies, diabetes mellitus, chemical irritation, poor hygiene, low socioeconomic status, cosmetics, and the elderly. Diagnosis can be made based on anamnesis and ophthalmological examination which a general practitioner or eye specialist can perform. Based on the diagnosis, further management is given to avoid complications. The management that can be given is maintaining eyelid hygiene, warm compresses, not rubbing the eyes, and giving topical antibiotics (in anterior blepharitis) which can be added with systemic antibiotics (posterior blepharitis). Complications that can occur are eyelash abnormalities, lacrimal punctum malposition, eyelid malposition, recurrent hordeolum, keratitis, dry eye, keratopathy, corneal ulcers, and corneal opacities that can cause impaired visual function.
Co-Authors Adhiwardan, Anggraeni Adianto, Raymond Adiwardhani, Anggraeni Adlani, Hadianti Ahmed, Dina Alsayed, Raghda Alvina Alvina Andrianjah Andrianjah, Andrianjah Anggiat, Desi Ariyani, Aziza Bella, Isa dianawati, dianawati Djebli, Noureddine Effendi, Ida Erlani Kartadinata, Erlani Eveline Margo, Eveline Faradila, Meutia Atika Ferdhian, Farrel Ferina, Mutiara Grace Nerry Legoh Gusti G. Suardana, Gusti G. Hadi Sumarsono Hairunisa, Nany Hameed, Seenar Hosea Jaya Edy Husain, Amani Johan Hutauruk Joice Viladelvia Kalumpiu, Joice Viladelvia Kadhom, Mohammed Kudaer, Nuha B LEKOK, WIDYAWATI Lira Panduwaty Maharani, Ronaningtyas Mahdi, Sarah Marja, Triyoko Septio Mashabi, Yasmine Monica Dwi Hartanti, Monica Dwi Mun’im, Abdul Mustopa, Ita Tazkiatul Izzati Natadidjaja, Ronald Irwanto Nazma, Diani Oladimeji, Ashaolu Victoria Parwanto, Edy Pertiwi, Iin Indra Prasetyaningsih, Noviani Pratiwi, Megawati Yulia Wina Rachmiyani, Irmiya Raheem, Rasha Rantung, Alvin Lekonardo Ratna Sitompul Redwan, Amamer M Risan, Mohsen Hashim Sabrina, Isra Salman, Israa Samira, Jihan Sri Mulyani Thamer, Hamsa Tjahyadi, David Trilaksmi, Antin Tubagus Ferdi Fadilah, Tubagus Ferdi Widya Artini Witjaksana, Riani YENNY YENNY Yohana Yohana Yousif, Emad Yuliana Yuliana Yuliarsa, Cyntha Nasyanda Yusop, Rahimi M Zaina, Nashita Amira Zainulabdeen, Khalid Zalfa, Afifah