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All Journal Journal of Biomedicine and Translational Research Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh SCRIPTA SCORE Scientific Medical Journal International Journal Of Science, Technology & Management (IJSTM) MAKILA: Jurnal Penelitian Kehutanan Borobudur Journal on Legal Services Repong Damar: Jurnal Pengabdian Kehutanan dan Lingkungan Jurnal Kedokteran Ibnu Nafis Journal of Pharmaceutical and Sciences. Indonesian Journal of Biomedicine and Clinical Sciences
Tri Widyawati, Tri
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Evaluasi Formulasi Teh Celup dari Kombinasi Kulit Jeruk Manis (Citrus sinensis L.) dan Buah Ara (Ficus carica L.) sebagai Antibakteri terhadap Staphylococcus aureus Husni, M. Irgisyach Aqilla; Simat, Marcelina Oktavia Mayang Sari; Suhartomi, Suhartomi; Hendrianto, Hendrianto; Syarifah, Siti; Putri, Maulinda; Widyawati, Tri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1205

Abstract

The development of natural-based antibacterial agents is essential to reduce dependency on antibiotics and the risk of resistance. Sweet orange peel and fig fruit contain bioactive compounds with potential antibacterial effects. This study aimed to develop tea bag formulations made from sweet orange peel with the addition of fig fruit as an additive and to evaluate their in vitro antibacterial activity against Staphylococcus aureus. This experimental study employed two approaches, including disc diffusion and microdilution on several combination formulations of sweet orange peel and fig tea bags. The formulations consisted of F1 (1 g sweet orange peel and 1 g fig), F2 (1.5 g sweet orange peel and 0.5 g fig), and F3 (1.75 g sweet orange peel and 0.25 g fig). The disc diffusion assay showed that all formulations exhibited weak antibacterial activity against Staphylococcus aureus, producing inhibition zones of approximately 6–7 mm, except for F3 infusion, which demonstrated the widest inhibition zone with a mean diameter of about 8.21 mm (P-Value = 0.688). In the microdilution test, the MIC of F3 infusion was found to be 40 mg/mL, while the MBC was not detected at the tested concentrations. Overall, it can be concluded that the infusion of the tea bag formulation containing 1.75 g sweet orange peel and 0.25 g fig was the most promising combination; however, its antibacterial activity remained weak and was bacteriostatic rather than bactericidal.
The Effect of Dendrophthoe pentandra (L.) Miq Ethanol Extract on Malondialdehyde (MDA) in Hyperglycemic Rats Syafitri, Anggun; Yuandani, Yuandani; Widyawati, Tri
International Journal of Science, Technology & Management Vol. 4 No. 2 (2023): March 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i2.758

Abstract

Dendrophthoe pentandra (L.) Miq is a parasitic plant with medicinal potential found in 3000 other plant species. The duku parasite is usually considered a parasite on the duku plant and is often discarded because it is thought to interfere with the growth of the duku plant. The purpose of this study was to see the effect of the duku parasite leaf extract on the reduction of malondialdehyde (MDA) in hyperglycemic rats. MDA levels were measured by thiobarbituric acid-reactive substance (TBARS) assay with doses of duku mistletoe leaf ethanol extract of 400, 200, and 100 mg/kg BW. MDA levels were analysed using rat blood plasma, which was measured using a spectrophotometer at a wavelength of 532 nm. Oral administration of EEDBD 400, 200, and 100 mg/kg BW reduced MDA levels in hyperglycemic rats. However, only EEDBD 400 mg/kg BW showed a significant difference between the negative control (CMC-Na), but with glibenclamide and the normal groups, there was no significant difference.
Combination Effect of Slow Interval Training and Lemongrass Ethanol Extract (Cymbopogon citratus) on Body Weight and Fat Mass in Male Wistar Rats (Rattus norvegicus Sp) Obesity Model Siahaan, Sulyaprilawati Battri; Machrina, Yetty; Widyawati, Tri; Rusdiana, Rusdiana; Savira, Maya
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.28284

Abstract

Background: Obesity, a global health crisis affecting over 890 million adults, requiring effective and safe management strategies. Lifestyle-based interventions, such as physical exercise and herbal supplementation, provide promising non-invasive alternatives. Slow Interval Training (SIT) improves fat metabolism with low injury risk, while lemongrass (Cymbopogon citratus) contains bioactive compounds with anti-obesity potential.Objective: This study investigates the combined effects of SIT and lemongrass ethanol extract on body weight and fat mass in a high-fat diet (HFD)-induced obese male Wistar rat model.Methods: Thirty-five male Wistar rats were divided into five groups: healthy control, obese control, SIT only, lemongrass extract only, and SIT + lemongrass. Obesity was induced through a high-fat diet before intervention. Body weight was measured weekly, and fat mass was analyzed after eight weeks of treatment.Results: Obese controls showed significant weight gain (p<0.001). The lemongrass-only group showed a 12.7% weight reduction, while the combination group achieved the lowest final weight (200 g) and the lowest fat mass (2.39 g, p=0.048). Significant intergroup differences appeared from week 1 and persisted until week 13 (p<0.05). The combination group maintained stable weight after intervention, outperforming SIT or lemongrass alone.Conclusion: The combination of SIT and lemongrass ethanol extract significantly reduces body weight and fat mass in obese rats, demonstrating synergistic efficacy. Lemongrass inhibits fat absorption and enhances metabolic regulation, while SIT promotes fat oxidation. This dual approach offers a viable, non-invasive strategy for obesity management, warranting further clinical exploration.
Co-Authors Abraham Simatupang Agustin, Aprillia Bella Cithra Putri Ali Wafa Andriyani, Yunilda Arief Darmawan Arief Pratama bin Nur, Taufiq Ceng Asmarahman Christine Wulandari Darlan, Dewi Masyithah Dwi Jalma, Monica Fitriani Fitriani Fitrista Utamita, Aidilia Hendrianto Hendrianto, Hendrianto Husni, M. Irgisyach Aqilla Ichwan, M Jamal, Monica Dwi Kaskoyo, Hari Kurniaty, Linggom Mahabuana, Bintang Maya Savira Muhammad Rozan Fawwaz Syariq Muhammad Yusuf Mulyadi Djojosaputro, Mulyadi Neni Susilaningsih Putri, Maulinda Rahmat Safe'i Rambe, Aldy Safruddin Rambe, Irfah Tut Alwiyah Rezka Zuhra Maulida Riyawan, I Nyoman Rudi Hilmanto Rusdiana Rusdiana Saddam Haikal Sarah Rahmayani Siregar Satria, Fauzi Sembiring, Rosita Juwita Septia Nugraha Siahaan, Sulyaprilawati Battri Silaban, Hertina Simat, Marcelina Oktavia Mayang Sari SUHARTOMI . Sumantri, Imam Bagus Syafitri, Anggun Syarifah, Siti Tarisa Olivia Teddy Prayoga, Teddy Tobing, Romauli Trisna Noviasari, Dilli Wicaksono, Muhammad Prasetyo Yahya, Agil Yetty Machrina Yuandani