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All Journal Journal of Biomedicine and Translational Research Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh SCRIPTA SCORE Scientific Medical Journal International Journal Of Science, Technology & Management (IJSTM) MAKILA: Jurnal Penelitian Kehutanan Borobudur Journal on Legal Services Repong Damar: Jurnal Pengabdian Kehutanan dan Lingkungan Jurnal Kedokteran Ibnu Nafis Indonesian Journal of Biomedicine and Clinical Sciences Jurnal Kesehatan
Tri Widyawati, Tri
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation

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The Effect of Dendrophthoe pentandra (L.) Miq Ethanol Extract on Malondialdehyde (MDA) in Hyperglycemic Rats Syafitri, Anggun; Yuandani, Yuandani; Widyawati, Tri
International Journal of Science, Technology & Management Vol. 4 No. 2 (2023): March 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i2.758

Abstract

Dendrophthoe pentandra (L.) Miq is a parasitic plant with medicinal potential found in 3000 other plant species. The duku parasite is usually considered a parasite on the duku plant and is often discarded because it is thought to interfere with the growth of the duku plant. The purpose of this study was to see the effect of the duku parasite leaf extract on the reduction of malondialdehyde (MDA) in hyperglycemic rats. MDA levels were measured by thiobarbituric acid-reactive substance (TBARS) assay with doses of duku mistletoe leaf ethanol extract of 400, 200, and 100 mg/kg BW. MDA levels were analysed using rat blood plasma, which was measured using a spectrophotometer at a wavelength of 532 nm. Oral administration of EEDBD 400, 200, and 100 mg/kg BW reduced MDA levels in hyperglycemic rats. However, only EEDBD 400 mg/kg BW showed a significant difference between the negative control (CMC-Na), but with glibenclamide and the normal groups, there was no significant difference.
Combination Effect of Slow Interval Training and Lemongrass Ethanol Extract (Cymbopogon citratus) on Body Weight and Fat Mass in Male Wistar Rats (Rattus norvegicus Sp) Obesity Model Siahaan, Sulyaprilawati Battri; Machrina, Yetty; Widyawati, Tri; Rusdiana, Rusdiana; Savira, Maya
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.28284

Abstract

Background: Obesity, a global health crisis affecting over 890 million adults, requiring effective and safe management strategies. Lifestyle-based interventions, such as physical exercise and herbal supplementation, provide promising non-invasive alternatives. Slow Interval Training (SIT) improves fat metabolism with low injury risk, while lemongrass (Cymbopogon citratus) contains bioactive compounds with anti-obesity potential.Objective: This study investigates the combined effects of SIT and lemongrass ethanol extract on body weight and fat mass in a high-fat diet (HFD)-induced obese male Wistar rat model.Methods: Thirty-five male Wistar rats were divided into five groups: healthy control, obese control, SIT only, lemongrass extract only, and SIT + lemongrass. Obesity was induced through a high-fat diet before intervention. Body weight was measured weekly, and fat mass was analyzed after eight weeks of treatment.Results: Obese controls showed significant weight gain (p<0.001). The lemongrass-only group showed a 12.7% weight reduction, while the combination group achieved the lowest final weight (200 g) and the lowest fat mass (2.39 g, p=0.048). Significant intergroup differences appeared from week 1 and persisted until week 13 (p<0.05). The combination group maintained stable weight after intervention, outperforming SIT or lemongrass alone.Conclusion: The combination of SIT and lemongrass ethanol extract significantly reduces body weight and fat mass in obese rats, demonstrating synergistic efficacy. Lemongrass inhibits fat absorption and enhances metabolic regulation, while SIT promotes fat oxidation. This dual approach offers a viable, non-invasive strategy for obesity management, warranting further clinical exploration.
DETERMINANTS OF ANTIRETROVIRAL THERAPY ADHERENCE AMONG PEOPLE LIVING WITH HIV IN NORTH SUMATERA, INDONESIA Hutapea, Lidya; Widyawati, Tri; Rahmawaty Lubis, Rodiah; M. Ichwan, M. Ichwan; Isti Ilmiati Fujiati, Isti Ilmiati Fujiati
Jurnal Kesehatan - STIKes Prima Nusantara Vol 17 No 2 (2026): Jurnal Kesehatan (on progress)
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v17i2.1647

Abstract

Background: Human Immunodeficiency Virus (HIV) continues to pose a major global public health challenge, especially in low and middle income countries. Sustained adherence to Antiretroviral Therapy (ART) is fundamental to achieving viral suppression, preventing disease progression, and reducing transmission. Despite advances in treatment availability, suboptimal adherence continues to hinder optimal clinical outcomes. Aims: This study aimed to examine the key determinants influencing ART adherence among people living with HIV (PLHIV) in North Sumatra, Indonesia. Methods: A quantitative cross-sectional study was conducted from April to December 2024 at Dr. Ferdinand Lumbantobing General Hospital, Sibolga City. All 88 PLHIV receiving ART during the period were recruited using total sampling. Data were collected via structured questionnaires and analyzed using univariate analysis, chi-square tests, and multivariate logistic regression to identify significant adherence predictors. Results: ART adherence was significantly associated with treatment-related knowledge, family support, healthcare provider support, and access to healthcare facilities (p < 0.05). Multivariate logistic regression revealed that treatment knowledge was the most influential determinant of adherence, followed by family support, healthcare provider support, and healthcare accessibility. Conclusion: ART adherence in this tropical setting is shaped by a dynamic interplay of individual understanding and social and healthcare system support. Strengthening patient education, fostering family engagement, and improving access to healthcare services are essential strategies for sustaining treatment adherence over time. Future longitudinal research is warranted to explore adherence trajectories and evaluate targeted intervention models
Co-Authors Abraham Simatupang Agustin, Aprillia Bella Cithra Putri Ali Wafa Andriyani, Yunilda Arief Darmawan Arief Pratama Ceng Asmarahman Christine Wulandari Darlan, Dewi Masyithah Dwi Jalma, Monica Fitriani Fitriani Fitrista Utamita, Aidilia Hutapea, Lidya Ichwan, M Isti Ilmiati Fujiati, Isti Ilmiati Fujiati Jamal, Monica Dwi Kaskoyo, Hari Kurniaty, Linggom M. ICHWAN M. ICHWAN Mahabuana, Bintang Maya Savira Muhammad Rozan Fawwaz Syariq Muhammad Yusuf Mulyadi Djojosaputro, Mulyadi Neni Susilaningsih Nur, Taufiq Bin Rahmat Safe'i Rahmawaty Lubis, Rodiah Rambe, Aldy Safruddin Rambe, Irfah Tut Alwiyah Rezka Zuhra Maulida Riyawan, I Nyoman Rudi Hilmanto Rusdiana Rusdiana Saddam Haikal Sarah Rahmayani Siregar Satria, Fauzi Sembiring, Rosita Juwita Septia Nugraha Siahaan, Sulyaprilawati Battri Silaban, Hertina Sumantri, Imam Bagus Syafitri, Anggun Tarisa Olivia Teddy Prayoga, Teddy Tobing, Romauli Trisna Noviasari, Dilli Wicaksono, Muhammad Prasetyo Yahya, Agil Yetty Machrina Yuandani