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All Journal Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Jurnal Kartika Kimia Journal of Midwifery and Nursing JFIOnline JCPS (Journal of Current Pharmaceutical Sciences) JITEKGI Jurnal Ilmiah dan Teknologi Kedokteran Gigi ad-Dawaa : Journal of Pharmaceutical Sciences Science Midwifery Jurnal Buana Farma Jurnal Abdimas Kartika Wijayakusuma Journal of Science and Technology Research for Pharmacy Jurnal Farmasi Indonesia Kartika : Jurnal Ilmiah Farmasi Jurnal Kefarmasian Indonesia
Suci Nar Vikasari, Suci Nar
Fakultas Farmasi, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Efek Iritasi Sabun Mandi Batang Mengandung Susu Produk Usaha Kecil Menengah di Kota Cimahi Vikasari, Suci Nar; Hermanto, Faizal; Simatupang, Elivas; Sutjiatmo, Afifah Bambang; Sutarna, Titta Hartyana; Puspadewi, Ririn; Rachmawan, Lucky; Haq, Fahmy Ahsanul
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2592

Abstract

One of the ways to increase profit in small and medium business (UKM) in Cimahi is by diversifying its products, through manufacturing of bar soap derived from cow's milk from UKM. The requirement of bath soap is proper acidity (pH) level, otherwise it will make the skin dry, itchy or even increase irritation. Therefore, this in vivo non-clinical irritation evaluation is conducted to evaluate the effects of bar soap produced by UKM in Cimahi according to the guidelines in rat test animals. The animals is divided into five groups and exposed to soap for four hours. Five soap samples is obtained from UKM in Cipageran area, Cimahi. Observations is made at the hours of 1, 4, 24, 48, and 72 hours after exposure and is continued for 14 days. The measured parameters is erythema and edema, and the primary irritation index. The results showed that bar soap containing cow milk produced by UKM in Cimahi did not cause erythema and edema. Primary irritation index of all bath soap samples was 0.0 . It can be concluded that soap bars containing cow's milk produced by Cimahi City UKM including into the category of very mild irritation (negligigle).
Potensi Ekstrak Kelopak Bunga Rosela (Hibiscus sabdariffa L.) dalam Menghambat Denaturasi Protein secara In Vitro Vikasari, Suci Nar; Septiani, Vina; Rahajeng, Dea Julianti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.216

Abstract

Inflammation is a normal response to injury, which is characterized by protein and fluid leakage from blood vessels, causing pain and swelling. This study was conducted to determine the in vitro protein denaturation inhibition activity of roselle calyx extract (Hibiscus sabdariffa L.). Roselle flowers were extracted in stages by maceration with n-hexane, ethyl acetate, and 96% ethanol. The comparator used was diclofenac sodium. Several concentration series of extracts and comparators were prepared, and protein denaturation inhibition experiments on bovine serum albumin (BSA) were conducted. The parameters measured were the inhibition value of protein denaturation at each concentration and the value of 50% inhibition (IC50). The results of the study indicated that n-hexane extract, roselle calyx ethyl acetate, and roselle calyx ethanol (96%) could inhibit protein denaturation. Roselle calyx n-hexane extract exhibited an IC50 46.6748g/mL, ethyl acetate extract exhibited an IC50 225.8391g/mL, and 96% ethanol extract exhibited an IC50 191.5105g/mL, whereas diclofenac sodium exhibited an IC50 8.5437g/mL. The conclusion revealed that roselle calyx extracts in n-hexane, ethyl acetate, and 96% ethanol display potentials as anti-inflammatory potential agents by inhibiting protein denaturation.
Phytochemical constituent, α-amylase and α-glucosidase inhibitory activities of Black Soybean (Glycine soja (L.) Merr.) ethanol extract Sutjiatmo, Afifah Bambang; Narvikasari, Suci; Solihat, Ananda Khairunisa; Widowati, Wahyu; Kusuma, Hanna Sari Widya; Zahiroh, Fadhilah Haifa
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.29919

Abstract

Diabetes is characterized as a hyperglycemic condition impacted by β-cell dysfunction and insulin deficiency. Black soybean (Glycine soja (L.) Merr.) is widely known as an origin of nutritious food that has shown activities in preventing cardiovascular disease and reducing hyperglycemia. This research aimed to evaluate the potential of black soybeans ethanol extract (BSEE) as an α-amylase and α-glucosidase activity inhibitor. Black soybean seeds were extracted using the Soxhlet method with 50% ethanol as a solvent. The extract Soybean seeds were screened for the presence of phytochemicals. Inhibitory activity of α-amylase and α-glucosidase enzymes was tested in vitro with acarbose as a control. The absorbance measurement was conducted at 565 nm and 400 nm, respectively. BSEE contained alkaloids, flavonoids, polyphenols, saponins, quinones, tannins, and terpenoids. The results indicated that BSEE exhibited a weak inhibitory effect of α-amylase enzyme activity, with an IC50 value of 360.37 ± 20.80 µg/ml, in contrast to acarbose, which showed a significantly lower IC50 of 4.02 ± 0.56 µg/ml. Meanwhile, BSEE was classified as an active inhibitor of α-glucosidase enzyme activity, presenting 25.67 ± 0.27 µg/mL IC50 value, while acarbose demonstrated 10.85 ± 0.5 µg/mL IC50 value. In conclusion, BSEE inhibits α-amylase and α-glucosidase.
Evaluation of Medication Use in Patients with Gastroesophageal Reflux Disease (GERD) in the Inpatient Unit at a Hospital in Cimahi Syarifuddin, Syarifuddin; Septiani, Vina; Khoirunnisa, Syifa; Kristian, Randi; Vikasari, Suci Nar
Journal of Midwifery and Nursing Vol. 7 No. 1 (2025): January: Health Science
Publisher : Institute Of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/jmn.v7i1.5888

Abstract

Gastroesophageal Reflux Disease (GERD) is a pathological condition characterized by the regurgitation of gastric contents into the esophagus, resulting in symptoms affecting both the esophagus and extra-esophageal regions. The aim of this study is to ascertain the usage pattern and rationality of GERD medication consumption. This study utilizes an observational approach with a descriptive cross-sectional design. The data collection was performed retrospectively by examining the treatment histories of GERD patients documented in the medical records at the Inpatient Installation of Dustira Hospital from January to June 2023. The sample comprised 200 persons who met the inclusion criteria. Research indicated that individuals with GERD were predominantly female, comprising 73.5%, while males constituted approximately 26.5%. The predominant age range was 18-45 years, comprising 63.5%, followed by 46-59 years at 23.5%. 61 patients received a combination of omeprazole and sucralfate as the predominant medication. The analysis showed that 100% of patients utilized the medication with the appropriate indication, 97.5% with accurate drug selection, 100% with precise dosage, 100% with the right method of administration, and 100% with the appropriate administration interval
Exploring the Alpha-Amylase Inhibitory Potential of Roselle Calyx Extracts (Hibiscus sabdariffa L) in n-Hexane and Ethyl Acetate Fractions Wahyuningsih, Sri; Vikasari, Suci Nar; Kusmayadi, Anandita Tiara
Jurnal Kartika Kimia Vol 8 No 1 (2025): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v8i1.899

Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood sugar levels, which result from impaired insulin excretion or sensitivity. Among the various medicinal plants utilized by the Indonesian population, roselle (Hibiscus sabdariffa L) stands out as a potential remedy for several diseases including diabetes mellitus. This study aims to assess the inhibitory potential of roselle on α-amylase enzyme activity. The roselle calyx extraction method was performed through multilevel maceration using n-hexane and ethyl acetate solvents. Testing the activity of inhibiting the α-amylase enzyme was carried out in vitro using acarbose as a comparison. The findings revealed that the n-hexane extract of roselle calyx exhibited potent α-amylase enzyme inhibition with an IC50 value of 20.43 µg/mL. Similarly, roselle calyx ethyl acetate extract demonstrated strongl α-amylase enzyme inhibitory activity, characterized by an IC50 value of 10.13 µg/mL. Meanwhile, acarbose exhibited robust α-amylase inhibitory activity, possessing an IC50 value of 4.04 µg/mL. It is worth noting that all these substances displayed α-amylase enzyme inhibitory activity in the very active category, although their efficacy was not equivalent to acarbose.
Acute Antinflammatory Effect of Marsdenia tinctoria Leaf Water Extract in Carragenan-induced Rats Supito, Sarasvati Sekar Ayu; Sutjiatmo, Afifah Bambang; Kusumawardhana, Gelar Taufiq; Vikasari, Suci Nar
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.52967

Abstract

Introduction: Tarum areuy (Marsdenia tinctoria) is a plant whose efficacy has not been widely explored. Traditionally used for infections and inflammation related disease.. Aims: To determine the anti-inflammatory effect of M. tinctoria leaf water extract on animals induced by carrageenan.Methods: Extract preparation by boiling in water. Animals were divided into groups, namely control, comparison (diclofenac sodium 4.5 mg/kgBW) and M. tinctoria leaf water extract (20, 40, 80 mg/kgBW). Induction of 0.1 mL of 1% carrageenan was given as much as intraplantar and the test preparation was given orally. Inflammatory and inflammatory inhibition percentages were measured every 30 minutes for 240 minutes. The t-test was utilized in data analysis.  Result: All test doses of M. tinctoria leaf water extract was effective to reduce inflammation in comparison to the control (p<0.05). A dose of 20 mg/kgBW was the optimal anti-inflammatory.. Conclusion: M. tinctoria leaf water extract has the potential as an anti-inflammatory.
Tantangan Industri Farmasi Indonesia di Era Pandemik COVID-19 Windyaswari, Ari Sri; Hermanto, Faizal; Vikasari, Suci Nar; Riyanti, Soraya; Syam, Akhirul Kahfi; Febrinella, Catellya
Jurnal Abdimas Kartika Wijayakusuma Vol 1 No 2 (2020): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (522.939 KB) | DOI: 10.26874/jakw.v1i2.74

Abstract

Abstrak: Situasi pandemik COVID-19 di Indonesia mempengaruhi beberapa sektor penting, diantaranya adalah sektor kesehatan. Farmasi sebagai salah satu garda penting di bidang kesehatan mempunyai tugas fungsi pokok untuk menyediakan obat yang aman, berkhasiat dan berkualitas. Industri farmasi merupakan bagian terdepan yang memiliki peranan penting tersebut sekaligus merupakan bagian terdepan yang terkena dampak dari situasi pandemik COVID-19. Tekanan untuk penemuan vaksin/obat baru sebagai antivirus COVID19 hingga produksi vitamin dan produk nutrisi lain sebagai upaya preventif untuk melindungi masyarakat Indonesia dari peningkatan penularan virus COVID-19 di Indonesia menghadapi berbagai kendala. Pembatasan Sosial Berskala Besar (PSBB), kegiatan karantina serta isolasi merupakan salah satu kendala di dalam bidang produksi. Disisi lain, permintaan akan produk obat meningkat tajam. Apoteker industri dan apoteker komunitas bekerja sama untuk memastikan ketersediaan dan efek terapi obat dapat digunakan oleh masyarakat Indonesia. Tujuan dilaksanakannya webinar ini adalah untuk mengubah paradigma permasalahan menjadi suatu tantangan yang harus diselesaikan oleh sejawat apoteker di seluruh Indonesia. Metode webinar dilaksanakan melalui penyampaian materi dan diskusi panel dari platform ZOOM dan youtube. Hasil post test yang dilaksanakan terhadap 1.700 peserta secara garis besar menunjukkan pemahaman dan kepedulian masyarakat dalam mengatasi berbagai permasalahan di bidang farmasi industry Indonesia. Kata kunci: Apoteker, Industri Farmasi, COVID-19.
ANALISIS FAKTOR RESIKO PENYEBAB PELAYANAN ANTIBIOTIK TANPA RESEP DOKTER DI APOTEK: A REVIEW Tupak, Helma Malini Marol; Vikasari, Suci Nar
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1514

Abstract

The dispensing of antibiotics without a doctor’s prescription in pharmacies remains a common practice and contributes significantly to the rise of antibiotic resistance, which poses a major threat to public health. This phenomenon is driven by interrelated risk factors, including easy access, limited public knowledge, socioeconomic influences, and weak regulatory enforcement. This study aims to identify the risk factors underlying the dispensing of antibiotics without prescriptions in pharmacies. A literature review was conducted by collecting and analyzing Indonesian and English journal articles published between 2015 and 2025. Data were retrieved from Google Scholar and PubMed using keywords related to the sale and purchase of antibiotics without a doctor’s prescription. The findings were analyzed narratively and grouped into three perspectives: business actors, patients or consumers, and regulators. From the perspective of business actors, the risk factors include pharmacy staff attitudes that facilitate non-prescription antibiotic sales, financial motivations, consumer pressure and demand, and insufficient professional knowledge. From the perspective of patients, risk factors involve the ease of obtaining antibiotics without a prescription, economic, social, and cultural influences, lack of awareness and understanding, and prior personal experiences of antibiotic use. From the perspective of regulators, weak supervision and poor law enforcement remain key drivers of this practice. In conclusion, comprehensive efforts are required to address this issue. These include strengthening regulations, improving public education, and enhancing the training of pharmacy personnel. Such interventions are critical to preventing antibiotic misuse and mitigating the long-term consequences of antibiotic resistance on public health.
Co-Authors Afifah B. Sutjiatmo Afifah B. Sutjiatmo Afifah B. Sutjiatmo Afifah Bambang Sutjiatmo Afifah Bambang Sutjiatmo, Afifah Bambang Aisyah, Salmanda Akhirul Kahfi Syam Ambarsundari Ambarsundari Andi Supriatna Andri R. Rahmadi Andri Reza Rahmadi Anna Choirunnisa, Anna Ari Sri Windyaswari, Ari Sri Asri Wulandari Astuti, Niken Juni Ayu Nurfitiria Rahmi Ayu Nurfitiria Rahmi, Ayu Nurfitiria Bintussolihah, Falna Candra Candra Candra candra Dewi Lidya Ichwana Nasution Dwi Yuliana Prasita Dzikrial Sa’id Elin Yulinah Elin Yulinah Sukandar Elin Yulinah Sukandar ELIN YULINAH SUKANDAR Elivas Simatupang Elivas Simatupang Encep Abdurahman Faizal Hermanto Febrinella, Catellya Fikri Alatas Grace S. Mardiana Hanna Sari Widya Kusuma, Hanna Sari Widya Haq, Fahmy Ahsanul Hartyana Sutarna, Titta Ita Nur Anisa Ita Nur Anisa Khansa Rana Khalifa Kristian, Randi Kuatrina Kuatrina Kuatrina, Kuatrina Kusmaningati, Suswini Kusmayadi, Anandita Tiara Kusumawardhana, Gelar Taufiq Lucky Rachmawan Lucky Rachmawan Melani, Beta Nengdiana Permana Niken Juni Astuti Nindy Dwi Siftiani Novia Anggraeni Hanafi Novia Anggraeni Hanafi, Novia Anggraeni Oskar Skarayadi, Oskar Pudjiastuti Kartidjo Pudjiastuti Kartidjo Puput Ayu Perdana Puput Ayu Perdana, Puput Ayu Purwoko, Agus Puspa Sari Dewi Solihah Rachmawan, Lucky Raden Mohamad Herdian Bhakti Rahajeng, Dea Julianti Ramadhan Muhamad Syahrul Redya Hernawati Redya Hernawati, Redya Regita Ayu Lestari Ririn Puspadewi Ririn Puspadewi, Ririn Ririn Sinaga Ririn Sinaga, Ririn RR. Ella Evrita Hestiandari Salmanda Aisyah Setiani, Nur Asni Sheba, Shiane Hanako Shifa A. Savitri Siftiani, Nindy Dwi Simatupang, Elivas Solihah, Puspa Sari Dewi Solihat, Ananda Khairunisa Soraya Riyanti, Soraya Sri Wahyuningsih Sujiatmo, Afifah Bambang Sulaeman Al Jati Supito, Sarasvati Sekar Ayu Suryani Suryani Suryani Sutandi Tatan Syarifuddin Syarifuddin Syarifuddin Syarifuddin Syifa Khoirunnisa, Syifa Tupak, Helma Malini Marol Vina Septiani, Vina WAHYU WIDOWATI Wita Anggraeni Wulan Anggraeni Yulia Ratnawati, Yulia Yulianti, Maulidya Yuliartati, Ni Luh Ade Zahiroh, Fadhilah Haifa