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All Journal Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Jurnal Kartika Kimia Journal of Midwifery and Nursing JFIOnline JCPS (Journal of Current Pharmaceutical Sciences) JITEKGI Jurnal Ilmiah dan Teknologi Kedokteran Gigi Pharmacoscript ad-Dawaa : Journal of Pharmaceutical Sciences Science Midwifery Jurnal Buana Farma Jurnal Abdimas Kartika Wijayakusuma Journal of Science and Technology Research for Pharmacy Jurnal Farmasi Indonesia Kartika : Jurnal Ilmiah Farmasi Jurnal Kefarmasian Indonesia
Suci Nar Vikasari, Suci Nar
Fakultas Farmasi, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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 1 
EFEK ANTIDIABETES HERBA CIPLUKAN (Physalis angulata LINN.) PADA MENCIT DIABETES DENGAN INDUKSI ALOKSAN Sutjiatmo, Afifah B.; Sukandar, Elin Yulinah; Ratnawati, Yulia; Kusmaningati, Suswini; Wulandari, Asri; Narvikasari, Suci
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 4 (2011)
Publisher : Indonesian Research Gateway

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Abstract

Antidiabetic effects of water extract of ciplukan (Physalis angulata L.) herbs has been done with the test method of alloxan diabetes induction. Water extract was fractionated using n-hexane, ethyl acetate and water.The results showed that ciplukan water extract dose of 10 mg/kgbw and the water fraction dose of  4.84 mg/kgbw have similar effect with glibenclamide dose of  0.65 mg/kgbw. The phytochemical screening showed that ciplukan water extract contains alkaloids, flavonoids, saponins, polyphenols, steroids and triterpenoids, monoterpenoids and sesquiterpenoids. ABSTRAK Telah dilakukan uji efek antidiabetes ekstrak air herba Ciplukan (Physalis angulata L.) dengan metode uji diabetes induksi  aloksan. Selanjutnya ekstrak air difraksinasi dengan pelarut n-heksan, etil asetat dan air. Hasil uji membuktikan bahwa ekstrak air herba ciplukan dosis 10 mg/kgbb dan fraksi air 4,84 mg/kgbb mempunyai efek antidiabetes yang sama dengan pembanding glibenklamid dosis 0,65mg/kgbb. Hasil penapisan fitokimia menunjukkan bahwa simplisia dan ekstrak air herba ciplukan mengandung alkaloid, flavonoid, saponin, polifenol, steroid dan triterpenoid, monoterpenoid dan seskuiterpenoid.
Efek Antihipertensi Ekstrak Etanol Daun Sembung (Blumea balsamifera) pada Model Hewan Uji Induksi Epinefrin Sutjiatmo, Afifah Bambang; Bintussolihah, Falna; Vikasari, Suci Nar
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1160.17 KB) | DOI: 10.35617/jfi.v11i1.592

Abstract

Hypertension is a non-communicable disease that has a high prevalence. Blumea balsamifera(Asteraceae) is one of the plants that has traditionally been used to treat high blood pressure. The aim of this study is to evaluate antihypertensive effect of ethanol extract of Blumea balsamiferaleaves on animal models induced epinephrine. The extract was made in 50% ethanol. Extraction was done using a set of Soxhlet tools. The antihypertensive effect test was carried out on male Wistar rats using epinephrine 0.25 mg/kg bwas inductor and blood pressure was measured indirectly through the tail using Kent Scientific's CODA system. The dose of extract was 8.75; 17.5 and 35 mg/kg bw, while propranolol at dose dose 1.8 mg/kg bw was used as comparator. The parameters were diastolic and systolic blood pressure. The results showed that the ethanol extract at doses of 8.75; 17.5 and 35mg/kg bw can prevent the increase in diastolic and systolic blood pressure in animals model induced epinephrine when compared to controls (p <0.05), where the best results is shown by the ethanol extract at dose of 17.5 mg/kg bw. The ability of the ethanol extract is equivalent to propranolol (p> 0.05). It can be concluded that Blumea balsamiferaleaves can be developed and have the potential to be antihypertensive.
EFEK PENAMBAHAN EKSTRAK ETANOL HERBA CIPLUKAN (PHYSALIS ANGULATA L) SEBAGAI SUPLEMEN TERAPI PADA RHEUMATOID ARTRITIS Vikasari, Suci Nar; Sujiatmo, Afifah Bambang; Sukandar, Elin Yulinah; Wahyuningsih, Sri; Solihah, Puspa Sari Dewi; Suryani, Suryani; Aisyah, Salmanda; Kuatrina, Kuatrina; Astuti, Niken Juni; Siftiani, Nindy Dwi
Jurnal Farmasi Indonesia Vol 11, No 2 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i2.667

Abstract

Rheumatoid arthritis is an autoimmune disease characterized with chronic joint inflammation. Chronic inflammation leads to liver function abnormality. Previous study showed that Physalis angulata L. had antiinflammatory, hepatoprotector, and immunosupressan effect. This research aims was to evaluate the effect of ethanol extract of P.angulata as adjuvant on liver function of RA animals model. Animals was induced with 0.1 mL complete freund adjuvant (CFA) intraplantar. The dose of P.angulata extract was 50 mg/kg bw po. The extract was given for 10 days as adjuvant of 0.1125 mg/kg bw methotrexate. Evaluation of liver function consisted of measurement of aminotransferase (AST and ALT), alanine phosphatase (ALP), organ index, and histology. The result showed that CFA could increase the level of AST and ALP and decrease the level of ALT and organ index of control group. The extract of P.angulata as adjuvant of methotrexate could decrease the level of AST and ALP and increase the level of ALT and organ index compare to control group, but could not reach its normal value. Histology showed that the extract also could improve liver regeneration. The extract of P.angulata at dose of 50 mg/kg bw used as adjuvant could improve liver function of RA animals model. 
Co-Authors Afifah B. Sutjiatmo Afifah B. Sutjiatmo Afifah B. Sutjiatmo Afifah Bambang Sutjiatmo Afifah Bambang Sutjiatmo, Afifah Bambang Aisyah, Salmanda Akhirul Kahfi Syam Ambarsundari Ambarsundari Andi Supriatna Andri R. Rahmadi Andri Reza Rahmadi Anna Choirunnisa, Anna Ari Sri Windyaswari, Ari Sri Asri Wulandari Astuti, Niken Juni Ayu Nurfitiria Rahmi Ayu Nurfitiria Rahmi, Ayu Nurfitiria Bintussolihah, Falna Candra candra Candra Candra Dewi Lidya Ichwana Nasution Dwi Yuliana Prasita Dzikrial Sa’id Elin Yulinah Elin Yulinah Sukandar ELIN YULINAH SUKANDAR Elin Yulinah Sukandar Elivas Simatupang Elivas Simatupang Encep Abdurahman Fahmy Ahsanul, Haq Faizal Hermanto Febrinella, Catellya Fikri Alatas Grace S. Mardiana Hanna Sari Widya Kusuma, Hanna Sari Widya Haq, Fahmy Ahsanul Hartyana Sutarna, Titta Ita Nur Anisa Ita Nur Anisa Khansa Rana Khalifa Kristian, Randi Kuatrina Kuatrina Kuatrina, Kuatrina Kusmaningati, Suswini Kusmayadi, Anandita Tiara Kusumawardhana, Gelar Taufiq Lucky Rachmawan Lucky Rachmawan Melani, Beta Muhamad Ridho, Maulana Nengdiana Permana Niken Juni Astuti Nindy Dwi Siftiani Novia Anggraeni Hanafi Novia Anggraeni Hanafi, Novia Anggraeni Oskar Skarayadi, Oskar Pudjiastuti Kartidjo Pudjiastuti Kartidjo Puput Ayu Perdana Puput Ayu Perdana, Puput Ayu Purwoko, Agus Puspa Sari Dewi Solihah Rachmawan, Lucky Raden Mohamad Herdian Bhakti Rahajeng, Dea Julianti Ramadhan Muhamad Syahrul Redya Hernawati Redya Hernawati, Redya Regita Ayu Lestari Ririn Puspadewi Ririn Puspadewi, Ririn Ririn Sinaga Ririn Sinaga, Ririn RR. Ella Evrita Hestiandari Salmanda Aisyah Setiani, Nur Asni Sheba, Shiane Hanako Shifa A. Savitri Siftiani, Nindy Dwi Simatupang, Elivas Solihah, Puspa Sari Dewi Solihat, Ananda Khairunisa Soraya Riyanti, Soraya Sri Wahyuningsih Sujiatmo, Afifah Bambang Sulaeman Al Jati Supito, Sarasvati Sekar Ayu Suryani Suryani Suryani Sutandi Tatan Syarifuddin Syarifuddin Syarifuddin Syarifuddin Syifa Khoirunnisa, Syifa Tupak, Helma Malini Marol Vina Septiani, Vina WAHYU WIDOWATI Wita Anggraeni Wulan Anggraeni Yulia Ratnawati, Yulia Yulianti, Maulidya Yuliartati, Ni Luh Ade Zahiroh, Fadhilah Haifa