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All Journal HAYATI Journal of Biosciences Perspektif : Review Penelitian Tanaman Industri Indonesian Journal of Pharmaceutical Science and Technology Elkawnie Majalah Obat Tradisional Abditani : Jurnal Pengabdian Masyarakat Jurnal Ilmiah Farmasi Farmasyifa Perspektif, Review Penelitian Tanaman Industri Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Riset Informasi Kesehatan AGRIC kawanad Jurnal Medika: Medika Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia Jurnal Farmasi Galenika
Akhirul Kahfi Syam
Fakultas Farmasi Universitas Jenderal Achmad Yani
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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ANTIOXIDANT ACTIVITY OF COMBINATION OF WHITE-PURPLE Orthosiphon aristatus (Blume) Miq HERB EXTRACT AND Stevia rebaudiana Bertoni USING FRAP METHOD Faramayuda, Fahrauk; Syam, Akhirul Kahfi; Putri, Dhiffa Namira Alifia; Ismail, Nursafira Khairunnisa; Akbar, Tzazkia Febriyana; Farhan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1612

Abstract

Oxidative stress is caused by an increase or decrease in the antioxidant defense activity. Orthosiphon aristatus (Blume) Miq and Stevia are two plants that contain antioxidant compounds and can bind free radical compounds. The combination of Orthosiphon aristatus (Blume) Miq and Stevia was expected to increase antioxidant activity. This study aimed to determine the antioxidant activity of a combination of the Orthosiphon aristatus (Blume) Miq white-purple variety and Stevia rebaudiana Bertoni extract. Antioxidant activity was tested using the FRAP method with a UV-visible spectrophotometer at a wavelength of 710 nm. The results of phytochemical screening showed that both plant extracts and dry material contained secondary metabolite compounds, including flavonoids, polyphenols, saponins, quinones, steroid-triterpenoids, and monoterpenes-sesquiterpenes. A qualitative test relating to antioxidants using TLC showed positive antioxidant activity, which was proven by the presence of green or blue light on the TLC plates. This was due to electron transfer in the compound, which reduced Fe3+ to Fe2+. On the other hand, quantitative measurements using the FRAP method showed the antioxidant capacity values consecutively, F1 combination extract (1:1) of 43.725 mg of QE/g extract, F2 combination extract (2:1) of 57.963 mg of QE/g extract, and combination extract of F3 (3:1) of 64.849 mg of QE/g extract. The extract combination of F3 showed the best formula, with a value of 64.849 mg QE/g extract.  Keywords: Orthosiphon aristatus (Blume) Miq, Stevia, antioxidants, FRAP
ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS OF JARAK TINTIR (Jatropha multifida L.) STEM, PHENOLIC AND FLAVONOID CONTENT Syam, Akhirul Kahfi; Windyaswari, Ari Sri; Ratnawati, Julia
JURNAL FARMASI GALENIKA Vol 7 No 3 (2020): Jurnal Farmasi Galenika Vol 7 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v7i3.182

Abstract

Background: Jarak tintir (Jatropha multifida L.) was identified as one of family Euphorbiaceae and used by Indonesian people as traditional medicine. This study aimed to measure IC50 of inhibition DPPH as free radicals and make statistical analysis of flavonoid and phenolic content and correlation with their IC50 of free radicals. Methods: Hot continuous extraction was done with Soxhlet apparatus using various polarity solvents (n-hexane, ethyl acetate, and methanol). Results: Methanol extract had the lowest IC50 32.26 ± 0.37 µg/mL of DPPH inhibition activity. Ethyl acetate extract had highest phenolic and highest flavonoid content with 35.21 ± 1.50 mg TAE/g extract and 49.41 ± 1.65 mg QE/g extract. Conclusion: Flavonoid and phenolic content in extracts had linier correlation with their IC50 of inhibition free radicals.
Tantangan Industri Farmasi Indonesia di Era Pandemik COVID-19 Windyaswari, Ari Sri; Hermanto, Faizal; Vikasari, Suci Nar; Riyanti, Soraya; Syam, Akhirul Kahfi; Febrinella, Catellya
Jurnal Abdimas Kartika Wijayakusuma Vol 1 No 2 (2020): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (522.939 KB) | DOI: 10.26874/jakw.v1i2.74

Abstract

Abstrak: Situasi pandemik COVID-19 di Indonesia mempengaruhi beberapa sektor penting, diantaranya adalah sektor kesehatan. Farmasi sebagai salah satu garda penting di bidang kesehatan mempunyai tugas fungsi pokok untuk menyediakan obat yang aman, berkhasiat dan berkualitas. Industri farmasi merupakan bagian terdepan yang memiliki peranan penting tersebut sekaligus merupakan bagian terdepan yang terkena dampak dari situasi pandemik COVID-19. Tekanan untuk penemuan vaksin/obat baru sebagai antivirus COVID19 hingga produksi vitamin dan produk nutrisi lain sebagai upaya preventif untuk melindungi masyarakat Indonesia dari peningkatan penularan virus COVID-19 di Indonesia menghadapi berbagai kendala. Pembatasan Sosial Berskala Besar (PSBB), kegiatan karantina serta isolasi merupakan salah satu kendala di dalam bidang produksi. Disisi lain, permintaan akan produk obat meningkat tajam. Apoteker industri dan apoteker komunitas bekerja sama untuk memastikan ketersediaan dan efek terapi obat dapat digunakan oleh masyarakat Indonesia. Tujuan dilaksanakannya webinar ini adalah untuk mengubah paradigma permasalahan menjadi suatu tantangan yang harus diselesaikan oleh sejawat apoteker di seluruh Indonesia. Metode webinar dilaksanakan melalui penyampaian materi dan diskusi panel dari platform ZOOM dan youtube. Hasil post test yang dilaksanakan terhadap 1.700 peserta secara garis besar menunjukkan pemahaman dan kepedulian masyarakat dalam mengatasi berbagai permasalahan di bidang farmasi industry Indonesia. Kata kunci: Apoteker, Industri Farmasi, COVID-19.
Co-Authors Adinda Fitriani Adinugraha, Irham M. Akbar, Tzazkia Febriyana Ami Soega Dwigantina Ananda Tunjung Pertiwi Anggita Esa Putri Fitrichia Anna Choirunnisa Anna Choirunnisa, Anna Ari Sri Windyaswari Ari Sri Windyaswari Ari Sri Windyaswari Ari Sri Windyaswari, Ari Sri Azhar, Farah Salsabilla Saidah Dadan Suryasaputra Desti Hermawati Dewilestari, Meyra Pratami Dwi Ayu Pratiwi Elfahmi Elfahmi, Elfahmi Ema Mutya Esanda Zulfi Amedea Fahrauk Faramayuda Fahrauk Faramayuda, Fahrauk Faizal Hermanto Farah Salsabilla Saidah Azhar Faramayudha, Fahrauk Farhan Febrinella, Catellya Florence Meliawaty Handayani, Dewi Ratih Hermawati, Desti Hestiary Ratih Ismail, Nursafira Khairunnisa Jaka Permana Julia Ratnawati Julia Ratnawati Julia Ratnawati Julia Ratnawati, Julia Juliastuti, Henny Khaerunnisa, Rahmadaniah Komar Ruslan Wirasutisna Lahagu, Helga Nitulo Berliana Mardiana, Grace Selly Meyra Pratami Dewilestari Muhamad Insanu Muhammad Irwan Nandi Agustian Purwoko, Agus Puspita Satriyani Permatasari Surasa Putri, Dhiffa Namira Alifia Rahaju, Asih Rakhmat, Iis Inayati Ramdhani, Amalia Kusuma Remare Halomoan Limbong Renata Ananda Marthasedana Renti Mutiara Dewi Sabirin, Indah Puti R. Septiani, Vina Sheila Nur Hasanah Sheila Nur Hasanah Sigid Pamungkas Wicaksono Soraya Riyanti Soraya Riyanti Soraya Riyanti Soraya Riyanti Soraya Riyanti, Soraya Sri Restu Andriyani Suci Nar Vikasari, Suci Nar Sufyan Zainul Arifin Sukrasno Suntana, Mutiara Sukma Surasa, Puspita Satriyani Permatasari SURYANI Syahra Asfi Sabilia Totik Sri Mariani Trialisa Aprilia Usi Septiani Vina Septiani Wulan Anggraeni Yeni Karlina Yeni Karlina Yesi Wulandari Yuslianti, Euis Reni