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All Journal Jurnal Berkala Epidemiologi Folia Medica Indonesiana Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Rheumatology Care : Jurnal Ilmiah Ilmu Kesehatan Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Majalah Biomorfologi (Biomorphology Journal) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Jurnal Rumpun Ilmu Kesehatan Jurnal Penyakit Dalam Indonesia Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD) JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Hermina Novida, Hermina
Division Of Endocrinology, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Adrenal Incidentaloma In Patient with Bilateral Nephrolithiasis and Infectef Right Kidney Cyst kholidatul husna; Hermina Novida
Current Internal Medicine Research and Practice Surabaya Journal Vol. 1 No. 2 (2020): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE JOURNAL SURABAYA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v1i2.21557

Abstract

Adrenal incidentaloma (AI) is a rare case, with a prevalence of 3-7% in the general population. We report a case of a 66 year old female, presented with the history of bilateral flank pain. The patient was performed urologic evaluation due to suspicion of right perirenal abscess and left kidney tumor, and from abdominal CT scan it was found suprarenal mass. There were no signs and symptoms of hormonal hyperfunction. Radiological evaluation in the patient showed the present of malignant lesion. Therefore, adrenalectomy was planned. Before undergoing adrenalectomy, the patient had passed away 6 days after first surgery (right pyelolitotomy and unroofing cyst), with septic shock suspected as cause of death due to hospital-acquired pneumonia.
A Type 2 Diabetes Patient who Suffered with Fournier’s Gangrene Kholidatul Husna; Hermina Novida
Current Internal Medicine Research and Practice Surabaya Journal Vol. 2 No. 1 (2021): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v2i1.23806

Abstract

Diabetes mellitus increases the risk of infection, including Fournier’s gangrene. Fournier’s gangrene (FG) is a rare case, with an average incidence of 1.6 cases per 100,000 population per year. We report a case of a 60 year old male, presented with the history of wounds of the buttocks, penis and scrotum. The patient had a history of uncontrolled diabetes mellitus for 3 years. There were perianal abscesses and necrotic tissue on the penis and scrotum. Radiological evaluation in the patient showed the present of gas forming in scrotal area. Therefore, incision and drainage procedure with necrotomy and debridement were performed, together with antibiotics and blood glucose regulation, then followed by closure of the defect with skin graft and use of flap. The patient was discharge with an improved clinical condition.
MANAGEMENT OF GESTASIONAL DIABETES MELLITUS IN A BETA MAJOR THALASSEMIA PATIENT Troy Fonda; Hermina Novida
Current Internal Medicine Research and Practice Surabaya Journal Vol. 2 No. 2 (2021): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v2i2.26255

Abstract

Gestational diabetes mellitus (GDM) is a hyperglycemic condition that is first discovered during pregnancy. GDM is a high-risk condition during pregnancy, for both mother and fetus. GDM affects about 1–14% of pregnancies. In the last 20 years, the incidence of gestational diabetes has been increasing. High iron load and disorders of iron metabolism have been associated with glucose metabolism. The beta thalassemias are a group of hereditary hemoglobinopathies. Treatment for beta thalassemias patients is transfusion, but intensive transfusion can aggravate iron overload in patients. In this study, a case of GDM in a pregnant woman with beta-thalassemia was reported.
DIAGNOSTIC AND MANAGEMENT PROBLEMS OF HYPERTHYROIDISM IN A PATIENT WITH TESTICULAR SEMINOMA Dicky Febrianto; Hermina Novida
Current Internal Medicine Research and Practice Surabaya Journal Vol. 3 No. 1 (2022): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v3i1.29969

Abstract

Patients   with   thyroid   dysfunction   are   well   represented   in   the general   population. Hyperthyroidism can develop as a paraneoplastic syndrome in germ cell tumors. Testicular seminoma as a form of germ cell tumors, can express human chorionic gonadotropin (hCG). Beta-hCG strongly resembles TSH. A 26-year-old male with a history of cryptorchidism, came to Dr. Soetomo Hospital with the complaints of palpitation, diarrhea, weight loss, fatigue,  nervousness,  excessive  sweating,  and  heat intolerance.  He  also  complained  of enlarged breast and a palpable mass in lower abdomen for 4 months. From the TSH and FT4 examinations, patient’s symptoms were in accordance with thyrotoxicosis. Anti-TPO and thyroid USG examination were within normal limits. Patient was treated with beta-blocker and thiamazole. Histopathology of abdominal mass showed a testicular seminoma. After surgery and chemoterapy, the clinical symptoms of hyperthyroidism gradually improved. Administration of beta-blocker and thiamazole was stopped in 4 months after surgery. Many of germ cell tumors in male are associated with cryptorchidism, half of them being testicular seminoma. Seminoma expresses hCG.  At  very high levels, hCG can stimulate the TSH receptors,  causing  hyperthyroidism  or  thyrotoxicosis.  TSH  and  FT4  measurement  were needed in patient with suspected hyperthyroidism. Anti-TPO test is performed to exclude autoimmune cause of thyroid disease. Symptomatic management of beta-hCG induced hyperthyroidism is not different from hyperthyroidism in general, namely administration of beta-blocker  and  anti-thyroid  drugs.  However,  the  definitive  treatments  are  surgery and chemotherapy. Hyperthyroidism in germ cell tumors almost all responds well to surgery and chemotherapy.  
Overview of Lifestyle and Anthropometry of Students of the Faculty of Medicine Airlangga University During COVID-19 Pandemic Jihadna Prima Santika Ruslan Musanip; Hermina Novida; Gadis Meinar Sari; Reny I’tishom
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 3 (2022): Indian Journal of Forensic Medicine and Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i3.18283

Abstract

Background: The COVID-19 pandemic has spread worldwide, forcing governments to implement quarantines asa preventive measure against the spread of the virus. Quarantine causes changes in lifestyle and anthropometrystatus among communities.Objective: To describe the lifestyle and anthropometric status of medical students batch 2018 FM UA during thepandemic. Methods: This was a descriptive study using online questionnaires from September 2020 to February2021.Results: There were variations in students’ anthropometry. Students’ average height is 161.110 cm, the averageweight is 60.308 cm, the average body mass index is 23.193 cm, the average upper arm circumference is 27.846 cm,and the average abdominal circumference is 79.621 cm. Furthermore, 145 respondents (81.9%) stated that theyexperienced changes in their lifestyle during the pandemic. A total of 89 respondents (50.3%) continued to exerciseand the other 88 respondents (49.7%) did not. Regarding the sleep pattern, 108 respondents (61%) had quitegood sleep quality and 50 respondents (28.2%) had quite poor sleep quality. For the food consumption pattern,46 respondents (26%) ate more sweet foods. Furthermore, 156 respondents (88.1%) did sedentary activities, with77 respondents (43.5%) doing sedentary behavior for more than 6 hours a day.Conclusion: During the COVID-19 pandemic, the anthropometric status of medical students batch 2018 FMUAvaried; and tend to maintain their physical activity, have quite good sleep quality, prefer eating sweet foods, anddo a sedentary behavior for a longer duration
The Effect of Polyunsaturated Fatty Acids Omega-3 Supplementation on the Components of Rheumatoid Arthritis Disease Activity: A Systematic Literature Review Nadia Hidayat; Awalia Awalia; Betty Agustina Tambunan; Hermina Novida
Indonesian Journal of Rheumatology Vol. 14 No. 2 (2022): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v14i2.191

Abstract

Background: Rheumatoid arthritis (AR) is a chronic disease that causes deformity in most productive age and can lead to death as disease activity increases. Omega-3 polyunsaturated fatty acids (PUFAs) have the potential to complement available therapies in reducing disease activity. Currently, the effect of omega-3 PUFAs on disease activity components is still unclear. This study aimed to determine the effect of omega-3 PUFAs’ supplementation on the components of RA disease activity. Methods: This research is a systematic study with PRISMA guidelines. Literature identification using Pubmed, MDPI, and clinicaltrials.gov. The inclusion criteria used were: giving omega-3 PUFAs, free full-text, RCT, in English or Indonesian, and assessing disease activity and its components; while the exclusion criteria were: unpublished, comparisons were inappropriate. Assessment of literature quality with the Cochrane Collaboration tool. Results: The study included six studies from 1994 to 2017. The effect of omega-3 PUFAs is diversity in changes of disease activity in 4 of 5 studies. Another effect is a significant reduction in the number of joint pains in the literature by daily doses above 2.9 grams or at lower doses taking longer, and swollen joints in 2 studies that were only affected in doses above 2.9 grams. Another change is a significant reduction in pain severity in the studies. Change increases with higher doses. There are variable LED and CRP changes with minimal study resources. Conclusion: Omega-3 PUFAs depend on their dose and administration duration and can, directly and indirectly, affect disease activity through the influence of most of its components, namely: the number of joints affected, the degree of pain, but the results of the ESR and CRP examinations are not sufficient.
Correlation between Glycemic Control in Type 2 Diabetes Mellitus Patients with Natural Killer Cell Activity Ristanti, Dian; Soegiarto, Gatot; Novida, Hermina
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Most of the previous studies showed decreased polymorphonuclear cells and monocytes/macrophages in type 2 diabetes mellitus (T2DM). Natural killer (NK) cell functions were rarely studied in T2DM. This study aimed to evaluate NK cell activity and determine its correlation with glycemic control in T2DM patients. Methods. Type 2 diabetes mellitus (T2DM) patients who regularly visit the diabetes outpatient clinic of Dr. Soetomo General Hospital during July – August 2018 and fulfill the inclusion-exclusion criteria were recruited to the study. The HbA1c level was measured according to the standard procedure. The NK cell activity was measured using flow cytometry and expressed as the percentage of activated NK cells from total NK cell numbers. Correlation between the two variables was determined. Results. There were 38 subjects eligible for this study, consisted of 15 males and 23 females, with mean of age 52 (standard deviation [SD] 6) years. The subjects routinely received OAD (36.8%), insulin (44.7%), or OAD-Insulin combination therapy (18.4%). Median HbA1c was 7.8% (range: 5.5 – 13%). Median NK cell activity was 7.08% (range: 2.95 – 21.55%). Using a Spearman test, there was no significant correlation between HbA1c levels and NK cell activity (r=0.292; p=0.075). Conclusions. The glycemic control in T2DM did not significantly influence NK cell activity. Further exploration and research should be done to determine whether there were changes in NK cells that contribute to innate immune dysfunction in T2DM patients.
MEDICATION ADHERENCE IN TYPE 2 DIABETES MELLITUS PATIENTS WITH CORONARY HEART DISEASE Shafiero Muhammad Elsya Putera; Sony Wibisono; Andrianto; Hermina Novida
Majalah Biomorfologi Vol. 33 No. 2 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i2.2023.109-117

Abstract

Highlights                                                                                                                                      Type 2 diabetes mellitus (T2DM) that is not appropriately handled can result in macro- or micro-complications. Medication adherence is one of the most important efforts to do to prevent complications in chronic diseases such as T2DM. Abstract Background:  Diabetes medication non-adherence can aggravate the patient's condition and raise the chance of acquiring diabetes complications such as coronary heart disease. Medication adherence can help prevent micro- and macrovascular problems. Objective: This study aimed to investigate the medication adherence of type 2 diabetic patients with coronary heart disease. Material and Method: This research used a systematic literature review for the research design, with a PRISMA chart as a guideline. Researchers searched 3 databases using predefined keywords: PubMed, Google Scholar, and ScienceDirect. Result:  The search yielded 3.373 pieces of literature, and six pieces that fit the requirements were chosen. The total number of people who responded was 9.950. More men over 60 years old who have had diabetes for more than 5 years, who are taking oral medication, insulin, or combination treatment, and who are ex-smokers were shown to have characteristics of people with type 2 diabetes mellitus and coronary heart disease. Results from a systematic literature review revealed five kinds of literature with low medication adherence levels and one literature with a high medication adherence rate. Conclusion:  Medication adherence differs among type 2 diabetic patients with coronary heart disease. More research, however, has revealed that the level of medication adherence in type 2 diabetic patients with coronary heart disease remains low.
Perbandingan Efektivitas Antara Metformin dan Glimepiride Berdasarkan Kadar Gdp pada Pasien Dm Tipe 2 di Rsud Dr.M.Soewandhie pada Tahun 2019 Muhammad Zaim Abbas Hisyam; Sri Purwaningsih; Hermina Novida
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v8i8.13466

Abstract

Diabetes Mellitus is a chronic metabolic disease characterized by elevated blood sugar levels and impaired carbohydrate, lipid, and protein metabolism due to betta pancreatic-cell dysfunction or insulin resistance in body cells. The prevalence of diabetes mellitus continues to increase worldwide. Indonesia itself has a prevalence of type 2 diabetes mellitus reaching 90% of all diabetes (WHO, 2016) (Riskesdas, 2018). The management of type 2 diabetes mellitus is very diverse, ranging from non-pharmacological therapy to pharmacological therapy such as insulin injection and oral anti-diabetes. Each anti-diabetic drug has a variety of ways of working, administration, and side effects. This study aims to analyze the comparison of the effectiveness of anti-diabetic medications based on blood sugar levels from the use of metformin and glimepiride (sulfonylureas) or a combination of both in patients with type 2 diabetes mellitus at Dr. Soewandhie Regional Public Hospital. This research is an analytic retrospective observational using secondary data in the form of medical records of patients with type 2 Diabetes Mellitus (outpatient) at Dr. Soewandhie Regional Public Hospital in 2019. The sample of this study consisted of 121 samples that met the inclusion criteria (43 patients on metformin therapy, 40 patients on glimepiride therapy, and 38 patients on combination therapy). The analysis of this study used data on FBG (Fasting Blood Glucose) before and three months after receiving metformin or sulfonylurea (glimepiride) therapy or a combination of both in the medical record. Data analysis of this study was performed using the Friedman test. This study showed that there was no significant difference in glycemic control (∆FBG) of metformin, glimepiride, and combination therapy in patients with type 2 diabetes mellitus (p value=0.575). There was no significant difference in the effectiveness of metformin, glimepiride, and combination therapy in patients with type 2 diabetes mellitus in Dr. Soewandhie Regional Public Hospital in 2019. In a study conducted in Japan showed that there’s efficacy of high-dose metformin use in patients with type 2 diabetes mellitus in Japan. The efficacy and safety of metformin are similar when used either twice daily or thrice daily. Further research needs to be done to assess the glycemic control (∆FBG) rate of metformin, glimepiride, and combination therapy in patients with type 2 diabetes mellitus by taking into account other factors such as medication adherence, diet, and physical activity.
THE HDL LEVEL IN DIABETIC FOOT ULCER PATIENTS WITH AND WITHOUT AMPUTATION AT DR. SEOTOMO GENERAL ACADEMIC HOSPITAL SURABAYA Ahmed Eliaan Shaker Abuajwa; Hermina Novida; Heroe Soebroto; Yan Efrata Sembiring
Majalah Biomorfologi Vol. 33 No. 1 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i1.2023.30-37

Abstract

Highlights1. Diabetes mellitus is a category of metabolic disease characterized by uncontrolled hyperglycemia.2. This study revealed no statistically significant differences in total cholesterol, TG, LDL, HDL, or LDL/HDL ratio between amputated and non-amputated DFU patients. AbstractBackground: Diabetic foot ulcers (DFU) are microvascular and macrovascular consequences of diabetes and are associated with neuropathy, vascular disease, and immunosuppression. Increased blood glucose levels may result in the glycosylation of proteins in the nerve cells of the foot, leading to ischemia and cellular disturbances that can damage muscular, sensory, and autonomic neurons. Objective: To compare the lipid profiles of amputated and non-amputated DFU patients. Material and Method: This was a cross-sectional, analytic, retrospective research using total sample approach to analyze the medical records of all diabetes patients admitted to Dr. Soetomo General Academic Hospital between February 2018 and December 2020, with or without amputation. Result: The average age of DFU patients at Dr. Soetomo General Academic Hospital was 55.6 9.4 years, and the majority of patients were female (57%). Diabetic foot ulcers were most prevalent in the age group ≥50 years old (74%), amputated DFU patients had larger mean total cholesterol, TG, LDL, and HDL than non-amputated DFU patients, although the difference was not statistically significant. While the mean LDL/HDL ratio was greater in non-amputated DFU patients, the difference was statistically insignificant. The HDL level was low in 84% of amputated DFU patients, whereas in non-amputated DFU patients it was 81%. Conclusion: This research showed no significant variation in total cholesterol, TG, LDL, HDL, or the LDL/HDL ratio between amputated and non-amputated DFU patients. Most DFU patients with and without amputations had low HDL values.
Co-Authors Agung Dwi Wahyu Widodo Agung Pranoto AGUNG PRANOTO Ahmed Eliaan Shaker Abuajwa Alviano Satria Wibawa Andriana, RA Meisy Andrianto Andriati Andriati Ari Sutjahjo, Ari Arisvia Sukma Hariftyani Aryati Aryati Askandar Tjokroprawiro Asmarawati, Tri Pudy Awalia Awalia Awalia, Awalia Betty Agustina Tambunan Bodová, Klára Caesar Lagaliggo Givani Cindy Muazizah Deasy Ardiany Desak Gde Ushadi Bulan Dewata Dian Galuh Maharani Dian Ristanti Dicky Febrianto Drestha Pratita Windriya Fajar Setiyawan Fauzi, Machfud Febrian Daru Setiawan Gatot Soegiarto Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** HERAWATI, LILIK Hidayat, Nadia Humairah, Ira I'tishom, Reny Isnin Anang Marhana Jihadna Prima Santika Ruslan Musanip Jongky H Prajitno, Jongky H Jongky Hendro Prajitno kholidatul husna Lutfi, Delfitri Martino Handoyo Mouli Edward Muhammad Faizi Muhammad Zaim Abbas Hisyam Nadia Hidayat Nariswari, Rachma Putri Novianto, Rifky Alif Nurina Hasanatuludhhiyah Nurul Bashirah Aminy Pawana, I Putu Alit Prabowo, Gwenny Ichsan Purwati Putri, Anandia Nafisah Qurnianingsih, Ema Ramadhani, Rizqi Nabila Rejeki, Purwo Sri Ristanti, Dian Rizki Adrian Hakim Robert Dwitama Adiwinoto Sari, Gadis Meinar Sembiring, Yan Efrata Shafiero Muhammad Elsya Putera Soebroto, Heroe Soelistijo, Soebagijo Adi Soenarnatalina Melaniani Sony Wibisono Sony Wibisono Sri Purwaningsih Stepanus Massora Syahraya, Indira Troy Fonda Wardani, Erlisa Pramodya Wardhani, Puspa William, Andrew