Hermina Novida, Hermina
Division Of Endocrinology, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya

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Effect of High Fat Diet on Weight Loss Through the Expression of Uncouple Protein 1 in Mice Visceral Fat Syahraya, Indira; Novida, Hermina; Herawati, Lilik; Rejeki, Purwo Sri
Folia Medica Indonesiana Vol. 56, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Obesity has become an epidemic around the world. High fat diet (HFD) have been implemented as one of intervention to battle obesity. Uncouple protein 1 (UCP1) is one of the key factor on energy expenditure. The aim of this experiment is to see the macronutrients composition on weight loss and UCP1 expression in the visceral fat. Fifty male mice, 2-3 months old, 18-30 grams, were put in five different groups. K1 were fed (20% protein, 62.0% carbohydrate, 12% fat), K2 (60% protein, 0% carbohydrate, 30% fat), K3 (45% protein, 0% carbohydrate, 45% fat), K4 (30% protein, 0% carbohydrate, 60% fat), K5 (15% protein, 0% carbohydrate, 75% fat). The experiment was done in four weeks, mice body weight was measured every week. UCP1 expression seen using immunohistochemistry staining was measured at the end of the fourth week. Significant weight loss was achieved by K4 (-9.60±3.81) gram by the end of week four (p<0.05). K4 had the least amount of visceral fat. The result was that K4 achieved a significant visceral fat mass (0.02±0.06) gram compared to K1 (0.53±0.08) gram. Compared to other groups K5 expressed UCP1 more than the others (3.78±3.72) cphfp. HFD fed groups produced significant weight loss, group that had the greatest weight loss is K4. Meanwhile, each group had a variety of UCP1 expression.
Karakteristik Luaran Kehamilan Pada Pasien Diabetes Dalam Kehamilan Di Rumah Sakit Tersier Indonesia Iftinan, Alisia Nuwayyarotul; Novida, Hermina; Sa'adi, Ashon; Wironegoro, Rio
Bahasa Indonesia Vol 6 No 2 (2025): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

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Diabetes dalam kehamilan merupakan salah satu masalah kesehatan yang dapat meningkatkan risiko morbiditas dan mortalitas maternal maupun perinatal. Penelitian ini bertujuan untuk mengetahui luaran persalinan pada pasien dengan diabetes dalam kehamilan di RSUD Dr. Soetomo, Surabaya, pada periode Januari–Desember 2023. Penelitian ini menggunakan desain deskriptif retrospektif dengan pengambilan data dari rekam medis pasien yang memenuhi kriteria inklusi. Variabel yang dikaji meliputi karakteristik luaran berupa cara persalinan, usia kehamilan, dan berat badan lahir bayi. Dari 97 pasien dengan diabetes dalam kehamilan, terdapat 86 pasien dengan Diabetes Melitus Gestasional (DMG) dan 11 pasien dengan Diabetes Melitus Pregestasional (DMP). Sebagian besar pasien menjalani persalinan melalui sectio caesarea, dengan total 75 kasus (77,3%), sedangkan 22 pasien (22,7%) melahirkan secara spontan. Dibandingkan DMG, kelompok DMP lebih sering menjalani sectio caesarea (90,9%). Hasil ini menunjukkan bahwa pada populasi penelitian terdapat proporsi yang cukup tinggi untuk persalinan caesar, dan kelahiran prematur. Pemantauan ketat kadar glukosa darah dan penatalaksanaan komprehensif sejak awal kehamilan diperlukan untuk meminimalkan risiko terjadinya komplikasi pada ibu dan bayi.
Perbedaan Kontrol Glikemik Terapi Metformin Dibandingkan Glimepiride pada Pasien Diabetes Melitus Tipe 2 di RSI Jemursari Surabaya pada Tahun 2018 Rachma Putri Nariswari; Gwenny Ichsan Prabowo; Hermina Novida; Nurina Hasanatuludhhiyah
Majalah Kedokteran Indonesia Vol 71 No 1 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.1-2021-281

Abstract

Introduction: Type 2 diabetes mellitus is caused by decreased tissue sensitivity to insulin. The prevalence of diabetes in the world has almost doubled since 1980, from 4.7% to 8.5% in adult population. Early diagnosis and treatment aimed at normalizing glycemic control are very important. The objective of this study was to evaluate and compare glycemic control of metformin and glimepiride in monotherapy of type 2 diabetes mellitus patients at Islamic Jemursari Hospital Surabaya. Method: This was a retrospective observational study using secondary data (medical record), include glycemic control (RPG) before and two months after receiving therapy of outpatients’ type 2 diabetes mellitus with metformin or glimepiride therapy in 2018. 96 samples were found that fit the inclusion criteria. The data were analyzed by Mann-Whitney test. Result: Most patients were female, aged 50-69 years old, and dosage of metformin therapy 1500 mg/day or glimepiride therapy 2 mg/day. There was no significant difference (p greater than 0.05) of glycemic control (RPG) of metformin compared to glimepiride therapies in type 2 diabetes mellitus patients at Islamic Jemursari Hospital Surabaya in 2018. Conclusion: Metformin and glimepiride were not significantly different in glycemic control (RPG). There were patients with RPG greater than 200 mg/dl after two months of metformin or glimepiride therapy.
Pregnancy Following Recent Radioactive Iodine Ablation in Thyroid Cancer Patient A Case Report Robert Dwitama Adiwinoto; Soebagijo Adi Soelistijo; Hermina Novida; Agung Pranoto
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
Publisher : PP PERKENI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66266/inajemd.v1i1.7

Abstract

Well-differentiated thyroid carcinoma (DTC) is common among females of reproductive age. Pregnancy is associated with hormonal (TSH and HCG) and metabolic changes that might affect the thyroid gland. Informationregarding the outcome of babies born to mothers who have recently undergone radioactive Iodine-131 ablation (RAI) is scarce. A 24-year-old pregnant woman with a history of thyroid cancer was consulted by the obstetrics and gynecology for further evaluation. She complained of a lump under the left jaw, and a thyroid nodule was found from further examination. Postoperative pathology of the right thyroid tissue revealed follicular and solid variant papillary thyroid carcinoma. Postoperative Thyroglobulin (Tg) level before ablation was 16.14 ng/mL. Ablation with Iodine-131 of 100 mCi was performed. Whole-body scintigraphy (WBS) indicated remaining functional thyroid tissue in the right thyroid field and thyroid tissue metastases in the left supraclavicular area. The patient waspregnant 3 months after the radioablation. Fetomaternal examination results 6 months pregnancy revealed fetal biometry according to gestational age (31 – 32 weeks) with an estimated fetal weight of 1787 grams and fetal doppler was normal. The patient is treated with levothyroxine 125 μ g once daily, folic acid 400 μ g twice daily, calcium lactate twice daily, and aspirin 80 mg once daily. The TSH level was 0.01 (0.55 – 4.78) μ IU/mL and the fT4 was 1.14 (0.7 – 1.48) ng/dL. The latest thyroid ultrasound indicated no discrete mass in the thyroid fossa and non-specific lymphadenopathies. The baby was born normally, weighed 2680 grams, with normal thyroid function tests (neonatal TSH 1.02 μ IU/mL, fT4 2.6 ng/dL).