Hermina Novida, Hermina
Division Of Endocrinology, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya

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Faktor Risiko Kematian pada Pasien Diabetes Melitus dan Penyakit Jantung: Systematic Review Cindy Muazizah; Hermina Novida
Jurnal Rumpun Ilmu Kesehatan Vol. 4 No. 2 (2024): Juli: Jurnal Rumpun Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jrik.v4i2.4145

Abstract

Word Health Organization defines a cause of death as an illness, disease or injury that causes or contributes to death. Diabetes mellitus is a major comorbidity and cardiac arrest is the highest cause of death. Cardiovascular disease is more common in men with an average age of 57 years. There are many types of cardiovascular disease, but the most common and well-known are coronary heart disease and stroke. Basic Health (Riskesdas) in 2018 reported that the incidence of heart and blood vessel disease is increasing from year to year. The main factor in heart disease is uncontrolled blood sugar, while the most common macrovascular complication of diabetes mellitus is coronary heart disease. Causative factors The prevalence of type 2 diabetes mellitus is caused by the interaction between gene susceptibility factors and environmental exposure as follows Genetics and Environment The occurrence of coronary heart disease is closely related to the presence of disorders affecting the blood vessels called atherosclerosis. This research uses a systematic review based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). with inclusion and exclusioncriteria, the risk of cardiovascular death and myocardial infarction was higher with increasing values ​​of lysis time and maximum turbidity.
Omega-3 Polyunsaturate Fatty Acid Supplementation Potential to Improve Activity Components of Rheumatoid Arthritis: A Systematic Review Hidayat, Nadia; Awalia, Awalia; Tambunan, Betty Agustina; Novida, Hermina
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.32613

Abstract

Introduction: Rheumatoid arthritis (RA) is a chronic disease that causes deformity in most productive age and can lead to death as disease activity increases. Omega-3 polyunsaturated fatty acids have the potential to complement available therapies in reducing disease activity. Currently, the effect of omega-3 PUFAs on disease activity components is still unclear. The current systematic reviews determine the effect of omega-3 PUFAs' supplementation on the components of RA disease activity. Methods: This research is guided by the PRISMA guidelines systematically. Literature was searched in the databases: PubMed, MDPI, and Clinicaltrials.gov. The inclusion criteria used were: giving omega-3 PUFAs, free full-text, RCT, in English or Indonesian, assessing disease activity and its components; while the exclusion criteria were: unpublished, comparisons were inappropriate. Assessment of literature quality with the Cochrane Collaboration's tool. The study included six studies from 1994 to 2017. Results: The effect of omega-3 PUFAs is diversity in changes of disease activity in 4 of 5 studies. There are significant reductions in the number of joint pains in the literature by daily doses above 2.9 grams or at lower doses taking longer; and swollen joints in 2 studies that were only affected in doses above 2.9 grams. There are significant reductions in pain severity in the studies. Change increases with higher doses. There are variable LED and CRP changes. Conclusion: Depending on their dose and administration duration, omega-3 PUFAs can directly and indirectly affect disease activity through the influence of most of its components, namely: the number of joints affected and the degree of pain.
The Clinical Outcome of COVID-19 Infection on Chronic Diabetic Complications Patients Wardani, Erlisa Pramodya; Tri Pudy Asmarawati; Isnin Anang Marhana; Hermina Novida
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 1 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i1.51748

Abstract

Introduction: COVID-19 is an infectious disease resulting from the SARS-CoV-2 virus. The virus targets the respiratory system and leads to a significant number of fatalities worldwide. Consequently, it was officially classified as a pandemic in 2020. The Covid varians is now being monitored by the World Health Organization. Diabetes mellitus is one of the disorders that might deteriorate following an infection. Diabetes mellitus and its associated comorbidities continue to pose a significant health challenge in Indonesia, while it is also a focus of concern of the Sustainable Development Goals (SDGs). The study was aimed to assess the risks and outcomes associated with COVID-19 infection and the long-term consequences of diabetes mellitus.Methods: This was a descriptive study using a retrospective design. Research data were taken from the medical records of patients confirmed positive for COVID-19 infection and also had chronic complications of diabetes mellitus who were treated at Dr Soetomo General Academic Hospital, Surabaya, Indonesia in 2021. There were 156 patients who met the criteria of this research.Results: There were 156 patients (97 males, 59 females). The average age of the patients was 58, while most of the patients (84%) died and the rest of the patients (16%) survived. Most of the patients with fatality (55.8%) were those with critical severity level and complications of microangiopathy, while the patients who survived (10.3%) were those with moderate severity level and complications of microangiopathy. Conclusion: COVID-19 patients with diabetes and comorbidities had a higher mortality rate than those who recovered, while most of the patients with fatality were those with significant COVID-19 and diabetic microangiopathy complications.
Effect of High Fat Diet on Weight Loss Through the Expression of Uncouple Protein 1 in Mice Visceral Fat Syahraya, Indira; Novida, Hermina; Herawati, Lilik; Rejeki, Purwo Sri
Folia Medica Indonesiana Vol. 56 No. 3 (2020): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1264.238 KB) | DOI: 10.20473/fmi.v56i3.24576

Abstract

Obesity has become an epidemic around the world. High fat diet (HFD) have been implemented as one of intervention to battle obesity. Uncouple protein 1 (UCP1) is one of the key factor on energy expenditure. The aim of this experiment is to see the macronutrients composition on weight loss and UCP1 expression in the visceral fat. Fifty male mice, 2-3 months old, 18-30 grams, were put in five different groups. K1 were fed (20% protein, 62.0% carbohydrate, 12% fat), K2 (60% protein, 0% carbohydrate, 30% fat), K3 (45% protein, 0% carbohydrate, 45% fat), K4 (30% protein, 0% carbohydrate, 60% fat), K5 (15% protein, 0% carbohydrate, 75% fat). The experiment was done in four weeks, mice body weight was measured every week. UCP1 expression seen using immunohistochemistry staining was measured at the end of the fourth week. Significant weight loss was achieved by K4 (-9.60±3.81) gram by the end of week four (p<0.05). K4 had the least amount of visceral fat. The result was that K4 achieved a significant visceral fat mass (0.02±0.06) gram compared to K1 (0.53±0.08) gram. Compared to other groups K5 expressed UCP1 more than the others (3.78±3.72) cphfp. HFD fed groups produced significant weight loss, group that had the greatest weight loss is K4. Meanwhile, each group had a variety of UCP1 expression.
Dyslipidemia is Associated with Coronary Heart Disease in Patients with Type 2 Diabetes Mellitus at a Tertiary Hospital in Surabaya, Indonesia Ramadhani, Rizqi Nabila; Humairah, Ira; Novida, Hermina; Qurnianingsih, Ema
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 1 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i1.64560

Abstract

Introduction: Diabetes mellitus ranks as the third leading cause of mortality in Indonesia. The commonly found comorbidity of diabetes mellitus is cardiovascular disease, which contributes to elevated mortality rates. Diabetes mellitus sufferers face a heightened risk of cardiovascular disease, in part, due to dyslipidemia. This study aimed to establish the association between dyslipidemia and coronary heart disease (CHD) in type 2 diabetes mellitus (T2DM) patients receiving treatment at the diabetes subdivision of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: This retrospective cross-sectional investigation examined 100 eligible individuals with T2DM and dyslipidemia at the diabetes subdivision of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, to assess the prevalence of CHD. Statistical analysis was performed using Pearson's chi-squared test to determine whether there was an association between dyslipidemia and CHD in the T2DM sufferers. If the p-value was below 0.05, the findings of the analysis were considered significant. The statistical test was conducted through IBM SPSS Statistics for Windows, version 26.0 (IBM Corp., Armonk, N.Y., USA). Results: Dyslipidemia was present in 74% of the T2DM patients. Patients who had dyslipidemia and T2DM were primarily female and aged between 51 and 60 years. Meanwhile, CHD affected 40 T2DM patients (40%). These patients were predominantly male and between the ages of 51 and 60. T2DM patients who also suffered from CHD typically presented with dyslipidemia (85%). Conclusion: This study demonstrates that the presence of dyslipidemia in T2DM sufferers is associated with CHD.   Highlights: 1. This study examined type 2 diabetes mellitus patients receiving treatment in a tertiary hospital to determine the association between dyslipidemia and coronary heart disease, an important concern given the rising prevalence of the disease in Indonesia. 2. The analysis revealed that type 2 diabetes mellitus patients who also have dyslipidemia face an elevated risk of developing coronary heart disease. 3. This study offers additional information, particularly related to the presence of dyslipidemia and coronary heart disease, which may enhance the management of type 2 diabetes mellitus throughout primary, secondary, and tertiary health facilities.
Pregnancy Following Recent Radioactive Iodine Ablation in Thyroid Cancer Patient A Case Report Robert Dwitama Adiwinoto; Soebagijo Adi Soelistijo; Hermina Novida; Agung Pranoto
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
Publisher : PP PERKENI

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Abstract

Well-differentiated thyroid carcinoma (DTC) is common among females of reproductive age. Pregnancy is associated with hormonal (TSH and HCG) and metabolic changes that might affect the thyroid gland. Informationregarding the outcome of babies born to mothers who have recently undergone radioactive Iodine-131 ablation (RAI) is scarce. A 24-year-old pregnant woman with a history of thyroid cancer was consulted by the obstetrics and gynecology for further evaluation. She complained of a lump under the left jaw, and a thyroid nodule was found from further examination. Postoperative pathology of the right thyroid tissue revealed follicular and solid variant papillary thyroid carcinoma. Postoperative Thyroglobulin (Tg) level before ablation was 16.14 ng/mL. Ablation with Iodine-131 of 100 mCi was performed. Whole-body scintigraphy (WBS) indicated remaining functional thyroid tissue in the right thyroid field and thyroid tissue metastases in the left supraclavicular area. The patient waspregnant 3 months after the radioablation. Fetomaternal examination results 6 months pregnancy revealed fetal biometry according to gestational age (31 – 32 weeks) with an estimated fetal weight of 1787 grams and fetal doppler was normal. The patient is treated with levothyroxine 125 μ g once daily, folic acid 400 μ g twice daily, calcium lactate twice daily, and aspirin 80 mg once daily. The TSH level was 0.01 (0.55 – 4.78) μ IU/mL and the fT4 was 1.14 (0.7 – 1.48) ng/dL. The latest thyroid ultrasound indicated no discrete mass in the thyroid fossa and non-specific lymphadenopathies. The baby was born normally, weighed 2680 grams, with normal thyroid function tests (neonatal TSH 1.02 μ IU/mL, fT4 2.6 ng/dL).
PROFIL DATA PASIEN DIABETES MELITUS TIPE 2 DENGAN KOMPLIKASI ULKUS DIABETIKUM DI RSU DR.SOETOMO SURABAYA TAHUN 2012 Drestha Pratita Windriya; Ari Sutjahjo; Hermina Novida
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 2 No 1 (2013): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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Abstract

WHO mencatat terdapat 120 juta penderita DM pada tahun 1996 dan jumlahnya akanmeningkat dua kali lipatnya pada tahun 2025. Pasien dengan DM memiliki peluang lima kalilebih besar terkena gangren. Penelitian ini bertujuan untuk mengetahui profil dan distribusi datapasien DM tipe 2 (DMT 2) dengan komplikasi ulkus maupun gangren diabetikum. Penelitian inimerupakan penelitian deskriptif dengan desain potong lintangberdasarkan data dari DokumenMedik Kesehatan (DMK) pasien. Dari 101 pasien yang diteliti, 61% pasien berjenis kelaminwanita dan rentang usia pasien terbanyak adalah 51-60 tahun. Lima puluh persen pasien telahmenderita DMT2 selama 1-5 tahun. Pada pemeriksaan radiologis,gambaran terbanyak yangdidapat adalah ulkus saja tanpa kelainan (32%) dan gangren (27%).Sebanyak 28% pasiendatang dengan kadar gula darah acak (GDA) 201-300 mg/dL. Dari 30% pasien yang melakukanpemeriksaan kultur nanah, Staphylococcus sp. merupakan kuman terbanyak yang ditemukan(25%). Perawatan 25% pasien DMT 2 dengan ulkus diketahui membutuhkan waktu selama 6-10 hari dengan 70% pasien dipulangkan karena kondisinya yang membaik, meski beberapadiantaranya harus dilakukan tindakan amputasi.
Effectiveness of Radioiodine Therapy for Graves' Hyperthyroidism: A Quality-of-Life Assessment Fauzi, Machfud; Prajitno, Jongky Hendro; Prabowo, Gwenny Ichsan; Novida, Hermina
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.53131

Abstract

Introduction: Graves' disease, an autoimmune disorder characterized by hyperthyroidism, is commonly managed through radioactive iodine therapy, antithyroid drugs, and thyroidectomy. Previous reports suggest that individuals undergoing radioactive iodine therapy exhibit superior overall quality of life and satisfaction compared to those opting for alternative therapeutic modalities. This study systematically reviewed evidence on the effectiveness of radioiodine therapy for Graves' hyperthyroidism, specifically emphasizing its impact on patients' quality of life. Methods: A systematic review was conducted on studies evaluating the quality of life of adult patients with Graves’ hyperthyroidism following radioiodine therapy. A literature search was carried out utilizing the PubMed, ScienceDirect, and Sage Journals online databases. The search results were screened according to the eligibility criteria for inclusion in a narrative synthesis. Results: The search yielded 203 items, of which four articles fulfilled the eligibility criteria and were included in the review. radioiodine therapy demonstrated improvements in the quality of life of patients with Graves' disease compared to other therapeutic modalities or no treatment at all. Enhancement in quality of life was observed across various scales, encompassing physical symptoms (goiter, hyperthyroidism, eye symptoms, and hypothyroidism), psychological symptoms (depression and anxiety), functioning and well-being (fatigue, cognitive impairment, and emotional vulnerability), and participation (social life disruptions, daily life interference, and cosmetic complaints). Conclusion: Findings concerning quality of life underscore the long-term effectiveness of radioiodine therapy as a preferred intervention for Graves' disease, contributing valuable insights for clinical decision-making.   Highlights: 1. This systematic review comprehensively synthesizes research findings regarding the impact of radioiodine therapy on the long-term quality of life of patients with Graves’ hyperthyroidism compared to surgery or antithyroid medication. 2. The findings suggest that radioiodine therapy offers improvement in the quality of life, which may be indicated by physical and psychological symptoms, functioning, well-being, and participation.
Analysis of Risk Factors for Antimicrobial Resistance in Bacterial Infections among Diabetic Foot Ulcer Patients William, Andrew; Sembiring, Yan Efrata; Widodo, Agung Dwi Wahyu; Novida, Hermina
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.64804

Abstract

Introduction: Diabetic foot ulcer (DFU) is a chronic and progressive complication of diabetes mellitus resulting from macroangiopathy and microangiopathy disorders. Acknowledging the relationship between the Wagner diabetic foot ulcer classification system and infection severity may offer a promising instrument for guiding empirical antibiotic selections in clinical settings. This study aimed to assess the relationship between Wagner grades and the pathogen profiles of patients with DFU, along with their susceptibility to antibiotic therapy.Methods: A cross-sectional study was conducted from January 2021 to August 2023, utilizing 33 secondary datasets obtained from electronic medical records. The data contained the patients' Wagner grades alongside the results of their complete microbiological analysis and antibiotic susceptibility test. The association between determinant factors and patients' pathogen profiles and antibiotic susceptibility patterns was examined using the Chi-square bivariate analysis (p<0.05).Results: Positive culture results were observed in 32 patients (97%), with 59% exhibiting resistance to first-line antibiotics. The most commonly isolated pathogen was Staphylococcus aureus. The antibiotic susceptibility patterns indicated that gentamicin-syn demonstrated the highest activity against Gram-positive bacteria (GPB) isolates, while erythromycin was the most effective against Gram-negative bacteria (GNB) isolates. With escalating Wagner grades, there was an increased proportion of mixed infections, GNB infections (n=8, X²=23.28, p=0.003), and antibiotic resistance (n=8, X²=39.97, p=0.000). GNB isolates showed higher resistance compared to GPB isolates (n=18, X²=42.15, p=0.001).Conclusion: Our findings suggest that DFU patients with varying Wagner grades exhibit different bacterial profiles, infection patterns, and antibiotic sensitivities.   Highlights:1. This is the first study conducted in Indonesia to analyze the relationship between the Wagner diabetic foot ulcer classification system and patients' pathogen profiles and antimicrobial susceptibility.2. This study incorporated an in-depth analysis of several infection patterns and the occurrence of antimicrobial resistance, hence offering valuable information on the application of the Wagner classification system not only as a tool for grading infection severity but also for guiding clinicians in selecting the appropriate antibiotics for patients with diabetic foot ulcers.
Retrospective Analysis of Numerical Pain Rating Scale (NPRS) Scores in Diabetic Neuropathy Patients Receiving Gabapentin and Non-Gabapentin Therapies at an Indonesian Tertiary Hospital Novianto, Rifky Alif; Hidayati, Hanik Badriyah; Novida, Hermina; Bodová, Klára
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.66470

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Introduction: Diabetic neuropathy is a common complication of diabetes, affecting over half of patients and frequently leading to diabetic neuropathic pain (DNP), which can be difficult to treat. Gabapentin is commonly used as a first-line therapy for DNP and works by modifying calcium channels to reduce pain. This study aimed to evaluate and compare Numerical Pain Rating Scale (NPRS) profiles in DNP patients receiving gabapentin and non-gabapentin therapies at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: This retrospective study analyzed the medical records of 24 DNP patients at Dr. Soetomo General Academic Hospital from January to December 2023. The inclusion criteria comprised patients diagnosed with diabetic neuropathy, according to the International Statistical Classification of Diseases, Tenth Revision (ICD-10) code E11.4, and treated for pain using gabapentin and/or other therapies. Patients with incomplete records or unrelated neuropathic conditions were excluded. The data encompassed NPRS scores, demographics, diabetes mellitus duration, pain characteristics, drug types, doses, and therapy durations. Results: Among 24 patients, the majority were female (54.1%) and over 60 years old (58.3%), with a diabetes duration of 6–10 years (54.1%). Tingling was the most frequently observed symptom (75%). Gabapentin administered as monotherapy (1×300 mg) was the predominant treatment (56.5%) and provided the greatest reduction in NPRS scores (7 points) after 4–12 weeks. Combination therapies showed smaller reductions. Conclusion: Gabapentin used as monotherapy is effective for managing DNP, especially over 4–12 weeks. Patients with long-standing diabetes, particularly older adults, are the most affected and benefit from targeted therapy.   Highlights: 1. This study evaluates the demographic, clinical, and therapeutic profiles of patients with diabetic neuropathic pain, focusing on gabapentin and non-gabapentin therapies.2. Novel insights into the distribution of therapies and numerical pain rating scale (NPRS) scores among patients offer a foundation for optimizing pain management strategies.3. This research contributes to identifying patterns in drug efficacy and therapy duration, particularly with the administration of gabapentin for managing diabetic neuropathic pain.
Co-Authors Agung Dwi Wahyu Widodo Agung Pranoto AGUNG PRANOTO Ahmed Eliaan Shaker Abuajwa Alviano Satria Wibawa Andriana, RA Meisy Andrianto Andriati Andriati Ari Sutjahjo, Ari Arisvia Sukma Hariftyani Aryati Aryati Askandar Tjokroprawiro Asmarawati, Tri Pudy Awalia Awalia Awalia, Awalia Betty Agustina Tambunan Bodová, Klára Caesar Lagaliggo Givani Cindy Muazizah Deasy Ardiany Desak Gde Ushadi Bulan Dewata Dian Galuh Maharani Dian Ristanti Dicky Febrianto Drestha Pratita Windriya Fajar Setiyawan Fauzi, Machfud Febrian Daru Setiawan Gatot Soegiarto Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** HERAWATI, LILIK Hidayat, Nadia Humairah, Ira I'tishom, Reny Isnin Anang Marhana Jihadna Prima Santika Ruslan Musanip Jongky H Prajitno, Jongky H Jongky Hendro Prajitno kholidatul husna Lutfi, Delfitri Martino Handoyo Mouli Edward Muhammad Faizi Muhammad Zaim Abbas Hisyam Nadia Hidayat Nariswari, Rachma Putri Novianto, Rifky Alif Nurina Hasanatuludhhiyah Nurul Bashirah Aminy Pawana, I Putu Alit Prabowo, Gwenny Ichsan Purwati Putri, Anandia Nafisah Qurnianingsih, Ema Ramadhani, Rizqi Nabila Rejeki, Purwo Sri Ristanti, Dian Rizki Adrian Hakim Robert Dwitama Adiwinoto Sari, Gadis Meinar Sembiring, Yan Efrata Shafiero Muhammad Elsya Putera Soebroto, Heroe Soelistijo, Soebagijo Adi Soenarnatalina Melaniani Sony Wibisono Sony Wibisono Sri Purwaningsih Stepanus Massora Syahraya, Indira Troy Fonda Wardani, Erlisa Pramodya Wardhani, Puspa William, Andrew