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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Science and Technology Indonesia Jurnal Pemberdayaan Masyarakat Madani (JPMM) Molecular and Cellular Biomedical Sciences (MCBS) Resona : Jurnal Ilmiah Pengabdian Masyarakat Dinamisia: Jurnal Pengabdian Kepada Masyarakat Journal of Islamic Medicine Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Abdimas Ilmiah Citra Bakti (JAICB) MAHESA : Malahayati Health Student Journal Pharmaceutical Sciences and Research (PSR) Journal Community Service Consortium Jurnal Farmasi Indonesia Journal of Food and Pharmaceutical Sciences
Marisca Evalina Gondokesumo, Marisca Evalina
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Science and Technology Indonesia

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Anticancer Effectivity of Nanocrystals Derived from Mangosteen (Garcinia mangostana) Peel Extract on Leukemia HL-60 Cells Gondokesumo, Marisca Evalina; Novilla, Arina; Prahastuti, Sijani; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Zahiroh, Fadhilah Haifa; Hadiprasetyo, Dhanar Septyawan; Surakusumah, Wahyu
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.228-237

Abstract

Leukemia, characterized by abnormal leukocyte proliferation, ranks ninth in Indonesia as the most common cancer. While treatments such as chemotherapy and radiation effectively target cancer cells, they also risk damaging healthy blood cells. This has spurred interest in exploring low-toxicity herbal compounds as potential therapies, with mangosteen peel emerging as a widely researched option. Nanotechnology, which has the potential to enhance the bioavailability of herbal compounds, is also a focus of extensive research. This study objective was to assess the impact of Mangosteen Peel Nanocrystal (MPN) on HL-60 leukemia cells by analyzing various parameters, including cytotoxicity, reactive oxygen species (ROS) levels, senescence, and gene expression changes. MPN was prepared with high-speed milling and characterized using particle size analyzers, microscopy, and stability assessments. HL-60 cells were cultured and subjected to MPN treatment. Cytotoxicity was evaluated using WST-8 assays, ROS levels were assessed using flow cytometry, and senescence analyses using Senescence-Associated b-Galactosidase Staining. AKT and FLT-1 gene expression were determined via qRT-PCR. MPN has been successfully characterized as a nanoparticle based on size, stability, and morphology. MPN has an impact on leukemia cells by increasing cytotoxicity, decreasing ROS levels, inducing senescence, and modulating AKT and FLT-1 gene expressions. The findings suggest potential implications for MPN in targeting leukemia cells. The study sheds light on the promising effects of MPN in leukemia cell models, indicating its potential applications in targeting cancer cells, inducing senescence, decreasing ROS levels, and modulating gene expressions related to cell survival and proliferation.
Co-Authors Abdul Aziz Anggraeni, Reta Anita Purnamayanti Ardiansyahmiraja, Bobby Auliyana, Iftitah Putri Azis, Rizal Azminah Azminah Azminah Badriah, Rani Nur Budipramana, Krisyanti Djayapranata, Grace Felicia Elisabeth, Mariska Faisal Akhmal Muslikh Girsang, Ermi Gunanegara, Rimonta Febby Hadiprasetyo, Dhanar Septyawan Hanna Sari Widya Kusuma, Hanna Sari Widya Harjanti, Mathelda Weni Haryanti, Mathelda Weni Hayati, Syafira Nur Herawati, Fauna Ma'arif, Burhan Mariana Wahjudi, Mariana Mars, Nicholas Muthmainnah, Anis Syabani Nindya, Faradhina Salfa Novilla, Arina Pratama, Jainuri Erik Putri, Rizky Ayu Artama RAHMAT, DENI Retno Wilujeng Susilowati, Retno Wilujeng Saksono, Astrella Amanda Putri Saufa, Zahra Qisthi Setiadi, Adji Prayitno Setiadi, Antonius Adji Prayitno Sijani Prahastuti Simanjuntak, Inana Ratu Soripada Suryaningsih, Dwie Retna Suryaningsih, Retna Sutejo, Erwin Takasenserang, Oktaviana Teresa Liliana Wargasetia Triharsiwi, Dwi Nur Wahyu Surakusumah WAHYU WIDOWATI Wibowo, Yosi Irawati Widya, Reta Anggraeni Zahiroh, Fadhilah Haifa