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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Science and Technology Indonesia Jurnal Pemberdayaan Masyarakat Madani (JPMM) Molecular and Cellular Biomedical Sciences (MCBS) Journal of Islamic Medicine Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Abdimas Ilmiah Citra Bakti (JAICB) MAHESA : Malahayati Health Student Journal Pharmaceutical Sciences and Research (PSR) Journal Community Service Consortium Jurnal Farmasi Indonesia Journal of Food and Pharmaceutical Sciences
Marisca Evalina Gondokesumo, Marisca Evalina
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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α-/β-Glucosidase and α-Amylase Inhibitory Activities of Roselle (Hibiscus sabdariffa L.) Ethanol Extract Gondokesumo, Marisca Evalina; Kusuma, Hanna Sari Widya; Widowati, Wahyu
Molecular and Cellular Biomedical Sciences Vol 1, No 1 (2017)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v1i1.3

Abstract

Background: Diabetes mellitus is a metabolic disease, characterized by hyperglycemia due to disturbance in both insulin secretion and function. One of theurapeutic approaches is to reduce blood glucose levels by inhbiting α-/β-glucosidase and α-amylase involved in carbohydrate digestion. Thus, inhibition of these enzymes play important role in the treatment of diabetes mellitus. Roselle (Hibiscus sabdariffa L.) has been known to have several medicinal properties and potency as an antidiabetics agents. This reseacrh aimed to observe antidiabetic properties of roselle ethanol extract (REE) towards α-glucosidase, β-glucosidase and α-amylase.Materials and Methods: REE was done with maceration technique using diluent of 70% ethanol. Antidiabetic properties were measured by inhibitory activity of α-amylase, α-glucosidase and β-glucosidase.Results: REE was able to inhibit α-/β-glucosidase and α-amylase in the highest concentration with inhibition percentage of 72.68, 47.34 and 73.08% respectively, and were comparable with Acarbose of 81.49, 50.97, 73.08%. The median inhibitory concentration (IC50) of α-/β-glucosidase and α-amylase of REE were 15.81, 41.77, 18.09 μg/mL respectively, and Acarbose were 9.45, 22.57, 3.64 μg/mL respectively.Conclusions: REE inhibits α-/β-glucosidase and α-amylase.Keywords: Roselle, Acarbose, α-glucosidase, β-glucosidase, α-amylase, antidiabetic
In Silico Analysis of Phytoestrogens' Neuroprotective Effect on N-methyl-D-aspartate (NMDA) Receptors Muslikh, Faisal Akhmal; Pratama, Rizki Rahmadi; Ma'arif, Burhan; Gondokesumo, Marisca Evalina
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.21381

Abstract

cause of death and disability globally. One of the causes is associated with cell signaling disorders, neuronal apoptosis, inflammation, and the deposition of aggregate proteins. The N-methyl-D-aspartate (NMDA) receptor is a glutamate receptor that, when activated, causes synaptic dysfunction and leads to neuronal death. Phytoestrogen compounds are able to replace the role of estrogen in maintaining body homeostasis, including in the CNS.  Objectif: This study aims to determine the role of phytoestrogen compounds in inhibiting NMDA activation (1PBQ), which causes neurodegenerative diseases. Methods: The method used is molecular docking with the AutoDockTools 1.5.6 program. The prediction of pharmacokinetic and pharmacodynamic properties used SwissADME, while the toxicity used pkCSM and ProTox II. Results:  The results of docking using the 1PBQ protein showed that the compounds α-amyrin, β-amyrin and eudesmin had the best binding potential compared to 17β-estradiol which was the positive control. Pharmacokinetic and pharmacodynamic tests showed that the three compounds had good permeability and strong lipophilicity, so they could penetrate cell membranes, and were not toxic, except for eudesmin, which was included in class IV in the toxicity test using ProTox II. Conclusion :   α-amyrin and β-amyrin compounds have the potential to treat neurodegenerative diseases against NMDA receptors (1PBQ).
BENEFITS OF INDONESIAN SAINTIFIC JAMU IN THE TREATMENT OF VARIOUS DISEASES: A REVIEW Gondokesumo, Marisca Evalina; Muthmainnah, Anis Syabani
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.53808

Abstract

One of Indonesia's treasures is herbal medicine. Jamu comes from Sanskrit, namely from the word djamoe which stands for djampi and oesodo. Djampi means healing with medicinal herbs or prayers and mantra while oesodo means health, so it is concluded that medicinal herbs are beneficial for health. Jamu is an ancestral heritage of the Indonesian Nation that has been passed down from generation to generation has high advantages because it comes from cultural diversity, local wisdom, and high biodiversity. Empirical evidence shows that herbal medicine can maintain and improve public health. The government, through the Ministry of Health, issued a regulation on the Saintification of Jamu to provide scientific evidence regarding the efficacy and safety of herbal medicine through health service-based research. Scientific herbs approved by the National Herbal Saintification Commission are sourced from research that has been conducted by the Center for Research and Development of Medicinal Plants and Traditional Medicines (B2P2TOOT). Currently there are 12 scientific jamu concoctions, but in the future it will definitely increase. This literature review uses a narrative method of grouping similar research results according to the established journal criteria. Based on the results of the literature review that has been carried out, it can be concluded that 12 scientific jamu concoctions are safe and have health benefits.
The Potential Application of Clitoria ternatea for Cancer Treatment Purnamayanti, Anita; Budipramana, Krisyanti; Gondokesumo, Marisca Evalina
Pharmaceutical Sciences and Research Vol. 9, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The Clitoria ternatea flower, known as bunga telang in Indonesia, is commonly mixed with food and beverages to provide a natural blue colour. Aside from its popular culinary use, it is a traditional medicine in Indonesia for diseases in the eyes, urinary tract and skin, as well as functioning as an anti-toxin. Furthermore, recent advances in science and technology have revealed that the C. ternatea flower contains a high level of polyphenol compounds that possess anticancer activity, including saponins, tannins, steroids, triterpenoids, kaempferol, and quercetin. This review aims to identify and analyse recent articles regarding the phytochemical activities of C. ternatea flower extract as an anticancer agent. The literature on main databases from 2011 to 2021 was searched systematically using the keywords “Anticancer activity of Clitorea ternatea” and “Phytochemical activities of Clitorea ternatea flower extract against cancer cells”. The various extracts of C. ternatea flower display a moderate cytotoxic, IC50 = 21 µg/mL - 200 µg/mL, for many cancer cell lines, such as MCF-7, MDA-MB-231, CaoV-3, HEp-G2 in aquadest extract and the DLA cell line in petroleum ether extract. The bioactive compounds responsible for the anticancer effect include ternatins, delphinidin, kaempferol, quercetin, sitosterol, and tocopherols. In addition, there have been no reports of any toxic effect on normal cells (Hs27) and oral consumption in mice. According to many studies, the extract is active on multi-molecular targets, with the most conclusive effect on polymerase enzymes, whose inhibition can be an important therapeutic strategy to treat hyperproliferation in cell cancer. Therefore, the findings suggest a potential application of C. ternatea for cancer treatment.
Anticancer Effectivity of Nanocrystals Derived from Mangosteen (Garcinia mangostana) Peel Extract on Leukemia HL-60 Cells Gondokesumo, Marisca Evalina; Novilla, Arina; Prahastuti, Sijani; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Zahiroh, Fadhilah Haifa; Hadiprasetyo, Dhanar Septyawan; Surakusumah, Wahyu
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.228-237

Abstract

Leukemia, characterized by abnormal leukocyte proliferation, ranks ninth in Indonesia as the most common cancer. While treatments such as chemotherapy and radiation effectively target cancer cells, they also risk damaging healthy blood cells. This has spurred interest in exploring low-toxicity herbal compounds as potential therapies, with mangosteen peel emerging as a widely researched option. Nanotechnology, which has the potential to enhance the bioavailability of herbal compounds, is also a focus of extensive research. This study objective was to assess the impact of Mangosteen Peel Nanocrystal (MPN) on HL-60 leukemia cells by analyzing various parameters, including cytotoxicity, reactive oxygen species (ROS) levels, senescence, and gene expression changes. MPN was prepared with high-speed milling and characterized using particle size analyzers, microscopy, and stability assessments. HL-60 cells were cultured and subjected to MPN treatment. Cytotoxicity was evaluated using WST-8 assays, ROS levels were assessed using flow cytometry, and senescence analyses using Senescence-Associated b-Galactosidase Staining. AKT and FLT-1 gene expression were determined via qRT-PCR. MPN has been successfully characterized as a nanoparticle based on size, stability, and morphology. MPN has an impact on leukemia cells by increasing cytotoxicity, decreasing ROS levels, inducing senescence, and modulating AKT and FLT-1 gene expressions. The findings suggest potential implications for MPN in targeting leukemia cells. The study sheds light on the promising effects of MPN in leukemia cell models, indicating its potential applications in targeting cancer cells, inducing senescence, decreasing ROS levels, and modulating gene expressions related to cell survival and proliferation.
The Antiaging Potential of Serum Formulations from Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA on Injured Human Fibroblast Cells Girsang, Ermi; Wargasetia, Teresa Liliana; Rahmat, Deni; Gondokesumo, Marisca Evalina; Harjanti, Mathelda Weni; Widowati, Wahyu; Zahiroh, Fadhilah Haifa; Saufa, Zahra Qisthi; Takasenserang, Oktaviana; Hadiprasetyo, Dhanar Septyawan
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.623-631

Abstract

External aging factors such as UV exposure, pollution, and lifestyle choices contribute to skin aging, resulting in deep wrinkles, fine lines, and rough skin, which can lower self-confidence. Plant extracts have been widely studied for their antiaging potential, while Salmon DNA has shown promise in stimulating collagen production. This study explores the formulation of a serum combining Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA for its antiaging effects on injured human fibroblast cells. The serum was formulated using extracts from C. asiatica, C. longa, A. vera, R. centifolia, and Salmon DNA. Antioxidant activity was evaluated with the DPPH method, cytotoxicity using the WST-8 assay, and gene expression through qRT-PCR for COL1A1, TGF-β1, HYAL-1, and FGF-2. The serum exhibited weak antioxidant activity (IC50 = 373.33 µg/ml) and reduced cell viability at high concentrations. Gene expression analysis revealed increased expression of COL1A1, TGF-β1, and FGF-2, along with reduced HYAL-1 expression in injured BJ cells. The formulated serum shows potential as an antiaging agent, promoting collagen production and reducing hyaluronidase activity.
EDUKASI DAN PEMERIKSAAN KULIT: UPAYA MENINGKATKAN KESADARAN MASYARAKAT TENTANG PERAWATAN KULIT Widowati, Wahyu; Wargasetia, Teresa Liliana; Elisabeth, Mariska; Haryanti, Mathelda Weni; Rahmat, Deni; Girsang, Ermi; Gondokesumo, Marisca Evalina; Nindya, Faradhina Salfa; Triharsiwi, Dwi Nur
Jurnal Abdimas Ilmiah Citra Bakti Vol. 6 No. 1 (2025)
Publisher : STKIP Citra Bakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38048/jailcb.v6i1.4471

Abstract

Penuaan kulit merupakan proses alami yang tidak dapat dihindari oleh setiap individu. Proses penuaan ini dapat dipengaruhi secara intrinsik maupun ekstrinsik. Faktor penuaan ekstrinsik yang berlebih dapat memberikan pengaruh signifikan pada kesehatan kulit. Di saat bersamaan, sejumlah masyarakat belum mengetahui pentingnya menjaga kualitas kulit. Maka dari itu, bersama dengan Universitas Kristen Maranatha, diselenggarakan penyuluhan untuk meningkatkan kesadaran penjagaan kualitas kulit hingga memperoleh kulit yang optimal. Kegiatan ini juga dilengkapi dengan pemeriksaan kulit menggunakan Skin Analyzer, serta pemberian skincare berbasis ekstrak bahan alam. Penyuluhan disampaikan dengan metode ceramah yang dilengkapi dengan presentasi visual. Kegiatan yang dilaksanakan dievaluasi melalui pengisian formulir evaluasi oleh seluruh peserta. Kegiatan penyuluhan ini dihadiri oleh 129 orang dengan mayoritas peserta berasal dari kelompok usia dewasa. Hasil formulir evaluasi penyuluhan menunjukkan bahwa mayoritas peserta (>50%) menilai bahwa sistematika penyuluhan, isi penyuluhan, organisasi, dan media yang digunakan selama kegiatan tergolong sangat baik. Hasil formulir evaluasi produk menunjukkan lebih dari 60% peserta yang mengikuti pemeriksaan kulit dapat menilai bahwa tekstur, kemasan, kandungan, kualitas, informasi produk, aroma, dan warna dari produk perawatan kulit berada dalam kategori sangat baik. Hasil formulir penilaian menunjukkan tujuan dari penyuluhan telah tercapai, yaitu kemampuan dalam pemahaman terkait karakteristik produk perawatan kulitdan memperoleh respons baik dari peserta. Setelah penelitian ini diharapkan masyarakat dapat lebih selektif dalam menggunakan produk perawatan kulit.
Implementation of process technology and diversification of Astiri Oil products to improve community economy Gondokesumo, Marisca Evalina; Azminah, Azminah; Ardiansyahmiraja, Bobby; Suryaningsih, Dwie Retna
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol. 10 No. 1 (2025): February 2025
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v10i1.14830

Abstract

Jatijejer Village, located between the slopes of Mount Penanggungan and Mount Welirang, has significant potential for cultivating aromatic plants, particularly lemongrass (Cymbopogon citratus) and citronella (Cymbopogon nardus). These plants are sources of essential oils with various benefits, including uses in aromatherapy, antibacterial, and anti-inflammatory applications, and are widely utilized in the cosmetics and healthcare industries. Despite this potential, the community of Jatijejer Village previously only utilized lemongrass as raw material, yielding suboptimal economic value and welfare improvement. This community service program aims to enhance the welfare of Jatijejer Village through the production and diversification of essential oil-based products. Activities included training in steam distillation techniques, quality measurement of essential oils, and the development of derivative products such as inhalers and diffusers. Evaluation results showed a significant improvement in participants' knowledge and skills. The average pre-test score of 58.4 percent increased to 97.2 percent in the post-test. Additionally, the essential oils produced were successfully developed into value-added products, such as inhalers and diffusers, which have begun to be marketed locally. Solid waste from the distillation process was also utilized as organic fertilizer, reinforcing the program's sustainability. This training effectively improved the skills, income, and economic independence of the Jatijejer Village community.
Literature Review: Analisis Manajemen Logistik Obat di Instalasi Farmasi Dinas Kesehatan Kabupaten/Kota Sutejo, Erwin; Setiadi, Adji Prayitno; Wibowo, Yosi Irawati; Gondokesumo, Marisca Evalina
MAHESA : Malahayati Health Student Journal Vol 5, No 4 (2025): Volume 5 Nomor 4 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i4.16917

Abstract

ABSTRACT Drug logistics management is a series of activities related to planning, storing, distributing, and disposing of drugs that are managed optimally to ensure the right amount and type of drugs and medical supplies. This study analyzes drug logistics management at the District/City Health Service Pharmacy Installation. Ten articles were retrieved through Google Scholar to conduct a literature review using drug logistics, pharmaceutical installation, and health service. The search results show that the implementation of logistics management is directly related to several problems, including human resources, facilities and infrastructure, planning, storage, distribution, recording, and reporting of drugs. All health services, especially pharmacy, must meet the requirements of drug logistics management. From the literature review results, if implemented properly, drug logistics management at the district/city health service pharmacy installation can increase the efficiency and productivity of services in health facilities Keywords: Disease Drug Logistics, Pharmacy Installation, Health Service ABSTRAK Manajemen logistik obat adalah rangkaian kegiatan yang berkaitan dengan perencanaan, penyimpanan, pendistribusian, dan penghapusan obat yang dikelola secara optimal untuk memastikan jumlah dan jenis obat dan perbekalan kesehatan yang tepat. Studi ini menganalisis pengelolaan manajemen logistik obat di Instalasi Farmasi Dinas Kesehatan Kabupaten/Kota. Untuk melakukan peninjauan literatur, sepuluh artikel diambil melalui Google Scholar dengan  kata kunci logistik obat, instalasi farmasi, dan dinas kesehatan. Hasil penelusuran menunjukkan bahwa penerapan manajemen logistik terkait langsung dengan beberapa masalah, termasuk sumber daya manusia, sarana dan prasarana, perencanaan, penyimpanan, pendistribusian, pencatatan, dan pelaporan obat. Semua layanan kesehatan, terutama kefarmasian, harus memenuhi persyaratan manajemen logistik obat. Dari hasil literatur review dapat diambil kesimpulan yaitu manajemen logistik obat di instalasi farmasi dinas kesehatan kabupaten/kota dapat meningkatkan efisiensi dan produktivitas pelayanan di fasilitas kesehatan jika diterapkan dengan baik. Kata Kunci: Logistik Obat, Instalasi Farmasi, Dinas Kesehatan
Penggunaan DAPT (Dual Antiplatelet) Pada CVA (Cerebrovascular Accident) Trombosis atau Stroke Iskemik dengan Riwayat PJK (Penyakit Jantung Koroner) Putri, Rizky Ayu Artama; Badriah, Rani Nur; Anggraeni, Reta; Pratama, Jainuri Erik; Setiadi, Antonius Adji Prayitno; Herawati, Fauna; Gondokesumo, Marisca Evalina
MAHESA : Malahayati Health Student Journal Vol 4, No 12 (2024): Volume 4 Nomor 12 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i12.16289

Abstract

ABSTRACT Ischemic stroke is the sudden development of focal neurological deficit due to inadequate blood supply to an area of the brain, which can be thrombotic or embolic. CAD (Coronary Artery Disease) is pathological process characterized by the formation of atherosclerotic plaque followed by rupture, ulceration, or erosion. CAD can take the form of CCS (Chronic Coronary Syndrome). The 2018 AHA/ASA Guidline Antiplatelet Therapy used for ischemic stroke is Aspirin at a dose of 160mg-300mg 1x1. In the 2019 ESC Guidline, CCS patient therapy uses DAPT (Dual antiplatelet). In a 2021 AHA meta-analysis compared with aspirin alone, short-term DAPT within 24 hours after mild-moderate ischemic stroke reduced the risk of recurrent stroke at the expense of a higher risk of major bleeding. Here we present a case of a 76 year old female patient with ischemic stroke and CCS who used DAPT. Complaints of sluggishness, weakness in the left half of the body, acute dysarthria onset on the first day, when waking up. Hemiplegia S 1 week ago onset of waking up and being treated at Mataram Regional Hospital. The patient received the antiplatelet Aspirin 160mg 1x1 a day then switched DAPT (Aspirin 80mg 1x1 and Clopidogrel 75mg 1x1) due to a history of CCS. Keywords: CVA Thrombosis, Ischemic stroke, Aspilet, Clopidogrel, Coronary Artery Disease  ABSTRAK Stroke iskemik adalah perkembangan fokal yang tiba-tiba terjadi defisit neurologis akibat suplai oksigen tidak memadai ke suatu area pada otak, dapat bersifat trombotik atau emboli. PJK (Penyakit Jantung Koroner) atau CAD (Coronary Artery Disease) adalah proses patologis ditandai dengan terbentuknya plak aterosklerotik diikuti dengan pecah, ulserasi, atau erosi. PJK dapat berupa penyakit CCS (Chronic Coronary Syndrome). Terapi Antiplatelet Guidline AHA/ASA 2018 yang digunakan pada stroke iskemik adalah Aspirin dosis 160mg-300mg 1x1. Pada Guidline ESC 2019 terapi pasien CCS digunakan DAPT (Dual antiplatelet). Pada meta analisis AHA 2021 dibandingkan dengan aspirin saja, DAPT jangka pendek dalam waktu 24 jam setelah stroke iskemik ringan-sedang mengurangi risiko stroke berulang dengan mengorbankan risiko perdarahan besar yang lebih tinggi. Berikut kami presentasikan sebuah kasus pasien Perempuan 76 tahun dengan Stroke Iskemik dan CCS yang menggunakan DAPT. Keluhann pelo, kelemahan separuh badan kiri, acute disartria onset hari pertama, saat bangun tidur. Hemiplegia S 1 minggu lalu onset bangun tidur di rawat di RSUD Mataram. Pasien menerima antiplatelet Aspirin 160mg 1x1 sehari lalu switch DAPT (Aspirin 80mg 1x1 dan Clopidogrel 75mg 1x1) karena Riwayat CCS.  Kata Kunci: CVA trombosis, Ischemic stroke, Aspilet, Clopidogrel, Penyakit Jantung Koroner.
Co-Authors Abdul Aziz Anggraeni, Reta Anita Purnamayanti Ardiansyahmiraja, Bobby Auliyana, Iftitah Putri Azminah Azminah Azminah Badriah, Rani Nur Budipramana, Krisyanti Elisabeth, Mariska Faisal Akhmal Muslikh Girsang, Ermi Hadiprasetyo, Dhanar Septyawan Hanna Sari Widya Kusuma, Hanna Sari Widya Harjanti, Mathelda Weni Haryanti, Mathelda Weni Herawati, Fauna Ma'arif, Burhan Mariana Wahjudi, Mariana Muthmainnah, Anis Syabani Nindya, Faradhina Salfa Novilla, Arina Pratama, Jainuri Erik Putri, Rizky Ayu Artama RAHMAT, DENI Retno Wilujeng Susilowati, Retno Wilujeng Saksono, Astrella Amanda Putri Saufa, Zahra Qisthi Setiadi, Adji Prayitno Setiadi, Antonius Adji Prayitno Sijani Prahastuti Simanjuntak, Inana Ratu Soripada Suryaningsih, Dwie Retna Suryaningsih, Retna Sutejo, Erwin Takasenserang, Oktaviana Teresa Liliana Wargasetia Triharsiwi, Dwi Nur Wahyu Surakusumah WAHYU WIDOWATI Wibowo, Yosi Irawati Zahiroh, Fadhilah Haifa