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Potensi Kurma Sebagai Sumber Nutrasetikal dan Pangan Fungsional Gondokesumo, Marisca Evalina; Susilowati, Retno Wilujeng
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Dates are cultivate as a staple food in many countries, especially in the Arabian Peninsula, North Africa, and the Middle East. Dates fruits and date seeds as their by-products have nutritional and health values. It is an abundant source of carbohydrates, dietary fiber, and protein. They are high-source minerals and B complex vitamins, such as thiamine (B1), riboflavin (B2), niacin (B3), pantothenate (B5), pyridoxine (B6), and folate (B9). Based on literature studies, the fruit and seeds of dates are also rich in phytochemicals, such as phenolics, anthocyanins, carotenoids, tocopherols, tocotrienols, and phytosterols. However, date fruits and seeds have not been fully utilized as functional food ingredients with numerous potential to be developed into foods that promote health benefits. Several studies have reported the health benefits of dates in in-vitro and in-vivo conditions. Further research will provide valuable information for the potential utilization of date fruit and seeds as nutritional and functional food ingredients. This review article provides comprehensive information on the bioactive compounds and nutraceutical properties of date fruits and seeds, as well as their potential for use as functional food ingredients.

Kajian Literatur : Harapan Pasien Terhadap Layanan Konseling di Apotek Auliyana, Iftitah Putri; Setiadi, Antonius Adji Prayitno; Wibowo, Yosi Irawati; Gondokesumo, Marisca Evalina
MAHESA : Malahayati Health Student Journal Vol 5, No 6 (2025): Volume 5 Nomor 6 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i6.18098

ABSTRACT Drug Counseling is an interactive process between pharmacists and patients/families to increase knowledge, understanding, awareness and compliance so that changes in behavior in drug use occur and resolve problems faced by the patients. This literature review aims to look at the expectations that affect patient or consumer involvement in counseling at the pharmacy. The articles in this literature review use one database, namely Pubmed. Search results using the keyword combination (community pharmacy) AND (counseling OR communication OR patient counseling factors OR patient participation) AND (patient expectations) yielded 408 articles that met the inclusion criteria in this study are 13 articles. The results of the literature review show that the expectations that affects the patient or consumer involvement in counseling at the pharmacy are providing good information with appropriate communication skills, the layout of the pharmacy and the relationship between the pharmacist or pharmacist staff and the patient being good, friendly and polite. Keywords: Community Pharmacy, Counseling, Patient Counseling, Patient Expectations, Patient Participation. ABSTRACT Konseling Obat merupakan proses interaktif antara apoteker dengan pasien/keluarga untuk meningkatkan pengetahuan, pemahaman, kesadaran dan kepatuhan sehingga terjadi perubahan perilaku dalam penggunaan obat dan menyelesaikan masalah yang dihadapi pasien. Kajian literatur ini bertujuan untuk melihat harapan yang mempengaruhi keterlibatan pasien atau konsumen dalam konseling di Apotek. Artikel pada kajian literatur ini menggunakan satu database yaitu Pubmed. Hasil pencarian dengan kombinasi kata kunci (community pharmacy) AND (counseling OR communication OR patient counseling factors OR patient participation) AND (patient expectations) menghasilkan 408 artikel yang memenuhi kriteria inklusi dalam kajian ini yaitu sebanyak 13 artikel. Hasil kajian literatur menunjukkan bahwa harapan yang mempengaruhi keterlibatan pasien atau konsumen dalam konseling di Apotek yaitu pemberian informasi yang baik dengan keterampilan komunikasi yang tepat, tata letak apotek dan hubungan apoteker atau staf apoteker dengan pasien baik, ramah dan sopan. Kata Kunci: Farmasi Komunitas, Konseling, Konseling Pasien, Harapan Pasien, Partisipasi Pasien

Upaya Peningkatan Pengetahuan Lansia Tentang Penggunaan Produk Obat Herbal di Kecamatan Kalirungkut, Surabaya, Jawa Timur Gondokesumo, Marisca Evalina; Purnamayanti, Anita
Journal Community Service Consortium Vol 2 No 1 (2021): Journal Community Service Consortium
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/consortium.v2i1.3290

Indonesia merupakan negara yang memiliki banyak sumber daya tanaman yang dapat digunakan sebgai sumber bahan obat. Penggunaan obat herbal di Indonesia telah mencapai tahap industri sehingga banyak ditemukan produk obat herbal beredar di masyarakat. Namun. literasi masyarakat mengenai produk obat herbal ini masih tergolong rendah. Oleh karena itu, diperlukan upaya untuk meningkatkan literasi masyarakat akan penggunaan produk obat herbal. Pengabdian pada masyarakat ini bertujuan untuk meningkatkan level pengetahuan dan sikap lansia mengenai penggunaan obat herbal. Pengabdian dilakukan di 3 Posyandu Lansia (POSLA) di daerah Kecamatan Kalirungkut, Surabaya, Jawa Timur. Penyampaian materi juga dibantu dengan inforgrafis dalam bentuk kalender meja. Pelatihan dilakukan melelui tiga tahap yaitu, 1) tahap sosilalisai; 2) tahap pelaksanaan; dan 3) tahap monitoring dan evaluasi. Peningkatan pengetahuan lansia diukur menggunakan metode one group post-test and pre-test. Hasil pengabdian menunjukkan bahwa terdapat peningkatan yang signifikan (wilcoxon test, P>0.05) pada semua aspek penilaian meliputi aspek legal produk herbal, tanggal kadaluarsa dan tanggal pembuatan kroduk herbal, enggolongan dan pelabelan produk obat herbal tradisional, serta nteraksi obat tradisional dengan obat sintetis atau makanan/minuman pasca diberikan pernyuluhan Penyuluhan yang dilakukan juga efektif dalam merubah perilaku masyarakat terkait penggunaan produk obat herbal.

STRATEGY FOR IMPROVING LEMONGRASS AGRICULTURE BASED ON SMART FARMING IN JATIJEJER VILLAGE Gondokesumo, Marisca Evalina; Azminah; Ardiansyahmiraja, Bobby; Suryaningsih, Retna
Jurnal Pemberdayaan Masyarakat Madani (JPMM) Vol. 9 No. 1 (2025): Jurnal Pemberdayaan Masyarakat Madani (JPMM) (DOAJ & SINTA 4 Indexed) 
Publisher : Fakultas Ekonomi dan Bisnis Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JPMM.009.1.01

Lemongrass (Cymbopogon citratus) and citronella (Cymbopogon nardus L.) are flagship crops cultivated by farmers in Jatijejer Village. Lemongrass is commonly used as a culinary spice, while citronella is widely utilized for producing essential oil rich in citronellal, geraniol, and citronellol. The essential oil from citronella has high economic value due to its applications in the cosmetics and health industries. This community service activity aims to enhance local farmers' understanding and skills in proper lemongrass cultivation and the potential processing of essential oils as value-added products. The program focuses on strategies to optimize agricultural potential using proper cultivation techniques with organic farming systems based on smart farming technology. Farmers were educated on the stages of lemongrass cultivation, including land preparation, planting, crop maintenance, fertilization, pest and disease control, as well as harvesting and post-harvest handling. Participants were given pre-tests and post-tests to assess their understanding. The test results showed a significant improvement in participants' comprehension of proper lemongrass cultivation using smart farming methods, as well as the benefits and processing of essential oils. This activity successfully raised awareness of the importance of innovation in the agricultural sector and laid the foundation for the development of local businesses based on natural resources.

Impaired Liver Function in the Use of Clozapine as an Antipsychotic Aziz, Abdul; Herawati, Fauna; Pratama, Jainuri Erik; Gondokesumo, Marisca Evalina
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.20811

Clozapine is an atypical antipsychotic used to treat psychosis, mainly as a second choice for patients with refractory schizophrenia and recommended to manage schizophrenia that does not respond to other therapies. Clozapine is also often associated with elevated transaminase levels without clinical symptoms. In this case, a 45-year-old man, who had been diagnosed with schizophrenia since October 2020, was undergoing treatment with various antipsychotic drugs, including clozapine. About a week before hospitalization, there was a change in the patient's behavior. Due to this condition, the patient was brought to the outpatient psychiatric clinic at Airlangga University Hospital Surabaya, the patient was given clozapine 25 mg therapy at night, but the symptoms experienced were getting worse. The patient was finally taken for hospitalization at Dr. Soetomo Hospital Surabaya. While undergoing treatment at the hospital, the patient was given clozapine 10 mg therapy in the morning and at night, in addition, Olanzapine 10 mg was given intramuscularly if needed. However, on the third day after starting treatment, the patient began complaining of low-grade fever (37.8°C), nausea, and fatigue. Laboratory tests showed an increase in liver enzyme levels. However, several cases of severe liver toxicity due to clozapine use have been reported, and there are no specific guidelines for physicians to prevent or treat this condition. Close monitoring of liver function test (LFT) results is crucial in clozapine therapy, especially in considering the decision to stop treatment early if necessary.

Impaired Liver Function in the Use of Clozapine as an Antipsychotic Aziz, Abdul; Herawati, Fauna; Pratama, Jainuri Erik; Gondokesumo, Marisca Evalina
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.20811

Clozapine is an atypical antipsychotic used to treat psychosis, mainly as a second choice for patients with refractory schizophrenia and recommended to manage schizophrenia that does not respond to other therapies. Clozapine is also often associated with elevated transaminase levels without clinical symptoms. In this case, a 45-year-old man, who had been diagnosed with schizophrenia since October 2020, was undergoing treatment with various antipsychotic drugs, including clozapine. About a week before hospitalization, there was a change in the patient's behavior. Due to this condition, the patient was brought to the outpatient psychiatric clinic at Airlangga University Hospital Surabaya, the patient was given clozapine 25 mg therapy at night, but the symptoms experienced were getting worse. The patient was finally taken for hospitalization at Dr. Soetomo Hospital Surabaya. While undergoing treatment at the hospital, the patient was given clozapine 10 mg therapy in the morning and at night, in addition, Olanzapine 10 mg was given intramuscularly if needed. However, on the third day after starting treatment, the patient began complaining of low-grade fever (37.8°C), nausea, and fatigue. Laboratory tests showed an increase in liver enzyme levels. However, several cases of severe liver toxicity due to clozapine use have been reported, and there are no specific guidelines for physicians to prevent or treat this condition. Close monitoring of liver function test (LFT) results is crucial in clozapine therapy, especially in considering the decision to stop treatment early if necessary.

In Vitro α-Glucosidase Enzyme Inhibition Activity Test of Water Extract From Sintok (Cinnamomum sintoc Blume) Bark Saksono, Astrella Amanda Putri; Simanjuntak, Inana Ratu Soripada; Wahjudi, Mariana; Gondokesumo, Marisca Evalina
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Diabetes mellitus is a condition characterized by elevated blood glucose levels beyond the normal limits. One therapeutic approach for managing diabetes mellitus involves inhibiting the α-glucosidase enzyme, which plays a role in glucose absorption in the body. However, the use of oral antidiabetic drugs from the α-glucosidase inhibitor class often causes gastrointestinal side effects. Therefore, exploring natural materials as alternative treatments is a promising option. In Indonesia, one plant with potential as an alternative treatment is sintok (Cinnamomum sintoc Blume), a member of the Cinnamomum genus, which is widely utilized in traditional medicine for chronic diseases such as diabetes mellitus. This study aimed to evaluate the α-glucosidase inhibitory activity of a water extract of sintok bark. Preliminary tests were conducted to determine the optimal conditions for measuring α-glucosidase enzyme inhibition activity in vitro using a UV- vis spectrophotometer. The results showed optimal enzyme activity at a wavelength of 405 nm, an incubation time of 40 minutes, and a substrate concentration of 12.5 mM. The water extract of sintok bark exhibited the highest inhibitory activity at a concentration of 5 ppm, with an inhibition value of 28.66%, while acarbose, used as a positive control, achieved the highest inhibition value of 96.36% at a concentration of 4.5 ppm. In conclusion, the aqueous extract of sintok bark demonstrates inhibitory activity against the α-glucosidase enzyme, indicating its potential as a natural antidiabetic agent.

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