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All Journal Biospecies Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE CHEMPUBLISH JOURNAL Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Harapan Ibu (JPHI) Khazanah Intelektual MEDIC MEdical Dedication Yayasan Cita Cendikiawan Al Khwarizmi Jurnal Abdimas Kartika Wijayakusuma Indonesian Journal of Chemical Studies (Indones. J. Chem. Stud.) Mafaza : Jurnal Pengabdian Masyarakat Sciences of Pharmacy Riset Informasi Kesehatan Jurnal Pengabdian Harapan Ibu (JPHI) Jurnal Abdimas Kesehatan
Santi Perawati, Santi
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Exploratory Study of Digoxin Safety Based on Pharmacokinetic Approach and Drug Interactions in Patients with Congestive Heart Failure Sadli, Nurul Kamilah; Perawati, Santi; Neldi, Vina; Astuti, Novia Tri; Pondawinata, Marizki; Humaira, Syaza Putri
Sciences of Pharmacy Volume 5 Issue 3 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502636

Abstract

Digoxin has a narrow therapeutic index, requiring close monitoring to prevent toxicity, particularly in patients with heart failure, polypharmacy, and impaired renal function. Due to limitations in therapeutic drug monitoring (TDM), we estimated digoxin serum levels using pharmacokinetic formulas based on creatinine clearance. This retrospective observational study aimed to conduct an initial risk screening by estimating digoxin concentrations, evaluating drug interactions, and assessing heart rate in 17 heart failure patients at a regional general hospital in Jambi (January–August 2025). Descriptive analysis revealed that 76% of patients were within the therapeutic range, while 24% exceeded it, with elevated levels correlating with higher creatinine serum and lower creatinine clearance. Common drug interactions involved furosemide, bisoprolol, and proton pump inhibitors, with spironolactone posing a severe risk. Clinically, bisoprolol combined with hypokalemia appeared associated with lower heart rates in patients with predicted toxic concentrations. While the formula-based pharmacokinetic approach serves as a useful exploratory initial screening tool, these findings require further validation through laboratory-based TDM and larger studies.
Aktivitas Antibakteri Ekstrak Etanol Daun Sembung Rambat (Mikania micrantha Kunth): Aktivitas Antibakteri Ekstrak Etanol Daun Sembung Rambat (Mikania micrantha Kunth) Perawati, Santi; Andriani, Lili; Pratiwi, Putri
Chempublish Journal Vol. 3 No. 2 (2018): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (155.375 KB) | DOI: 10.22437/chp.v3i2.5554

Abstract

ABSTRAK Daun sembung rambat secara tradisional digunakan sebagai obat luka.Oleh karena itu diduga tumbuhan tersebut berpotensi sebagai antibakteri. Tujuan penelitian ini adalah untuk mengetahui potensi daun sembung rambat sebagai antibakteri Staphylococcus aureus. Serbuk daun sembung rambat dimaserasi dengan etanol 70%, dilanjutkan dengan uji fitokimia. Kemudian dilakukan uji aktivitas antibakteri menggunakan metode cakram terhadap bakteri Staphylococcus aureus variasi konsentrasi 5%, 15%, dan 25%. Dari hasil maserasi didapatkan rendemen sebesar 9,37%. Uji fitokimia positif mengandung alkaloid, flavonoid, polifenol, saponin, dan steroid. Uji aktivitas antibakteri Staphylococcus aureus memiliki kategori daya hambat kuat pada semua konsentrasi. Ekstrak daun Sembung Rambat memiliki aktivitas antibakteri yang kuat terhadap bakteri Staphylococcus aureus. Kata Kunci: Mikania micrantha Kunth; uji fitokimia; antibakteri; Staphylococcus aureus
Aktivitas koagulan ekstrak dan fraksi daun Sembung Rambat (Mikania micrantha Kunth.) Perawati, Santi; Andriani, Lili; Pratama, Septa; Humayroh, Humayroh
Chempublish Journal Vol. 4 No. 1 (2019): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.712 KB) | DOI: 10.22437/chp.v4i1.6909

Abstract

ABSTRAK Sembung Rambat (Mikania micrantha Kunth) merupakan tumbuhan yang tumbuh merambat mengandung zat aktif dalam bentuk metabolit sekunder seperti alkaloid, saponin, flavonoid, steroid, tanin, terpenoid dan kaya akan senyawa fenolik. Penelitian ini dilakukan untuk mengetahui kemampuan ekstrak dan fraksi dari daun sembung rambat sebagai koagulan. Ekstraksi daun segar sembung rambat menggunakan metode maserasi dengan pelarut etanol 96% , ekstrak etanol difraksinasi menggunakan metode ekstrak cair-cair dengan pelarut n-heksan, etil asetat dan n-butanol. Aktivitas koagulan diukur dengan cara melihat waktu terbentuk benang fibrin dan waktu henti darah pada hewan uji Mencit Putih Galur (Deutschland, Denkenand and Yoken). Ekstrak dengan dosis 60mg/20g BB mencit menunjukkan hasil aktivitas koagulan yang terbaik dibandingkan dengan variasi dosis lain dengan waktu terbentuk benang fibrin (77 detik) dan waktu henti darah (86 detik). Pada fraksi etil asetat memiliki aktivitas koagulan terbaik dibandingkan dengan ekstrak dan fraksi lain dengan waktu terbentuk benang fibrin (64 detik) dan waktu henti darah (86 detik). Ekstrak dan fraksi daun sembung rambat pada dosis 60mg/20g BB mencit memiliki aktivitas koagulan yang baik. Kata kunci: Koagulan, Sembung Rambat (Mikania micrantha Kunth.) ABSTRACT Sembung Rambat (Mikania micrantha Kunth.) Is a climbing plant containing alkaloids, saponins, flavonoids, steroids, tannins, terpenoids and rich in phenolic compounds. This aim was to determine the ability of extracts and fractions of sembung rambat leaves as coagulant. Extraction of fresh leaves of used maceration method with ethanol 96% as a solvent, ethanol extract fractionated used liquid-liquid extract method with n-hexane, ethyl acetate and n-butanol. Coagulant activity was measured by looking at the time of formation of fibrin yarn and the time of blood stops in theanimals test of White Mice (Deutschland, Denkenand and Yoken). Extracts with a dose of 60 mg / 20 g BB mice showed the best results of coagulant activity compared to other dose variations with the time of formation of fibrin yarn 77 seconds and blood stop time 86 seconds. The ethyl acetate fraction has the best coagulant activity compared to extracts and other fractions with fibrin yarn formed time 64 seconds and blood stop time 86 seconds. In conclusion, the extracts and fractions of sembung rambat have coagulant activity. Key words: Coagulant, Mikania micrantha Kunth
Co-Authors 'Aliyah, Siti Hamidatul Aguspairi Andani, Hasma ani astuti, ani Ara Ofiana Ardila, Eti Arfiah, Besek armini hadriyati, armini Aryani, Silvi Febri Astridawati, Indah Atmaja, Anggito Surya Barmi Hartesi Desi Sagita Diah Merdekawati, Diah Efendi, M. Rifki Elisma Elisma Eryunita, Putri ETI KURNIAWATI Fitria Fitria Fitrianingsih Fitrianingsih Hasanah, Rifdatul Humaira, Syaza Putri Humayroh, Humayroh Lia Anggresani Lili Andriani Luri Mekeama M. Henityo Agung As'adi M. Rifqi Efendi Maharini, Indri Maimum Medina, Fhatia Muhaimin Muhaimin Nadia Putri Naurasyifa, Hairania Neldi, Vina Novia Tri Astuti Nurfadilah Nurfadilah Pondawinata, Marizki Puspa Dwi Pratiwi Putri Mariska, Ruri Putri Pratiwi Rahmadevi Rahman, Havizur Ramadani, Arum Kinasih Randa, Muhammad Risnawati, Ida Rizky Yulion Ruri Putri Mariska Sadli, Nurul Kamilah Sani K, Fathnur Siregar, M Ridho Afandy Siti Hamidatul 'Aliyah Sutrisno , Deny Swinche, Ulfa Deni Tahta Kirana, Sahla Tri Astuti, Novia Uce Lestari Wijanarko, Ardi WULANDARI, APRILIA Yuliana Yuliana Yuliana Yuliana Yuliandani, Yuliandani Yuliawati Yuni Andriani Zaitun Zaitun ‘Aliyah, Siti Hamidatul