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Preparation and Characterization of Red Dragon Fruit (Hylocereus polyrhizus) Starch as Solid Medicinal Additive Alfiona, Melisa Nia; Intan Martha Cahyani; Sari, Wulan Kartika
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.11873

Starch is often used as a filler, crusher, and binder in solid preparations. One source of starch can be found in red dragon fruit stems. When making starch, browning often occurs which causes the flour to become brownish, which can reduce public acceptance. Efforts are made to prevent browning in the starch making process by using sodium bisulfite solution. This study aims to determine the effect of different sodium bisulfite soaking times on the characteristics of red dragon fruit stem starch (Hylocereus polyrhizus) to be used as a solid preparation additive and to determine the length of sodium bisulfite soaking time that can produce red dragon fruit stem starch (Hylocereus polyrhizus) characteristics that meet the standards of solid preparation additives. The results of the analysis showed significant differences in yield, moisture content, flow velocity, angle of repose, pH, solubility, expandability, compressibility index, bulk density, tap density, true density, and Hausner index. FTIR analysis showed that red dragon fruit stem starch contains starch functional groups. Based on the results of the red dragon fruit stem characterization test, the best treatment was obtained, namely 1 hour soaking, producing starch with physical characteristics suitable for solid preparation additives.

Teh Celup Daun Salam dan Sereh Wangi Sebagai Penunjang Primary Health Care Penyakit Diabetes Mellitus di Desa Kertosari Kabupaten Kendal Sari, Wulan Kartika; Herlyanti, Kyky; Nugraheni, Bekti; Sulistyowati, Etty; Prahasiwi, Masitoh Suryaning
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 7, No 4 (2024): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar

Diabetes merupakan salah satu penyebab kematian terbanyak ketiga setelah penyakit kanker dan kardiovakular pada penduduk dengan rentang usia 30-70 tahun. Beberapa penduduk di Desa Kertosari Kabupaten Kendal menderita Diabetes Melitus (DM) bahkan dengan beberapa komplikasi. Dari insidensi DM yang sangat tinggi dan bahaya komplikasi yang ditimbulkan, dibutuhkan penunjang dalam Primary Health Care (PHC) salah satunya dengan memanfaatkan ketersediaan tanaman obat keluarga (TOGA) dalam apotek hidup sebagai bahan baku utama pada manajemen pencegahan dan penanganan penyakit DM. Tanaman yang dapat dimanfaatkan untuk menunjang dalam pencegahan dan penanganan DM yaitu daun salam dan sereh wangi. Daun salam dan sereh wangi merupakan tanaman yang memiliki manfaat tidak hanya bagi kesehatan, namun juga memiliki nilai ekonomi. Tanaman ini dapat diolah menjadi berbagai obat herbal hingga bahan baku produk perawatan kulit. Daun Salam dan sereh wangi dapat tumbuh baik di daerah tropis, seperti halnya di Desa Kertosari Kabupaten Kendal. Daun salam dan sereh wangi diketahui memiliki banyak khasiat, salah satunya untuk Diabetes Melitus. Kegiatan ini bertujuan meningkatkan wawasan dan pengetahuan masyarakat mengenai daun salam dan sereh wangi serta manfaatnya, serta dan meningkatkan pengetahuan masyarakat mengenai pengolahan dan berbagai produk olahan berbasis daun salam dan sereh wangi. Metode pelaksanaan kegiatan dilakukan secara langsung melalui sosialisasi dengan cara presentasi dan pemutaran video pembuatan teh celup daun salam dan sereh wangi. Masyarakat menunjukkan antusiasme atas materi pembuatan yang disampaikan dan akan mengaplikasikan dalam lingkungan masyarakat

THE IN VITRO AND IN VIVO EFFECTS OF Persea Americana ETHANOL EXTRACT AS AN ANTIHYPERTENSIVE AND ANTIOXIDANT IN PREDNISONE-INDUCED RATS Elisa, Novi; Dian Advistasari, Yustisia; Sari, Wulan Kartika; Pratiwi, Mustika Endah; Tobi, Claudius Hendraman Boli; Murti, Bayu Tri; Putri, Athika Darumas
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.6583

Hypertension impacts the quantity of free radicals within the body. This study aimed to investigate the effect of antihypertension based on free radical levels in the predni-sone-induced rats, focusing on evaluating specific anti-hypertensive fraction of avoca-do leaves. The study's methods conducting GC-MS, anti-hypertensive, and assessing malondialdehyde levels and catalase enzyme. Systolic blood pressure measurements indicated that the positive control (131 ± 3 mmHg) and ethyl acetate fraction (136 ± 4 mmHg) were statistically similar, significantly different from the negative control group. Diastolic blood pressure measurements showed a blood pressure decreasing in posi-tive control (105 ± 7) that similar statistically with ethyl acetate fraction (104 ± 6), and significantly difference with negative control group. Malondialdehyde levels were nota-bly elevated in both the positive control (37.79 ± 5.47) and ethyl acetate fraction (38.01 ± 5.47) compared to the negative control (-9.07 ± 10.10), indicating increased free rad-ical. Catalase activity demonstrated significant differences, with the positive control (44.06 ± 5.44) and ethyl acetate fraction (44.05 ± 5.45) showing similar levels, both substantially higher than the negative control (13.90 ± 21.50). In summary, this study indentificates several flavonoid compounds that promising anti-hypertension effect from ethyl acetate fraction of avocado leaves extract.

Optimization of Liquid Paraffin as an Emollient and Propylene Glycol as a Humectant in the Formulation of Body Lotion containing Alpha-Arbutin Pradipta, Singgih Ardi; Ariani, Lilies Wahyu; Sari, Wulan Kartika
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.17766

Dry skin due to sun exposure can be prevented by using moisturizer. Moisturizer can be found in body lotion preparations in the form of emollients such as liquid paraffin and humectants such as propylene glycol. The purpose of this study was to determine the effect and optimum concentration of liquid paraffin and propylene glycol on the physical characteristics and moisturizing power of body lotion and to determine the antioxidant activity and physical stability of the optimum formula of alpha-arbutin body lotion. The comparison of liquid paraffin and propylene glycol concentrations was determined based on the design expert 10.0.1 simplex lattice design method. The formula for the comparison of liquid paraffin and propylene glycol is FI (8.5:10.5); FII (10:9); III (10:9); FIV (5.5:13.5); FV (7:12); FVI (4:15); FVII (4:15); FVIII (7:12). The test parameters used in determining the optimum formula are pH, viscosity, adhesion, spreadability and moisture. The results of the test using the T-test. Based on the results of the study, the optimum formula was obtained at a concentration of 10% liquid paraffin and 9% propylene glycol. The conclusion of this study is that liquid paraffin or propylene glycol increases pH, viscosity, spreadability, adhesion and moisture content while the combination of the two materials increases spreadability, adhesion, moisture content and decreases pH and viscosity. The results were validated by the T-test showing that all parameter results were not significantly different. The optimum antioxidant formula test produced an IC50 value of 159.09 ppm which is included in very weak antioxidants and after going through a cycling test, an increase in pH value, adhesion, spreadability and decreased viscosity were obtained but were still stable in color, odor and homogeneity.

Optimization of Liquid Paraffin as an Emollient and Propylene Glycol as a Humectant in the Formulation of Body Lotion containing Alpha-Arbutin Pradipta, Singgih Ardi; Ariani, Lilies Wahyu; Sari, Wulan Kartika
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.17766

Dry skin due to sun exposure can be prevented by using moisturizer. Moisturizer can be found in body lotion preparations in the form of emollients such as liquid paraffin and humectants such as propylene glycol. The purpose of this study was to determine the effect and optimum concentration of liquid paraffin and propylene glycol on the physical characteristics and moisturizing power of body lotion and to determine the antioxidant activity and physical stability of the optimum formula of alpha-arbutin body lotion. The comparison of liquid paraffin and propylene glycol concentrations was determined based on the design expert 10.0.1 simplex lattice design method. The formula for the comparison of liquid paraffin and propylene glycol is FI (8.5:10.5); FII (10:9); III (10:9); FIV (5.5:13.5); FV (7:12); FVI (4:15); FVII (4:15); FVIII (7:12). The test parameters used in determining the optimum formula are pH, viscosity, adhesion, spreadability and moisture. The results of the test using the T-test. Based on the results of the study, the optimum formula was obtained at a concentration of 10% liquid paraffin and 9% propylene glycol. The conclusion of this study is that liquid paraffin or propylene glycol increases pH, viscosity, spreadability, adhesion and moisture content while the combination of the two materials increases spreadability, adhesion, moisture content and decreases pH and viscosity. The results were validated by the T-test showing that all parameter results were not significantly different. The optimum antioxidant formula test produced an IC50 value of 159.09 ppm which is included in very weak antioxidants and after going through a cycling test, an increase in pH value, adhesion, spreadability and decreased viscosity were obtained but were still stable in color, odor and homogeneity.

UJI AKTIVITAS GEL EKSTRAK ETANOL BUAH OKRA (Abelmoschus esculentus) TERHADAP PENYEMBUHAN LUKA BAKAR DERAJAT II KULIT PUNGGUNG KELINCI JANTAN GALUR NEW ZEALAND Abdurrahman, Arrum Fadlillah; Puspitaningrum, Ika; Sari, Wulan Kartika
CENDEKIA EKSAKTA Vol. 6 No. 1 (2021)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v6i1.4407

Luka bakar (burn) merupakan cedera akibat paparan dengan sumber panas seperti listrik, zat kimia, atau radiasi. Tanaman yang terdapat senyawa fitokimia dengan aktivitasnya dalam penyembuhan luka bakar salah satunya adalah buah okra (Abelmoschus esculentus). Tujuan dari penelitian ini untuk mengetahui aktivitas penyembuhan luka bakar derajat II, dan konsentrasi efektif gel ekstrak etanol buah okra pada kulit punggung kelinci jantan galur New Zealand. Penelitian menggunakan 6 ekor kelinci jantan galur New Zealand, berumur 4 sampai 5 bulan dan berat badannya 2 sampai 3 kg. Masing-masing kelinci diberikan 5 kelompok perlakuan. Kelompok perlakuan F1, F2 dan F3 diolesi gel ekstrak etanol buah okra 5%, 10%, dan 20%, kelompok F4 diolesi basis gel karbopol 940 dan kelompok F5 diolesi gel BioplacentonÂ®. Setiap hari diamati secara makroskopis hingga diameter luka tertutup sempurna (d=0). Pengujian statistika menunjukkan adanya perbedaan signifikan antara K(-) dengan ketiga konsentrasi gel ekstrak etanol buah okra dalam pengujian pH, daya lekat, daya sebar dan viskositas, disimpulkan bahwa konsentrasi ekstrak etanol buah okra berpengaruh terhadap karakteristik gel. Gambaran makroskopis setelah pemberian gel ekstrak etanol buah okra F2 dan F3 menunjukkan adanya perbedaan tidak signifikan dibandingkan dengan K(+), menunjukkan bahwa konsentrasi 10% dan 20% merupakan konsentrasi efektif penyembuhan luka bakar. Kata kunci: buah okra (Abelmoschus esculentus), diameter luka, gel, luka bakar

EVALUASI KERASIONALAN INDIKATOR PERESEPAN WHO DI APOTEK KOTA SEMARANG TAHUN 2022 Ningrum, Erna Prasetya; Advistasari, Yustisia Dian; Sari, Wulan Kartika
CENDEKIA EKSAKTA Vol. 7 No. 2 (2022)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v7i2.7552

Resep adalah permintaan tertulis dari seorang dokter, dokter gigi dan dokter hewan kepada apoteker, baik dalam bentuk tulisan tangan ataupun cetakan komputer yang tujuannya adalah untuk menyediakan dan menyerahkan obat kepada pasien. Penggunaan obat rasional terdiri dari 3 indikator utama, salah satunya indicator peresepan menurut WHO, 1993. Parameter indicator tersebut diantaranya rata-rata jumlah item obat per lembar resep, persentase peresepan obat dengan nama generik, persentase peresepan antibiotik, persentase peresepan sediaan injeksi, persentase peresepan obat yang sesuai dengan DOEN. Tujuan penelitian untuk mengetahui kerasionalan peresepan obat berdasarkan indikator WHO di kota Semarang. Objek penelitian, yang digunakan adalah lembar resep di 3 apotek Kota Semarang selama bulan April-Juli 2022. Sample yang digunakan adalah semua resep yang ada di 3 Apotek Kota Semarang pada periode April-Juni 2022 yang memenuhi kriteria inklusi. Kriteria inklusi penelitian adala resep yang masuk di 3 Apotek Kota Semarang dan tidak berupa resep racik. Pengambilan data dilakukan secara retrospektif dan teknik sampling yang digunakan dalam penelitian adalah pengambilan sampel secara purposive sampling. Hasil peneltian didapat rata-rata jumlah iten resep per lembar resep 3.38, % obat dengan nama generik 81,80%, % peresepan antibiotika 42,25%.Kata Kunci : Indikator peresepan, antibiotik, generik, injeksiÂ

COST EFFECTIVENESS ANALYSIS NEUROPROTEKTIF CITICOLIN INJEKSI TUNGGAL DAN KOMBINASI PADA PASIEN STROKE ISKEMIK DI RUMAH SAKIT BHAKTI WIRA TAMTAMA SEMARANG Ardianti, Djulia Shiendy Soes; Palupi, Dwi Hadi Setya; Sari, Wulan Kartika
VISIKES Vol. 24 No. 1 (2025): VISIKES
Publisher : Dian Nuswantoro Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60074/visikes.v24i1.12485

Neuroprotective drugs are used to reduce the occurrence of cell damage due to obstruction of blood flow that supplies oxygen to the brain, thus limiting the tissue that experiences ischemia. However, the relatively high cost of treatment in ischemic stroke patients requires a cost-effectiveness analysis. The purpose of this study was to determine the characteristics of ischemic stroke patient treatment and the cost-effectiveness between the use of the neuroprotective drug citicoline and the combination of citicolin-piracetam injections at Bhakti Wira Tamtama Hospital Semarang. This study is a descriptive study with retrospective data collection techniques and purposive sampling. The effectiveness of neuroprotective drugs used in ischemic stroke patients was assessed from the average length of stay or LOS. The average LOS in the study was 3.17 days for a single citicolin injection and 3.7 days for a combination of citicolin-piracetam injections. Cost-Effectiveness Analysis was obtained by calculating the Average Cost Effectiveness Ratio (ACER) value of the average direct medical costs of using a single citicolin and a combination of citicolin-piracetam injections. Based on the ACER calculations, the most cost-effective neuroprotective drug is the combination of citicoline-piracetam injections with an ACER value of 1,651,786/day.

Histopathological study of renal hypertension with avocado leaf extract and fractional in male wistar rats Novi, elisa; Advistasari, Yustisia Dian; Lepangkari, Jaka Sepriantor; Sari, Wulan Kartika
Riset Informasi Kesehatan Vol 13 No 1 (2024): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v13i1.823

Background: The first of the cardiovascular diseases that may turn deadly is hypertension, which has elevated blood pressure. The causes of hypertension, which causes an average rise of 140/90 mmHg, are based on epidemiological factors such as stroke, heart failure, myocardial infarction, arterial fibrillation, and peripheral artery disease. Hypertension is also known as the silent killer. Objective: Known histopathology in kidney cells and avocado leaf compounds that could potentially inhibit hypertension. Methods: Methods that can be used in histopathological testing with hematoxylin and eosin (HE) dying and compound determination by analysis Gas Chromatography-Spectrometry Mass (GC-MS) Results: The study obtained GC-MS (Gas Chromatography-Spectrometry Mass) analysis results at an area of 36.50%, molecular weight 17,03 with 9-Octadecenoic acid compounds, and an area of 10,18%, molécular weight 2,54 with a compound of 9-Oktadecenosic acid (z)-methyl esters (CAS). An extract of 250 mg/kgBW has a slightly low renal cell damage value (138), and an effective avocado leaf fraction test is ethanol acetate 250 mg/kgBW, with a small renal cell damage value (146), where as a negative control has a high renal cell damage value (189).

Pengembangan Permen Jelly Dari Tanaman Herbal Untuk Meningkatkan Imunitas Pada AnakMEN JELLY DARI TANAMAN HERBAL UNTUK MENINGKATKAN IMUNITAS PADA ANAK Syukur, Mighfar; Sari, Wulan Kartika; Prasetyawan, Nanda Daffa
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 8, No 3 (2025): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v8i3.8894

Indonesia merupakan negara yang memiliki iklim tropis serta memiliki siklus musim kemarau, pancaroba, dan musim hujan. Pada saat musim pancaroba terjadi perubahan cuaca yang cukup ekstrem, Kondisi tubuh yang kurang baik dan stamina yang turun dalam menghadapi perubahan cuaca secara drastis menjadi anak lebih mudah terserang penyakit. Anak merupakan kelompok yang rentan terkena dampak perubahan musim. Apabila daya tahan tubuh dari anak turun maka dapat mengalami kesulitan belajar, mudah lelah, mengantuk, pusing, daya konsentrasinya hilang, dan kurang semangat dalam belajar. Keanekaragaman tanaman herbal dapat dimanfaatkan untuk meningkatkan imunitas antara lain daun kelor, rimpang temulawak, dan bunga telang. Tanaman herbal tersebut dapat diformulasikan menjadi permen jelly sehingga dapat diterima oleh anak-anak. Pengabdian ini dilakukan dengan edukasi tentang tanaman herbal dan pemanfaatannya untuk meningkatkan sistem imun serta pelatihan pembuatan permen jelly yang dilaksanakan kepada siswa SD Muhammadiyah Pucanggading. Kegiatan dilakukan secara interaktif dengan melibatkan siswa dalam praktek pembuatan permen jelly dan memberikan kesempatan siswa untuk mengikuti post test sebagai bentuk evaluasi dan bertanya secara langsung. Hasil yang didapatkan dari kegiatan tersebut adalah siswa mendapatkan pengetahuan tentang tanaman herbal dan pemanfaatannya untuk meningkatkan sistem imun, serta pengalaman dan keterampilan membuat permen jelly yang mudah diaplikasikan dengan bahan yang mudah diperoleh

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