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All Journal Health Science Journal of Indonesia Jurnal Kebijakan Kesehatan Indonesia Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kesehatan Andalas Berkala Kedokteran MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Penelitian Kesehatan Suara Forikes Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Pada Masyarakat Jurnal Kesehatan Komunitas BIOEDUSCIENCE Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Window of Health : Jurnal Kesehatan Media Keperawatan Indonesia IKRA-ITH ABDIMAS Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education INTEGRITAS : Jurnal Pengabdian Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Journal of Applied Data Sciences SEGARA : Jurnal Pengabdian Kepada Masyarakat Journal of Research in Pharmacy and Pharmaceutical Sciences Jurnal Kedokteran Meditek The Health Researchers Journal Journal of Religion and Public Health Medicosphere
Makkiyah, Feda Anisah
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Journal : The Indonesian Biomedical Journal

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Effect of the High-Intensity Interval Training on BDNF Level in Ischemic Stroke Rat Model on the Recovery of Motor Function Yani, Sri; Harris, Salim; Jusuf, Ahmad Aulia; Goenarjo, Roman; Makkiyah, Feda Anisah; Sabita, Rifqi; Ibrahim, Nurhadi
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2911

Abstract

BACKGROUND: Stroke is one of the major causes of disability in the world. High-intensity interval training (HIIT) is known as a novel treatment to promote stroke recovery. However, the results differ in their effects on irisin, which is a regulator of brain-delivered neurotrophic factor (BDNF). Therefore, this study was conducted to investigate the effect of HIIT on BDNF and irisin levels in a rat model of ischemic stroke with middle cerebral artery occlusion (MCAO) induction on recovery motor function.METHODS: Rats were categorized into 4 groups: sham, MCAO, MCAO+moderate-intensity interval training (MIIT), and MCAO+HIIT. MCAO induction was performed to create the ischemic stroke rats model. The motor function was assessed through rotarod and footprint tests. Blood samples were obtained 6 days before MCAO and 14 days after MCAO to examine BDNF and irisin levels with enzyme-linked immunosorbent assay (ELISA). Brain tissue samples were collected 14 days after MCAO for histopathological examination of cortical tissue with hematoxylin-eosin (HE) staining.RESULTS: Rats in the MCAO+HIIT group exhibited an enhanced ability to walk on the rotarod (p=0.016). The stride-length hind paw right in the MCAO+HIIT group demonstrated a noteworthy increase in comparison to baseline value (p=0.036), and the stride-length fore paw right showed a significant increase in both the MCAO+HIIT (p=0.036) and MCAO groups (p=0.034). BDNF significantly improved in the MCAO+MIIT (p=0.043) and MCAO+HIIT groups (p=0.018). The irisin level only showed a significant enhancement in the MCAO+HIIT group (p=0.018).CONCLUSION: HIIT increased motor function, while BDNF level increased with HIIT and MIIT intervention. This preclinical research is useful for supporting the recovery of stroke patients by HIIT intervention.KEYWORDS: BDNF, HIIT, MIIT, irisin, ischemic stroke, MCAO
Co-Authors Abd. Rasyid Syamsuri Ahmad Aulia Ahmad Taufik Aisyah, Ammara Alifah Safira Amperatmoko Alya Roza Lisanti Anisah Anisah Antoni, Darius Apriningsih, Apriningsih Apriningsih Arfiyanti Arfiyanti Arfiyanti, Arfiyanti Aritonang, Hosianna Stephany Ayu Devania Dipta Gayatri, Gusti Ayu Magdalena Natalia Situmeang Basuki Supartono Bintang Bayu Aryandi Buana, Gherriandi Raja Budiman, Anisa Novita Dian Pertiwi Dian Pertiwi Digna, Audrey Alvura Erna Harfiani Faustine, Gracella Fitriana Fitriana Goenarjo, Roman Gracella Faustine Heni Pujiastuti Heristyorini, Ayodya Herkan, Muhamad Thariq Imam Prabowo, Imam Juliana, Dian Kamaludin, Fahmi Marlina Dewiastuti Marlina Dewiastuti, Marlina Masiran, Ruziana` Meiskha Bahar Melly Kristanti Muhammad Ferrel Privansyah Cader Cader Muhammad Reihan Arianda Nabila Aulia Ainaya Nafira, Amodya Dahayu Napitupulu, Partogi Natanel, Handro Steve Nugrahana, Raisa Yunika Nurfitri Bustamam Nurhadi Ibrahim Nurrahmah, Rahma Nida Nurrizka, Rahmah Huda Oktafiani, Devi Oktavia, Sabina Pasiak, Taufiq Fredrik Prita Maya Savitri Rachmawati, Alfira Rahayu, Melinda Dwi Rahma Hida Nurrizka Rahmah Hida Nurrizka Rahmah Huda Nurrizka Rizkyta, Bunga Mentari Rosadi, Andrea Salsabila Sabita, Rifqi Safira, Lisa Salim Harris, Salim Sembiring, Rinawati Setyaningsih, Yuni Shelly Nobel Shofiy, Alifya Rayyani Sihotang, Theodora Caroline Subeno, Setia Syahrin, Rosita Alfi Taufik Jamaan Taufiq Fredrik Pasiak Tiwuk Susantiningsih Wahyudi, Dhyani Paramita Widayani Wahyuningtyas Yani, Sri Yuni Setyaningsih Yuri Nurdiantami Zulfa , Fajriati