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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Jurnal Matematika & Sains Journal of Mathematical and Fundamental Sciences INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Pharmacology and Clinical Pharmacy Research JFIOnline Jurnal Ilmu Kefarmasian Indonesia Narra J Pharmaceutical Sciences and Research (PSR) Journal of Scientific Insights Jurnal Kefarmasian Indonesia
Slamet Ibrahim -
Faculty Of Pharmacy, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi 40633, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Isolasi Dan Karakterisasi Asam Asiatat Dari Ekstrak Etanol Herba Pegagan (Centella Asiatica. (L.) Urban) Musfiroh, Ida; Nursyamsiah, Tresna; Sutisna, Entris; Muhtadi, Ahmad; Kartasasmita, Rahmana E; Ibrahim, Slamet
Jurnal Farmasi Indonesia Vol 7, No 4 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (456.476 KB) | DOI: 10.35617/jfi.v7i4.262

Abstract

Asam asiatat merupakan senyawa golongan triterpenoid pentasiklik yang terdapat dalam tanaman pegagan (Centella Asiatica. (L.) Urban). Penelitian ini bertujuan untuk mengisolasi senyawa asam asiatat dari ekstrak etanol herba pegagan. Isolasi dilakukan dengan metode maserasi dan teknik kromatografi, dan karakterisasi dilakukan dengan spektrofotometri UV Vis, IR, MS dan LC/MS-MS. Hasil isolasi berupa serbuk berwarna putih, dan memberikan serapan pada panjang gelombang maksimum (λmax) 206 nm, mempunyai gugus fungsi yang terdiri dari regang â??OH (3433 cm-1), regang C-H alifatik (2929 cm-1), regang C=O (1709,82) dan ulur C-H (1462-1380 cm-1) serta ulur C-O (1242-1147 cm-1). Senyawa mempunyai massa molekul sebesar 489,4982. Isolat adalah asam asiatat yang mempunyai rumus molekul C30H48O5.
HUBUNGAN KUANTITATIF STRUKTUR DAN AKTIFITAS SENYAWA TURUNAN AGLIKON CURCULIGOSIDA A SEBAGAI ANTIKANKER Nursamsiar, Nursamsiar; Ibrahim, Slamet; H.Tjahjono, Daryono
Jurnal Farmasi Indonesia Vol 7, No 2 (2014)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v7i2.171

Abstract

Curculigosida A adalah senyawa bioaktif utama dari congkok (Curculigo orchioides) yang diketahui mempunyai aktivitas biologi. Studi Hubungan Kuantitatif Struktur dan Aktivitas (HKSA) telah dilakukan untuk mengetahui variabel atomik dan molekuler (deskriptor) yang berpengaruh terhadap aktifitas antikanker turunan aglikon curculigosida A. Pemilihan deskriptor dilakukan dengan metoda Hansch, perhitungan deskriptor dilakukan dengan program Molecular Operating Environment (MOE 2009.10), dan pemodelan molekul serta optimasi geometri dilakukan dengan metoda semi empirik AM1 Hyperchem 8.01. Derivat senyawa baru hasil perancangan didoking pada reseptor hER-α untuk melihat afinitasnya. Hasil penelitian menunjukkan bahwa model persamaan HKSA antikanker turunan aglikon curculigosida A yang terbaik dengan program SPSS 19.0 mengikuti persamaan: logIC50 = â?? 4.805(±1.246) + 1.486(±0.593)AM1_LUMO + 0.726(±0.132)logs â?? 4.10-5(±23.10-5)AM1_E + 23.10-5(±5.797.10-6)AM1_Eele + 2.2323(±0.327)mr, dengan AM1_LUMO = energi LUMO; logS = logaritma kelarutan; AM1_E = energi total; AM1_Eele = energi elektronik, dan mr = refraktivitas molar. Modifikasi aglikon curculigosida A berdasarkan analisis farmakofor dan skema topless, menyarankan sejumlah senyawa baru untuk disintesis, dan senyawa 3,5-dihydroxybenzyl-3,5-dihydroxybenzoate (senyawa 3) dan 2,5-dihydroxy-4-nitrobenzyl-2,6-dimethoxy-4-nitro-3-(trifluoromethyl) benzoate (senyawa 25) diprediksi mempunyai aktivitas antikanker lebih baik dibanding aglikon curculigosida A dengan IC50 (teoritis) masing- masing sebesar 0,35 dan 2,45.10â??11µM  
SINTESIS SORBENT EKSTRAKSI FASE PADAT DENGAN TEKNIK MOLECULAR IMPRINTING DENGAN MONOMER AKRILAMID UNTUK EKSTRAKSI GLIBENKLAMID DARI SERUM DARAH Hasanah, Aliya Nur; Kartasasmita, Rahmana Emran; Ibrahim, Slamet
Jurnal Farmasi Indonesia Vol 7, No 4 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.131 KB) | DOI: 10.35617/jfi.v7i4.255

Abstract

Glibenklamid merupakan obat yang digunakan dalam penanganan diabetes melitus dan digunakan dalam jangka waktu yang panjang. Efisiensi pemisahan glibenklamid dibutuhkan untuk monitoring kadar obat dalam darah dalam upaya memastikan efektivitas obat. Penelitian ini dilakukan untuk memperoleh sorben Molecular Imprinted Solid Phase Extraction (MI-SPE) untuk pemisahan glibenklamid dari sampel serum. Penelitian dilakukan dengan tahapan sintesis metode polimerisasi ruah,karakterisasi MI-SPE yang dihasilkan dan aplikasinya pada sampel serum. Sintesis MI-SPE dilakukan menggunakan dua komposisi rasio template:monomer:cross linker dalam kloroform sebagai porogen. Hasil pengujian menunjukkan bahwa adsorpsi MI-SPE dengan rasio 1:6:70 menghasilkan persentase adsorpsi 88,47% pada Molecular Imprinted Polymer (MIP) dan 54,33% terhadap Non Imprinted Polymer (NIP). Aplikasi sorben MIP dalam ekstraksi fase padat dilakukan menggunakan 200 mg polimer pada cartridge 3 mL. Sampel serum yang ditambahkan glibenklamid kemudian dilewatkan ke dalam MIP menghasilkan nilai persen perolehan kembali 89,67;93,75;92,64 dan 82,82% untuk konsentrasi 0,5;2;4 dan 6 mg L-1. Hasil penelitian menunjukkan bahwa MI-SPE yang dibuat dari monomer akrilamid dengan komposisi 1:6:70 dapat digunakan sebagai pretreatment untuk ekstraksi glibenklamid dari serum darah.
Determination of Iodate and Iodide Content in Iodized Salt By Ion Pair High Performance Liquid Chromatography Method Wisnu Cahyadi; Kurnia Firman; Slamet Ibrahim; Embit Kartadarma
Jurnal Teknologi dan Industri Pangan Vol. 15 No. 1 (2004): Jurnal Teknologi dan Industri Pangan
Publisher : Departemen Ilmu dan Teknologi Pangan, IPB Indonesia bekerjasama dengan PATPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3499.518 KB)

Abstract

Two species of iodine, i.e. iodide and iodate in commercial iodized salt were determined using ion pair HPLC. From 15 samples analysed, the iodide and iodate content ranged from 24,05 ± 2,51 to 70,25 ± 3,78 ppm and from 31,43 ± 8,10 to 87,59 ± 0,44 ppm, respectively. The method used was found satisfactory in terms of precission, accuracy, sensitivity and selectivity, therefore the method seem acceptable for the determination of iodide and iodate content in iodized salt samples. Key words : Iodine species, determination of iodine species content, and ion-pair HPLC
SENYAWA ASAM 2- METILESTER-1-H-PIROL-4-KARBOKSILAT DALAM EKSTRAK ETIL ASETAT BUAH SALAK VARIETAS BONGKOK SEBAGAI ANTIOKSIDAN DAN ANTIHYPERURICEMIA [Studies on 2-Methylester-1-H-Pyrolle-4-Carboxylic Acid Compound in Ethylacetate Extract of Snake Fruit Var Leni Herliani Afrianti; Elin Yulinah Sukandar; Slamet Ibrahim; I Ketut Adnyana
Jurnal Teknologi dan Industri Pangan Vol. 21 No. 1 (2010): Jurnal Teknologi dan Industri Pangan
Publisher : Departemen Ilmu dan Teknologi Pangan, IPB Indonesia bekerjasama dengan PATPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.817 KB)

Abstract

The aim of the study was to determine the antioxidant and antihyperuricemia activity of ethyl acetate extract of snake fruit (Salacca edulis Reinw.) var. Bongkok. The research methods used in this study comprised  of three stages. First stage, the isolation processes, consist ed of maceration, fractionation, and purification using several techniques of chromatography. The chemical structures of the isolated compounds were determined based on UV, IR, 1-D NMR, and 2-D NMR spectral data. The ethyl acetate extract of snake fruit var. Bongkok isolated was a new compound 2-methylester-1-H-pyrolle-4- carboxylic acid. In the second stage the antioxidant activity of the extract and the isolated compounds were measured by 1,1 diphenol  (DPPH) method. The antioxidant activity of the extracts and the isolated compounds were expressed as IC50, The ethyl acetate extracts at concentrations of 0.2, 2, 20, 200, 400, and 2000 µg/mL showed inhibition of 9.67, 4.47, 41.89, 96.06, 82.54, and 90.60 % respectively, with an IC50 of 1.6 µg/mL. Ascorbic acid standards at the same concentration range showed an  IC50 of 0.54 µg/mL. Meanwhile, at the same concentrations the 2-methylester-1-H-pyrolle-4-carboxylic acid showed free radical inhibition of 17.48, 21.48, 18.14, 31.87, and 62.34 % respectively, with an  IC50 of 3.27  µg/mL. During the third stage,  the antihyperuricemic properties of the extracts and the isolated compound were examinated in vitro using inhibition of xanthin oxidase method. The ethyl acetate extracts at concentrations of 0.01, 0.02, 0.2, 2, and 2000  µg/mL showed xanthin oxidase inhibition of 49.24, 49.58, 50.28 and 52.26 % respectively, with an  IC50 of 24.75 µg/mL. At the same concentrations, the 2-methylester-1-H-pyrolle-4- carboxylic acid, showed xanthin oxidase inhibition of 27.7, 30.5, 37.3, 50.27 and 50.55 % respectively, with an IC50 of 48.86 µg/mL.  Allopurinol as a standard drug showed an IC50 of 0.92 µg/mL.
AKTIVITAS ANTIHIPERURIKEMIA EKSTRAK ETIL ASETAT DAN ETANOL BUAH SALAK VARIETAS BONGKOK (Salacca edulis Reinw.) PADA TIKUS GALUR WISTAR [Antihyperuricemic Activity of Ethyl Acetate and Ethanol Extracts of Snake Fruit var. Bongkok (Salacca edulis Reinw.) o Leni Herliani Afrianti; Elin Yulinah Sukandar; I Ketut Adnyana; Slamet Ibrahim -
Jurnal Teknologi dan Industri Pangan Vol. 22 No. 1 (2011): Jurnal Teknologi dan Industri Pangan
Publisher : Departemen Ilmu dan Teknologi Pangan, IPB Indonesia bekerjasama dengan PATPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.961 KB)

Abstract

The aims of the study was to determine antihyperuricemic activity of ethyl acetate and ethanol extractsof snake fruit (Salacca edulis Reinw.) var. Bongkok on Wistar male rats. Wistar male rats administered with 100 and 200 mg/kg b.w ethyl acetat extract and 200 mg/kg b.w ethanol extract and simulationsly induced with potassium oxonate peritoneally and uric acid orally showed descreased uric acid serum level significantly as compared to control group at 6th and 7thhour (p < 0.05). Meanwhile ethanol extract at 100 mg/kg bw did not affect uric acid serum level significantly. Determination of uric acid level in urine of the rats, indicated that administration ofethanol extract at 200 mg/kg bw, orprobenecid as a standard at 45 mg/kg bw, increased excretion of urine uric acid level significantly as compared to control group at 7thhour (p < 0.05). Additionally, administration of ethyl acetate extract at 100 and 200 mg/kg bw did not show an increase of uric acid excretion in urine. Mechanism of action of the ethyl acetate extract and ethanol extract as an antihyperuricemic agent has been proposed by inhibition of xanthine oxidase activity wich decrease the synthesis of uric acid. Hence, the mechanism of action of antihyperuricemia of the ethanol extract was suggested to be an uricosuric i.e. increases the excretion of urine uric acid and xanthine oxidase inhibitory.
OPTIMALISASI PENANDAAN 99mTc-DTPA-KETOKONAZOL SEBAGAI RADIOFARMAKA UNTUK DETEKSI INFEKSI FUNGI Maula Eka Sriyani; Slamet Ibrahim S2 Ibrahim S; Aang Hanafiah WS
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 14, No 1 (2013): Februari 2013
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/jstni.2013.14.1.681

Abstract

Kemiripan gejala yang timbul akibatpenyakit infeksi, baik oleh bakteri, fungi atau virus pada stadium awal, mengakibatkanpengobatan seringkali tidak tepat. Diagnosis yang tepat sasaran dapat menjadikan pengobatanlebih efektif dan memiliki tingkat kesembuhan yang maksimal. Pada penelitian ini dilakukanpengembangan diagnosis infeksi fungi berbasis drug-targeting relationship antara radiofarmaka99mTc-DTPA-ketokonazol sebagai radioperunut dan fungi yang terdapat di dalam tubuh sebagaitargetnya. Penelitian ini bertujuan untuk mendapatkan sediaan radiofarmasi 99mTc-DTPAketokonazolmenggunakan teknik penandaan tidak langsung dengan ko-ligan atau bifunctionalagent sebagai penghubung antara radionuklida 99mTc dengan ketokonazol. Bifunctional agentyang digunakan dalam penelitian ini yaitu dietilen triamin pentaasetat (DTPA). Dari penelitian inidiperoleh kondisi optimal penandaan 99mTc-DTPA-ketokonazol, yaitu komposisi jumlahketokonazol 2 mg; DTPA 1,125 mg; SnCl2.2H2O 37,5 μg; pH 4,5 dan waktu inkubasi selama 5menit, sehingga diperoleh kemurnian radiokimia sebesar 97,77±0,33 %. Uji uptake in-vivo99mTc-DTPA-ketokonazol dilakukan terhadap Candida albicans yang diinfeksikan ke dalam pahakiri mencit. Hasil percobaan menunjukkan bahwa rasio organ terinfeksi dan tidak terinfeksi(T/NT) setelah 2 jam injeksi sebesar 3,16±0,04 (n=5). Dari hasil yang diperoleh, dapatdisimpulkan bahwa 99mTc-DTPA-ketokonazol berhasil dibuat dan memenuhi syarat sebagairadiofarmaka.
Radioiodination of andrographolide and its biodistribution in mice for inflammatory tracer Jutti Levita; Cahya Nova A.; As’ari Nawawi; Slamet Ibrahim
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (489.965 KB) | DOI: 10.14499/indonesianjpharm0iss0pp258-265

Abstract

Andrographolide,  a  bioactive  component  of  Andrographis  paniculata (Burm.F)  Nees,  is  the  major  lactone  diterpenoidal  bicyclic  constituent  in  this plant  which  has  proven  to  exert  anti-inflammatory  activity  in  vitro  which  was occurred via  several mechanism, e.g inhibition of inducible nitric oxide synthase (iNOS),  inhibition  of  radical  oxygen  species,  and  inhibition  of  NF-kappaB activation. The labeling with radionuclide is often used for therapy, detection and quantification of metabolites in the body. Even though the metabolites are very low  in  concentration  they  can  be  detected  by  the  energy  they  emitted. Radionuclide  can  be  used as  radiotracer  to  detect  whether  drug  really interacts with  its  target.  The  objective  of  this  research  is  to  synthesize 131I-labelled andrographolide  and  to  study  its  biodistribution  in  mice  to  understand  the location  of  its  organ  target.  Indirect  radioiodination  of  andrographolide  wascarried  out  by  using  bromine  as  the  leaving  group  and  followed  by  fast iodination  at  40oC,  yielded  72.6  %  purity  of  the  labeled  compound.  Iodination was occurred through proton substitution at C-12. Then the andrographolide-131I was  injected  into  lateral  vein  of  mice’s  tail  to  study  its  biodistribution.  The compound  was  distributed  in  all organs  with the  highest  accumulation  occurred in  the  stomach  (16.87  %/gram  organ).  The  result  showed  that  inducing  the animals  with  LPS  caused  inflammation  in  the  stomach  and  increased  the production  of  prostaglandin  as  proven  by  the  distribution  of  the  radioligand  in that organ.Key words: andrographolide, radioiodination, anti-inflammatory, biodistribution
FTIR Method for Peptide Content Estimation and Degradation Kinetic Study of Canarium Nut Protein Rozana Oktaviary; Ilma Nugrahani; Slamet Ibrahim Surantaatmadja; Tutus Gusdinar Kartawinata; Cintya Nurul Apsari
Indonesian Journal of Pharmacy Vol 31 No 2, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss2pp78

Abstract

Quantitative analysis of bioactive peptide mostly conducted by measuring the activity. While the determination of peptide content in natural sources has been conducted using various instruments, vibrational spectroscopy remains underutilized. Here, we attempted new developed method in peptide quantification and degradation kinetic analysis using Fourier-Transform Infrared Spectroscopy. Bovine Serum Albumin was used as standard protein in method development and validation. Peptide content was estimated by converting peak area to concentration. The method was used to estimate peptide content in Canarium nut protein and its hydrolysates, which potentially hold biological activity. Kinetic study was conducted with microwave as an accelerator for hydrolysis, an apparatus rarely used in peptide study. Amide I band on wavenumber range of 1724.05-1619.91 cm-1 was selected for analysis, considering its selectivity and linearity. The method also met other validation requirement, including accuracy and precision. When applied in quantitative analysis, the method was able to calculate peptide content decrease in Canarium nut protein after hydrolysis using papain (38.24%), pepsin (33.67%) and alkaline reagent (28.53%). In kinetic study, microwave-assisted peptide degradation exhibited logarithmic profile with the equation of y=-0.148ln(x)+0.9591 and R² value of 0.963. Based on these results, FTIR is useful in estimating peptide content and in analyzing degradation kinetic profile. 
Identification of physical interaction between levodopa–benzerazide hydrochloride Ilma Nugrahani; Sukmadjaja Asyarie; Sundani Noerono Soewandhi; Slamet Ibrahim
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1353.355 KB) | DOI: 10.14499/indonesianjpharm0iss0pp96-104

Abstract

The aim of this research was to investigate the possibility physical interaction occurred between of levodopa and benzerazide hydrochloride, which known as compounds used in combination for the the antiparkinson. The “cold contact methods” was used which was developed from Kofler contact method’s (hot stage methods). Thermograms Differential Scanning Calorimetry and difractograms X-Ray indicated that levodopa – benzerazide hydrochloride tent to form a peritecticum-molecular compound physical interaction with eutectics point at 4:6 and 9:1 molar ratios.Key words: benzerazide hydrochloride, cold contact method, levodopa, physical interaction.
Co-Authors Aang Hanafiah WS Abdul Mutalib Abdul Mutalib Abdul Mutholib Ahmad Muhtadi Aiyi Asnawi Aliya Nur Hasanah Amir Mursadad As&#039;ari Nawawi As'ari Nawawi As'ari Nawawi As’ari Nawawi Batari A. Larasati Bina Lohita Sari Cahya Nova A. Cintya Nurul Apsari Damayanti, Sophi Daryono H. Tjahjono Daryono Hadi Tjahjono Dea Dwi Puspita Eli Halimah Eli Halimah, Eli Elin Yulinah Elin Yulinah Sukandar Embit Kartadarma Enade P. Istyastono Engrid Juni Astuti Engrid Juni Astuti Entris Sutisna, Entris Fauzan Fikri Fikri, Fauzan Gumilar, Anggi H.Tjahjono, Daryono H.Tjahjono, Daryono Hidehiro Uekusa I Ketut Adnyana I Ketut Adnyana Ida Musfiroh, Ida Ika Ratna Hidayati Ilma Nugrahani Ilma Nugrahani Ilma Nugrahani Ilma Nugrahani Iwan J. P. de Esch Jutti Levita Kartasasmita, Rahmana E Kartasasmita, Rahmana E Kurnia Firman Leni Herliani Afrianti Leni Herliani Afrianti Lina Rahmawati Rizkuloh Mardiana Mardiana Mardiana, Mardiana Marlia Singgih Maula Eka Sriyani MEGANTARA, SANDRA Mira Andam Dewi, Mira Andam Muhammad Ali Zulfikar Muhammad Ali Zulfikar Mursadad, Amir Mutakin Mutakin N.S, Sundani Nawawi, Asari Nursalam Hamzah Nursamsiar Nursamsiar Nursyamsiah, Tresna Nursyamsiah, Tresna Nyi M. Saptarini Nyi M. Saptarini Okky Dwichandra Putra Pusparani Krisnamurthi Putri, Adinda Triani Rachmat Mauludin Rahmana Emran Kartasasmita Rahmana Emran Kartasasmita Rozana Oktaviary Saeful Amin Saeful Amin Saeful Amin, Saeful Saptarini, Nyi M. Sophi Damayanti Sophi Damayanti Sophi Damayanti Sophi Damayanti Sophi Damayanti Sri A. Sumiwi Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sumiwi, Sri A. Sundani N.S. Sundani Noerono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Tutus Gusdinar Kartawinata Yogiyanto Yogiyanto