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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Jurnal Matematika & Sains Journal of Mathematical and Fundamental Sciences INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Pharmacology and Clinical Pharmacy Research JFIOnline Jurnal Ilmu Kefarmasian Indonesia Narra J Pharmaceutical Sciences and Research (PSR) Journal of Scientific Insights Jurnal Kefarmasian Indonesia
Slamet Ibrahim -
Faculty Of Pharmacy, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi 40633, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Identifikasi Interaksi Kimia Fisika Pada Kombinasi Antibiotika Amoksisilina Trihidrat - Kalium Klavulanat Dengan Kalorimeter Larutan Dan Rekristalisasi Nugrahani, Ilma; Asyarie, Sukmadjaja; N.S, Sundani; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 4, No. 3
Publisher : UI Scholars Hub

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Abstract

Physico-chemical interaction of amoxicillin trihydrate - potassium clavulanate has been investigated. The method used in this experiment was solution calorimeter analysis that was collaborated by the re-crystallization observation. Amoxicillin-clavulanate were mixed on the variety ratios (0:10; 9:1; ...; 1:9; 0:10) and analyzed by solution calorimeter in the HCl 0,1 N and phosphate buffer pH 6,8 solution as the gastrointestinal liquids. After that, the re-crystallizations of amoxicillin-clavulanate on the variety ratios were analyzed by polarization microscope and digital camera. The results of observation showed that amoxicillin-clavulanate have the physical-chemical interactions in the ratios 3:7; 5:5; 7:3 respectively in both of pH models of gastrointestinal liquids.
Pengamatan Visual Tahap-Tahap Pembentukan Kristal Sistem Eutektikum Asetaminofen-Pseudoefedrin Hidroklorida Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

The aim of this research was to observe the recrystallization process of two component, acetaminophen-pseudoephedrine hydrochloride in ethanol and the thermal profiles. The visual data resulted from polarization microscope observation confirmed with thermograph DSC showed that the crystal habit was represented to the intrinsic character representative by thermodynamic properties of the binary system.The visualization process proved that in different molar ratios, the binary system formed crystals habit with different and step by step showed inhibit, to form polycrystalline until at molar ratio 6:4 formed the fines single crystals mixture which was smaller than before co-recrystallization. Acetaminophen was observed as monoclinic hexagonal crystals while pseudoephedrine hydrochloride was observed monoclinic/orthorombic forms.
Polimorfisasi dan Solvatomorfi Amoksisilina Trihidrat setelah Proses beku Kering Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 2
Publisher : UI Scholars Hub

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Abstract

The polymorphismof amoxicillin has been identified after freeze drying process. The freeze dried amoxicillin have some specific physical properties different from their raw material, that was proved by DSC, XRD, and polarize microscope. Exothermal curve from DSC thermogram changes to endothermal curve, diffractogram XRD changes to different profile, and the crystal shows different habit. All of data showed that freeze drying process improve amoxicillin to different crystal form which has higher melting oxidation point and lower hydrate. The improvement of the crystal structure might be impact to change physical-pharmaceutical properties like dissolution, absorption, and change it antibiotic potency.
A Deep Overview of Anticoagulant Drugs: Recent Synthesis and Their Activity Assay Engrid Juni Astuti; Slamet Ibrahim; Muhammad Ali Zulfikar; Sophi Damayanti
Indonesian Journal of Chemistry Vol 24, No 2 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.87252

Abstract

During the unprecedented COVID-19 pandemic, anticoagulant drugs have emerged as a crucial component of treatment alongside antivirus medications. Patients with severe COVID-19 frequently have critical conditions marked by blood clot development, necessitating the administration of anticoagulants. This review aims to provide a comprehensive overview of various anticoagulant drugs, their synthesis methods, and assays employed to predict their anticoagulant activity. Notable anticoagulant categories frequently utilized include oral anticoagulants heparin, non-vitamin K antagonists, and vitamin K antagonists. In recent years, the development of new anticoagulants has seen a shift towards a multifaceted approach that combines in silico prediction with in vitro and in vivo assays. In silico prediction techniques play a pivotal role in the initial screening process. This integrated approach has yielded promising results, paving the way for the synthesis of novel anticoagulant candidates, as substantiated by a battery of in vitro, in vivo, and ex-vivo tests.
Evaluation of phenolic compounds as cross-linkers to improve the qualities of halal gelatin from milkfish scales (Chanos chanos) Hamzah, Nursalam; Ibrahim, Slamet; Tjahjono, Daryono H.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.907

Abstract

Gelatin is a versatile substance extensively used in medical and pharmaceutical industries for many applications, including capsule shells, X-ray film, infusion for plasma substitute, and the fabricating of artificial tissue. Fish scale gelatin is a profitable alternative source as a halal material despite its inferior quality. An addition of phenolic cross-linker may enhance the qualities of fish scale gelatin. The aim of this study was to determine the ability of phenolics to act as cross-linkers for fish scale gelatin and to identify the factors affecting this process. Gelatin production from fish scales (Chanos chanos) was carried out through basic pre-extraction and acidic pre-extraction. Thereafter, the gelatin was reacted with 10 different phenolics (phenol, pyrocatechol, resorcinol, α-naphthol, vanillin, L-tyrosine, curcumin, gallic acid, quercetin, and tannic acid). The resultant gelatins were characterized by infrared spectrum, X-ray diffraction pattern, swelling index, degree of cross-linking, viscosity, gel strength, mechanical profile, thermal profile, and water vapor permeability. Gelatin with the most favorable characteristics was further investigated for the effects of acidity (pH 4, 7, and 10) and cross-linker concentrations (2.5–10%). The findings revealed the formation of cross-linkage through shifted vibrational peaks of amide A, amide B, and amide II in the infrared spectrum. Shifted X-ray diffraction peaks in the gelatin with phenol addition also indicated the formation of cross-linkage. Significant improvement in the gelatin characteristics, such as swelling index, degree of cross-linking, viscosity, gel strength, mechanical profile, thermal profile, and water vapor permeability, could be attributed to the addition of phenolics cross-linkers. The highest improvement was observed in gelatin added with basic tannic acid 10%. Gelatin cross-linked with basic tannic acid 10% had a moisture content of 9.24±0.14%, swelling index of 323±17%, degree of cross-linking of 69.99±0.84%, viscosity of 8.48±0.23 cP, gel strength of 151.5±6.9 Bloom, melting temperature of 213.5°C, tensile strength of 7.00±0.54 N.cm-2, elongation at the break of 114.08±14.63%, elastic modulus of 58.45±8.20 N.cm-2 and water vapor permeability of 0.57±0.07 g.mm.m-2.h-1. kPa-1. The qualities of tannic acid-cross-linked gelatin films and film-forming gel increased when manufactured under basic conditions in comparison to acidic or neutral conditions. Furthermore, increasing the quantity of tannic acid to 10% improved the overall characteristics as compared to non-cross-linked gelatin. In conclusion, tannic acid has the ability to cross-link the fish gelatin, thereby enhancing its qualities.
Synthesis and Characterization Molecularly Imprinted Polymers for Analysis of Dimethylamylamine Using Acrylamide as Monomer Functional Amin, Saeful; Damayanti, Sophi; Ibrahim, Slamet
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i2.330

Abstract

A selective separation techniques with Molecularly Imprinted Polymer (MIP) for High-Performance Liquid Chromatography (HPLC) has been developed for the assay of Dimethylamylamine (DMAA) doping compounds. Molecular imprinted polymer (MIP) is a technique to produce a polymer having the cavity due to the disposal of the templates, in which the cavity serves to recognize the molecules of the same size, structure, chemical and physical properties. The selectivity and affinity of the templates itself will increase, while the concentration value is increasing. MIP is made by DMAA as template, acrylamide as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross linking, azobisisobutyronitrile (AIBN) as the initiator and chloroform as a porogen solvent; using bulk method. The aim of research are conduct the MIP for the DMAA compound analysis, then the formed MIP is characterized by using Fourier Transform Infra Red (FTIR) and Scanning Electron Microscopy (SEM) to find out the polymer complexes formed and the morphological form of the MIP. The MIP formed then was analyzed by using High-Performance Liquid Chromatography (HPLC) to know the amount of the DMAA, the adsorption capacity, and the adsorption condition found in the MIP. The result of analysis on the content of DMAA in the MIP by using UV-Vis Spectrophotometer is 1.957 mg. Scanning Electron Microscopy (SEM) shows that the MIP has irregular and rough morphological structure; while the NIP has irregular morphology structures and smooth surfaces shape
Toxicity Test of Red Yeast Rice Extract as A Product of Solid Fermentation of Monascus purpureus Lina Rahmawati Rzkuloh; Slamet Ibrahim; Marlia Singgih
Journal of Scientific Insights Vol. 1 No. 2 (2024): August
Publisher : Science Tech Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69930/jsi.v1i2.168

Abstract

Red yeast rice (Known as Angkak in Indonesia) is a product of rice fermentation from Monascus purpureus, a specific type of mold that produces a secondary metabolite, namely monacolin K; found to be effective in reducing cholesterol levels. Subsequently, toxicity is the ability of a substance to induce functional, biochemical, or physiological disturbances leading to pain, and discomfort, as well as interfering with general body conditions. Therefore, this study aims to determine the potential toxic effects, mortality rates, and liver function damage, as indicated by SGPT and SGOT parameters, in rats. Solid fermentation method was used for rice fermentation. Test animals used were 25 white rats, exposed to graded doses: dose 1 (5mg/kg BW rats), dose 2 (50mg/kg BW rats), dose 3, (300mg/kg BW rats), and dose 4 (2000mg/kg BW mice). Observations were carried out for 14 days with a single dose. To determine liver damage, blood was taken through the lateral vein on day 14, the resulting data was processed using statistical analysis. The results showed that Angkak extract containing monacolin K did not exhibit a toxic effect and did not cause death. However, there was an impact on liver damage parameters, as evidenced by elevated SGPT and SGOT levels at doses of 300 mg/kg BW rats and 2000 mg/kg BW rats, exceeding normal levels.
PEGEMBANGAN DAN VALIDASI METODE HEPARIN ATAU ENOKSAPARIN MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI PASANGAN ION Astuti, Engrid Juni; Hidayati, Ika Ratna; Ibrahim, Slamet; Zulfikar, Muhammad Ali
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24659

Abstract

One of the drugs used to treats and prevents COVID-19 thromboembolic problems is heparin or enoxaparin sodium. Heparin and enoxaparin have the side effect of bleeding when used, so monitoring of therapy is necessary. This present study aims to validate an ion pair high-performance liquid chromatography (HPLC) condition to analyse the adsorption of heparin or enoxaparin at molecularly imprinted polymer (MIP) after synthesis. The chromatographic system consists of a C8 column with a Diode Array Detector (DAD). The optimal chromatographic condition was obtained using mobile phase A (300mM NaCl + 10mM tetra n-butyl ammonium hydroxide) and mobile phase B (acetonitrile) under gradient elution, and 100 µl injection volume. The heparin or enox was detected at 231 nm, generating symmetrical peaks and good separation in 4.1 minutes after injection. The method indicated good selectivity with a resolution of 3.49 for heparin and 3.74 for enox. A linear detector response with R2 of 0.9965 and 0.9994 for heparin and enox. The method yields good precision and good accuracy. The proposed method has met the method validation requirements for adsorption heparin or enox analysis before using validation in biological samples.
Penentuan Kadar Selenium dalam Suplemen Kesehatan dengan Metode Spektrofotometri Menggunakan Reagen Kolorimetri 2,3-Diaminonaftalena Gumilar, Anggi; Putri, Adinda Triani; Dewi, Mira Andam; Ibrahim, Slamet
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.24847

Abstract

Health supplements containing selenium are now increasingly used by public . However, so far, a simple analytical method for determining selenium in health supplements are still rare. The latest method for determining selenium is based on  Inductively Coupled Plasma (ICP) spectrometry. The cost of this method is very expensive. This study aims to apply and validate the UV-Vis Spectrophotometry method for determining selenium in health supplements using 2,3 Diaminonaphthalene as  reagent. The study began by testing the specificity of reaction between Selenium with the reagent, that it is showed in specific spectrum with maximum absorbance wavelength at 483 nm. The linearity test using calibration curve, the results obtained were a linear regression equation y = 0.0126x + 0.0736 with the value of r2 = 0.9974 and Vx0 = 0.01%. Limit of detection = 0.00917 mg/mL and limit of quantitation = 0.02777 mg/mL. The accuracy of this method expressed as an average of % Recovery was 97.84% and the precision expressed as % RSD was 0.02%. The final step of this study was the determination of selenium in supplement samples using the standard addition method. The average results obtained based on the determination of selenium levels in supplements were 58.82% (sample A); 111.17% (sample B); and 98.08% (sample C) calculated against the selenium levels listed on the label of each sample, namely 25, 30, and 50 mg Se, with the requirement being in the range of 90 - 110% of the levels listed on the label. Thus, only sample C meets the requirements.
Co-Authors Aang Hanafiah WS Abdul Mutalib Abdul Mutalib Abdul Mutholib Ahmad Muhtadi Aiyi Asnawi Aliya Nur Hasanah Amir Mursadad As'ari Nawawi As'ari Nawawi As'ari Nawawi As’ari Nawawi Batari A. Larasati Bina Lohita Sari Cahya Nova A. Cintya Nurul Apsari Damayanti, Sophi Daryono H. Tjahjono Daryono Hadi Tjahjono Dea Dwi Puspita Eli Halimah Eli Halimah, Eli Elin Yulinah Elin Yulinah Sukandar Embit Kartadarma Enade P. Istyastono Engrid Juni Astuti Engrid Juni Astuti Entris Sutisna, Entris Fauzan Fikri Fikri, Fauzan Gumilar, Anggi H.Tjahjono, Daryono H.Tjahjono, Daryono Hidehiro Uekusa I Ketut Adnyana I Ketut Adnyana Ida Musfiroh, Ida Ika Ratna Hidayati Ilma Nugrahani Ilma Nugrahani Ilma Nugrahani Ilma Nugrahani Iwan J. P. de Esch Jutti Levita Kartasasmita, Rahmana E Kartasasmita, Rahmana E Kurnia Firman Leni Herliani Afrianti Leni Herliani Afrianti Lina Rahmawati Rizkuloh Mardiana Mardiana Mardiana, Mardiana Marlia Singgih Maula Eka Sriyani MEGANTARA, SANDRA Mira Andam Dewi, Mira Andam Muhammad Ali Zulfikar Muhammad Ali Zulfikar Mursadad, Amir Mutakin Mutakin N.S, Sundani Nawawi, Asari Nursalam Hamzah Nursamsiar Nursamsiar Nursyamsiah, Tresna Nursyamsiah, Tresna Nyi M. Saptarini Nyi M. Saptarini Okky Dwichandra Putra Pusparani Krisnamurthi Putri, Adinda Triani Rachmat Mauludin Rahmana Emran Kartasasmita Rahmana Emran Kartasasmita Rozana Oktaviary Saeful Amin Saeful Amin Saeful Amin, Saeful Saptarini, Nyi M. Sophi Damayanti Sophi Damayanti Sophi Damayanti Sophi Damayanti Sophi Damayanti Sri A. Sumiwi Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sumiwi, Sri A. Sundani N.S. Sundani Noerono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Tutus Gusdinar Kartawinata Yogiyanto Yogiyanto