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Formulasi dan Evaluasi Sediaan Cleansing Balm Berbahan Dasar Minyak Jarak (Ricinus communis L.) dan Minyak Kelapa Murni (Cocos nucifera L.) Sukma Wibowo, Sepvia Putri; Zahra, Aliya Azkia; Sholi, Mally Ghinan
Jurnal Integrasi Kesehatan dan Sains Vol 6, No 2 (2024): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v6i2.13717

AbstrakCleansing balm merupakan sediaan berbahan dasar minyak dan lilin, berupa produk pembersih yang digunakan sebagai penghapus makeup dan kotoran di wajah. Tujuan penelitian ini adalah memformulasikan sediaan cleansing balm berbahan dasar minyak jarak dan minyak kelapa murni dengan variasi konsentrasi (10%, 15%, dan 20%) yang memenuhi syarat mutu fisik dan kimia serta memiliki daya pembersihan yang baik sebagai make-up remover. Penelitian ini dilaksanakan di Laboratorium Teknologi Farmasi dan Laboratorium Farmasetika Fakultas Ilmu Kesehatan Universitas Singaperbangsa Karawang. Penelitian ini dilangsungkan pada Desember 2023 hingga Maret 2024. Sediaan cleansing balm dibuat dengan metode peleburan dan pencampuran minyak dengan bahan lainnya. Evaluasi mutu yang dilakukan pada sediaan cleansing balm meliputi uji organoleptik, homogenitas, daya sebar, pH, titik leleh, daya bersih, iritasi, kesukaan, dan uji stabilitas cycling test. Berdasarkan hasil uji organoleptik didapatkan sediaan berwarna putih gading, berbentuk semi padat dan memiliki aroma blueberry. Hasil uji homogenitas menunjukkan sediaan yang homogen pada semua formula. Pada uji daya sebar dan pH menunjukkan hasil yang memenuhi persyaratan. Pada uji titik leleh didapatkan formula blanko 38,66oC, formula 1: 37,66oC; formula 2: 37,33oC; dan formula 3: 36,66oC. Pada uji iritasi dan daya bersih didapatkan sediaan cleansing balm tidak menimbulkan iritasi dan dapat memberikan daya pembersihan yang baik sebagai make-up remover. Setelah dilakukan cycling test pada sediaan, didapatkan cleansing balm yang stabil dan tetap homogen. Simpulan, minyak jarak dan minyak kelapa murni dapat diformulasikan sebagai sediaan cleansing balm memiliki mutu yang baik dan efektif sebagai make-up remover.Formulation and Evaluation of Cleansing Balm based on Castor Oil (Ricinus communis L) and Pure Coconut Oil (Cocos nucifera L)AbstractThe cleansing balm is an oil and wax-based preparation in the form of a cleansing product used as a make-up remover and facial dirt cleanser. This study aims to formulate a cleansing balm preparation based on castor oil and pure coconut oil with variations in concentration (10%, 15%, and 20%) that meet the physical and chemical quality requirements and have good cleansing efficacy as a make-up remover. This research was conducted at the Pharmaceutical Technology Laboratory and Pharmaceutical Laboratory, Faculty of Health Sciences, Singaperbangsa University, Karawang. This research was carried out from December 2023 to March 2024. The cleansing balm preparation is made using the melting and mixing method of oils with other ingredients. The quality evaluation of the cleansing balm preparation includes organoleptic tests, homogeneity, spreadability, pH, melting point, cleansing efficacy, irritation, preference, and stability testing through cycling tests. Based on the organoleptic test results, a pearl white preparation was obtained, semi-solid in form, with a blueberry aroma. Homogeneity test results showed homogeneous preparations in all formulas. Spreadability and pH tests indicated results that met the requirements. The melting point test results were as follows: blank formula 38.66°C, formula 1 37.66°C, formula 2 37.33°C, and formula three 36.66°C. Irritation and cleansing efficacy tests showed that the cleansing balm preparation did not cause irritation and provided good cleansing efficacy as a make-up remover. After cycling tests on the preparation, a stable and homogeneous cleansing balm was obtained. Based on the research results, it was found that castor oil and pure coconut oil can be formulated as a cleansing balm preparation with good quality and effectiveness as a make-up remover.

Formulasi dan Evaluasi Sediaan Cleansing Stick dengan Kombinasi Sodium Cocoyl Isethionate dan Cocamidopropyl Betaine sebagai Surfaktan Anggraini, Shafira Intan; Sholih, Mally Ghinan; Zahra, Aliya Azkia
Jurnal Integrasi Kesehatan dan Sains Vol 6, No 2 (2024): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v6i2.13713

AbstrakKulit wajah adalah salah satu organ tubuh yang terlihat pertama kali ketika timbul permasalahan pada kulit, seperti wajah kusam. Wajah kusam biasanya disebabkan oleh pengaruh radiasi sinar matahari dan polusi udara sehingga diperlukan perawatan kulit, salah satunya menggunakan sabun pembersih wajah. Kulit wajah memiliki pH yang sedikit asam sehingga penggunaan produk yang bersifat basa, salah satunya sabun akan menimbulkan efek negatif pada kulit wajah. Synthetic detergents (syndets) merupakan pembersih bebas sabun yang tidak melibatkan penggunaan basa kuat sehingga pH produk yang dihasilkan mendekati pH kulit. Metode penelitian yang digunakan adalah eskperimental laboratorium dengan memformulasikan sediaan cleansing stick yang dilakukan di Laboratorium Fakultas Ilmu Kesehatan Universitas Singaperbangsa Karawang pada bulan November 2023–Februari 2024. Penelitian ini bertujuan untuk memformulasikan dan mengevaluasi sediaan pembersih wajah menggunakan kombinasi surfaktan sodium cocoyl isethionate dan cocamidopropyl betaine dalam bentuk stick. Hasil evaluasi sediaan memenuhi persyaratan pada uji organoleptis, homogenitas, tinggi busa, dan stabilitas busa. Sediaan cleansing stick yang dihasilkan memiliki nilai pH yang sesuai dengan rentang pH kulit wajah, yaitu 5,16–5,43. Efektivitas daya pembersihan pada semua formulasi sediaan cleansing stick memenuhi persyaratan, dengan F1 memiliki efek pembersihan terbaik (66%). Pengujian keamanan menunjukkan hasil bahwa sediaan cleansing stick tidak menimbulkan reaksi iritasi pada kulit sehingga aman untuk digunakan. Dengan demikian, sediaan cleansing stick dapat menjadi alternatif yang aman dan efektif sebagai perawatan kulit wajah.Formulation and Evaluation of Cleansing Stick With a Combination of Sodium Cocoyl Isethionate and Cocamidopropyl Betaine as SurfactantsAbstractThe facial skin is one of the first visible organs of the body when problems arise on the skin, such as a dull face. The cause of a dull face is usually the influence of sun radiation and air pollution, which necessitates using skin care products, such as facial cleansing soap. The pH of facial skin is slightly acidic, which means using alkaline products, such as soap, will negatively affect facial skin. Synthetic detergents (synsets) are soap-free cleansers that do not contain strong bases, resulting in a pH similar to the skins. This research aims to formulate a facial cleansing product using a combination of sodium cocoyl isethionate and cocamidopropyl betaine surfactants in stick form. The evaluation results met the organoleptic test requirements, including homogeneity, foam height, and foam stability. The pH value of the cleansing stick preparation was found to be within the pH range of facial skin, which is 5.16 to 5.43. The effectiveness of cleaning power in all cleansing stick formulations met the requirements, with F1 having the best cleaning effect (66%). The safety test demonstrated that the cleansing stick did not elicit any irritation reactions on the skin, thereby confirming its safety for use. Hence, the cleansing stick formulation can be a safe and effective alternative for facial skincare.

DEVELOPMENT OF PLASMID-BASED FOR EXTERNAL CONTROL MATERIALS OF CYP2D6*10 (rs1065852) GENE PCR-BASED DETECTION Malau, Jekmal; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Rahmasari, Ratika; Raekiansyah, Muhareva; Rohmah, Siti; Meilani, Nanda Diva; Septi, Annisa Frastica; Zahro, Aurora Fatimatuz; Annajla, Fathina; Hermosaningtyas, Anastasia Aliesa; Hilmi, Indah Laily
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2557

Reliable clinical diagnosis of Single Nucleotide Polymorphisms (SNPs) is necessary for personalizing tamoxifen medication according to CYP2D6*10 genetic variations. Our research aimed to create a recombinant plasmid for external control material with a molecular size of 3812 bp. The recombinant plasmid was achieved by cloning an 838 bp gene insert of CYP2D6*10 rs1065852 into a 2974 bp pJET1.2 plasmid into Escherichia coli DH10B and selection on ampicillin agar medium. Isolated E. coli recombinants provided the plasmid molecules for analysis. Bi-directional sequencing and Real-Time PCR confirmed the presence of wild-type and mutant rs1065852 DNA fragments in the plasmid, namely homozygote CC and TT. The conclusion is that we have successfully introduced a novel recombinant plasmid developed by cloning the SNP rs1065852, which carries the 100C>T mutation, using pJET 1.2/blunt system, which could significantly enhance the accuracy of clinical SNP diagnostics for personalized medicine in breast cancer treatment.

Aktivitas Antibakteri dan Antioksidan dari Senyawa Bioaktif Asal Bakteri Endofit Tanaman Nyatoh (Palaquium amboinense B.) : Antibacterial and Antioxidant Properties of Bioactive Compounds Derived from Endophytic Bacteria Isolated from Nyatoh (Palaquium amboinense B.) Putra, Rayhan Helmyana; Retnowati, Dwi; Cordova, Datu Muhammad; Zahra, Aliya Azkia; Primahana, Gian; Dewi, Rizna Triana; Filailla, Euis; Sukirno; Prastya, Muhammad Eka
Jurnal Sumberdaya Hayati Vol. 10 No. 1 (2024): 2024
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.10.1.25-32

Nyatoh plant (Palaquium amboinense B.) is native to Indonesia which is known to have the ability to produce potential secondary metabolites. The aim of this study was to evaluate the antibacterial and antioxidant activities from bioactive compounds produced by endophytic bacteria from nyatoh leaves. Five endophytic bacteria were tested against 4 targeted bacteria including Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 15442, Bacillus subtilis ATCC 19659, and Staphylococcus aureus ATCC 6538. Bacterial isolate which had the strongest antibacterial activity was then fermented and extracted. The corresponding extract was further tested on disc diffusion method, determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values, antioxidant evaluation, and analyzed for its bioactive compound components via GC-MS analysis. The results showed that one isolate, namely D1 can produce secondary metabolite which act as antibacterial and antioxidant potentials. This corresponding extract has the strongest MIC and MBC against B. subtilis with value of 39.5 and >78.1 µg/ml and exhibited antioxidant activity against 2,2-difenil-1-pikrilhidrazil (DPPH) with inhibition value of 85.37%. Based on GC-MS analysis, secondary metabolites derived from this potential extract contained some major active constituents including Tributyl acetylcitrate and bis (2-ethylhexyl) ester which might act as antibacterial and antioxidant agents.

Review Artikel: Penggunaan Polimer dalam Formulasi Gel Minyak Atsiri Julianti, Nurlia; Zahra, Aliya Azkia
Jurnal Sehat Mandiri Vol 19 No 1 (2024): Jurnal Sehat Mandiri, Volume 19, No.1 Juni 2024
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v19i1.1392

Essential oil gel is a preparation that contains essential oil in gel form. Gelling agent is an important factor that affects the physical properties produced such as colour, shape, odour, spreadability, adhesion and viscosity. The purpose of this review article is to look at the use of various types of polymers as gelling agents in the formulation of essential oil gels and how it can affect the physical properties. The method of writing this article is to use the literature review method, which is research using data collection from literature sources such as articles that are relevant to the topic. The data sources used in this article are 50 articles using national and international journals published in the last 10 years, namely 2014 - 2024. The results obtained show that the physical properties of essential oil gels produced can be influenced by the active substance and the type of polymer used, synthetic polymers with the type of gelling agent carbomer is the most widely used gelling agent based on the amount and carbomer gelling agent can produce good physical properties in essential oil gels. Thus, the conclusion of this review article is that the choice of polymer type as a gelling agent in the formulation of essential oil gel can affect the physical properties produced in essential oil gel. It is suggested that further research can consider well in the development of essential oil gel formulations.

DEVELOPMENT OF PLASMID-BASED FOR EXTERNAL CONTROL MATERIALS OF CYP2D6*10 (rs1065852) GENE PCR-BASED DETECTION Malau, Jekmal; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Rahmasari, Ratika; Raekiansyah, Muhareva; Rohmah, Siti; Meilani, Nanda Diva; Septi, Annisa Frastica; Zahro, Aurora Fatimatuz; Annajla, Fathina; Hermosaningtyas, Anastasia Aliesa; Hilmi, Indah Laily
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2557

Reliable clinical diagnosis of Single Nucleotide Polymorphisms (SNPs) is necessary for personalizing tamoxifen medication according to CYP2D6*10 genetic variations. Our research aimed to create a recombinant plasmid for external control material with a molecular size of 3812 bp. The recombinant plasmid was achieved by cloning an 838 bp gene insert of CYP2D6*10 rs1065852 into a 2974 bp pJET1.2 plasmid into Escherichia coli DH10B and selection on ampicillin agar medium. Isolated E. coli recombinants provided the plasmid molecules for analysis. Bi-directional sequencing and Real-Time PCR confirmed the presence of wild-type and mutant rs1065852 DNA fragments in the plasmid, namely homozygote CC and TT. The conclusion is that we have successfully introduced a novel recombinant plasmid developed by cloning the SNP rs1065852, which carries the 100C>T mutation, using pJET 1.2/blunt system, which could significantly enhance the accuracy of clinical SNP diagnostics for personalized medicine in breast cancer treatment.

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