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All Journal PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) TRANSPUBLIKA INTERNATIONAL RESEARCH IN EXACT SCIENCES (TIRES) Jurnal Pengabdian Masyarakat Bangsa Heca Journal of Applied Sciences Malacca Pharmaceutics Leuser Journal of Environmental Studies Ekonomikalia Journal of Economics Journal of Educational Management and Learning Infolitika Journal of Data Science Grimsa Journal of Science Engineering and Technology Grimsa Journal of Business and Economics Studies
Ghazi Mauer Idroes
Department Of Occupational Health And Safety, Faculty Of Health Sciences, Universitas Abulyatama, Aceh Besar 23372, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Grimsa Journal of Science Engineering and Technology

 1 
Evaluating Extraction Methods for Caffeine Content in Gayo Arabica Coffee Oil through Gas Chromatography-Mass Spectroscopy Khairan, Khairan; Musvira, Intan; Lala, Andi; Diah, Muhammad; Maulana, Aga; Idroes, Ghazi Mauer; Awang, Khalijah
Grimsa Journal of Science Engineering and Technology Vol. 2 No. 1 (2024): April 2024
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v2i1.31

Abstract

This study aims to determine physicochemical properties, and caffeine analysis of green bean coffee essential oil (GBCEO) and roasted bean coffee essential oil (RBCEO) by maceration and soxhlet extraction methods. The results indicated that RBCEO by maceration method have higher percentage of yield compared to GBCEO. By the same to soxhlet extraction method, RBCEO also showed higher percentage of yield compared to GBCEO. The refractive index of the GBCEOm and GBCEOs have a lower acid value compared to RBCEOm and RBCEOs. The specific gravity obtained for GBCEOm, RBCEOm, GBCEOs, and RBCEOs ranged from 0.87 to 0.97. The results showed that GBCEOm has the highest saponification value followed by RBCEOs. GBCEOm has the highest iodine value followed by RBCEOs, while RBCEOm and GBCEOs have a similar iodine value. The peroxide value showed that GBCEOs, and RBCEOs by soxhlet extraction method have higher peroxide value. The GC-MS analysis revealed that GBCEOm has higher caffeine followed by GBCEOs with the percentages area of 9.31% and 7.36% respectively. Meanwhile RBCEOm has lower caffeine followed by RBCEOs with the percentages area of 7.36% and 4.28% respectively. This finding showed that GBCEO shows higher caffeine compound compared with RBCEO.
Geothermal Flora and AgNPs Synergy: A Study on the Efficacy of Lantana camara and Acrostichum aureum-Infused Hand Sanitizers Harera, Cheariva Firsa; Maysarah, Hilda; Kemala, Pati; Idroes, Ghazi Mauer; Maulydia, Nur Balqis; Patwekar, Mohsina; Idroes, Rinaldi
Grimsa Journal of Science Engineering and Technology Vol. 2 No. 2 (2024): October 2024
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v2i2.38

Abstract

Hand hygiene is an important factor that needs to be observed in controlling the spread of diseases transmitted through hand-to-hand contact. Synthesis of silver nanoparticles from tembelekan (Lantana camara) and paku laut (Acrostichum aureum) using the green synthesis method has good antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria. Therefore, a preparation formulation was made, namely hand sanitizer, which is still rarely used. Formulations that have successfully entered the evaluation stage include organoleptic tests, homogeneity tests, spreadability tests, adhesion tests, viscosity tests, pH tests, accelerated stability tests, and irritation tests. Antibacterial activity was evaluated against bacteria Staphylococcus aureus and Escherichia coli. The hand sanitizer is formulated to contain 5% tembelekan AgNPs (F1); paku laut AgNPs 5% (F2); and a combination of 2.5% paku laut AgNPs and 2.5% tembelekan AgNPs. The resulting hand sanitizer has good organoleptic characteristics, except for the color of the preparation, which changed during the accelerated stability test. Test results for pH, adhesion, spreadability, viscosity, and homogeneity of hand sanitizer meet the requirements of a good test. Irritation tests on ten volunteers showed no irritation reaction. Antibacterial tests show that hand sanitizer has bacterial antibacterial activity with an average ± standard deviation of the inhibition zone Staphylococcus aureus is 6.605±0.459(F1); 6.665±0.615(F2); 6.380±0.282(F3) dan Escherichia coli namely 6.575 ± 0.219 (F1); 6.860 ± 0.155 (F2); 6.810 ± 0.056 (F3). Making hand sanitizer AgNPs-based ingredients from plants can be used as hand sanitizer, but stabilizers are required to prevent color changes during storage.
Fine-Tuning ChemBERTa for Predicting Activity of AXL Kinase Inhibitors in Oncogenic Target Modeling Noviandy, Teuku Rizky; Idroes, Ghazi Mauer; Patwekar, Mohsina; Idroes, Rinaldi
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 2 (2025): October 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i2.98

Abstract

The development of selective kinase inhibitors remains a key objective in cancer drug discovery, where predictive computational models can significantly accelerate the identification of leads. In this study, we investigate the fine-tuning strategies of the transformer-based ChemBERTa model for quantitative structure–activity relationship (QSAR) modeling of AXL receptor tyrosine kinase inhibitors, an important therapeutic target implicated in tumor progression and metastasis. A dataset of AXL inhibitors was curated from the ChEMBL database. Three fine-tuning configurations, namely baseline, full fine-tune, and aggressive, were implemented to examine the influence of learning rate, weight decay, and the number of frozen transformer layers on model performance. Models were evaluated using accuracy, precision, recall, F1-score, and calibration metrics. Results showed that both the full fine-tune and aggressive configurations outperformed the baseline model, achieving higher precision and F1-scores while maintaining robust recall. The aggressive configuration achieved the most balanced performance, with improved calibration and the lowest expected calibration error, indicating reliable probabilistic predictions. Overall, this study highlights that controlled fine-tuning of ChemBERTa significantly enhances predictive performance and confidence estimation in QSAR modeling, offering valuable insights for optimizing transformer-based chemical language models in kinase-targeted drug discovery.
Co-Authors Abas, Abdul Hawil Abd Rahman, Sunarti Ahmad, Noor Atinah Akmal Muhni Alfizar Alfizar Ali Bakri Anggi, Tiara Aprianto . Arkadinata, Teguh Asep Rusyana Azhar, Fauzul Bachtiar, Boy Muhclis Bahri, Ridzky Aulia Bako, Winanda Celik, Ismail Delya, Mussa Issack Diah, Muhammad Diana Setya Ningsih, Diana Diana Setya Ningsih, Diana Setya Diki, Diki Eko Suhartono El-Shazly, Mohamed Emran, Talha Bin Erkata Yandri Faisal, Farassa Rani Fajar Fakri Fauziah, Niken Fazli, Qalbin Salim Hafni Zahara Harahap, Saima Putri Harera, Cheariva Firsa Hewindati, Yuni Tri Hizir Sofyan Idroes, Ghalieb Mutig Ifandi, Ilham Imelda, Eva Irvanizam, Irvanizam Irwana, Salman Jainury, Aldi Jauna, Jauna Kemala, Pati Khairan Khairan Khalijah Awang Kihwili, Erick Hironimus Kurniadinur, Kurniadinur Kusumo, Fitranto Lala, Andi Lukman Hakim Maria Paristiowati Marwan Marwan Maulana, Aga Maulydia, Nur Balqis Maysarah, Hilda Medyan Riza Mirda, Erisna Mirja, Mirja Misbullah, Alim Muhammad Adam, Muhammad Muhammad Ichsan Muhammad Ichsan Muhammad Sabri Muhammad Subianto Muhammad Yanis Muhammad Yusuf Mukhlisuddin Ilyas Muliadi Ramli Muslem Muslem, Muslem Musvira, Intan Natasya Natasya Nizamuddin Nizamuddin Nova Yanti Pasyamei Rembune Kala Patwekar, Mohsina Prasetio, Rasi Purnama, M. Risky Putri Raisah Raisah, Putri Raudhatul Jannah Razief Perucha Fauzie Afidh Rinaldi Idroes Rizkia, Tatsa Sasmita, Novi Reandy Shofi, Shofi Siti Maulina Rukmana Souvia Rahimah Suhendra , Rivansyah Suhendra, Rivansyah Suhendrayatna Suhendrayatna Surna, Muhammad Ipan Susanna Susanna Syamsiar, Syamsiar Taufiq Karma Teuku Rizky Noviandy Teuku Zulfikar Tjut Chamzurni TRINA EKAWATI TALLEI Wahyuni, Srie Wangi, Putri Ayu Sekar Wildan Seni, Wildan Wiranatakusuma, Dimas Bagus Wiwik Handayani Yustiana Yustiana, Yustiana Zahriah, Zahriah Zuchra Helwani, Zuchra Zulkarnain Jalil