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Journal : MEDISAINS

The effectiveness of topical gel formulation extract Centella asiatica and Curcuma domestica to fading striae gravidarum Oktavia, Eva Zuli; Hadisaputro, Suharyo; Rahayu, Sri
MEDISAINS Vol 21, No 3 (2023)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v21i3.19130

Abstract

Background: The incidence of striae gravidarum in Indonesia is 95%, and 79.7% are primigravida. Striae gravidarum is not a direct physical health risk but is associated with body image and decreased self-confidence. Curcuma domestica contains curcumin and vitamin C, which can stimulate the synthesis of type IV collagen. In contrast, the Centella asiatica plant contains triterpenoids and saponins, which can stimulate the synthesis of type I collagen, which helps regenerate skin cells and improve skin elasticity. However, it is necessary to see the effectiveness of the two herbs, Centella asiatica and Curcuma domestica, in fading striae gravidarum. Purpose: To prove the effectiveness of topical gel formulation extract Centella asiatica and Curcuma domestica for fading of striae gravidarum.Methods: This is a quasi-experimental study with a pretest-posttest control group design. The sample consisted of 32 primigravida pregnant women divided into two groups: the intervention group was given a combination of Curcuma domestica and Centella asiatica gel at a dose of 5 mg twice a day for 14 days, and the control group was given a mineral oil gel at a quantity of 5 mg twice a day for 14 days—measurement of striae gravidarum using Davey score. The statistical test used the Friedman and Wilcoxon test.Results: The average fading of striae gravidarum in the intervention group was more significant than in the control group, 11.44±4.131 to 4±3.033 vs.12.19±5.788 to 8.56±4.320 treatment on the 14th day. The analysis results showed that the topical gel formulation of Centella asiatica and Curcuma domestica was more effective in fading striae gravidarum than the placebo gel (p<0.001).Conclusion: Administering topical gel containing 12% Centella asiatica extract and a 10% Curcuma domestica dose of 5 mg twice a day for 14 days affected the fading of striae gravidarum.
Topical Jatropha multifida L. ointment improves perineal wound healing in postpartum mothers: a randomized controlled trial Fera, Fitria Candra; Marsum; Sri Rahayu
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.26811

Abstract

Background: Postpartum perineal wound care may lead to infection if not managed properly. Jatropha multifida L. contains various secondary metabolites that may accelerate wound healing; however, clinical evidence remains limited. Objective: This study aimed to evaluate the effectiveness of Jatropha multifida L. extract ointment compared with standard clean and dry wound care in promoting perineal wound healing. Methods: This was a true experimental study with a pre–posttest control group design. A total of 60 postpartum mothers with second-degree perineal lacerations were randomly assigned into three groups: control, 15% extract, and 20% extract. The interventions were applied twice daily for 7 days. Wound healing was assessed on days 3, 5, and 7 using the REEDA (Redness, Edema, Ecchymosis, Discharge, Approximation) score. Results: The Friedman test showed a significant reduction in REEDA scores across all groups (p < 0.001). The greatest decrease was observed in the 15% concentration group (mean = 0.4). Cohen’s d indicated a very large effect size (d = 1.835). Conclusions: Jatropha multifida L. extract ointment at a 15% concentration was effective in improving perineal wound healing in postpartum mothers.
Co-Authors - Anggorowati Andisetyana Putri, Hanifa Andriyani, Luluk Ari Suwondo Ari Suwondo Arum Budiyati Arum Estiyani Astari, Ni Kadek Yunita Ari Aulia Choirunnisa Choiroel, M. Dewa Ayu Mirah Jayantini Dewi, Ida Ayu Dhian Permana Diksi Laksmita Dewi Dina Hanifa Ditha Rizky Oktavianti Diyah Fatmasari Donny Kristanto Mulyantoro Donny Kristanto Mulyantoro Erna Widyastuti Erna Widyastuti Fachry Abda El Rahman Fajrin, Rafika Faridah, Salsabila Nur Fera, Fitria Candra Gandi, Putri Indra Gusti Ayu Marhaeni Hadi Hadi Hadi Hadi Hadi Hadi Hanifa Putri I Gusti Agung Ayu Novya Dewi Ima Nurcahyanti Putri Imam Djamaluddin Mashoedi Iman Surihartini Isnu Kurnia Nugrahaeni Kadek Ditha Ari Sevtiani Karmika, Ni Nyoman Kalih Kertiani, Ni Putu Devi Kiki Yusika Kun Aristiati Susiloretni Kuswanto Kuswanto Lailatul Hidayah Librawati, Susi Listyaning Eko Martanti Listyaning Eko, Martanti Made Dita Argya Prabaswari Made Widhi Gunapria Darmapatni Mahendra, Ida Bagus Made Putra Mardiyana, Shinta Lia Nana Marsum Marsum Marsum Melyana Nurul Widyawati Melyana Nurul Widyawati Mutiara Ayu Muthiatulsalimah Ngadiyono Ngadiyono Ni Kadek Ratna Dewi Ni Ketut Somoyani Ni Komang Erny Astiti Ni Komang Yuni Rahyani Ni Komang Yuni Rahyani Ni Made Dwi Mahayati Ni Nyoman Budiani, Ni Nyoman Ni Nyoman Suartini Ni Nyoman Suindri Ni Wayan Suarnit Ni Wayan Suarniti Nia Dwi Yuliati Noor Pramono Noor Pramono Novita Novita Nur Anisa Nurul Jannah Octaviani, Dhita Aulia Oktavia, Eva Zuli Purnamayanti, Ni Made Dwi Putri, Noviyati Rahardjo Putu Ayu Oktarini Putu Rosita Saraswati Retno Kusuma Dewi Rica Anjayani Rizkie Aulia Amini Rizky Amelia Runjati Senjaya, Asep Arifin Setya Prihatin Setyo, Prihatin Siti Erniyati Berkah Pamuji Soeharyo Hadisaputro Soeharyo Hadisaputro Sri Endang Windiarti Sri Purwati Sri Sumarni Sri Sumarni Sri Wahyuni Sri Wahyuni Suhartono Suhartono Suharyo Hadisaputro Suharyo Hadisaputro Suharyo Hadisaputro Suparmi Suparmi Supriyadi Supriyadi Supriyana Supriyana Syarief Taufik Hidayat Tecky Afifah Santi Amartha Titi Suherni Triana Sri Hardjanti Umaroh Umaroh Umaroh Umaroh Umaroh Umaroh Utami, Fetty Satu Ryan Utami, Vina Nurul Verena Meirike Arbella Wahyuni, Sri Warih Handayani Tri Murti Yoga, Ida Ayu Putu Pradya Kirana Yudrika, Filza Yuni Nor Aini