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Angiotensin-Converting Enzyme Genetic Polymorphism rs4343 as Risk of Diabetic Nephropathy in Jambi-Malay Population Elfiani, Elfiani; Puspasari, Anggelia; Arif, Cut Wulan; Maharani, Citra; Ali, Zulkhair; Suhaimi, Novadian; Effendi, Ian; Suprapti, Suprapti; Shafira, Nyimas Natasha Ayu
Molecular and Cellular Biomedical Sciences Vol 8, No 1 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i1.410

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Background: Diabetic nephropathy (DN) is one of the frequent complications of type II diabetes mellitus (T2DM) in Jambi province. Controlling blood glucose and blood pressure does not guarantee DN prevention, since genetic factors may also contribute to this disease. Multi-ethnic studies showed that one of the strongest genetic factors associated with DN was single nucleotide polymorphism rs4343 of angiotensin-converting enzyme (ACE) gene. Study regarding phenotype-genotype association of ACE rs4343 and DN has not yet been performed in Jambi Province, which is dominated by Malay ethnicity. This study was conducted to reveal the association between ACE rs4343 and the risk of DN in the Jambi-Malay population.Materials and methods: This was a cross-sectional study involving 75 subjects (44 with DN and 31 without DN) who suffered from T2DM and hypertension. DN was defined as albumin to creatinine ratio (ACR) ≥30 mg/g. Genotyping was performed with one-step tetra amplification refractory mutation system-polymerase chain reaction (PCR) using specific primer for ACE rs4343. Bivariate and multivariate analyses were performed to analyze the genetic risk for DN.Results: The bivariate analysis showed the proportion of DN subjects was higher than non-DN within the AG genotype (11:1) than within the AA (33:30) genotype. This difference was statistically significant (p=0.012; OR (95% CI): 10.00 (1.22-82.15)). Multivariate analysis showed that AG genotype (p=0.047; OR (95% CI): 10.04 (1.03-97.31)) and uncontrolled blood pressure (p=0.001; OR (95% CI): 6.72 (2.08-21.71)) were the risk factors of DN in the Jambi-Malay population.Conclusion: Polymorphism of ACE rs4343 is a risk factor of DN in the Jambi-Malay Population.Keywords: rs4343, angiotensin-converting enzyme gene, diabetic nephropathy, Malay, Jambi
EDUKASI KESEHATAN MATA DAN DETEKSI DINI PENURUNAN TAJAM PENGLIHATAN SEBAGAI UPAYA PENCEGAHAN KELAINAN REFRAKSI PADA ANAK USIA SEKOLAH DI MADRASAH TARBIYATUSSHOLATIYAH JAMBI Tarawifa, susan; Rina Nofri Enis; Nyimas Natasha Ayu Shafira; Anggelia Puspasari; Citra Maharani
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 7 No. 2 (2024): MEDIC. Medical dedication
Publisher : Universitas Jambi

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ABSTRACTEye health is a vital aspect in supporting the physical and cognitive development of children, especially at school age. Disruptions in eye health, or even blindness, can have negative impacts on their lives. This community service project aims to provide eye health education and vision examinations for children enrolled in the Al-Qur'an memorization program at Madrasah Tarbiyatussholatiyah Jambi, as an effort to maintain their visual health. The activity involved 40 tahfidz children, and data was collected regarding their vision conditions and reading habits. The examination results indicated that 62.5% of the children had normal vision (6/6), while 35% experienced significant vision impairment of varying degrees, and 2.5% were blind. The education provided included proper reading techniques and the importance of adequate lighting to raise awareness among both children and parents. This community service activity emphasizes the necessity of integrating eye health programs in tahfidz educational institutions, particularly at Madrasah Tarbiyatussholatiyah, to detect and prevent vision disorders early on, as well as to effectively support the learning and memorization of the Al-Qur'an.Keyword: Eye health, Visual impairment, Reading habits. ABSTRAKKesehatan mata merupakan aspek vital dalam mendukung perkembangan fisik dan kognitif anak, terutama pada usia sekolah. Pada saat terjadi gangguan pada kesehatan mata atau bahkan kebutaan akan berdampak negatif pada kehidupan. Pengabdian kepada masyrakat ini bertujuan untuk memberikan edukasi kesehatan mata dan pemeriksaan visus pada anak-anak tahfidz Al-Qur'an di Madrasah Tarbiyatussholatiyah Jambi sebagai Upaya untuk menjaga kesehatan penglihatan mereka. Kegiatan ini melibatkan 40 anak tahfidz, data dikumpulkan mengenai kondisi visus dan kebiasaan membaca. Hasil pemeriksaan menunjukkan bahwa62,5% anak memiliki visus normal (6/6), sementara 35% lainnya mengalami penurunan tajam penglihatan, dengan berbagai derajat dan 2,5% mengalami kebutaan. Edukasi yang diberikan terkait teknik membaca yang benar dan pentingnya pencahayaan yang dibutuhkan untuk meningkatkan kesadaran anak dan orang tua. Kegiatan peengabdian ini menekankan perlunya integrasi program kesehatan mata di lembaga pendidikan tahfidz khususnya di Madrasah Tarbiyatussholatiyah untuk mendeteksi dan mencegah gangguan penglihatan sejak dini, serta mendukung proses belajar dan menghafal Al-Qur'an secara efektif.Kata Kunci: Kesehatan mata, Gangguan Penglihatan, Kebiasaan membaca
Effectiveness Of Using The Skeletal System Pocketbook on The Grade of Anatomy Practicum For Medical Students at Universitas Jambi Enis, Rina Nofri; Hz, Tia Wida Ekaputri; Tarawifa, Susan; Aurora, Wahyu Indah Dewi; Shafira, Nyimas Natasha Ayu; Puspasari, Anggelia; Maharani, Citra; Halim, Rita; Virginsia, Sonya; Vivekanantharasa, Raveenthiran
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 12 No. 2 (2024): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v12i2.37311

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ABSTRACT Background: Bone markings must be studied and mastered in learning skeletal system anatomy. The short and interesting material in the pocketbook helps students identify preparations during the practicum, increasing their understanding and gaining practical grades. Objective: This research aims to determine the effectiveness of using the Skeletal System pocketbook on grades practical anatomy block of the Integumentary System and Locomotion for medical students in the first semester of the Universitas Jambi in 2023. Method: This research used a quasi-experimental method with a pre-test and post-test control group. The 106 sample students were from the Medical Study Program at Universitas Jambi class of 2023. Result: The mean pre-test and post-test grades for students with pocketbooks were 61.86 and 78.04, while those without pocketbooks were 63.74 and 71.35. In the mean pre-test grade, there was no significant difference between the experimental and control groups' mean grades (p-value = 0.488). Meanwhile, in the mean post-test grades, there was a significant difference between the two groups (p-Value = 0.005), where the experimental group had a higher mean grade. Conclusion: There is a significant difference in using the skeletal system anatomy pocketbook on the grade of anatomy practicum for medical students at Universitas Jambi. Keywords: Anatomy, Practicum, Skeletal System, Pocket Book.
Interprofessional Learning Development In Indonesia Health Study Program Quzwain, Fairuz; Shafira, Nyimas Natasha Ayu; Aryanty, Nindya; Raudhoh, Siti; De Jonge, Laury P.J.W.M.
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 12 No. 2 (2024): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v12i2.37316

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Background: Interprofessional education (IPE) is a joint learning process between two or more students from the health profession to develop collaboration skills and improve the quality of health services. With  IPE, students develop a deeper understanding of various health professions' roles and responsibilities, enhancing their ability to communicate and collaborate effectively. This study aims to develop IPE learning involving five health professions at the Faculty of Medicine and Health Sciences Universitas Jambi. Methods: This study uses a research and development design. This study utilized a qualitative approach, specifically through Focus Group Discussions (FGDs) at the research and information gathering (define) stage. A total of ten lecturers and five heads of study programs from medical, nursing, pharmacies, psychology, and public health programs were involved in this study. Results: Three themes were derived from the results: Curriculum, Faculty Development, and Institutional Support. Community-based IPE allows students from various health study programs at FKIK UNJA to be involved in these activities. To ensure effective implementation of IPE learning,  it is crucial to conduct training for faculty facilitators and field instructors related to IPE learning and to form a team responsible for developing, delivering, and managing the IPE program. Institutional support for interprofessional education (IPE), namely facilities, infrastructure, and a partnership with primary health centers, is critical for implementing and sustaining community-based IPE. Conclusion: The IPE learning that will be implemented at FKIK UNJA is community-based IPE. Three crucial elements must be prepared to implement IPE: curriculum, faculty development, and institutional support. Keywords: Interprofessional Education; Community-Based Setting
Overview of Learning Motivation and Learning Strategies of Students In The Medical Study Program Sholahuddin Tumanggor; Hasna Dewi; Patrick William Gading; Rina Nofri Enis; Nyimas Natasha Ayu Shafira
Journal of Medical Studies Vol. 4 No. 3 (2024): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v4i3.38958

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ABSTRACT Background: Medical education is not easy and requires concentration and a strong will to be able to complete all stages of education. Students must have strong motivation and learning strategies that are considered to have contributed to the success of the learning process because of a lack of motivation and strategy in learning. With that, motivation and learning strategies influence a person's activities to achieve the results he wants. Method: This research is included in the category of associative research using a quantitative approach. The sample is 285 undergraduate students of the Medical Education Study Program at the Faculty of Medicine and Health Sciences active in the odd semester of the 2022/2023 academic year. The data analysis technique used is univariate analysis. Results: The results show that 75.5% of students from the class of 2020 have moderate learning motivation, 86.6% of students from the class of 2021 have moderate learning motivation, 72.8% of the class of 2020 students have moderate learning strategies, and 90.3% of the class of 2021 students have moderate learning strategies. Conclusion: Most of the 2020 and 2021 active Medical Education Study Program undergraduate students at the Faculty of Medicine and Health Sciences in the odd semester of the 2022/2023 academic year have moderate motivation and learning strategies. Keywords: learning motivation; learning strategy; medical student
Cervical Cancer Knowledge, Attitudes, and VIA Willingness among Married Women Shabrina Nadilah Zahra; Erny Kusdiyah; Hanina; Wahyu Indah Dewi Aurora; Nyimas Natasha Ayu Shafira
Journal of Medical Studies Vol. 4 No. 3 (2024): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v4i3.38964

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ABSTRACT Background: Indonesia has the highest rate of cervical cancer in Southeast Asia. However, early detection through Visual Inspection of Acetate Acid (VIA) among Women of Childbearing Age (WCA) in Indonesia, including Jambi City, remains low. This research aims to determine knowledge and attitudes toward cervical cancer prevention, and the willingness undergo VIA examination among married WCA at the Kenali Besar Public Health Center in Jambi City. Methods: An observational-analytical study with a cross-sectional design was conducted using questionnaires. 110 samples were chosen by accidental sampling technique and analyzed using descriptive statistics. Results: Most participants were in early adulthood (52.7%), had secondary education (50.9%), were unemployed (59.1%), had sufficient knowledge (40%) and attitudes (51.8%), but low willingness for VIA (47.3%). The main reason for not undergoing VIA was the absence of symptoms (22.7%). Most who had VIA had only been tested once (70%), with all results negative (100%). Conclusion: The willingness to undergo VIA screening is still low. Increasing the VIA screening coverage requires the improvement of knowledge about cervical cancer and attitudes toward cervical cancer prevention through effective health promotion. Keywords: cervical cancer; women of childbearing age; VIA test; knowledge; attitudes; willingness; behavior
AT Genotype of FTO rs9939609 Enhances Risk for Central Obesity Under Obesogenic Lifestyle Maharani, Citra; Puspasari, Anggelia; Enis, Rina Nofri; Ekaputri, Tia Wida; Shafira, Nyimas Natasha Ayu
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i1.38811

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Background: Central obesity is a major risk factor for cardiovascular diseases, influenced by both genetic and lifestyle factors. The rs9939609 variant of Fat Mass and Obesity-Associated (FTO) gene has been associated with increased risk of central obesity, potentially modulated by dietary intake and physical activity. Objective: This study aimed to investigate the association between the FTO rs9939609 variant and central obesity, and its interaction with dietary intake and physical activity among adults in Jambi, Indonesia. Method: A cross-sectional study was conducted on 175 adults. Central obesity was defined using NCEP ATP III criteria. Dietary intake and physical activity were assessed using 24-hour food recall and the IPAQ, respectively. Genotyping was performed using the Tetra ARMS-PCR. Bivariate analysis was used to assess associations. Results: Individuals with the AT genotype had a significantly increased risk of central obesity (OR= 3.29; 95% CI: 1.30–8.35; p= 0.01). Under the dominant model (AAAT), the association remained significant (OR= 2.90; 95% CI: 1.17-7.16; p= 0.02). The risk was higher among individuals with high caloric intake (OR= 4.64) and low to moderate physical activity (OR= 4.77). Conclusion: The FTO rs9939609 variant is associated with increased central obesity risk, and in the presence of obesogenic lifestyle factors.
ATHEROGENIC INDEX OF PLASMA ASSESSMENT AS AN EFFORT TO DETECT THE RISK OF CORONARY HEART DISEASE IN PRODUCTIVE AGE INDIVIDUALS WITH OBESITY IN THE WORKING AREA OF THE SIMPANG SUNGAI DUREN HEALTH CENTER Puspasari, Anggelia; Maharani, Citra; Halim, Rita; Enis, Rina Nofri; Shafira, Nyimas Natasha Ayu; Tarawifa, Susan
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 1 (2025): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Prospective studies indicate that the Atherogenic Index of Plasma (AIP) is a superior marker compared to isolated assessments of triglycerides (TG) and High-Density Lipoprotein (HDL) in predicting Coronary Heart Disease (CHD). Simpang Sungai Duren Community Health Center serves a large population with a high proportion of productive-age and obese individuals. Routine metabolic screening for CHD risk stratification in obese residents has been hindered by limited facilities and healthcare financing systems. This community service initiative aimed to assess AIP for CHD risk stratification in obese individuals. Participants included residents aged 19–64 years with a body mass index (BMI) ≥25 kg/m², no recent lipid-lowering medication use (within 3 months), and an 8–10 hour fasting period. AIP scores (logarithm of TG/HDL ratio) were used to stratify CHD risk. Results were communicated to participants alongside health promotion leaflets. Among 61 participants, AIP-based screening identified 14.8% as high-risk, 26.2% as moderate-risk, and 59% as low-risk for CHD. Modifiable cardiometabolic risk factors in the high-risk group revealed 100% with central obesity and hypertriglyceridemia, and 50% with hypertension and/or low HDL levels. The high-risk cohort exhibited multiple cardiometabolic risks requiring comprehensive management.
COMMUNITY SCREENING OF STROKE RISK FACTORS AMONG PRODUCTIVE AGE POPULATION Maharani, Citra; Shafira, Nyimas Natasha Ayu; Puspasari, Anggelia; Enis, Rina Nofri; Iskandar, Mirna Marhami
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 1 (2025): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Abstract

Stroke is a neurological disease caused by multiple risk factor and can be prevented through early screening and lifestyle modifications. However, the misconception that stroke only affects the elderly leads to low screening interest among younger adults. This community service activity aimed to screen for stroke risk factors, particularly lipid profile examination among the productive age population in the working area of Simpang Sungai Duren Public Health Center. A total of 90 respondents aged 19-59 years participated, most of whom were office workers with sedentary lifestyles and unhealthy dietary habits. The screening included blood pressure measurement, body mass index assessment, total cholesterol and Low-Density Lipoprotein (LDL) levels. All respondents fasted for 8-10 hours before venous blood sampling. Screening results were delivered along with individual consultation and lifestyle education. The results revealed that 20% of respondents had hypercholesterolemia, 22% had elevated LDL levels, 23.26% had hypertension, 21% were overweight, and 39% were obese. These findings indicate that individuals in the productive age group may already have stroke risk factors despite being asymptomatic. Therefore, regular screening from early adulthood is essential as a primary prevention strategy against stroke.
Impact of 5:2 Intermittent Fasting and Physical Activity on Liver Enzymes in Overweight and Obese Individuals Haifa Nida Firdausa; Esa Indah Ayudia; Nyimas Natasha Ayu Shafira; Huntari Harahap; Tia Wida Ekaputri
Journal of Medical Studies Vol. 5 No. 1 (2025): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v5i1.43277

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ABSTRACT Background: Overweight and obesity are linked to liver disease and dysfunction, as obesity can adversely affect liver function through various mechanisms. The study aims to determine the effect of intermittent fasting type 5:2 and physical activity on SGOT, SGPT, body weight, and BMI levels. Methods: The research design used a pre-post-test group research design. The subjects of the study were overweight and obese individuals at the Faculty of Medicine and Health Sciences, University of Jambi. Results: The study concluded that intermittent fasting and physical activity did not significantly affect SGOT and SGPT levels, with minimal changes (SGOT: 29.40 to 27.85, p=0.699; SGPT: 30.85 to 29.35, p=0.735). However, there were significant reductions in body weight (from 80.02 kg to 77.35 kg, p<0.001) and Body Mass Index (BMI) (from 29.69 to 28.68, p<0.001). Conclusion: Intermittent fasting and physical activity impacted body weight and BMI but did not affect SGOT and SGPT levels. Keyword: Intermittent fasting; Physical activity; SGOT; SGPT; Body weight; BMI
Co-Authors Abdul Haris Agnesia Feronika Panggabean Ahmad Syauqy Albashir Feriohadi Amatullah, Afifah Amelda Mutia Sabrini Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri, Amelia Dwi Anati Purwakanthi Anati Purwakanthi, Anati Anggelia Puspasari Annissa Delfira Anwar Jusuf Arif, Cut Wulan Armaidi Darmawan Aryanti, Nindya ATTIYA ISTARINI Ave Olivia Rahman Bulqis, Ratu Citra Maharani Citra Maharani De Jonge, Laury P.J.W.M. Dhea Assyifa Effendi, Ian Ekaputri, Tia Wida Elfiani Erny Kusdiyah Esa Indah Ayu, Esa Indah Faila Sufa Fairuz Quzwain Fauzan, Randy Fenny Febrianty Firmansyah Firmansyah Gading, Patrick William Haifa Nida Firdausa Hanina Harahap, Asro Hayani Hasmita, Debby Hasna Dewi Herlambang Herlambang Herlambang HERLAMBANG HERLAMBANG Herlambang Herlambang Huntari Harahap Irlianissa, Mutiara Iskandar, Mirna Marhami JMJ, Jurnal Lipinwati ., Lipinwati Lisa, Mei Nabila, Risa Nindya Aryanty Nofrans Eka Saputra, Nofrans Eka Nur Id&#039;ys Nuriyah, Nuriyah Oktari, Intan Patrick William Gading Putri Sari Wulandari Putri, Loli Melatina Putri, Nadhilah Aulia Raudhoh, Siti Rina Nofri Enis Rina Nofrienis Rita Halim Rita Halim Sabar Hutabarat Salsabila, Amalya Sari, Anggia Rohdila Setyawati Budiningsih Shabrina Nadilah Zahra Sholahuddin Tumanggor Siti Hediaty Sri Mulyani Suhaimi, Novadian Suprapti Suprapti Suryati Suryati Susan Tarawifa Syatria Esa Putra Tarawifa, Susan Tengku Arief Buana Perkasa Tia Wida Ekaputri Virginsia, Sonya Vivekanantharasa, Raveenthiran Wahyu Indah Dewi Aurora Zulkhair Ali