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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Molecular and Cellular Biomedical Sciences (MCBS) IRJE (Indonesian Research Journal in Education) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Daur Lingkungan MEDIC MEdical Dedication Journal of Medical Studies Neurona
Nyimas Natasha Ayu Shafira
Universitas Jambi, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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AT Genotype of FTO rs9939609 Enhances Risk for Central Obesity Under Obesogenic Lifestyle Maharani, Citra; Puspasari, Anggelia; Enis, Rina Nofri; Ekaputri, Tia Wida; Shafira, Nyimas Natasha Ayu
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i1.38811

Abstract

Background: Central obesity is a major risk factor for cardiovascular diseases, influenced by both genetic and lifestyle factors. The rs9939609 variant of Fat Mass and Obesity-Associated (FTO) gene has been associated with increased risk of central obesity, potentially modulated by dietary intake and physical activity. Objective: This study aimed to investigate the association between the FTO rs9939609 variant and central obesity, and its interaction with dietary intake and physical activity among adults in Jambi, Indonesia. Method: A cross-sectional study was conducted on 175 adults. Central obesity was defined using NCEP ATP III criteria. Dietary intake and physical activity were assessed using 24-hour food recall and the IPAQ, respectively. Genotyping was performed using the Tetra ARMS-PCR. Bivariate analysis was used to assess associations. Results: Individuals with the AT genotype had a significantly increased risk of central obesity (OR= 3.29; 95% CI: 1.30–8.35; p= 0.01). Under the dominant model (AAAT), the association remained significant (OR= 2.90; 95% CI: 1.17-7.16; p= 0.02). The risk was higher among individuals with high caloric intake (OR= 4.64) and low to moderate physical activity (OR= 4.77). Conclusion: The FTO rs9939609 variant is associated with increased central obesity risk, and in the presence of obesogenic lifestyle factors.
ATHEROGENIC INDEX OF PLASMA ASSESSMENT AS AN EFFORT TO DETECT THE RISK OF CORONARY HEART DISEASE IN PRODUCTIVE AGE INDIVIDUALS WITH OBESITY IN THE WORKING AREA OF THE SIMPANG SUNGAI DUREN HEALTH CENTER Puspasari, Anggelia; Maharani, Citra; Halim, Rita; Enis, Rina Nofri; Shafira, Nyimas Natasha Ayu; Tarawifa, Susan
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 1 (2025): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Abstract

Prospective studies indicate that the Atherogenic Index of Plasma (AIP) is a superior marker compared to isolated assessments of triglycerides (TG) and High-Density Lipoprotein (HDL) in predicting Coronary Heart Disease (CHD). Simpang Sungai Duren Community Health Center serves a large population with a high proportion of productive-age and obese individuals. Routine metabolic screening for CHD risk stratification in obese residents has been hindered by limited facilities and healthcare financing systems. This community service initiative aimed to assess AIP for CHD risk stratification in obese individuals. Participants included residents aged 19–64 years with a body mass index (BMI) ≥25 kg/m², no recent lipid-lowering medication use (within 3 months), and an 8–10 hour fasting period. AIP scores (logarithm of TG/HDL ratio) were used to stratify CHD risk. Results were communicated to participants alongside health promotion leaflets. Among 61 participants, AIP-based screening identified 14.8% as high-risk, 26.2% as moderate-risk, and 59% as low-risk for CHD. Modifiable cardiometabolic risk factors in the high-risk group revealed 100% with central obesity and hypertriglyceridemia, and 50% with hypertension and/or low HDL levels. The high-risk cohort exhibited multiple cardiometabolic risks requiring comprehensive management.
COMMUNITY SCREENING OF STROKE RISK FACTORS AMONG PRODUCTIVE AGE POPULATION Maharani, Citra; Shafira, Nyimas Natasha Ayu; Puspasari, Anggelia; Enis, Rina Nofri; Iskandar, Mirna Marhami
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 1 (2025): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Abstract

Stroke is a neurological disease caused by multiple risk factor and can be prevented through early screening and lifestyle modifications. However, the misconception that stroke only affects the elderly leads to low screening interest among younger adults. This community service activity aimed to screen for stroke risk factors, particularly lipid profile examination among the productive age population in the working area of Simpang Sungai Duren Public Health Center. A total of 90 respondents aged 19-59 years participated, most of whom were office workers with sedentary lifestyles and unhealthy dietary habits. The screening included blood pressure measurement, body mass index assessment, total cholesterol and Low-Density Lipoprotein (LDL) levels. All respondents fasted for 8-10 hours before venous blood sampling. Screening results were delivered along with individual consultation and lifestyle education. The results revealed that 20% of respondents had hypercholesterolemia, 22% had elevated LDL levels, 23.26% had hypertension, 21% were overweight, and 39% were obese. These findings indicate that individuals in the productive age group may already have stroke risk factors despite being asymptomatic. Therefore, regular screening from early adulthood is essential as a primary prevention strategy against stroke.
Impact of 5:2 Intermittent Fasting and Physical Activity on Liver Enzymes in Overweight and Obese Individuals Haifa Nida Firdausa; Esa Indah Ayudia; Nyimas Natasha Ayu Shafira; Huntari Harahap; Tia Wida Ekaputri
Journal of Medical Studies Vol. 5 No. 1 (2025): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v5i1.43277

Abstract

ABSTRACT Background: Overweight and obesity are linked to liver disease and dysfunction, as obesity can adversely affect liver function through various mechanisms. The study aims to determine the effect of intermittent fasting type 5:2 and physical activity on SGOT, SGPT, body weight, and BMI levels. Methods: The research design used a pre-post-test group research design. The subjects of the study were overweight and obese individuals at the Faculty of Medicine and Health Sciences, University of Jambi. Results: The study concluded that intermittent fasting and physical activity did not significantly affect SGOT and SGPT levels, with minimal changes (SGOT: 29.40 to 27.85, p=0.699; SGPT: 30.85 to 29.35, p=0.735). However, there were significant reductions in body weight (from 80.02 kg to 77.35 kg, p<0.001) and Body Mass Index (BMI) (from 29.69 to 28.68, p<0.001). Conclusion: Intermittent fasting and physical activity impacted body weight and BMI but did not affect SGOT and SGPT levels. Keyword: Intermittent fasting; Physical activity; SGOT; SGPT; Body weight; BMI
SEDENTARY LIFESTYLE: SKRINING POTENSI RISIKO KESEHATAN PADA CIVITAS AKADEMIKA UNIVERSITAS JAMBI TAHUN 2024 Shafira, Nyimas Natasha Ayu; Enis, Rina Nofri; Puspasari, Anggelia; Maharani, Citra; Tarawifa, Susan
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 7 No. 2 (2024): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Abstract

ABSTRACT The sedentary lifestyle among office workers is associated with various adverse health risks, such as increased rates of metabolic disorders such as diabetes mellitus, hypertension, and dyslipidemia, as well as depression and cognitive impairment. Data from the Jambi University Clinic shows that there are still many educational staff and educators who are overweight, and awareness of getting themselves checked before health problems arise is still low. Health screening related to adverse effects due to a sedentary lifestyle, such as obesity, hypertension, and diabetes mellitus, needs to be carried out so that preventive measures and further management can be carried out. The PPM was attended by educational staff or educators at Jambi University aged 19-64, who were checked for body mass index (BMI), blood pressure, and fasting blood sugar (GDP) measurements. Before taking venous blood for GDP examination, participants must fast for 8-10 hours. The examination results are sent to service participants along with health promotion media in the form of leaflets to avoid sedentary behavior. The activity was attended by 99 people who met the criteria. From the results of BMI measurements, it was found that 8.08% were underweight, 22.2% normoweight, 8.08% overweight, and 61.62% obese. The GDP examination found that 92.93% were normal, 3.03% pre-diabetic, and 4.04% were diabetic. From blood pressure measurements, it was found that 36.36% were normal, 39.39% were pre-hypertension, and 24.24% were hypertensive. It should be noted that service participants who are underweight, overweight, pre-diabetic, and pre-hypertensive need regular follow-up evaluations to prevent worsening of their health conditions. Participants who are obese, diabetic, and hypertensive need to receive further management in the form of treatment from a doctor according to the health problems they are experiencing. Keywords: Diabetic, Hypertension, Obesity, Sedentary lifestyle ABSTRAKGaya hidup yang kurang gerak (sedentary lifestyle) di kalangan pekerja kantoran memiliki hubungannya dengan berbagai risiko kesehatan yang merugikan seperti peningkatan angka gangguan metabolism seperti diabetes mellitus, hipertensi, dan dislipidemia, serta depresi, dan gangguan kognitif. Data dari Klinik Universitas Jambi, diketahui bahwa masih banyak tenaga kependidikan maupun pendidik yang memiliki berat badan berlebih, dan kesadaran untuk memeriksakan diri sebelum timbul masalah kesehatan yang masih rendah. Skrining kesehatan terkait efek buruk yang timbul karena perilaku sedentary seperti obesitas, hipertensi dan diabetes mellitus perlu dilakukan agar dapat dilakukan tindakan preventif maupun tatalaksanalanjutan. PPM diikuti oleh tenaga kependidikan atau pendidik di Universitas Jambi berusia 19-64 tahun, dilakukan pemeriksaan Indeks massa tubuh (IMT), tekanan darah dan pengukuran gula darah puasa (GDP). Sebelum pengambilan darah vena untuk pemeriksaan GDP, peserta diwajibkan berpuasa 8-10 jam. Hasil pemeriksaan dikirimkan kepada peserta pengabdian beserta media promosi kesehatan berupa leaflet untuk menghindari perilaku sedentary. Kegiatan diikuti oleh 99 orang yang memenuhi kriteria. Dari hasil pengukuran IMT didapatkan 8.08% underweight, 22.2% normoweight, 8.08% overweight dan 61.62% obese. Dari pemeriksaan GDP didapatkan 92.93% normal, 3.03% pre-diabetik, 4.04% diabetik. Daripengukuran tekanan darah didapatkan 36.36% normal, 39.39% pre-hipertensi, 24.24% hipertensi. Hendaknya menjadi perhatian untuk peserta pengabdian yang mengalami underweight, overweight, prediabetik, dan pre-hipertensi membutuhkan evaluasi lanjutan secara berkala agar tidak terjadi perburukan kondisi kesehatan. Para peserta yang mengalami obese, diabetik, dan hipertensi perlu untuk mendapat tatalaksana lanjutan berupa pengobatan dari dokter sesuai masalah kesehatan yang dialami.Kata kunci: Diabetes, Hipertensi, Obesitas, Sedentary lifestyle
PROFIL METABOLISME LIPID SIRKULASI SEBAGAI UPAYA DETEKSI DINI SINDROMA METABOLIK PADA WANITA USIA PRODUKTIF DI WILAYAH KERJA PUSKESMAS PAKUAN BARU Maharani, Citra; Enis, Rina Nofri; Herlambang, Herlambang; Syauqy, Ahmad; Puspasari, Anggelia; Shafira, Nyimas Natasha Ayu; Tarawifa, Susan; Halim, Rita
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 7 No. 2 (2024): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Abstract

ABSTRACT Metabolic syndrome is a cluster of conditions that increases the risk of cardiovascular disease, diabetes mellitus, and stroke. Among the components of dyslipidemia, triglyceride levels and high-density lipoprotein (HDL) are important indicators in assessing cardiovascular disease risk, making these examinations useful for screening risk factors associated with metabolic syndrome. However, healthcare facilities are often unable to conduct these assessments independently, necessitating a referral system to more comprehensive healthcare services. Our community service team aims to facilitate this by conducting lipid profile examinations at Puskesmas Pakuan Baru as an early detection effort for metabolic syndrome in women of reproductive age. The activities carried out included lipid profile testing, blood pressure measurement, and education regarding metabolic syndrome. The results from 26 participants indicated that 23.07% had elevated triglyceride levels, 73.08% had low HDL levels, and 19.33% were hypertensive. Based on these findings, women of reproductive age already exhibit risk factors for metabolic syndrome, suggesting that lipid profile assessments should be incorporated into routine screening programs to prevent the onset of metabolic syndrome. ABSTRAK Sindroma metabolik merupakan kumpulan kondisi yang meningkatkan risiko penyakit kardiovaskular, diabetes mellitus dan stroke. Komponen dislipidemia yang menjadi indikator penting dalam penilaian risiko penyakit kardiovaskular antara lain kadar trigliserida dan high-density lipoprotein (HDL), sehingga pemeriksaan ini dapat dimanfaatkan untuk skrining faktor risiko sindroma metabolik. Namun, fasilitas pelayanan kesehatan belum dapat melakukan pemeriksaan tersebut secara mandiri sehingga perlu dilakukan sistem rujukan ke fasilitas kesehatan yang lebih lengkap. Tim pengabdian berupaya memfasilitasi hal ini dengan melakukan kegiatan pengabdian pemeriksaan profil lipid di Puskesmas Pakuan Baru sebagai upaya deteksi dini sindroma metabolik pada wanita usia produktif. Kegiatan yang dilakukan meliputi pemeriksaan profil lipid, pemeriksaan tekanan darah, dan edukasi terkait sindroma metabolik. Dari hasil pemeriksaan yang telah dilakukan pada 26 orang peserta didapatkan hasil 23,07 % peserta memiliki kadar trigliserida tinggi, 73,08 % memiliki kadar HDL yang rendah, dan 19,33% mengalami hipertensi. Berdasarkan hasil tersebut, wanita usia produktif sudah menunjukkan adanya faktor risiko sindroma metabolik, sehingga pemeriksaan profil lipid sebaiknya dapat dimasukkan sebagai program skrining rutin di masyarakat untuk mencegah terjadinya sindroma metabolik.
HUBUNGAN KADAR GULA DARAH SEWAKTU DENGAN NEUROPATI DIABETIK PADA PASIEN DIABETES MELITUS TIPE 2 Lisa, Mei; Lipinwati, Lipinwati; Istarini, Attiya; Syauqy, Ahmad; Shafira, Nyimas Natasha Ayu
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 4 (2025): Volume 41 Nomor 4, September 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i4.721

Abstract

ABSTRACT Introduction: Diabetes mellitus can cause microvascular complications, one of the most common being neuropathy, which is triggered by persistent hyperglycemia. Aims: To determine the relationship between random blood glucose levels and the incidence of diabetic neuropathy in Type 2 Diabetes Mellitus patients. Methods: This analytical observational study used a cross-sectional design involving 92 Type 2 Diabetes Mellitus patients. Neuropathy was assessed using the DNS-Ina questionnaire, while random blood glucose levels were obtained through laboratory tests. Data were analyzed using the Chi-square test. Results: Among the respondents, 53.3% did not experience hyperglycemia, while 82.3% had diabetic neuropathy. The Chi-square test revealed a p-value of 0.017 with an odds ratio of 4.568, indicating a significant association between random blood glucose levels and diabetic neuropathy. Conclusion: There is a significant relationship between random blood glucose levels and the incidence of diabetic neuropathy in Type 2 Diabetes Mellitus patients at H. Abdul Manap Regional Hospital, Jambi City. Keywords: diabetic neuropathy, random blood glucose, Type 2 diabetes mellitus
Co-Authors Abdul Haris Agnesia Feronika Panggabean Ahmad Syauqy Albashir Feriohadi Amalya Salsabila Amelda Mutia Sabrini Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri, Amelia Dwi Anati Purwakanthi Anati Purwakanthi, Anati Anggelia Puspasari Anggelia Puspasari Anwar Jusuf Arif, Cut Wulan Armaidi Darmawan ATTIYA ISTARINI Ave Olivia Rahman Citra Maharani Citra Maharani De Jonge, Laury P.J.W.M. Dhea Assyifa Effendi, Ian Ekaputri, Tia Wida Elfiani Erny Kusdiyah Esa Indah Ayu, Esa Indah Faila Sufa Fairuz Quzwain Fenny Febrianty Gading, Patrick William Haifa Nida Firdausa Hanina Harahap, Asro Hayani Hasna Dewi Hendra Herman Herlambang Herlambang Herlambang Herlambang HERLAMBANG HERLAMBANG Herlambang Herlambang, Herlambang Huntari Harahap Iskandar, Mirna Marhami JMJ, Jurnal Lipinwati ., Lipinwati Lisa, Mei Nindya Aryanty Nofrans Eka Saputra, Nofrans Eka Nur Id&#039;ys Oktari, Intan Patrick William Gading Putri Sari Wulandari Putri, Loli Melatina Putri, Nadhilah Aulia Randy Fauzan Ratu Bulqis Raudhoh, Siti Rina Nofri Enis Rina Nofrienis Risa Nabila Rita Halim Rita Halim Sabar Hutabarat Sari, Anggia Rohdila Setyawati Budiningsih Shabrina Nadilah Zahra Sholahuddin Tumanggor Siti Hediaty Sri Mulyani Suhaimi, Novadian Suprapti Suprapti Suryati Suryati Susan Tarawifa Susan Tarawifa Syatria Esa Putra Tarawifa, Susan Tia Wida Ekaputri Virginsia, Sonya Vivekanantharasa, Raveenthiran Wahyu Indah Dewi Aurora Zulkhair Ali