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All Journal Sari Pediatri Paediatrica Indonesiana Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jurnal Kedokteran Anatomica (Anatomica Medical Journal) JURNAL IBNU SINA BIOMEDIKA Sumatera Medical Journal Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Jurnal Prima Medika Sains Jurnal Ners Journal of Telenursing (JOTING) JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK Indonesian Journal of Global Health research Prosiding Konferensi Nasional PKM-CSR Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Indonesian Journal of Global Health Research
Fujiati, Isti Ilmiati
Departemen Kedokteran Komunitas Fakultas Kedokteran Universitas Sumatera Utara
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The Relationship Between Lipid Profile and the Incidence of Relapsing Nephrotic Syndrome in Children Utari Olivina Tarigan; Rosmayanti Syafriani Siregar; Syamsidah Lubis; Isti Ilmiati Fujiati; Melda Deliana; Cynthea Prima
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.7017

Abstract

Nephrotic syndrome (NS) is one of the most common chronic kidney diseases in children, characterized by massive proteinuria, hypoalbuminemia, edema, and dyslipidemia. Relapse occurs in most cases and contributes to worsening the disease course. Dyslipidemia is suspected to influence relapse risk, but the specific relationship between lipid profile and relapsing NS remains unclear. Objective to analyze the association between total cholesterol, triglycerides, LDL, and HDL levels with relapse incidence in children with nephrotic syndrome. A retrospective study was conducted on 66 children aged 2–18 years with NS treated at H. Adam Malik General Hospital, Medan, in 2024. Subjects were divided into relapsing (n=54) and non-relapsing (n=12) groups. Data were obtained from medical records and analyzed using the Mann-Whitney test and Spearman correlation. Triglyceride (p=0.007), LDL (p=0.013), and HDL (p<0.001) levels differed significantly between the relapsing and non-relapsing groups. Total cholesterol showed no significant difference (p=0.164). The mean albumin level was significantly lower in the relapsing group (2.9 g/dL vs. 4.1 g/dL; p<0.001). A significant negative correlation was found between albumin and triglyceride levels (r=-0.326; p=0.008). Triglyceride, LDL, and HDL levels are significantly associated with relapse in pediatric nephrotic syndrome. Hypoalbuminemia is also an important risk factor. Lipid profile evaluation can serve as a useful indicator in monitoring and managing relapses.
The Effect of Glucocorticoids on Bone Profile in Pediatric Acute Lymphoblastic Leukemia Pramulya Prajogo; Bidasari Lubis; Siska Mayasari Lubis; Isti Ilmiati Fujiati; Tiangsa Sembiring; Hafaz Zakky Abdillah
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.229

Abstract

Glucocorticoids are essential in treating acute lymphoblastic leukemia (ALL) but may disrupt bone metabolism, affecting calcium, magnesium, phosphate, and alkaline phosphatase levels. This cross-sectional study enrolled 30 children ≤18 years with ALL at Adam Malik Hospital, Medan, during April–May 2025 using consecutive sampling. All had received at least one week of glucocorticoid therapy and had complete bone profile data. Data were obtained from medical records and laboratory tests. Associations were analyzed using Spearman’s correlation, Mann-Whitney test, and multiple linear regression. Most patients were male (53.3%) and classified as high-risk (60%), with 60% receiving dexamethasone for a median of 7 weeks. Calcium, phosphate, and alkaline phosphatase levels were generally within the normal range, but 50% of patients developed hypermagnesemia. Magnesium levels were significantly associated with the type of glucocorticoid (p=0.010), treatment duration (p=0.014), and age at diagnosis (p=0.006). No significant associations were found between glucocorticoid duration and calcium, phosphate, or alkaline phosphatase levels. Magnesium levels are influenced by glucocorticoid type, treatment duration, and age at diagnosis. Further studies with larger samples and additional biomarkers are needed to comprehensively understand the effects of glucocorticoids on the bone profile of children.
Co-Authors Adawiyah, Varihatul Alona, Ivana Arlinda Sari Wahyuni Armyn Nurdin Bidasari Lubis Cynthea Prima Dalimunthe, Naomi Niari Des Suryani Desi Isnayanti Dessy Dian Antarini Destariani, Cynthea Prima Dimyati, Yazid Elisabeth Elisabeth ELMAN BOY Erlinda Sari Pasaribu Fachrezi, Muhammad Alfian Faradila, Devita FARIDA UTAMI SIREGAR Faza Ulya Putri FIRDAUS ROSA Ginting, Andi Raga Gultom, Dapot Parulian Hafaz Zakky Abdillah Harahap, Juliandi Hendri Wijaya, Hendri Juliandi Harahap Kiking Ritarwan Kristina Ambarita Lily MAULIDA SHAFI Melda Deliana Munar Lubis Munthe, Imas Putri Mustafa Mahmud Amin Nababan, Windika Nasution, Siti Saidah Nelly Rosdiana Nst, Muhammad Solih Nursodik, Muhammad Nurul Riani Siregar Oke Rina Ramayani Panjaitan, Alfred Johnatan Pramulya Prajogo Purwoningsih, Emni Putri Chairani Eyanoer, Putri Chairani Putri Hasria Sri Murni Rafita Ramayati Ratih Yulistika Utami Ribawanto, Muhammad Rafif Rina Amelia Risqin, Muhammad Anas Fatah Rosmayanti Syafriani Siregar Rusda, Muhammad Rusdidjas Rusdidjas Salsabila, Anisa Sari, Farida Linda Satria, Fauzi Budi Sekali, Oktaviani Karo Sirait, Asima Rodiarta Siregar, Gurnal Rai Gandra Siska Mayasari Lubis Siti Zahara Nasution, Siti Zahara Syamsidah Lubis Tanjung, Riswani Tiangsa Sembiring Tjay Tan Tumanggor, Rustiana Ulfah Hidayah Almadany Utari Olivina Tarigan Wahyuni, Arlinda Sari Yunanda, Yuki