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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Riset Kimia CHEMPUBLISH JOURNAL Medical Laboratory Technology Journal Jurnal Penelitian Farmasi Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON JFL : Jurnal Farmasi Lampung Jurnal Ilmu Kefarmasian Indonesia Jurnal Midpro Jurnal Ilmiah Farmako Bahari Jurnal Farmasi Sains dan Praktis BATOBO: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Jurnal Bakti Nusantara Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal Of Pharmacy
Rahma Dona
Sekolah Tinggi Ilmu Farmasi Riau
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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The Isolatıon, Characterızatıon, and Antıfungal Assay of Lactıc Acıd Bacterıa Isolated from Green Glutınous Rıce Tape Agaınst Aspergillus flavus Nasution, Musyirna Rahmah; Aulya, Nurliza; Dona, Rahma; Ningsih, Yozi Fiedya
Medical Laboratory Technology Journal Vol. 11 No. 1 (2025): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i1.645

Abstract

Green glutinous rice tape is a fermented food made from glutinous rice, katuk leaves (Sauropus androgynus), and yeast, originating from Tembilahan, Riau Province. This product can serve as a source of lactic acid bacteria (LAB) capable of producing antimicrobial compounds to inhibit pathogenic microorganisms, including Aspergillus flavus, a well-known spoilage fungus in food products. However, to date, no reports have explored the ability of LAB from green glutinous rice tape to inhibit the growth of Aspergillus flavus. This study aimed to isolate LAB from green glutinous rice tape, conduct macroscopic, microscopic, and biochemical characterizations, and evaluate the antifungal activity of the LAB isolates against Aspergillus flavus using the good diffusion method. The isolation process yielded four LAB isolates from Tembilahan green tape (TKHT-2, TKHT-3, TKHT-5, and TKHT-7), which were identified as members of the genus Lactobacillus sp., with antifungal activities of 25.50 ± 5.78 mm, 24.33 ± 0.62 mm, 22.16 ± 6.56 mm, and 18.66 ± 4.28 mm, respectively. The corresponding cell-free supernatants (CFS) from these isolates (TKHT-S2, TKHT-S3, TKHT-S5, and TKHT-S7) also demonstrated antifungal activity with inhibition zones of 19.83 ± 3.47 mm, 19.83 ± 4.24 mm, and 14.50 ± 3.26 mm, respectively. LAB cells and their cell-free supernatants partially inhibited Aspergillus flavus, indicating a fungistatic effect. These findings suggest the potential application of LAB from green glutinous rice tape as a natural preservative or antifungal agent in food products.
Penyuluhan Pentingnya Pengetahuan Menjaga Kesehatan Ginjal Masyarakat di Stadion Utama Riau Novita, Gressy; utari, Mayang; Octaviani, Melzi; Dona, Rahma; Anggraeni, Silvana; Kasnaidi, Ahmad Faisal; Jonang, Aqila Rifdah; Khairiah, Kinanti Bahy; Sasnita, Nadya Ayu; Novita, Nova; Sari, Novita; Rizki Annisa A; Septiani Nindia Putri; Suci Anggela Soraya
Jurnal Bakti Nusantara Vol. 2 No. 3 (2025): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v2i3.87

Abstract

Penyakit ginjal merupakan salah satu masalah kesehatan global yang semakin meningkat prevalensinya. Penyakit ginjal kronik menempati urutan ke-12 sebagai penyebab kematian tertinggi di dunia, dengan tren peningkatan setiap tahunnya. Di Indonesia, prevalensi penyakit ginjal kronis mencapai 0,38%, namun diperkirakan angka sebenarnya lebih tinggi mengingat banyak kasus tidak terdeteksi pada tahap awal. Penyebab dari meningkatnya angka penderita penyakit ginjal di Indonesia adalah karena pola hidup yang tidak sehat, kurangnya pengetahuan dan terbatasnya akses informasi tentang cara mencegah penyakit ginjal. Pengabdian masyarakat ini bertujuan untuk mengedukasi masyarakat tentang kesehatan ginjal dan cara pencegahannya. Metode yang digunakan adalah penyuluhan secara langsung menggunakan media leaflet dan diskusi. Materi edukasi adalah mengenai kesehatan ginjal, mulai dari cara menjaga kesehatan ginjal, mengetahui gejala dan faktor resiko penyebab penyakit ginjal tersebut. Evaluasi kegiatan dilakukan dengan memberikan tes awal dan tes akhir. Berdasarkan hasil pretes dan postes dapat disimpulkan bahwa terdapat pengaruh pemberian penyuluhan secara langsung menggunakan media leaflet terhadap pengetahuan masyarakat di Stadion Utama Riau. Hal ini dapat dilihat pada uji Wilcoxon pada skor pretest dan posttest yaitu dengan nilai p value 0,000 (p<0,05). Melalui pengabdian ini, diharapkan masyarakat dapat lebih memahami pentingnya menjaga kesehatan ginjal serta mengubah pola hidup mereka menjadi lebih sehat. Pada akhirnya, seiring dengan meningkatnya pengetahuan masyarakat, maka diharapkan terjadi penurunan angka penderita penyakit ginjal di Indonesia.
Cytotoxic Activity Testing The Extract of Leaves and Yellow Sirsak Fruit (Annona montana) using Method Brine Shrimp Lethality Test (BSLT) Rahmawati, Noveri; Hari, Dewi Gulyla; Tri Nova Lovena; Nurdina Putri; Rahma Dona; Rahma Cintya Faiza; Amini, Rahmi
The Journal Of Pharmacy Vol. 2 No. 2 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The yellow sirsak plant (Annona montana) is an annonaceae family which has been used by the community as traditional medicine properties such as treating diarrhea, vitamin C deficiency and treating boils. This study aims to determine the cytotoxic activity of the larvae of Artemia salina Leach shrimp by using the BSLT method after giving extracts from the leaves and fruit of yellow sirsak (Annona montana). The results showed that the LC50 value of the n- hexane extract of yellow sirsak leaves was 45,84 µg/mL, the ethyl acetate extract of yellow sirsak leaves was 26,44 µg/mL and the ethanol extract of yellow sirsak leaves was 13,99 µg/mL. The n-hexane extract of yellow sirsak fruit was 31,46 µg/mL, the ethyl acetate extract was 40,45 µg/mL and the ethanol extract of the yellow sirsak fruit was 19,84 µg/mL. The mixture of n-hexane leaves and yellow sirsak fruit was 29,91 µg/mL, the ethyl acetate extract mixture of yellow sirsak leaves and fruit was 21,71 µg/mL and the mixture of ethanol extract and yellow sirsak fruit was 14,75 µg/mL. Based on the research results, it can be concluded that the ethanol extract of yellow sirsak leaves shows the most active cytotoxic activity with an LC50 value of 13,99 µg/mL.
Molecular Docking Study of Chalcone Analogue Compounds with Hydroxy and Methoxy Subtituents as Bcl-2 Inhibitors Frimayanti, Neni; Dona, Rahma; Solihin, Tabah
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.17487

Abstract

Molecular docking study of 6 chalcone analogues with protein target from the crystallographic structure modeling of Bcl-2 protein with PDB code 2W3L was carried out using computational media using the Molecular Operating Environment (MOE) program. The aim of this study is to determine the potentiality of the 6 chalcone analogue compounds as Bcl-2 inhibitors using molecular docking studies. In this study, venetoclax was used as positive control. Based on docking results, binding free energy was used as information to know which wheather chalcone analogue compounds are active or not as Bcl-2 inhibitors. According to the docking results that have been carried out, it showed that the 6 chalcone analogue compounds have no potential as Bcl-2 inhibitors. Due to the superimposition of the 6 compounds that did not stick to the positive control and most importantly the binding free energy values ​​(S) of the 6 chalcone analogue compounds were higher than the binding free energy values ​​of the positive control (Venetoclax).
Potensi Aktivitas Antimalaria Residu Hidrodestilasi Kulit Kayu Manis (Cinnamomum Burmanii) Melalui Penghambatan Polimerisasi Heme Dona, Rahma; Almurdani , M; Rivan , M; Ibad, M Zainul; Syafitri, Ikke Juwita; Azizah, Wahyu; Nur, Siti Rahmatun; Lestari, Putri
Jurnal Riset Kimia Vol. 15 No. 2 (2024): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v15i2.711

Abstract

Cinnamon (Cinnamomum burmanii) is a herbal plant from Indonesia which is widely used in cooking, cosmetics and medicine. Cinnamon bark isolate is thought to contain compounds with the structure of isoquinoline which are known to be used as antimalarials. The aim of this study was to examine the potential antimalarial activity of extracts and fractions of cinnamon bark hydrodistillation residue based on the % inhibition and IC50 value. These results will also be compared with extracts and fractions of cinnamon bark without hydrodistillation as controls. The test method is carried out in vitro by heme polymerization inhibitor. The test results showed that the n-hexane fraction, DCM fraction did not have inhibitory activity, while the ethyl acetate fraction had better potential than other extracts and fractions, where the ethyl acetate fraction after hydrodistillation (residue) had an IC50 value of 71.84 µg/mL, while the ethyl acetate fraction without hydrodistillation (control) had an IC50 value of 120.05 µg/mL. This result is better than hydroxychloroquine as positive control which has an IC50 value of 184.98 µg/mL. These results indicate that the ethyl acetate fraction from the hydrodistillation residue of cinnamon bark can be utilized and has potential as an antimalarial.
Edukasi Cara Identifikasi Boraks Pada Bakso Menggunakan Sari Bunga Telang (Clitoria ternatea L.) Di Desa Sungai Pinang Neni Frimayanti; Emma Susanti; Rahma Dona; Larasati Arsad; Rizda Fitriani; Fharisti Kirana; Della Vasmawati; R. Rizatita Fitriani; Kiranti Azlin; Kolista Sisilawati; Salsabila alhamdania Balqis; Raja adli husin; Salsabila Zahirah Ananda; Selvi Aulia Wibowo; Denisya amanda; Fadiyah Yueflen; Ramanda safitri
BATOBO: Jurnal Pengabdian Kepada Masyarakat Vol 1 No 2: BATOBO: Desember 2023
Publisher : Jurusan Teknik Elektro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/batobo.1.2.49-55

Abstract

Pengabdian kepada masyarakat ini dilaksanakan di Desa Sungai Pinang, Kecamatan Tambang, Kabupaten Kampar, Provinsi Riau dengan sasarannya masyarakat yang ada di desa tersebut. Pengabdian ini bertujuan agar masyarakat dapat mengetahui dan memahami identifikasi boraks pada makanan terutama bakso dengan penambahan boraks menggunakan sari bunga telang (Clitoria ternatea L) sebagai indikator alami. Diharapkan kepada masyarakat dapat melakukan identifikasi boraks secara mandiri sebagai bentuk kewaspadaan terhadap makanan yang belum diketahui keamanannya. Selain itu agar masyarakat dapat memahami perbedaan antara bakso yang baik (non boraks) dengan bakso yang sudah terpapar boraks. Pengabdian ini dilaksanakan pada 3 Agustus 2023 dan diikuti oleh 40 masyarakat desa. Bentuk kegiatan berupa edukasi melalui penyuluhan dan penampilan video yang menunjukkan langkah-langkah dalam mengidentifikasi boraks pada bakso menggunakan sari bunga telang sebagai indikator. Adapun untuk mengetahui tingkat pengetahuan masyarakat desa maka dilakukan pemberian kuisioner pre-test dan post-test. Hasil didapatkan bahwa kegiatan pengabdian masyarakat oleh Sekolah Tinggi Ilmu Farmasi Riau berjalan dengan baik karena adanya peningkatan pengetahuan masyarakat sesudah penyuluhan dibandingkan sebelum penyuluhan.
Uji Validasi Metode Penetapan Kadar Ibuprofen dalam Sediaan Tablet dengan Nama Dagang dan Generik Secara Spektrofotometri UV Wirda Tulljannah; Rahma Dona; Tilar Eka Widia Ningrum; Meiriza Djohari
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5247

Abstract

This study aims to determine the levels of ibuprofen in tablet preparations using the UV spectrophotometric method and determine the suitability of ibuprofen tablets with trade and generic names that meet the requirements according to the Indonesian Pharmacopoeia Edition VI. The determination of ibuprofen levels in tablet preparations was tested for validity based on linearity, limit of detection (LOD) and limit of quantitation (LOQ) parameters, accuracy with the spiked-placebo recovery method and precision. Based on the results obtained linearity value of r = 0.9993 with limit of detection (LOD) 0.2825 ppm and limit of quantitation (LOQ) 0.9418 ppm, accuracy obtained at 3 concentrations of 8, 10 and 12 ppm respectively 99.59%; 99.29%; and 99.99% and on precision obtained RSD results of 0.77%; 0.49%; 1.48%. The results of the determination of levels in the four samples of generic tablet preparations and trade names are 100.91%; 104.02%; 100.91%; and 100.99%. From the results of the study, it is concluded that the UV spectrophotometric method used has met the parameters set in the validation test and the ibuprofen levels obtained also meet the requirements set in the Indonesian Pharmacopoeia VI Edition, which is not less than 90% and not more than 110%.
Sintesis dan Karakterisasi Senyawa 4'-Aminokalkon dengan Metode Pengadukan dan Refluks Termodifikasi Rahma Dona; Enda Mora; Nurul Huda
JURNAL FARMASI DAN MAKANAN Vol 9 No 1 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i1.6559

Abstract

Chalcone is a secondary metabolite belonging to the minor group of flavonoids which has various biological activities. Several chalcone derivatives with amino groups attached to their rings have anti-inflammatory, antibacterial, antitumor and antimalarial activities. However, because the amount is limited, the percentage in plants is small, and the structural variations are relatively small, it needs to be synthesized in the laboratory. This study aims to compare the results of the synthesis of 4'-aminochalcone compounds using the stirrer method at room temperature and modified reflux at an increased temperature. Synthesis using the stirrer method was carried out for 4 hours at room temperature with NaOH 40% as catalyst, while synthesis using the modified reflux method was carried out using a monowave-50 for 11 minutes at a temperature of 80oC with the same catalyst. The molecular structures of the synthesized compound were confirmed by UV spectroscopy, FT-IR, and 1H-NMR spectral data. Based on this study results, it was found that the synthesis of 4'-aminochalcone compounds using the stirrer method had better results compared to the modified reflux method. The 4'-aminochalcone compound using the stirrer method had a pure compound yield of 47.36%, while the 4'-aminochalcone compound using the modified reflux method had an impure yield of 2.57%. Characterization using UV spectroscopy, FT-IR, and 1H-NMR shows that the synthesis results match the structure of the target molecule.
Synthesis and In Vitro Antimalarial Activity of Amino Chalcone Derivatives Compounds Through Inhibition of Heme Polymerization Rahma Dona; Jasril; Rudi Hendra; Neni Frimayanti
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.127-135.2024

Abstract

This study aims to investigate the potential of chalcone derivatives as antimalarial agents. The structure of the  chalcone derivatives was designed by inserting amino substituents on acetophenone and methoxy variants on benzaldehyde to  produce three amino chalcone derivatives (C1, C2, and C3). The synthesis was carried out by carrying out the Claisen-Schmidt  condensation reaction with NaOH 40% as catalyst, resulting in compound yields ranging from 66% - 83%. The structure of the  three compounds was determined by FTIR, MS, and 1H-NMR spectroscopy techniques, which confirmed that the compounds  had structures that were in line with the desired molecular structure. The antimalarial activity test was carried out by inhibiting  the heme polymerization process into hemozoin (β-hematin) using hydroxychloroquine sulfate as a positive control. Absorption  measurements were carried out at two different wavelengths, namely 415 nm and 630 nm. The results of the IC50 antimalarial  activity of the three compounds (C1, C2, C3) were obtained respectively at 227.61; 115.18; 260.01 µg/mL and positive control of  184.98 µg/mL. From these results, it was found that compound C2 showed better antimalarial activity compared to the other two  compounds and positive control.
HERBAL MEETS STEVIA: MINUMAN HERBAL STEVIA, MANIS SEHAT TANPA KOMPROMI Ratna Sari Dewi; Mira Febrina; Rahma Dona; Frans Timanta Ginting; Nur Suci Safitri; Nurul Huda; Puji Kurniawati; Putri Dewica; Putri Johanda; Rahidatul ‘Aisy; Rahmi Luffia Rezki; Raysa Afma Dewiputri; Rizka Aulia Nissa
BESIRU : Jurnal Pengabdian Masyarakat Vol. 3 No. 5 (2026): BESIRU : Jurnal Pengabdian Masyarakat, Mei 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v3i5.2529

Abstract

Prevalensi diabetes melitus tipe 2 terus meningkat akibat tingginya konsumsi gula. Penderita sering kesulitan mengontrol kadar glukosa darah karena kebiasaan mengonsumsi makanan dan minuman manis. Stevia sebagai pemanis alami rendah indeks glikemik dan bebas kalori berpotensi menjadi alternatif yang lebih sehat. Kegiatan pengabdian ini bertujuan memperkenalkan stevia dalam minuman herbal untuk mendukung gaya hidup sehat dan pencegahan diabetes. Metode meliputi sosialisasi, pelatihan melalui leaflet, penerapan teknologi sederhana, serta evaluasi dengan pre-test dan post-test. Peserta juga diberikan sampel minuman herbal dengan dan tanpa stevia. Hasil menunjukkan peningkatan pengetahuan masyarakat dari 50–58% menjadi 82–100%. Edukasi terbukti efektif meningkatkan kesadaran akan bahaya konsumsi gula berlebih dan manfaat stevia, serta mendorong minat konsumsi minuman herbal sehat. Penggunaan stevia berpotensi membantu pengendalian gula darah dan pencegahan penyakit degeneratif.
Co-Authors Abdi Wira Septama Abdi Wira Septama Adel Zamri Adel Zamri Adel Zamri Adel Zamri agistia, nesa Ainun Alfatma Almurdani , M Amini, Rahmi Anggraeni, Silvana Armon Fernando Aulya, Nurliza Azizah, Wahyu Benni Iskandar Della Vasmawati Denisya amanda Dwi Andreyas Emrizal Enda Mora Enda Mora Fadiyah Yueflen Fharisti Kirana Fikri Maulana Fikri Maulana, Fikri Fina Aryani, Fina Frans Timanta Ginting Furi, Mustika Gressy Novita Haiyul Fadhli Hari, Dewi Gulyla Husnawati Ibad, M Zainul Ihsan Ikhtiarudin Jasril Jasril Jasril Jonang, Aqila Rifdah Kasnaidi, Ahmad Faisal Khairiah, Kinanti Bahy Kiranti Azlin Kolista Sisilawati Laela Hayu Nurani Larasati Arsad Meiriza Djohari, Meiriza Melzi Octaviani Milianty, Jesy Mira Febrina Musyirna Rahmah Nst Muthui’ah Muthui’ah Nahdiah Nahdiah Nahdiah Nahdiah, Nahdiah Nanik Sulistyani Neni Frimayanti Ningrum, Tilar Eka Widia Ningsih, Yozi Fiedya Nofriyanti Nova Novita Nova Tantri Silalahi Noveri Rahmawati Novita Sari Nur Suci Safitri Nur, Siti Rahmatun Nurdina Putri Nurul Huda Nurul Huda Nurul Susianti Puji Kurniawati Putri Dewica Putri Johanda Putri Lestari, Putri R. Rizatita Fitriani Rahayu Utami Rahayu Utami Rahidatul ‘Aisy Rahma Cintya Faiza Rahmi Luffia Rezki Raja adli husin Ramanda safitri Ratna Sari Dewi Raysa Afma Dewiputri Rivan , M Rizda Fitriani Rizka Aulia Nissa Rizki Annisa A Rosnita Dewi Rahmawati Rudi Hendra Salsabila alhamdania Balqis Salsabila Zahirah Ananda Sasnita, Nadya Ayu Selvi Aulia Wibowo Selvia Selvia Septi Muharni Septiani Nindia Putri Silalahi, Nova Tantri Sinata, Novia Solihin, Tabah Suci Anggela Soraya Syafitri, Ikke Juwita Syahbandi, Ilham Tilar Eka Widia Ningrum Tri Nova Lovena Tyasakti Viryana utari, Mayang Vincent Tristan Winda Tria Safitri Wira Noviana, Wira Noviana Wirda Tulljannah YANTO YANTO