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All Journal Biota International Journal of Applied Biology Civil Engineering Journal Meditory : The Journal of Medical Laboratory Bioma : Jurnal Biologi dan Pembelajaran Biologi Jurnal Kreativitas PKM Cendekia : Jurnal Pengabdian Masyarakat Medicra (Journal of Medical Laboratory Science/Technology) JURNAL BIOSHELL Mitra Mahajana: Jurnal Pengabdian Masyarakat Journal of Multidisciplinary Applied Natural Science Jurnal Pengabdian Masyarakat (ABDIRA) Envirotek : Jurnal Ilmiah Teknik Lingkungan Biology Natural Resources Journal Journal of Natural Sciences and Learning PENITI BANGSA (Pemanfaatan Ilmu Pengetahuan dan Teknologi bagi Masyarakat) Journal of Biotropical Research and Nature Technology Metamorfosa: Journal of Biological Science Open Access DRIVERset
Kristianto, Sonny
Forensic Science, Postgraduate School, Airlangga University. Human Genetics Laboratory, Institute Of Tropical Disease, Airlangga University
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Journal of Multidisciplinary Applied Natural Science

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Modification of the QuEChERS Method for Drug Analysis in Biological Sample: A Review Rivai, Sitty Nurqomariah; Kristianto, Sonny; Putri, Rury Eryna; Fatiqin, Awalul; Abidin, Mohamad Hamdi Zainal
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.261

Abstract

Drug analysis in biological samples remains a significant challenge due to the complex matrix composition that can interfere with extraction and detection processes. The QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) method, initially developed for pesticide residue analysis, has been increasingly adapted for forensic toxicology, particularly in drug extraction from biological matrices. This review explores various modifications of the QuEChERS method applied to blood, urine, and liver samples, focusing on the effectiveness of different solvents, buffer salts, and sorbents in enhancing extraction efficiency. Furthermore, it highlights current challenges such as matrix effects and the critical importance of method validation to ensure reliability and reproducibility. By analyzing recent developments and trends in QuEChERS applications, this review offers valuable insights into optimizing extraction protocols for forensic purposes. The findings aim to support the advancement of more efficient, robust, and accessible analytical techniques in forensic toxicology, ultimately contributing to more accurate and reliable drug detection in complex biological samples.
Co-Authors Abid, Istiana Firqah Abidin, Mohamad Hamdi Zainal Adi Purnama Aditya Prana Iswara Afdhila, Zakia Agustini, Putu Ajeng Ahmad Yudianto Aidil Candri, Dining Aini, Anggun Qurrota ANGGITA SHAFIRA RIZKY Anis Rosalita Annisa Rahmawati Aprilia, Chatrina Aprilia, Maya Apriliani, Herlina Atta Ullah Khan Aulia Istiqomah, Dian Budiarti Utami Putri, Luckita Chairunnisa, Nadda Khalila Chamidah, Dina Chatarina Eka Berliyanti Putri Danar, Danar DANI FIRMANSYAH Deni Wahyudiarto Difa Putri Miarta Elpira, Ririn Fatiqin, Awalul Halimatus sa'diyah Hargono , Arief Hendro Pramono Huda, Qurrota A’yunil Imoliana, Wilhelmina Tania Indah Budhy, Theresia Indah Nuraini Masjkur Kumalasari, Nurul Chamidah Kurniasari, Paramita Tri Maharani, Norika Aurelia Marmi Marmi Marmi Marmi Marmi, Marmi Masruroh, Heni Minan Zuhri, Fu’ad Moh. Awaludin Adam Ni Luh Ayu Megasari NI'MATUR ROHMA Oedjijono Oedjijono, Oedjijono Pramita Laksitarahmi Isrianto Prayogo, Wisnu PRESTIANI PRESTIANI Putri, Rury Erina Qalbani Putri, Ardhanita Rahma Diyan Martha Rahmadani, Anindita Mutiara Rayditya Milanio, Roderikus Ripki, Nadia Rivai, Sitty Nurqomariah Rury Eryna Putri Sandhi, Dyan Vicky Selly Tria Amanda Setianingsih, Indri Setiawardani, Alvina Shella Ramadhanty, Erlinda Shofi Talbia, Husna SITI AINUNA ROHMA Sukian Wilujeng Sukian Wilujeng Sunaryo Sunaryo Sunaryo Sunaryo Sunaryo Sunaryo Sunaryo Tsaqifah, Fauziyyah Hanin Tuti Mutia Uktutias, Sendy Ayu Mitra ul Haq, Ihtisham Unsunnidhal, Lalu ur Rahman, Anees Ur Rahman, Ateeq Wilujeng, Sukian Wimbuh Tri Widodo Wimbuh Tri Widodo Yudianto , Ahmad Yuliani, Gandul Atik Zulqaida, Salma