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All Journal Jurnal Natur Indonesia Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Ilmiah Pertanian Jurnal Pengabdian UntukMu NegeRI Jurnal Gizi Klinik Indonesia Jurnal Kedokteran dan Kesehatan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Acta Chimica Asiana Unri Conference Series: Community Engagement Jurnal Katalisator Biomedika Media Penelitian dan Pengembangan Kesehatan
Ismawati ismawati
Universitas Riau
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Biomedika

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EFFECT OF INULIN EXTRACT FROM DAHLIA TUBER (dahlia variabilis) ON CORONARY ARTERY HISTOPATHOLOGY IN RATS WITH TYPE 2 DIABETES MELLITUS (DM) Hopi, Zikrilla mayuli; Ismawati, Ismawati; Saryono, Saryono; Romus, Ilhami; Putri, Veni Dayu; Yanti, Sri; Dyna, Fitri
Biomedika Vol 17, No 2 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.3734

Abstract

Atherosclerosis in diabetes mellitus (DM) patients is prevented by using inulin to increase glucose metabolism and reduce cholesterol synthesis. Therefore, this research aimed to analyze dahlia tuber inulin extract to determine the effect on coronary artery histopathology in type 2 DM rats. A total of 20 male Wistar rats were divided into five groups, namely negative control without treatment, DM, DM + 0.5 mg/gBW/day inulin extract, DM + 1 mg/gBW/day inulin extract, and DM + 1.5 mg/gBW/day inulin extract. Furthermore, DM induction was carried out by administering 60 mg/kgBB streptozotocin and 120 mg/kgBB nicotinamide. The results of coronary artery histopathology readings showed that the highest and lowest scores of atherosclerosis were in Groups II (0,91±0,17) and V (0,08±0,1), respectively. Data analysis using Kruskal Wallis test reported significant results (p<0.05), while Mann-Whitney test showed differences between control and DM, DM, and inulin groups (III, IV, V). In this context, the administration of dahlia tuber inulin extract to rats induced by Type 2 DM prevented atherosclerosis in histopathological image of coronary artery.
EFFECT OF DAHLIA TUBER INULIN EXTRACT ON THE THICKNESS OF THE THORACIC AORTIC TUNICA INTIMA-MEDIA IN TYPE 2 DIABETIC RATS MODEL Natswa Deanra, Cantika; Ismawati, Ismawati; Saryono, Saryono; Juananda, Desby; Anggraini, Suci; Agung S, Timotius; Dayu Putri, Veni; Yanti, Sri; Dyna, Fitri
Biomedika Vol 18, No 1 (2026): Biomedika February 2026
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Inulin is a natural polysaccharide that improves glucose metabolism and reduces cholesterol levels through the formation of short-chain fatty acids, which may contribute to preventing atherosclerosis in type 2 diabetes mellitus (T2DM). Therefore, this study aimed to evaluate the effect of dahlia tuber inulin extract on the thickness of the thoracic aortic tunica intima-media (TIM) in T2DM-induced rats. A total of 20 male Wistar rats were divided into five groups: control, T2DM, T2DM + 0.5 mg/gBW/day inulin extract, T2DM + 1.0 mg/gBW/day inulin extract, and T2DM + 1.5 mg/gBW/day inulin extract. T2DM induction was performed using 60 mg/kgBW streptozotocin and 120 mg/kgBW nicotinamide. Measurement of TIM thickness was conducted using a Leica light microscope with hematoxylin-eosin staining. The results showed no statistically significant differences among the groups (p = 0.051), although a decreasing trend in TIM thickness was observed at the 1.5 mg/gBW/day dose. In this context, dahlia tuber inulin extract demonstrated a tendency to reduce TIM thickness in T2DM-induced rats.
Co-Authors Adinda Aisyah Afifah Ramadhani Agung S, Timotius Angel Chen Anggraini, Suci Ardhi, Aulia Arfianti Arfianti Ariqa Rahma Abdullah Ariza Julia Paulina Dayu Putri, Veni Deanra, Cantika Natswa Desby Juananda, Desby Dhea Ayu Kartini Surya Putri Dyna, Fitri Dyna, Fitri Effendi, Fallgivando Elfima Aditya Utami Enikarmila Asni Enikarmila Asni Erwin Christianto Esy Maryanti Hopi, Zikrilla mayuli Ilhami Romus Ilhami Romus Ilhami Romus Ilhami Romus, Ilhami Imelda Tresia Pardede Indah Putri Arwandi Irfani Dhia Rafif Isnani Kurniyanti Kesya, Lunari Ligat Pribadi Sembiring Lovenia, Nia Lusi Yusrenti Luthfianty, Elfiah M Derillovyandra Dwi Anugrah M Yulis Hamidy Mifta Zahira Muhammad Fadhillah Arif Mukhyarjon Nabella Suraya Natswa Deanra, Cantika Nazla Hafizah NOVA WAHYU PRATIWI, NOVA WAHYU Noviardi Noviardi, Noviardi Nurafriza, Widya Nurfi Pratiwi, Nurfi Permatasari, Nopi Putra, Amrullah Syah Qryoga Irsyad Reyen Raissa Maharani Putik Kusuma Rijalun Arridho Salsabila Nurul Wildani Hasibuan Salsabila, Dinda Saputra, Nicko Pisceski Kusika Saryono Saryono Saryono Saryono Saryono Saryono Sasmita, Ellen Rosyelina Sera Faren Silvera Devi Sonia Dinda Paramitha Sri Yanti Sri Yanti suraya, nabella Timotius Agung Soripada Titania Tjandrawati Nugroho Veni Dayu Putri Veni Dayu Putri Winarto Winarto Yuhendri, Vitriyanna Mutiara