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All Journal Buletin Peternakan Jurnal Kedokteran Syiah Kuala Jurnal Kedokteran Diponegoro Berkala Ilmu Kesehatan Kulit dan Kelamin ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Keperawatan
Afif Nurul Hidayati
Departemen/ Staf Medik Fungsional Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Airlangga / Rumah Sakit Umum Daerah Dr. Soetomo Surabaya Rumah Sakit Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Renal Dose Adjustment Management for Herpes Zoster in Immunocompromised Patient with Renal Impairment: A Case Report and Literature Review Hapsari Kinanti; Hasnikmah Mappamasing; Trisiswati Indranarum; Medhi Denisa Alinda; Linda Astari; Afif Nurul Hidayati
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 2 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i2.48430

Abstract

  Background: Herpes zoster is a reactivation of varicella-zoster virus that is characterized by a painful dermatomal vesicle eruption. Herpes zoster can bring several burdens including a painful rash and complications such as herpetic neuralgia and other neurological disorder. Herpes zoster commonly affects persons with decreased immunity levels which can caused by several conditions including malignancy. Multiple myeloma is one of the haematological malignancies commonly associated with renal impairments. Acyclovir is excreted in an unchanged form through renal, thus in patients with renal impairment could decrease the excretion level and can increase the possibility of renal toxicity. Case Presentation: We present a case report of a 46-year-old herpes zoster patient with multiple myeloma and renal impairment. The renal dose adjustment for acyclovir was done in this patient becomes 800mg three times daily. One week after the administration of acyclovir this patient showed remarkable results, there was no new lesion was found. This patient resolved after 10 days of renal dose adjustment of oral acyclovir and continued the multiple myeloma treatment on day fourteen. Conclusion: The management of herpes zoster infection in a patient with multiple myeloma commonly accompanies with renal impairment thus the consideration of adjusting the dose for renal impaired condition is important to reduce the possibility of renal toxicity in concordance with maintaining its adequate dose to prevent the possibility of complication
Co-Authors Alfrid Asditya Alpha Fardah Athiyyah Amanda Gracia Manuputty Anang Endaryanto Annisa Fitriana Aprilawati, Dwi Arisia Fadila As'ad Naufal Astindari Astindari Astindari Budi Utomo Budi Utomo Budi Utomo BUDI UTOMO Budiono Budiono Chesia Christiani Liuwan Cita Rosita Sigit Prakoeswa Cut Shelma Maharani Damayanti Damayanti Damayanti Deasy Fetarayani Desiana Widityaning Sari Diah Mira Indaramaya Diah Mira Indramaya Dias Lidiana A.S Dwi Murtiastutik Dyah Ayu Pitasari Dyatiara Devy Rahadiyanti Efenina Ginting Emma Hidayati Sasmito Erwin Astha Triyono Evy Ervianti Fadila, Arisia Fatimah, Nurmawati Fikri Ardhani Hapsari Kinanti Hari Sukanto, Hari Hasnikmah Mappamasing I G.A. Kencana Wulan Icha Aisyah Indah Purnamasari Indah Purnamasari INDROPO AGUSNI Ingrid Suryanti Suryono Isaak Effendy Isaak Effendy Iskandar Zulkarnain Iskandar Zulkarnain Kristina Sihaloho KUSUMASTUTI, ETTY HARY laissa Bonita Linda Astari, Linda M. Yulianto Listiawan Maylita Sari Medhi Denisa Alinda, Medhi Denisa Melida Agustina Nurina Hasanatuludhhiyah Pepy Dwi Endraswari, Pepy Dwi Pramita Ariyanti Priangga Adi Wiratama Rahmadewi Rahmadewi Rahmadewi Renata Prameswari Retha Retha Ridha Ramadina Widiatma Saut Sahat Pohan Sawitri Sawitri Sawitri Sawitri Sawitri Senda Sulvain Rahmaningrat Septiana Widyantari Shinta Dewi Rahmadhani Sigit Eko Prabowo Siti Isrina Oktavia Salasia Sudjarwo Sunarso Suyoso Trisiswati Indranarum Wahyunita Desi Ratnaningtyas Wardiana, Maya Widodo J. Pudjirahardjo William Andrew Isaac Windhu Purnomo Wisnu Triadi Nugroho Yuri Widia, Yuri