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All Journal Buletin Peternakan Jurnal Kedokteran Syiah Kuala Berkala Ilmu Kesehatan Kulit dan Kelamin ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Keperawatan
Afif Nurul Hidayati
Departemen/ Staf Medik Fungsional Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Airlangga / Rumah Sakit Umum Daerah Dr. Soetomo Surabaya Rumah Sakit Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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The Difference of Serum Vitamin E Levels between Adolescent Patients with and without Acne Vulgaris Wahyunita Desi Ratnaningtyas; Sawitri Sawitri; Dwi Murtiastutik; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.40-47

Abstract

Background: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit, particularly among adolescents. The pathogenesis of AV is multifactorial, developing research studies  the role of free radicals and antioxidants imbalance that cause oxidative stress in AV. The main antioxidant found in the skin is vitamin E, which functions as a protector against lipid peroxide. Purpose: To compare serum vitamin E levels in adolescents with AV and healthy adolescents without AV (controls). Methods: This is a cross-sectional observational analytic study that involved 17 adolescents with AV and 17 controls in Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Academic Hospital Surabaya. The subjects have met the inclusion and exclusion criterias. Result: The mean of vitamin E level in adolescent patients with AV was 7.8 ± 1.07 mg/mL and 10 ± 1.06 mg/mL in controls with the p-value in this study was p = 0.0001. Conclusion:  It was found that serum vitamin E levels in adolescent AV patients were significantly lower than the controls. Further research is required to find out more about the role of antioxidants in the pathogenesis of AV.
Peran Biofilm terhadap Infeksi Saluran Genital yang disebabkan oleh Vaginosis Bakterial Afif Nurul Hidayati; Chesia Christiani Liuwan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 2 (2019): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (496.336 KB) | DOI: 10.20473/bikk.V31.2.2019.150-158

Abstract

Latar Belakang: Insidensi infeksi saluran genital, salah satunya Vaginosis Bakterial (VB) cukup tinggi pada banyak negara dan merupakan masalah kesehatan masyarakat yang cukup menonjol pada sebagian besar wilayah dunia. Kegagalan dalam mendiagnosis dan memberikan pengobatan dapat menimbulkan komplikasi yang serius dan berat dengan berbagai gejala sisa lainnya, antara lain infertilitas, kehamilan ektopik, infeksi pada neonatus, maupun penurunan kualitas bayi. Terdapat beberapa faktor yang memengaruhi patogenesis dan pengobatan VB, salah satunya biofilm. Tujuan: Tinjauan pustaka ini membahas peran biofilm dalam infeksi saluran genital akibat VB dalam patogenesis dan pengobatan. Telaah kepustakaan: Biofilm menghambat proses eliminasi dan terbunuhnya organisme patogen oleh antibiotik, sehingga infeksi menjadi lebih berat dan lama. Biofilm Gardnerella vaginalis menunjukkan resistensi yang tinggi dan mekanisme protektif yang kuat terhadap flora normal vagina, termasuk hidrogen peroksida dan asam laktat yang diproduksi oleh laktobasilus.  Hal itu merupakan penyebab terjadinya relapse dan rekurensi yang tinggi dari VB. Biofilm dapat memengaruhi patogenesis dan pengobatan BV. Biofilm juga berperan dalam resistensi antibiotik. Simpulan: Biofilm memegang peranan kunci tidak hanya dalam hal patogenesis dari VB tetapi juga berperan terhadap kegagalan terapi dan rekurensinya.
Uji Kepekaan Antibiotik Oral terhadap Bakteri Propionilbacterium acnes Pasien Akne Vulgaris Derajat Sedang Berat Alfrid Asditya; Iskandar Zulkarnain; Rahmadewi Rahmadewi; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.081 KB) | DOI: 10.20473/bikk.V31.3.2019.128-135

Abstract

Latar Belakang: Akne vulgaris (AV) merupakan penyakit kulit yang sering terjadi terutama pada usia remaja dan dapat berlanjut pada usia dewasa. Peningkatan penggunaan antibiotik menyebabkan pola bakteri Propionilbacterium acnes yang berubah, sehingga dilaporkan adanya resistensi terhadap beberapa antibiotik Tujuan: Mengevaluasi kepekaan antibiotik oral doksisiklin, klindamisin, azitromisin, dan eritromisin yang digunakan pada akne vulgaris derajat sedang-berat terhadap bakteri Propionilbacterium acnes. Metode: Deskriptif observasional, dengan 37 pasien AV baru dan lama yang memenuhi kriteria inklusi dan eksklusi. Sampel diambil dari lesi pustula akne vulgaris kemudian ditanam di media kultur anaerob, diidentifikasi dengan VITEK® 2, dan tes kepekaan antibiotik dengan metode disk difusi. Hasil: Akne vulgaris derajat sedang-berat terbanyak pada laki-laki usia 18-25 tahun dengan tingkat pendidikan sekolah lanjutan tingkat atas (SLTA), hasil uji kultur dan identifikasi menunjukkan terbanyak adalah bakteri Propionilbacterium acnes. Tiga puluh tujuh sampel isolat menunjukkan antibiotik yang memiliki kepekaan terhadap Propionilbacterium acnes adalah sebagai berikut: doksisiklin (100%), azitromisin (86%), klindamisin (76%), dan eritromisin (73%). Simpulan: Kepekaan antibiotik terhadap bakteri Propionilbacterium acnes menunjukkan yang pertama adalah doksisiklin, azitromisin, klindamisin, dan kepekaan paling rendah adalah eritromisin.
Efektivitas Lactobacillus plantarum terhadap Serum Imunoglobulin E Total dan Indeks Scoring Atopic Dermatitis (SCORAD) Pasien Dermatitis Atopik Dewasa laissa Bonita; Cita Rosita Sigit Prakoeswa; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.663 KB) | DOI: 10.20473/bikk.V31.3.2019.78-84

Abstract

Latar Belakang: Dermatitis Atopik (DA) dapat disebabkan oleh ketidakseimbangan sel T-helper (Th) 1 dan Th2 yang diduga memengaruhi kadar imunoglobulin (Ig) E, yang juga memengaruhi indeks Scoring Atopic Dermatitis (SCORAD). Studi mengenai efek terapi probiotik pada DA telah dilakukan, namun hanya sedikit dilakukan pada dewasa dan hasilnya bervariasi. Lactobacillus plantarum IS-10506 (LP IS-10506) adalah probiotik indigenous asal Indonesia yang telah diuji secara in vitro maupun in vivo. Tujuan: Mengevaluasi efek terapi probiotik LP IS-10506 terhadap serum Ig E total dan indeks SCORAD dalam pengobatan DA. Metode: Uji klinis acak terkontrol tersamar ganda terhadap 30 pasien, dilakukan randomisasi untuk mendapatkan probiotik atau plasebo selama 8 minggu. Kadar serum Ig E total dan indeks SCORAD dievaluasi sebelum dan sesudah intervensi. Hasil: Lima belas subjek kelompok probiotik dan 15 subjek kelompok plasebo telah menyelesaikan studi. Tidak didapatkan perbedaan bermakna rerata kadar Ig E total kelompok probiotik dan plasebo pada akhir studi, masing-masing 470,833 + 751,329 IU/ml dan 222,826 + 181,681 IU/ml (p=0,350). Rerata penurunan indeks SCORAD pada kelompok probiotik lebih besar dibandingkan plasebo dengan perbedaan bermakna pada akhir studi, masing-masing 9,6133 + 2,552 dan 13,133 + 5,029 (p= 0,022). Simpulan: Tidak didapatkan perbedaan bermakna pemberian probiotik dalam hal penurunan kadar serum Ig E total dibandingkan kelompok kontrol. Penurunan indeks SCORAD bermakna pada kelompok probiotik dibandingkan kelompok kontrol.
The Concordance of Three Diagnostic Test for Malassezia folliculitis using Potassium Hydroxide 20% + Blue-Black Parker Ink, May Grunwald Giemsa, and Potassium Hydroxide 10% + Chicago Sky Blue Dyatiara Devy Rahadiyanti; Evy Ervianti; Damayanti Damayanti; Dwi Murtiastutik; Sawitri Sawitri; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.33-39

Abstract

Background: Malassezia folliculitis is a pilosebaceous follicular infection disease caused by Malassezia species. There are many misdiagnosed Malassezia folliculitis cases, causing the maladministration of therapy. A routine diagnostic test performed for Malassezia folliculitis cases is the identification of fungal elements (spore) with a microscope using potassium hydroxide, but it has several weaknesses. Purpose: To evaluate the suitability of Malassezia folliculitis diagnostic test using Potassium Hydroxide 20% + Blue-Black Parker Ink, May Grunwald Giemsa, and Potassium Hydroxide 10% + Chicago Sky Blue. Methods: Analytic observational study conducted in the Dermatomycology Division of Dermatology and Venereology outpatient clinic, Dr. Soetomo General Hospital Surabaya. The samples were thirty patients with clinical features of Malassezia folliculitis. The research material was obtained from the body as many as three pieces of papulomoluscoid lesion extracted. The material obtained was then divided into three glass objects for Potassium Hydroxide 20% + Blue-Black Parker Ink, May Grunwald Giemsa, and Potassium Hydroxide 10% + Chicago Sky Blue staining. Result: The identification of spores using Potassium Hydroxide 20% + Blue-Black Parker Ink was 90%, May Grunwald Giemsa was 90%, and Potassium Hydroxide 10% + Chicago Sky Blue was 93% with a value of κ=0.348 and p=0.051. The diagnostic values of May Grunwald Giemsa and Potassium Hydroxide 10% + Chicago Sky Blue were 96.6% sensitivity, 33.3% specificity, 92.9% Positive Predictive Value, and 50 % Negative Predictive Value. Conclusions: There was no significant concordance between May Grunwald Giemsa and Potassium Hydroxide 10% + Chicago Sky Blue with Potassium Hydroxide 20% + Blue-Black Parker Ink in establishing the diagnosis of Malassezia folliculitis. Potassium Hydroxide 20% + Blue-Black Parker Ink is still needed as a routine examination in cases with clinical features of Malassezia folliculitis.
Long - Term Effects of Topical Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Fractional CO2 Laser in Photoaging Dyah Ayu Pitasari; Afif Nurul Hidayati; Muhammad Yulianto Listiawan; Sawitri Sawitri; Damayanti Damayanti; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.27-32

Abstract

Background: Photoaging causes wrinkles, lentigines, keratoses, dyspigmentation, telangiectasia, decreased elasticity, rough texture, and pale color. Facial wrinkles and mottled skin can negatively affect perceived attractiveness, self-esteem, personality, and level of acceptance. Stem cells are important cells in the skin, and they are the source for continuous regeneration of the epidermis. It can be extracted from many sources, including amnion. Amnion membrane stem cell (AMSC) can be cultured and secretes metabolite product, and it can rejuvenate aging skin. Laser-Assisted Drug Delivery (LADD) involves selective destruction of the layers of the epidermis and dermis to allow penetration and absorption of topical drugs as well as large molecular weight drugs such as stem cells. Purpose: To evaluate the long-term effects of topical administration of AMSC metabolite products (AMSC -MP) and fractional CO2 laser on the clinical improvement of photoaging compared to previous skin conditions. Methods: This was an observational study which was aimed to evaluate the long-term effects of clinical improvement after topical therapy of AMSC-MP and fractional CO2 laser in patients with photoaging. Results: The results of the analysis showed a decrease in wrinkles, dark spots, skin tone, and pores. Conclusion: Based on Janus-II® assessment, there was improvement degrees of wrinkles, dark spots, and pores in patients with photoaging who received fractional CO2laser fractional for 12 weeks. There were no side effects found in this study.
Side Effects of Methotrexate for Psoriasis Therapy Melida Agustina; Afif Nurul Hidayati; Nurina Hasanatuludhhiyah
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 2 (2020): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.2.2020.98-102

Abstract

Background: Psoriasis is a chronic and relapsing inflammatory disease of the skin, characterized by the presence of well-defined erythematous plaque covered by silvery-white scales. Methotrexate is a folic acid antimetabolic for psoriasis therapy and given systemically so unexpected effects can occur. Purpose: To evaluate the side effects of methotrexate as therapy in psoriasis. Methods: The descriptive research based on the medical record of psoriasis patients who were treated for hospitalization on at Kemuning I and II ward Dr. Soetomo General Academic Hospital Surabaya during the period January 2017 – December 2018. The sampling method used was total sampling. Result: Twenty two psoriasis patients receiving methotrexate therapy with the dose of methotrexate is 10-15 mg once weekly, there were 4.5% low erythrocyte level, 27.3% high leukocyte level, 13.6% high thrombocyte level, 18.2% high SGOT level, 22.8% high SGPT level, 18% nausea, 9.1% vomiting, 4.6% headache, and 4.6% shortness of breath. Conclusion: Methotrexate for psoriasis therapy may cause several side effects even not the severe ones, therefore careful dosing and side effect monitoring are necessary.
Combination of Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E for Photoaging Retha Retha; Sawitri Sawitri; Rahmadewi Rahmadewi; Afif Nurul Hidayati; Muhammad Yulianto Listiawan; Evy Ervianti; Linda Astari; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.1-6

Abstract

Background: It is hypothesized that combination of amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO2 laser as laser assisted drug delivery (LADD) provides better long-term effects on clinical improvement of photoaging. This is promising as an option for photoaging therapy in the future. Purpose: The study aimed to evaluate long-term effects of improving the degree of wrinkles, polarized black spots, ultraviolet (UV) black spots, pores, and skin tones in subjects who have received a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD. Methods: Thirty adult women with photoaging who had been treated with topical AMSC-MP mixed therapy with vitamin E and CO2 fractional laser three times, were then given maintenance therapy, tretinoin cream 0.025% and sunscreen SPF 30. Observation of improvement of wrinkles, polarized black spots, UV black spots, pores, and skin tones were performed computer-stimulated photographs, Janus-II Facial Skin Scope System, three times every month for three months after the last treatment. Results: The evaluation of wrinkles, polarized black spots, UV dark spots, pores and skin tones from the assessment for three months after being receiving treatment of a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD on photoaging obtained p>0.05. Conclusion: There was a long-term effect of the topical mixture of AMSC-MP with vitamin C and CO2 fractional laser on photoaging, and there was no side effect observed.
The Efficacy of Lactobacillus plantarum as Adjunctive Therapy of Bacterial Vaginosis: A Double-blind, Randomized, Placebo-controlled Trial Ridha Ramadina Widiatma; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Cita Rosita Sigit Prakoeswa; Sawitri Sawitri; Ingrid Suryanti Suryono; Linda Astari; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.214-220

Abstract

Background: Bacterial vaginosis (BV) is a clinical syndrome caused by the changing of Lactobacillus spp., a producer of hydrogen peroxide, in the normal vagina with a high concentration of anaerobic bacteria, Gardnerella vaginalis and Mycoplasma hominis. This study reports a resistance of BV therapy regimens, high recurrence rates, and side effects of an antibiotic. Therefore, adjunctive therapy for BV management is needed. Research has reported the therapeutic effects of probiotic in BV; however, the results are inconsistent. Purpose: To evaluate the efficacy of standard therapy using metronidazole and Lactobacillus plantarum for BV measured by the cure rate and vaginal flora balance. Methods: A randomized, double-blind, placebo-controlled trial, 30 subjects were randomized to take metronidazole 500 mg twice a day for seven days with weekly evaluation. The Lactobacillus plantarum or placebo group was evaluated every 4 weeks. The cure rate and vaginal flora balance were evaluated using the Amsel criteria and Nugent score before and after the intervention. Result: A total of 30 subjects returned for 28-day follow-up, of which 60% subjects of the antibiotic/probiotic group were cured compared to 40% in the antibiotic/placebo group (p>0.05). Conclusion: There was no difference in the increase of cure rate and vaginal flora balance between the treatment group and significant control group.
A Retrospective Study: Characteristics and Management of Gonorrhea Indah Purnamasari; Dwi Murtiastutik; Muhammad Yulianto Listiawan; Evy Ervianti; Rahmadewi Rahmadewi; Budiono Budiono; Astindari Astindari; Maylita Sari; Septiana Widyantari; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 1 (2021): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.1.2021.1-7

Abstract

Background: Gonorrhea (GO) is a sexually transmitted infection that remains an important clinical and public health problem worldwide. Its incidence tends to increase both in males and females. Given the scale of the public health impact of GO, the selection of appropriate therapy is essential. Purpose: This study aimed to evaluate the characteristics, management, and recovery of gonorrhea patients. Methods: The research material was obtained from the medical record of gonorrhea patients at the Sexually Transmitted Infections (STI) Outpatient Clinic, Dermatology and Venerelogy Department, Dr. Soetomo General Academic Teaching Hospital, Surabaya, from January 2016 to December 2018. Result: We found 84 new GO patients (0.02%) out of the total new outpatients at the Dermatology and Venereology Department, Dr. Soetomo General Academic Teaching Hospital, Surabaya. Most of them were males (92.9%), 17–25 years age group (52.4%), unmarried (67.9%), and heterosexual (90.5%). The majority of therapy is dual therapy, was combination of doxycycline and cefixime (78%). Only 34 patients (40.5%) attended the follow-up visits, and 94.1% of them recovered, and 5.9% presented with cystitis. Conclusion: The characteristics features of GO varies in each variable. One of important to control GO is provide effective and appropriate treatment and routinely clinical and laboratories were needed control.
Co-Authors Alfrid Asditya Alpha Fardah Athiyyah Amanda Gracia Manuputty Anang Endaryanto Annisa Fitriana Aprilawati, Dwi Arisia Fadila As'ad Naufal Astindari Astindari Astindari Budi Utomo Budi Utomo BUDI UTOMO Budi Utomo Budiono Budiono Chesia Christiani Liuwan Cita Rosita Sigit Prakoeswa Cut Shelma Maharani Damayanti Damayanti Damayanti Deasy Fetarayani Desiana Widityaning Sari Diah Mira Indaramaya Diah Mira Indramaya Dias Lidiana A.S Dwi Murtiastutik Dyah Ayu Pitasari Dyatiara Devy Rahadiyanti Efenina Ginting Emma Hidayati Sasmito Erwin Astha Triyono Evy Ervianti Fadila, Arisia Fatimah, Nurmawati Fikri Ardhani Hari Sukanto, Hari I G.A. Kencana Wulan Icha Aisyah Indah Purnamasari Indah Purnamasari INDROPO AGUSNI Ingrid Suryanti Suryono Isaak Effendy Isaak Effendy Iskandar Zulkarnain Iskandar Zulkarnain Kristina Sihaloho KUSUMASTUTI, ETTY HARY laissa Bonita Linda Astari, Linda M. Yulianto Listiawan Maylita Sari Medhi Denisa Alinda, Medhi Denisa Melida Agustina Nurina Hasanatuludhhiyah Pepy Dwi Endraswari, Pepy Dwi Pramita Ariyanti Priangga Adi Wiratama Rahmadewi Rahmadewi Rahmadewi Renata Prameswari Retha Retha Ridha Ramadina Widiatma Saut Sahat Pohan Sawitri Sawitri Sawitri Sawitri Sawitri Senda Sulvain Rahmaningrat Septiana Widyantari Shinta Dewi Rahmadhani Sigit Eko Prabowo Siti Isrina Oktavia Salasia Sudjarwo Sudjarwo Sunarso Suyoso Wahyunita Desi Ratnaningtyas Wardiana, Maya Widodo J. Pudjirahardjo William Andrew Isaac Windhu Purnomo Wisnu Triadi Nugroho Yuri Widia, Yuri