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All Journal Bioscience El-Hayah : Jurnal Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biosfer: Jurnal Tadris Biologi Biogenesis: Jurnal Ilmiah Biologi Quagga Jurnal Florea JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Al-Kimia BIOEDUSCIENCE Jurnal Biologi Tropis Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Jurnal Saintek Lahan Kering Jurnal BIOEDUIN : Program Studi Pendidikan Biologi Qalam: Jurnal Ilmu Kependidikan Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Biota Jurnal Mangifera Edu Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika JURNAL PENDIDIKAN MIPA Jurnal Pendidikan dan Konseling Biopendix: Jurnal Biologi, Pendidikan dan Terapan Jurnal Jejaring Matematika dan Sains Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Biogenerasi Journal On Teacher Education (Jote) JSMARTech : Journal of Smart Bioprospecting and Technology Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Ilmiah Medicamento Mattawang: Jurnal Pengabdian Masyarakat Jurnal Biosense Jurnal Ilmiah Wahana Pendidikan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Mandiri Makara Journal of Science Medical Sains : Jurnal Ilmiah Kefarmasian Edubiotik : Jurnal Pendidikan, Biologi dan Terapan

Bare, Yohanes

Program Studi Pendidikan Biologi, Fakultas Keguruan Dan Ilmu Pendidikan, Universitas Nusa Nipa, Indonesia

Author-ID : 946684

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Virtual Screening: Prediksi potensi 8-shogaol terhadap c-Jun N-Terminal Kinase (JNK) Yohanes Bare; Mansur S; Sri Sulystyaningsih Natalia Daeng Tiring; Dewi Ratih Tirto Sari; Andri Maulidi
Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Vol. 4 No. 1: March 2020
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/e-saintika.v4i1.157

JNK adalah gen yang berperan dalam metabolisme DMT2. Dalam pengobatan T2DM digunakan JNK sebagai potensi terapi dengan menggunakan bahan alam. 8-shogaol adalah komponen kimia yang terkandung dalam jahe yang memiliki aktivitas antioksidan. Tujuan dari penelitina ini adalah menginversitagasi dan menganalisis peran 8-shogaol terhadap JNK. Protein JNK (ID: 464Y) diperoleh dari Protein Data Bank dan ligan 8-shogaol (CID:6442560 ) didapat dari pubchem. Ligan dan protein didocking menggunakan Hex 8.0.0. File dalam bentuk pdb divisualtisasi dan analisis menggunakan Discovery Studio Client 4.1 software. Interaksi ligan-protein menunjukan ikatan hidrogen pada residu asam amino LYS93 dan van der Waals pada 18 residu asam amino dengan energi ikatan-289.68cal/mol. Interkasi ini berpotensi sebagai penghambat kerja JNK dan dapat digunakan dalam terapi DMT2.Virtual screening: potential prediction of 8-shogaol againts c-Jun N-Terminal Kinase (JNK)AbstractJNK is one of gene that has a role in T2DM condition. To curve T2DM use JNK as potential healing using natural compounds. Eight-shogaol which found in ginger has function as a antioxidant.. The aim of the research is to investigate and analyze role 8-shogaol againts JNK. Protein JNK (ID: 464Y) was taken from Protein Data Bank and ligand 8-shogaol (CID:6442560 ) acquired from pubchem. Ligand and protein model were docked using Hex 8.0.0 software. Visualization and analysis molecular interactions by the Discovery Studio Client 4.1 software. Interaction ligand-protein showed one hydrogen bond in amino acid residue LYS93 and formed van der Waals in eighteen amino acid residues which energy binding -289.68cal/mol. This interaction has a potential to inhibit JNK role and lead to therapy T2DM.

Profil Protein pada Organ Tikus (Rattus norvegicus) Model Diabetes Melitus Tipe 2 (DMT2) Yohanes Bare; Fatchiyah Fatchiyah
Biota Vol 11 No 1 (2018)
Publisher : Universitas Islam Negeri Mataram

Type 2 diabetes mellitus (T2DM) caused by resistance to insulin. Resistance insulin leads to hyperglycaemia. Prolong hyperglycaemia caused damaged organ and complication such as nephropathy (kidney), liver and cardiovascular diseases. Meanwhile, resistance insulin inhibits protein metabolism. This study focused on investigated of profile protein organ kidney, liver and heart in T2DM rat animal model. This research was used rats group T2DM (DM) and normal rats as a control (C). We isolated Protein from tissues and SDS-Page to investigated profile protein. This result we found has different profile protein in T2DM rats (DM) compared with control rats (C). Heart control (HC we found 5 bands protein, meanwhile organ HDM found 8 bands protein. In organ LiC we found 8 bands protein, besides organ LiDM 6 bands protein. Kideny control (KC) we found 7 bands protein, meanwhile organ KDM only 6 bands protein. This study concluded has different profile protein in rats group T2DM (DM) and rats control group (C).

In-silico Approach for The Prediction of Chlorogenic Acid as PPAR-γ Activator Yohanes Bare; Mansur S; Sukarman Hadi Jaya Putra; Margaretha Rika W G L; Dewi Ratih Tirto Sari
Biota Vol 13 No 1 (2020)
Publisher : Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/jb.v13i1.197

Coffee is one of the essential crops commonly cultivated in Indonesia. Coffee contains diverse bioactive compounds, which are associated with human health benefits. One of the compounds is Chlorogenic acid, which able to decrease the risk of type 2 diabetes mellitus (T2DM). However, the mechanism of chlorogenic acid toward anti-diabetes still unclear. This study aimed to analyze and investigate the potential role of chlorogenic acid as anti-diabetes through their interaction with Peroxisome proliferator-activated receptor gamma (PPAR-γ) as an enzyme to phosphorylate and regulate the mechanism of T2DM. The physicochemical properties of chlorogenic acid also performed in this study. The PPAR-γ was downloaded from the PDB database, and the chlorogenic acid was retrieved from the PubChem database. The protein and ligand were prepared using the PyRx program and were docked using Hex 8.0.0 software. Discovery Studio client 4.1 software was used to analyze the interaction between chlorogenic acid and PPAR-γ protein. Based on the physicochemical properties, chlorogenic acid is highly permeable to the cell and easily absorbed. Thirteen amino acid residues of PPAR-γ (GLN410, SER394, ASP396, GLY395, GLU407, LEUA401, LEU400, VAL403, LYS373, LYS438, LEU377, LYS434, and GLY437) were identified on the chlorogenic acid-PPAR-γ interaction. Interestingly, the kind of interactions, including hydrophobic interaction, hydrogen bond, and van der Waals, which are supported by the tight interaction. Our study indicated that chlorogenic acid might have anti-diabetes activity through PPAR-γ interaction.

Persepsi Guru dan Siswa terhadap Pemanfaatan Media Pembelajaran Google Classroom pada Mata Pelajaran Biologi SMA Yohanes Bare; Mansur S; Mira Kurniawati
Journal on Teacher Education Vol. 3 No. 2 (2022): Journal On Teacher Education
Publisher : Universitas Pahlawan

Google Classroom merupakan salah satu media pembelajaran jarak jauh yang dapat diakses hanya dengan menggunakanÂ internet. Persepsi guru dan siswaÂ terhadap media pembelajaran Google Classroom ini dapat memberikan dampak yang positif bagi siswa maupun guru. Tujuan penelitian ini adalah untuk menganalisis pemanfaatan media pembelajaran Google Classroom, persepsi guru dan siswa pada pembelajaran Biologi di SMA Negeri 2 Maumere. Jenis penelitian yang digunakan adalah deskriptif kualitatif. Kualitatif merupakan penelitian yang temuan-temuannya tidak melalui statistik. Hasil penelitian ini menunjukan bahwa media pembelajaran Google Classroom di SMAN 2 Maumere sangat membantu dalam pengecekan kehadiran dan keaktifan siswa, membantu siswa dalam melihat materi dan tugas yang sudah dikirimkan oleh guru dan dapat mengerjakan semua tugas yang diberikan selama pembelajaran daring. Pemahaman guru dan siswa terhadap media pembelajaran Google Classroom terdapat sedikit perbedaan, sebagian siswa dan guru memahami aplikasi Google Classroom dapat digunakan kapan saja dan dimana saja, tanpa ada kendala apapun.

Potensi Asam kafeat pada Kopi sebagai Simultan Gen Peroxixme proliferator-activated receptor gamma (PPAR-γ): Studi In silico Yohanes Bare; Maria Helvina; Agustina Elizabeth; Dewi Ratih Tirto Sari
Saintek Lahan Kering Vol 2 No 2 (2019): JSLK Desember 2019
Publisher : Fakultas Pertanian, Universitas Timor

Coffee plants are one of the cultivated plants of the Sikka Regency community. Coffee contains chemical compounds which is needed by humans. One of them is cafeic acid. Cafeic acid was recognized as having the potential as an anti-inflammatory, antioxidant, and healing type 2 diabetes mellitus (T2DM). The Peroxixme proliferator-activated receptor gamma gene (PPAR-γ) has a role in homeostasis regulation, so it can be used as hyperglycemia. But do not study on the interaction of cafeic acid as anti-diabetes molecularly. The purpose of this study was to analyze and predict the physico-chemical properties and potency of cafeic acid as anti-diabetes through the interaction of cafeic acid with PPAR- γ protein in silico. The method used consisted of downloading PPAR-γ protein through protein bank data (GDP) and cafeic acid through the PubChem database, protein preparation (PPAR-γ) and ligands (cafeic acid) with the PyRx program, protein analysis and ligand using the program using the Hex program 8.0 .0 and Discovery Studio V16.1.0.15360. The results showed that occur between cafeic acid and PPAR-γ show the role of anti-diabetes. This is evidenced by the presence of 11 amino acid residues (ASP441, LYS373, ASP396, LYS438, GLU407, PRO398, GLY399, ARG397, LEU400, GLY395, VAL403) which interacted with the chlorogenic acids and their energies of -168.5cal/mol. This function activates GLUT2 and GLUT4 as transportation routes inside and outside the cell. Caffeic acid is predicted to have potential as a natural ingredient in coffee which can be used for DMT2 therapy with genetic care (Nurtigenetics). We suggest further study is required in vivo experiment.

Physicochemical properties and biological activity of bioactive compound in Pepper nigrum: In silico study Dewi Ratih Tirto Sari; Yohanes Bare
SPIZAETUS: JURNAL BIOLOGI DAN PENDIDIKAN BIOLOGI Vol 1, No 2 (2020): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Universitas Nusa Nipa

Lada hitam merupakan salah satu tanama yang memikiki kandungan bahan kimia yang ebrmanfaat bagi tubuh manusia. Penelitian ini memiliki tujuan untuk karakterisasi fisiko kimia Serta prediksi fungsi biologis senyawa-senyawa bioaktif lada hitam secara in-silico. Metode yang digunakan adalah analisis in-silico dengan mengunduh bahan dari PubChem Piperine (ID:638024), Piperonylamine (ID:75799), Piperisida (ID:101422868), Sarmentosin (ID:5281123), Sarmentin (ID:6440616), dan Chavicine (ID:1548912) dianalaisis menggunakan perangkat lunak online SuperPred. Hasil penelitian menunjukan bahwa keenam senyawa yang terkandung dalam Pepper nigrum memiliki karakteristik fisiko kimia yang unik dengan chavicin dan piperin merupakan senyawa yang memiliki struktur isomer, kesamaan struktur pada kedua senyawa menyebabkan prediksi aktivitas biologi yang sama. Kata Kunci: fisiko kimia, in-silico lada hitam, PubChem

Studi In silico Potensi aktivitas 10-shogaol dalam Jahe (Zingiber officinale) terhadap gen ACE Mansur S; Yohanes Bare; Maria Helvina; Aprianus Pani Pili; Gabriella Chandrakirana Krisnamurti
SPIZAETUS: JURNAL BIOLOGI DAN PENDIDIKAN BIOLOGI Vol 1, No 3 (2020): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v1i3.23

Peningkatan tekanan darah tinggi (hipertensi) mengakibatkan terpicunya berbagai macam penyakit kronis serta komplikasinya. Salah satu activator dalam kondisi tekanan darah tinggi adalah aktivitas Angiotensin converting enzyme (ACE). ACE berperan dalam mengatur sistem renin-angiotensin. Penurunan hipertensi perlu untuk menekan aktivitas ACE. Tujuan dari penelitian ini adalah untuk menganalisis potensi 10-shogaol terhadap ACE. Metode yang digunakan adalah studi in silico. Protein model ACE (ID: 3bkk) didapatkan dari database Protein data Bank (PDB) sedangkan 10-shogaol (CID: 6442612) didapat dari database PubChem. Docking menggunakan Hex 8.0.0 sedangkan visualisasi dan analisis menggunakan Discovery Studio. Hasil Penelitian menunjukan bahwa bahwa senyawa 10-shogaol memiliki potensi sebagai inhibitor gen ACE dibuktikan 2 residu asam amino yang berikatan dengan ligan. Ikatan tersebut berupa ikatan hidropobik yang meningkatkan kekuatan tersebut dengan besar energi -291.3cal/mol.

PENGEMBANGAN LEMBAR KERJA MAHASISWA (LKM) BERBASIS INKUIRI PADA MATERI INTERAKSI MOLEKULER Yohanes Bare; Dewi Ratih Tirto Sari
Jurnal BIOEDUIN : Program Studi Pendidikan Biologi Vol 11, No 1 (2021): Bioeduin Februari
Publisher : Department of Biology Education UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/bioeduin.v11i1.12077

Pengembangan Lembar Kerja Peserta Didik (LKPD) Biologi Berbasis Pendekatan Scientific Materi Sistem Ekskresi Pada Manusia Kelas VIII SMP Negeri 2 Maumere Krisna Pada; Yohanes Bare; Sukarman Hadi Jaya Putra
Jurnal Ilmiah Wahana Pendidikan Vol 7 No 8 (2021): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Development in science and technology have a great influence in various aspect of human life. One of the aspectcs is education which is an inseparable part of the process of human maturation that needs to take advantage of advances in science and technology in order to be able to achieve goals effectively and efficiently. The lack of student participation in biology material like excretory system makes the expression material seen as difficult. This research study aims to develop a Biology Learning Based on a Scientific Approach to Human Excretion System Materials for Class VIII SMP Negeri 2 Maumere. The development model used is a 4D model. The results showed that the worksheets developed were declared valid by material experts, media experts and linguists. The LKPD being tested has criteria that fit the category that is appropriate for use in the excretory system at SMPN 2 Maumere.

Pengembangan LKPD Berbasis Inkuiri Terbimbing Pada Materi Sistem Pencernaan di SMAS Katolik St. Gabriel Ratna Susana Dawa; Yohanes Nong Bunga; Yohanes Bare
Jurnal Ilmiah Wahana Pendidikan Vol 7 No 8 (2021): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

This study aim to develop student worksheets based on guided inquiry on the human digestive system material. This research is a development research that adapts the 4D development model. The research instrument used is a questionnaire and documentation. The product developed was validated by material, media and language experts and then tested on a small and large scale, namely two biology teachers and thirty-four students of class XI MIA of SMAS Katolik Sint Gabriel Maumere. Based on the results of the validator of the student worksheets the digestive system was declared very valid and the responses of teachers and students concluded that the student worksheets developed was suitable to be used as a learning resource, especially biology subjects

Co-Authors Agustina Elizabeth Ahmad, Nurul Imaniyah Andri Maulidi Andri Maulidi Angeliana Desimaris Nita Angeliana Desimaris Nita Anselmus Dawa Apriani Herni Rophi Aprianus Pani Pili Aprianus Pani Pili Daeng Tiring, Sri Sulistyaningsih Natalia Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Eci, Margaretha Nona Elfi, Theresia Nona fatchiyah . Fitra Arya Dwi Nugraha Fransiskus Xaverius Ndia Frederiksen Novenrius Sini Timba Gabriella Candrakirana Krisnamurti Gabriella Candrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Galis, Rofinus Gaso, Maria Triswanti Hejo, Yosefina Suryanti Heny Yusuf Hiko, Maria Filestina Indahsari, Lilin Ika Nur Jatmiko Eko Witoyo Kari, Magdalena Letek Klementinus Bhato Krisna Pada Krisna Pada Krisnamurti, Gabriella Candrakirana Krisnamurti, Gabriella Chandrakirana Kristina Novita Kuki, Agustina Dua Lailiyah, Fatinatul Laily Sifaiyah Lele, Maria Nona Elci Lopa, Maria Imelda Lorenza, Margaretha Rika Wahyu Gabrella Lute, Maria Alvensia Lydia Efliani Coriessa Meak M A Yohanita Nirmalasari Magdalena Letek Kari Mansur S Mansur s Margaretha Rika W G L Margaretha Rika Wahyu Gabrella Lorenza Maria Alvensia Lute Maria Fatima Neno Maria Filestina Hiko Maria Helvina Maria Marcelina Dua Nurak Maria Marcelina Dua Nurak Maria Yuniati Nona Ade Marsiana Coo Mogi Marsiana Coo Mogi Maximus M Taek Meak, Lydia Efliani Coriessa Mira Kurniawati Misa, Aljefridus Mogi, Marsiana Coo Ngongo, Yosefina Nita, Angeliana Desimaris Nur Dina Camelia Nurak, Maria Marcelina Dua Nurul Imaniyah AHmad Oktavius Yoseph Tuta Mago Paula Yunita Seku Ra'o Paula Yunita Seku Ra'o Paulina Bewu Lele Ratna Susana Dawa S, Mansur Saputra, Mansur Sari, Dewi Ratih Tirto Selmin, Yosefina Sizi, Yosefina Sri Sulistyaningsih Natalia Daeng Tiring Sri Sulystyaningsih Natalia Daeng Tiring Sukarman Hadi Jaya Putra Taek, Maximus M Tematan, Yohanes Boli Theopilus W Watuguly Theresia Nona Elci Theresia Nona Elfi Ujiana, Wa Ode Ule, Kristina Novita Ustiatik, Reni Vincentius, Angelinus Wa Ode Ujiana Yoga Tribakti Rachmad Yoga Tribakti Rachmad Yohanes Boli Tematan Yohanes Boli Tematan Yohanes Nong Bunga

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