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All Journal Bioscience El-Hayah : Jurnal Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biosfer: Jurnal Tadris Biologi Biogenesis: Jurnal Ilmiah Biologi Quagga Jurnal Florea JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Al-Kimia BIOEDUSCIENCE Jurnal Biologi Tropis Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Jurnal Saintek Lahan Kering Jurnal BIOEDUIN : Program Studi Pendidikan Biologi Qalam: Jurnal Ilmu Kependidikan Biota Jurnal Mangifera Edu Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika JURNAL PENDIDIKAN MIPA Jurnal Pendidikan dan Konseling Biopendix: Jurnal Biologi, Pendidikan dan Terapan Jurnal Jejaring Matematika dan Sains Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Biogenerasi Journal On Teacher Education (Jote) JSMARTech : Journal of Smart Bioprospecting and Technology Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Ilmiah Medicamento Mattawang: Jurnal Pengabdian Masyarakat Jurnal Biosense Jurnal Ilmiah Wahana Pendidikan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Mandiri Makara Journal of Science Medical Sains : Jurnal Ilmiah Kefarmasian Edubiotik : Jurnal Pendidikan, Biologi dan Terapan

Bare, Yohanes

Program Studi Pendidikan Biologi, Fakultas Keguruan Dan Ilmu Pendidikan, Universitas Nusa Nipa, Indonesia

Author-ID : 946684

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Interaksi Senyawa Phloroglucinol sebagai Terapi Inflamasi melalui penghambatan gen Cyclooxygenase-2 (COX-2) Yohanes Bare
Jurnal Ilmiah Medicamento Vol 8 No 1 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i1.3162

Exploration of natural compounds is one of the projects in the context of curving disease, one of which is inflammatory therapy in the body, one of the natural ingredients used is Phloroglucinol which has anti-inflammatory properties but there is no information on molecular studies related to its activity. The purpose of this study was to explore the potential of Phloroglucinol as an anti-inflammatory mechanism. Phloroglucinol compound (CID 359) was downloaded from the PubChem Protein COX-2 database (PDB ID 6cox) downloaded from the Protein Data Bank database. The compound Phloroglucinol interacted with the Molegro virtual Docker 5 program with Grid docking X 66,44; Y 27.44; Z 107.23. The docking results were analyzed using Discovery Studio software ver 21.1.1. The results showed that Phloroglucinol binds to five COX-2 amino acid residues and may inhibit COX-2 performance and can be a strong candidate for inflammatory therapy when inflammation occurs. in the human body. The conclusion of this study is that Phloroglucinol compounds have the potential in inhibiting COX-2 (inflammatory mediators).

Meningkatkan Hasil Belajar Siswa pada Konsep Perubahan dan Pelestarian Lingkungan Hidup dengan Model Discovery Learning di SMAS Katolik ST Gabriel Maumere Mansur S; Yohanes Bare
BIOEDUSCIENCE Vol 3 No 2 (2019): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: Hasil belajar merupakan kemampuan tertentu baik secara kognitif, afektif maupun psikomotorik yang dicapai oleh siswa setelah mengikuti pembelajaran. Penelitian tindakan kelas (PTK) yang digunakan dalam penelitian ini, dengan tujuan untuk meningkatkan hasil belajar siswa SMAS Katolik St Gabriel Maumere pada konsep perubahan dan pelestarian lingkungan hidup, melalui penerapan model Discovery Learning. Metode: Penelitian Tindakan Kelas ini dilaksanakan pada siklus I dan siklus II dengan setiap siklus terdiri dari dari dua kali pertemuan. Presentase ketuntasan dari siklus I adalah 55% yang selanjutnya dilakukan siklus II dengan hasil presentase ketuntasan 90%. Hasil: penelitian yang dilakukan menunjukan adanya peningkatan hasil belajar siswa yang dilihat dari siklus II. Kesimpulan: Dengan demikian model Discovery Learning terbukti dapat meningkatkan hasil belajar siswa pada konsep perubahan dan pelestarian lingkungan hidup.

Analysis of Molecular Interactions of 8-Gingerol Compounds in Ginger (Zingiber officinale) as ACE Inhibitor Yohanes Bare; Mansur s; Aprianus Pani Pili; Maria Helvina
BIOEDUSCIENCE Vol 4 No 2 (2020): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: Hypertension is a disease with increasing characteristics of blood pressure. The ACE gene has a role in the conversion of ATI to ATII in hypertensive conditions. Healing is done by using the 8-gingerol content contained in ginger. The purpose of this study is to analyze the molecular interaction that occurs between 8-gingerol and ACE. Method: ACE model proteins (ID: 3bkk) were obtained from the Bank Data Protein database (PDB) through 8-gingerol ligands (CID: 168114) obtained from the PubChem database. ACE and 8-gingerol were docked by Discovery Study Client 4.1 software. Analysis of amino acid residues, binding energy, Van der Waals forces, and hydrogen bonds formed using Discovery Studio Client 4.1. Results: The interaction between 8-gingerol and ACE showed that there were seven amino acid residues that interacted with 8-gingerol, also found hydrogen bonds, hydrophobic and Van der Waals forces that strengthen and stabilize these bonds. Conclusion: the interaction of 8-ginger with the active side of ACE is determined as an ACE inhibitor, the inhibition is a significant effect on the obstruction of ACE conversion.

Effect of Organic Fertilizer on Growth and Productivity of Ipomoea reptans Poir Klementinus Bhato; Yohanes Bare; Oktavius Yoseph Tuta Mago
Jurnal Biologi Tropis Vol. 22 No. 1 (2022): January - March
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v22i1.3232

Kangkung Darat (Ipomoea reptans Poir) is the vegetable that is popular and consumed by the community. Chemical fertilizers bring negative impacts on soil and consumer health, lead to change thewith liquid organic fertilizer from cattle dung and tofu industrial waste with floating raft hydroponic planting techniques. The purpose of this study was to analyze the effect of liquid organic fertilizer on the growth and productivity of Ipomoea reptans Poir. The research was conducted on the campus of the University of Nusa Nipa Indonesia. The research method, quantitative data collection using a Randomized Block Design (RAK) consisting of 5 treatments, namely P0 = 0% (control), P1 = 20%, P2 = 40%, P3 = 60%, P4 = 80%. Parameters observed were plant height, number of leaves and wet weight. The data obtained were analyzed using SPSS version 16.0 with an advanced test, namely the DMRT (Duncan's Mutiple Range Test) test. The results showed that the application of liquid organic fertilizer from cow dung and tofu industrial waste had a significant effect on the growth and productivity of Ipomoea reptans Poir. The effects include the growth of plant height and number of leaves as well as the yield of Ipomoea reptans Poir including wet weight (fresh) with the best concentration of P2 treatment with 40% POC concentration This research provides benefits for the community, especially the potential as farmers to further motivate the use of liquid organic fertilizer made from cow dung and tofu waste to increase crop income and soil fertility.

Eksplorasi Senyawa Kulit Kopi sebagai Anti Covid-19 Melalui Penghambatan 3C-Like Protease Yohanes Bare; Frederiksen Novenrius Sini Timba; Maria Marcelina Dua Nurak; Marsiana Coo Mogi
JURNAL PENDIDIKAN MIPA Vol 12 No 2 (2022): JURNAL PENDIDIKAN MIPA
Publisher : Pusat Publikasi Ilmiah, STKIP Taman Siswa Bima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37630/jpm.v12i2.563

Corona virus 19 menjadi pandemic di dunia saat ini, oleh karena itu perlu dilakukan terapi sehingga menurunkan prevalensi di Indonesia dengan menghambat protein yang terlibat dalam virus corona (3CL Protease). Salah satunya pemanfaatan bahan alam yang tidak terpakai. Kulit kopi merupakan material sisa dari pengolahan biji kopi. Satu ton ampas kopi akan terbentuk dari 2 ton kopi yang diproduksi dan berdampak terhadap masalah lingkungan. Kulit kopi memiliki berbagai macam senyawa yang masih dibutuhkan. Produksi kopi Tujuan penelitian ini adalah pemanfaatan bahan aktif kulit kopi sebagai nutrisi tingkat gen dengan menghambat kinerja 3C-like protease (3CLPro). Metode penelitian in silico, senyawa kulit kopi Hexosa (ID. 206), Malic acid (ID. 525), D-manitol (ID. 88038555) diunduh dari PubChem, protein 3CL Protease diunduh dari database protein data bank (PDB) dengan ID 2zu2 diimport ke software Molegro virtual docker 5 dan dilakukan preparasi. Selanjutnya protein target diprediksi cavity (sisi aktif protein) dengan parameter expand van der Waals maximum 10. Hasil docking dilakukan superimposed dengan protein yang telah dipreparasi menggunakan software PyMol. Visualisasi hasil docking dilakukan menggunakan perangkat lunak HEX 8.0.0.0. Hasil penelitian senyawa yang terkandung dalam kulit kopi memiliki potensi sebagai anti covid-19, hal ini dibuktikan dengan aktivitas senyawa Hexosa, Malic acid, D-manitol yang mengikat masing-masing enam residu asam amino. Pengikatan terhadap delapan belas residu asam amino yang berbeda diprediksi menjadi alternatif nutrisi dengan menghambat 3CL Protease.

KAJIAN SENYAWA HEXOSE DAN MALIC ACID SEBAGAI INHIBITOR PAPAIN LIKE PROTEASE (PLPro) CORONA VIRUS Yohanes Bare; Frederiksen Novenrius Sini Timba; Sukarman Hadi Jaya Putra; M A Yohanita Nirmalasari; Dewi Ratih Tirto Sari; Maximus M Taek
JURNAL BIOSENSE Vol 5 No 01 (2022): Edisi Juni 2022
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas PGRI Banyuwangi, Jalan Ikan Tongkol No 01, Telp (0333) 421593, 428592 Banyuwangi 68416

Papain-like protease is a SARSCOV-2 protease that functions for ubiquitination in host cells. Caffeine compounds have been widely reported to have antioxidant, anti-inflammatory, antidiabetic, and antiobesity activities. However, hexose and malic acid compounds in coffee rind as potential inhibitors of the papain-like protease SARSCOV2 have not been reported. This study investigated the potential of malic acid and hexose compounds as PLPro inhibitor agents in inhibiting SARSCOV2 ubiquitination. In silico studies were used to identify the potential of the two compounds by interacting hexose and malic acid compounds with papain-like protease (PLPro) proteins with the Molegro virtual Docker 5 program. Next, the ligand-protein complex visualization was done with discovery studio version 5.0. hexose and malic acid compounds showed interactions with papain-like protease proteins on several active site residues. The interactions showed inhibition of ubiquitination and stimulation of interferon in host cells. The two compound complexes – PLPro protein showed hydrophobic interactions, hydrogen bonds, and van der Waals forces, which contributed to the formation of bond energy and strong bonds between compounds and proteins. In this study, it was concluded that hexose and malic acid compounds have the potential to act as inhibitors of papain-like protease (PLPro) protein.

Persepsi Mahasiswa Terhadap Pembelajaran Berbasis Blended Learning dengan Memanfaatkan Aplikasi Microsoft Teams Magdalena Letek Kari; Yohanes Bare; Oktavius Yoseph Tuta Mago
Qalam : Jurnal Ilmu Kependidikan Vol. 10 No. 2 (2021): Desember
Publisher : Universitas Muhammadiyah Sorong

Pandemi virus corona (Covid-19) menimbulkan dampak di setiap sektor kehidupan, salah satunya adalah sektor pendidikan di Indonesia. Wabah ini menyebabakan pemerintah pada awal tahun 2020, mengeluarkan himbauan untuk melakukan kegiatan pembelajaran dari rumah, dengan memanfaatkan teknologi dan internet. Penelitian ini bertujuan untuk menganalisis persepsi mahasiswa terhadap aspek kesiapan, proses dan hasil pembelajaran berbasis Blended Learning dengan memanfaatkan aplikasi Microsoft Teams di Fakultas Keguruan dan Ilmu Pendidikan, yang difokuskan pada tiga program studi yakni, Program Studi Pendidikan Biologi, Program Studi Pendidikan Fisika dan Program Studi Pendidikan Kimia. Penelitian dilakukan dengan metode kualitatif dengan pendekatan deskriptif. Subjek penelitian ditentukan menggunakan teknik purposive sampling. Data dikumpulkan melalui wawancara, angket dan dokumentasi. Keabsahan data ditentukan dengan menggunakan triangulasi sumber dan teknik. Hasil penelitian menunjukan bahwa mahasiswa Fakultas Keguruan dan Ilmu Pendidikan memiliki tanggapan atau respon yang baik terhadap aspek kesiapan, aspek proses dan hasil pembelajaran berbasis Blended Learning dengan memanfaatkan aplikasi Microsoft Teams.

IMPLEMENTATION BIOLOGY CLUB II: SMA NEGERI 1 TALIBURA Yohanes Bare; Sukarman Hadi Jaya Putra; Yohanes Nong Bunga; Oktavius Yoseph Tuta Mago; Yohanes Boli Tematan; Mansur S; Paula Yunita Seku Ra'o
JURNAL PENGABDIAN MANDIRI Vol. 1 No. 5: Mei 2022
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (342.107 KB)

Implementasi Biology Club merupakan salah satu kegiatan program studi pendidikan biologi yang berfokus terhadap pengembangan media dan kombinasi materi dan permainan (games) bidang Biologi. Kegiatan ini diadaptasi dari kajian materi biologi yang disesuaikan dengan media bersumber pada kearifan lokal setempat. Tujuan kegiatan ini adalah mengelaborasikan materi biologi dan permainan (games) di SMAN 1 Talibura dalam kegiatan Biology Club II. Metode yang digunakan adalah metode ceramah, simulasi dan deict instruction dalam membuat alat peraga games Biologi. Program Pengabdian Masyarakat dengan judul Implementasi Biology CLUB II dilakukan di SMA Negeri 1 Talibura memberikan nilai positif terhadap konsep-konsep biologi yang disederhanakan dalam bentuk media pembelajaran dan games. Pengembangan media (Biologi molekuler, botany, zoology, mikrobiologi, ekologi, pendidikan biologi) dan games (Botany, zoology dan ekologi) di sekolah diharapkan menjadi masukan dalam implemtasi di dalam kelas sehingga dapat meningkatkan hasil pembelajaran di kelas di SMA Negeri 1 Talibura.

Capsaicinoids from Capsicum annuum as an Alternative FabH Inhibitor of Mycobacterium Tuberculosis: In Silico Study Krisnamurti, Gabriella Chandrakirana; Sari, Dewi Ratih Tirto; Bare, Yohanes
Makara Journal of Science Vol. 25, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

The number of tuberculosis (TB) cases worldwide reached 1.5 million in 2018; thus, TB is considered a deadly disease. TB is caused by Mycobacterium tuberculosis and involves lipid synthesis. Considering the importance of lipid metabolism in bacteria, FabH may be an essential protein target for repressing lipid synthesis. Capsaicinoids from Capsicum annuum demonstrate potent antibacterial activity. This study predicted the ability of capsaicinoid compounds to inhibit FabH. In silico analysis was performed by retrieving the structure of FabH from PDB and those of selected capsaicinoid derivatives from PubChem. The compounds were docked using AutoDock Vina in PyRx 0.8 software. The interactions of FabH and different capsaicinoid derivatives showed identical binding characteristics. The bonding type most frequently observed was hydrogen bonds. In conclusion, capsaicinoid derivatives could block lipid synthesis through FabH. The relevant mechanism and biological processes should be studied further.

Kajian in silico Penghambatan Spesifik 3C-like Protease SARS-CoV-2 Senyawa Quinic Acid, Gluconic Acid, dan Ferulic Acid pada Kulit Kopi Yohanes Bare; Frederiksen Novenrius Sini Timba; Dewi Ratih Tirto Sari; Oktavius Yoseph Tuta Mago; Maria Marcelina Dua Nurak
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.3971

This study aims to explore the chemical compounds of the coffee pulp as an anti-covid-19 (anti-3C-like protease). In silico modeling was carried out by structure retrieval, protein preparation, and docking simulation. Specific Grid docking was used for ligands – protein interacting by using Molegro Virtual Docker 5, followed by visualizing Discovery studio version 21.1.1. Compounds contained in coffee pulp, quinic acid, gluconic acid, and ferulic acid separately bind to the same amino acid residues of 3CL Protease or each other. Furthermore, three compounds inhibited 3CLPro activity by catalytic site blocking of 3CLPro, indicating that coffee compounds have potential as molecular therapeutic materials for the coronavirus by inhibiting SARS-CoV-2 genome replication.

Co-Authors Agustina Elizabeth Ahmad, Nurul Imaniyah Andri Maulidi Andri Maulidi Angeliana Desimaris Nita Angeliana Desimaris Nita Anselmus Dawa Apriani Herni Rophi Aprianus Pani Pili Aprianus Pani Pili Daeng Tiring, Sri Sulistyaningsih Natalia Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Eci, Margaretha Nona Elfi, Theresia Nona fatchiyah . Fitra Arya Dwi Nugraha Fransiskus Xaverius Ndia Frederiksen Novenrius Sini Timba Gabriella Candrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Galis, Rofinus Gaso, Maria Triswanti Hejo, Yosefina Suryanti Heny Yusuf Hiko, Maria Filestina Indahsari, Lilin Ika Nur Jatmiko Eko Witoyo Kari, Magdalena Letek Klementinus Bhato Krisna Pada Krisna Pada Krisnamurti, Gabriella Candrakirana Krisnamurti, Gabriella Chandrakirana Kristina Novita Kuki, Agustina Dua Lailiyah, Fatinatul Laily Sifaiyah Lele, Maria Nona Elci Lopa, Maria Imelda Lorenza, Margaretha Rika Wahyu Gabrella Lute, Maria Alvensia Lydia Efliani Coriessa Meak Lydia Efliani Coriessa Meak M A Yohanita Nirmalasari Magdalena Letek Kari Mansur S Mansur s Margaretha Nona Eci Margaretha Rika W G L Margaretha Rika Wahyu Gabrella Lorenza Maria Alvensia Lute Maria Fatima Neno Maria Filestina Hiko Maria Helvina Maria Imelda Lopa Maria Marcelina Dua Nurak Maria Marcelina Dua Nurak Maria Nona Elci Lele Maria Triswanti Gaso Maria Yuniati Nona Ade Marsiana Coo Mogi Marsiana Coo Mogi Maximus M Taek Meak, Lydia Efliani Coriessa Mira Kurniawati Misa, Aljefridus Mogi, Marsiana Coo Ngongo, Yosefina Nita, Angeliana Desimaris Nur Dina Camelia Nurak, Maria Marcelina Dua Nurul Imaniyah Ahmad Nurul Imaniyah AHmad Oktavius Yoseph Tuta Mago Paula Yunita Seku Ra'o Paula Yunita Seku Ra'o Paulina Bewu Lele Rachmad, Yoga Tribakti Ratna Susana Dawa Rofinus Galis S, Mansur Saputra, Mansur Sari, Dewi Ratih Tirto Selmin, Yosefina Sizi, Yosefina Sri Sulistyaningsih Natalia Daeng Tiring Sri Sulystyaningsih Natalia Daeng Tiring Sukarman Hadi Jaya Putra Taek, Maximus M Tematan, Yohanes Boli Theopilus W Watuguly Theresia Nona Elci Theresia Nona Elfi Theresia Nona Elfi Ujiana, Wa Ode Ule, Kristina Novita Ustiatik, Reni Vincentius, Angelinus Wa Ode Ujiana Wa Ode Ujiana Yoga Tribakti Rachmad Yohanes Boli Tematan Yohanes Boli Tematan Yohanes Nong Bunga Yosefina Ngongo Yosefina Selmin Yosefina Sizi Yosefina Suryanti Hejo

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