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All Journal Bioscience El-Hayah : Jurnal Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biosfer: Jurnal Tadris Biologi Biogenesis: Jurnal Ilmiah Biologi Quagga Jurnal Florea JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Al-Kimia BIOEDUSCIENCE Jurnal Biologi Tropis Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Jurnal Saintek Lahan Kering Jurnal BIOEDUIN : Program Studi Pendidikan Biologi Qalam: Jurnal Ilmu Kependidikan Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Biota Jurnal Mangifera Edu Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika JURNAL PENDIDIKAN MIPA Jurnal Pendidikan dan Konseling Biopendix: Jurnal Biologi, Pendidikan dan Terapan Jurnal Jejaring Matematika dan Sains Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Biogenerasi Journal On Teacher Education (Jote) JSMARTech : Journal of Smart Bioprospecting and Technology Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Ilmiah Medicamento Mattawang: Jurnal Pengabdian Masyarakat Jurnal Biosense Jurnal Ilmiah Wahana Pendidikan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Mandiri Makara Journal of Science Medical Sains : Jurnal Ilmiah Kefarmasian Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Bare, Yohanes
Program Studi Pendidikan Biologi, Fakultas Keguruan Dan Ilmu Pendidikan, Universitas Nusa Nipa, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Capsaicinoids from Capsicum annuum as an Alternative FabH Inhibitor of Mycobacterium Tuberculosis: In Silico Study Krisnamurti, Gabriella Chandrakirana; Sari, Dewi Ratih Tirto; Bare, Yohanes
Makara Journal of Science Vol. 25, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The number of tuberculosis (TB) cases worldwide reached 1.5 million in 2018; thus, TB is considered a deadly disease. TB is caused by Mycobacterium tuberculosis and involves lipid synthesis. Considering the importance of lipid metabolism in bacteria, FabH may be an essential protein target for repressing lipid synthesis. Capsaicinoids from Capsicum annuum demonstrate potent antibacterial activity. This study predicted the ability of capsaicinoid compounds to inhibit FabH. In silico analysis was performed by retrieving the structure of FabH from PDB and those of selected capsaicinoid derivatives from PubChem. The compounds were docked using AutoDock Vina in PyRx 0.8 software. The interactions of FabH and different capsaicinoid derivatives showed identical binding characteristics. The bonding type most frequently observed was hydrogen bonds. In conclusion, capsaicinoid derivatives could block lipid synthesis through FabH. The relevant mechanism and biological processes should be studied further.
Kajian in silico Penghambatan Spesifik 3C-like Protease SARS-CoV-2 Senyawa Quinic Acid, Gluconic Acid, dan Ferulic Acid pada Kulit Kopi Yohanes Bare; Frederiksen Novenrius Sini Timba; Dewi Ratih Tirto Sari; Oktavius Yoseph Tuta Mago; Maria Marcelina Dua Nurak
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.3971

Abstract

This study aims to explore the chemical compounds of the coffee pulp as an anti-covid-19 (anti-3C-like protease). In silico modeling was carried out by structure retrieval, protein preparation, and docking simulation. Specific Grid docking was used for ligands – protein interacting by using Molegro Virtual Docker 5, followed by visualizing Discovery studio version 21.1.1. Compounds contained in coffee pulp, quinic acid, gluconic acid, and ferulic acid separately bind to the same amino acid residues of 3CL Protease or each other. Furthermore, three compounds inhibited 3CLPro activity by catalytic site blocking of 3CLPro, indicating that coffee compounds have potential as molecular therapeutic materials for the coronavirus by inhibiting SARS-CoV-2 genome replication.
PENGEMBANGAN LKPD MATERI KEANEKARAGAMAN HAYATI BERBASIS MODEL PROBLEM BASED LEARNING KELAS X SMA Kristina Novita; Yohanes Bare; Mansur S
Jurnal Biogenerasi Vol. 7 No. 2 (2022): Jurnal Biogenerasi Vol 7 Nomor 2 tahun 2022
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/biogenerasi.v7i2.1982

Abstract

Learning development is one of the innovations in improving student achievement, one of which is by adopting the Problem Based Learning model combined with the Student Worksheet (LKPD). This model of developments is adapted to the material on biodiversity. The purpose of this study is to validate and analyze the feasibility of the resulting LKPD. The development research method adopted is the research and development of the Four-D (4D) model. The results of the LKPD research were valid by material experts (80%), media experts (87.78%), and linguists (81.25%) with a very valid category and obtained a very decent feasibility score. The LKPD developed is expected to be a solution to classroom learning.
PENGEMBANGAN MODUL BIOLOGI MODEL PEMBELAJARAN DISCOVERY LEARNING PADA MATERI SISTEM ORGANISASI KEHIDUPAN KELAS VII Maria Fatima Neno; Yohanes Bare; Yohanes Boli Tematan
Jurnal Biogenerasi Vol. 7 No. 2 (2022): Jurnal Biogenerasi Vol 7 Nomor 2 tahun 2022
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/biogenerasi.v7i2.1983

Abstract

The Discovery learning model leads students to find their own concepts by providing problems to be solved. This study aims to analyze the validity and feasibility of the biology module of the discovery learning model on the material of life organization system in seventh-grade junior high school. The research method is Research and Development with a 4-D model. The study results show that the biology module of the discovery learning model on the material of living organization systems developed has a material validator validity value of 79.9 and is very valid by a language validator of 88, and from a media validator of 84.2. The small-scale module feasibility questionnaire by educators obtained an average score of 102, and the feasibility by students scored 101.5, where the value was categorized as very feasible to use, while the large-scale feasibility questionnaire by educators had a score of 105 and the feasibility questionnaire by students had a score of 104.65 categorized as very proper to use.
Improving Students' Interest in Reading at SDN Gembira Sikka Regency through the Reading Corner: Peningkatan Minat Baca Peserta Didik di SDN Gembira Kabupaten Sikka melalui Pojok Baca Maria Filestina Hiko; Yohanes Bare; Yohanes Nong Bunga; Sukarman Hadi Jaya Putra
Mattawang: Jurnal Pengabdian Masyarakat Vol. 3 No. 4 (2022)
Publisher : Yayasan Ahmar Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.143 KB) | DOI: 10.35877/454RI.mattawang1318

Abstract

Community service activities at SD Negeri Gembira, Sikka Regency are to create a reading corner in the library. The purpose of creating a reading corner is to increase students' interest and motivation to read, encourage better library management, and help students to be able to take advantage of free time by reading. The activity of making a reading corner is an effort made as an answer to the problems found in the learning process in the classroom, namely that there are still students who have not been able to manage smoothly even though they have been in class VI. The use of the reading corner is made to target specifically for class VI students but does not close the opportunity to all students of SD Negeri Gembira. A series of PkM activities have been carried out from August to November 2022. All components at SD Negeri Gembira strongly support the creation of a reading corner. Learners have shown progress in learning especially reading proficiency.
Potential of Squid Ink Compounds as Insilicate FabH Protein In Silico Angelinus Vincentius; Yohanes Bare
Jurnal Biologi Tropis Vol. 22 No. 3 (2022): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v22i3.4039

Abstract

Tuberculosis (TB) is a disease with the second number of cases in Indonesia. The therapy process is carried out by utilizing one of the waste materials, namely squid ink bags, which are predicted to have active compounds. In the TB cycle, the enzyme FabH is catalyzed as a mediator of lipid synthesis. Inhibition of FabH became the main target through the role of squid ink compounds. The squid ink has a potential as bactery inhibitor. The purpose of this study was to analyze the potential of squid ink as an alternative to TB therapy by inhibiting lipid synthesis (FabH). In silico approach was used in this research. Bioactive compound 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (CID: 119405), cinnamic acid (CID: 444539), betaine (CID: 247) were downloaded from PubChem, and FabH protein (PDB ID 2QO1) was downloaded from the protein data bank database. (GDP). Docking used HeX 8.0.0.0, visualization and analysis using Discovery studio ver 21.1.1. Results from the analysis, we found compounds 5,6-dihydroxyindole-2-carboxylic acid (DHICA), cinnamic acid, betaine contained in squid ink molecularly have potential as an alternative TB therapy by inhibiting FabH, the interaction lead to treatment the TB. In vitro and in vivo studies are needed to analyze further before human studies.
Pengembangan LKPD Berbasis Guided Inquiry Materi Pewarisan Sifat Maria Marcelina Dua Nurak; Yohanes Bare; Sukarman Hadi Jaya Putra
Journal on Teacher Education Vol. 4 No. 2 (2022): Journal on Teacher Education
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jote.v4i2.9332

Abstract

Media pembelajaran yang digunakan dalam pembelajaran harus sesuai dengan kondisi sekolah, peserta didik serta pemilihan media harus disesuaikan dengan tujuan pembelajaran. Penelitian ini bertujuan untuk menganalisis kerangka pengembangan dan kelayakan media LKPD berbasis guided inquiry pada materi pewarisan sifat pada makhluk. Penelitian ini dilakukan di SMP Yapenthom 2 Maumere. Jenis penelitian berupa pengembangan atau Research and Develompment dengan mengikuti model Borg and Gall. Hasil penelitian menunjukan bahwa produk produk LKPD berbasis guided inquiry dinyatakan sangat valid dengan rerata persentase kevalidan sebesar 93,76%. Selanjutnya dilakukan uji coba tahap 1 yang presentase kelayakan LKPD berbasis guided inquiry masing-masing sebesar 100% dan 98,67% dengan kategori sangat layak. Uji coba tahap kedua memperoleh rerata presentase kelayakan masing-masing sebesar 100% dan 99,50% dengan kategori sangat layak.
Implementation of Outing Class to Stimulate Student Motivation Paulina Bewu Lele; Sukarman Hadi Jaya Putra; Yohanes Bare; Yohanes Nong Bunga
Mattawang: Jurnal Pengabdian Masyarakat Vol. 4 No. 1 (2023)
Publisher : Yayasan Ahmar Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35877/454RI.mattawang1328

Abstract

An interesting teaching and learning process will further motivate students to be active in learning. Processes that are standard and tend to be rigid make students bored and disinterested in learning, moreover science learning materials usually keep students motivated. The concept of contextual science learning needs to be done, so that they experience real learning more. One of them is learning with a contextual approach is outing class. Learning that is directly in contact with nature. This PKM activity involved 25 grade 4 students at SDN Napungbiri Pante, Waigete District, and Sikka Regency. PKM is carried out by involving students to be actively involved in learning with the outing class model. The results of this PKM activity show that the level of student participation reaches 100% with very good motivation, namely 94%. These results indicate that outing class activities have a good impact on increasing student motivation, which in the end will have implications for increasing students' cognitive scores.
Pengembangan Lembar Kerja Peserta Didik (LKPD) Berbasis Inkuiri Terbimbing pada Materi Sistem Gerak Manusia Maria Alvensia Lute; Sukarman Hadi Jaya Putra; Yohanes Bare
Jurnal Pendidikan dan Konseling (JPDK) Vol. 4 No. 6 (2022): Jurnal Pendidikan dan Konseling
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jpdk.v4i6.9534

Abstract

Pembelajaran yang menarik adalah pembejaran yang menggunakan media pembejaran yang dapat membuat siswa betah untuk belajar dan mengerti dengan materi yang diajarkan. Dalam media disajikan materi secara jelas dan mudah dipaham dengan tujuan dan indikator yang jelas. Penelitian ini adalah menganalisis validitas dan kelayakan media LKPD berbasis inkuiri terbimbing pada materi sistem gerak pada manusia. Penelitian ini dilakukan di SMPK Rokatenda Palue. Jenis penelitian berupa pengembangan atau Research and Develompment dengan model 4-D. Hasil penelitian menunjukan bahwa produk produk LKPD berbasis inkuiri terbimbing sangat valid dengan rerata persentase kevalidan sebesar 92,75 % . Nilai hasil uji tahap 1 pada kelayakan LKPD dengan berbasis inkuiri terbimbing adalah masing-masing sebesar 97,3% dan 97,53% dengan kategori layak. Nilai hasil uji tahap 2 pada kelayakan LKPD dengan berbasis inkuiri terbimbing adalah masing-masing sebesar 96,7 % dan 92,18% dengan kategori sangat layak. Hasil validasai dari validator menyatakan LKPD adalah sangat valid dan nilai kelayakan pada uji coba tahap 1 dan uji coba tahap 2 adalah sangat layak sehingga produk LKPD yang dikembangkan sangat layak untuk digunakan sebagai media pembelajaran di sekolah.
Pengembangan Lembar Kerja Peserta Didik (LKPD) Berbasis Problem Based Learning (PBL) Pada Materi Sistem Peredaran Darah Anselmus Dawa; Sukarman Hadi Jaya Putra; Yohanes Bare
Jurnal Pendidikan dan Konseling (JPDK) Vol. 4 No. 6 (2022): Jurnal Pendidikan dan Konseling: Special Issue (General)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jpdk.v4i6.10014

Abstract

Pembelajaran IPA merupakan salah satu model implementasi kurikulum yang dianjurkan untuk diaplikasikan di jenjang sekolah dasar (SD) dan sekolah menengah pertama (SMP), dan pembelajaran IPA membutuhkan model pembalajaran yang tepat sehingga bisa membuat proses belajar mengajar jadi menarik perhatian peserta didik. Diperlukan suatu media yang baik dan bisa membuat interaksi peserta didik secara penuh. Penelitian ini bertujuan menganalisis validasi dan kelayakan LKPD Berbasis Model Problem Based Learning (PBL) Pada Materi Sistem Peredaran Darah Manusia Kelas VIII SMP. Penelitian ini dilakukan di SMPN Hangalande Kecamatan Kota Baru Kabupaten Ende. Metode penelitian yang digunakan adalah pengembangan atau Research and Develompment dengan model 4-D. Hasil penelitian menunjukan bahwa produk p Berbasis Model Problem Based Learning (PBL) Pada Materi Sistem Peredaran Darah Manusia Kelas VIII SMP sangat valid dengan rerata persentase kevalidan sebesar 92,75 % . Nilai hasil uji tahap 1 pada kelayakan LKPD dengan berbasis inkuiri terbimbing adalah masing-masing sebesar 97,3% dan 97,53% dengan kategori layak. Nilai hasil uji tahap 2 pada kelayakan LKPD dengan berbasis inkuiri terbimbing adalah masing-masing sebesar 96,7 % dan 92,18% dengan kategori sangat layak. Hasil validasai dari validator menyatakan LKPD adalah sangat valid dan nilai kelayakan pada uji coba tahap 1 dan uji coba tahap 2 adalah sangat layak sehingga produk LKPD yang dikembangkan sangat layak untuk digunakan sebagai media pembelajaran di sekolah.
Co-Authors Agustina Elizabeth Ahmad, Nurul Imaniyah Andri Maulidi Andri Maulidi Angeliana Desimaris Nita Angeliana Desimaris Nita Anselmus Dawa Apriani Herni Rophi Aprianus Pani Pili Aprianus Pani Pili Daeng Tiring, Sri Sulistyaningsih Natalia Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Eci, Margaretha Nona Elfi, Theresia Nona fatchiyah . Fitra Arya Dwi Nugraha Fransiskus Xaverius Ndia Frederiksen Novenrius Sini Timba Gabriella Candrakirana Krisnamurti Gabriella Candrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Galis, Rofinus Gaso, Maria Triswanti Hejo, Yosefina Suryanti Heny Yusuf Hiko, Maria Filestina Indahsari, Lilin Ika Nur Jatmiko Eko Witoyo Kari, Magdalena Letek Klementinus Bhato Krisna Pada Krisna Pada Krisnamurti, Gabriella Candrakirana Krisnamurti, Gabriella Chandrakirana Kristina Novita Kuki, Agustina Dua Lailiyah, Fatinatul Laily Sifaiyah Lele, Maria Nona Elci Lopa, Maria Imelda Lorenza, Margaretha Rika Wahyu Gabrella Lute, Maria Alvensia Lydia Efliani Coriessa Meak M A Yohanita Nirmalasari Magdalena Letek Kari Mansur S Mansur s Margaretha Rika W G L Margaretha Rika Wahyu Gabrella Lorenza Maria Alvensia Lute Maria Fatima Neno Maria Filestina Hiko Maria Helvina Maria Marcelina Dua Nurak Maria Marcelina Dua Nurak Maria Yuniati Nona Ade Marsiana Coo Mogi Marsiana Coo Mogi Maximus M Taek Meak, Lydia Efliani Coriessa Mira Kurniawati Misa, Aljefridus Mogi, Marsiana Coo Ngongo, Yosefina Nita, Angeliana Desimaris Nur Dina Camelia Nurak, Maria Marcelina Dua Nurul Imaniyah AHmad Oktavius Yoseph Tuta Mago Paula Yunita Seku Ra'o Paula Yunita Seku Ra'o Paulina Bewu Lele Ratna Susana Dawa S, Mansur Saputra, Mansur Sari, Dewi Ratih Tirto Selmin, Yosefina Sizi, Yosefina Sri Sulistyaningsih Natalia Daeng Tiring Sri Sulystyaningsih Natalia Daeng Tiring Sukarman Hadi Jaya Putra Taek, Maximus M Tematan, Yohanes Boli Theopilus W Watuguly Theresia Nona Elci Theresia Nona Elfi Ujiana, Wa Ode Ule, Kristina Novita Ustiatik, Reni Vincentius, Angelinus Wa Ode Ujiana Yoga Tribakti Rachmad Yoga Tribakti Rachmad Yohanes Boli Tematan Yohanes Boli Tematan Yohanes Nong Bunga