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All Journal Jurnal Kesehatan Lingkungan MPI (Media Pharmaceutica Indonesiana) KOVALEN: Jurnal Riset Kimia Jurnal Kimia Riset THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Wikrama Parahita : Jurnal Pengabdian Masyarakat Jurnal Surya Masyarakat Walisongo Journal of Chemistry AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Medical Technology and Public Health Journal INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Community Development Journal Indonesian Journal of Community Services Bali Medika Jurnal Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Community Development Journal: Jurnal Pengabdian Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat Medicra (Journal of Medical Laboratory Science/Technology) Jurnal Surya Masyarakat Indonesia Berdaya Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat Environmental and Toxicology Management (ETM) Journal of Health Community Service Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Jurnal Farmasi Sains dan Praktis Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Prominentia Medical Journal National Conference for Ummah
Devyana Dyah Wulandari
UNIVERSITAS NAHDLATUL ULAMA SURABAYA
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Journal : prominentia medical journal

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Analisis Efek Mitragynine Terhadap Metabolisme Glukosa melalui Uji Toleransi Glukosa (OGTT) dan Uji Toleransi Insulin (ITT) pada Model Tikus Diabetes Awwalia, Evi Sylvia; Faradis, RA. Hani; Wulandari, Devyana Dyah; Salim, Hotimah Masdan
Prominentia Medical Journal Vol 7 No 1 (2026): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v7i1.6054

Abstract

Mitragynine is the major alkaloid found in Mitragyna speciosa (kratom) and has been reported to possess various biological activities, including potential effects on glucose metabolism. However, scientific evidence regarding its role in glucose tolerance and insulin sensitivity remains limited. This study aimed to evaluate the effects of methanolic extract of Mitragyna speciosa containing mitragynine on glucose metabolism through the Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT) in experimental animals. Experimental animals were divided into groups consisting of a control and treatment groups receiving methanolic extract of M. speciosa at doses of 15 mg/kg BW and 30 mg/kg BW. Parameters observed included blood glucose levels at different time points following glucose administration (OGTT) and the response to exogenous insulin administration (ITT). Administration of mitragynine extract significantly reduced blood glucose levels compared with the control group in the OGTT, particularly at the 30 mg/kg BW dose. Furthermore, the ITT demonstrated improved insulin sensitivity, with a more rapid decline in blood glucose levels in the treatment groups. These effects showed a dose-dependent pattern, with the higher dose producing more pronounced improvements. Methanolic extract of Mitragyna speciosa containing mitragynine has the potential to enhance glucose metabolism by improving glucose tolerance and increasing insulin sensitivity. These findings suggest that mitragynine could be explored as a potential adjuvant agent in managing glucose metabolism disorders; however, further investigations are needed to elucidate its molecular mechanisms and long-term safety.
Co-Authors , Wirda Nur Fa'ida Adela Puspitasari Aditiya Putri, Ngiluhtara Dyah Aguslina Kirtishanti Aguslina Kirtishanti Aini, Fadlilah Nur Aishella, Maulida Akhmad, Nur Faradila Alfian Daffa Alkatiri, Wardah Andini, Ary Andreas Putro Ragil Santoso, Andreas Putro Ragil Ardyarini Dyah Savitri Ardyarini Dyah Savitri Arvian Nur Amalina Audina, Miea Awwalia, Evi Sylvia Ayu Wuryaningrum Baskara, Muhamad Damar Bintarti, Tri Wahyuni Choirotussanijjah Choirotussannijah Choirotussannijah Damar Baskara, Muhammad Dyah Dedi, Muhamad Derrizkie Divanda Herzhaputra Devyani Diah Wulansari Devyani Diah Wulansari Devyani Dyah Wulansari Dewi Masitah Dwi Handayani Emma Savitri Endah Budi Permana Putri Ersalina Nidianti Eva Tri Wulandari Fadlilah Nur Aini Faradis, RA. Hani Fauziah, Luqiana Fitriana Sari, Devi Gilang Nugraha Halimah Prisilia Herliani Rahmania Sari Hermawati, Septina Isro’ Hotimah Masdan Salim Illahi, Wahyu Imastufah Imratul Mukarramah Indah Lestari Janetra Yudhis Nata P Kifli, Nurolaini Krisdayanti, Affina Lili Susan Rahmawati Lysa Veterini Ma'at, Suprapto Maghfuroh, Qonita Iklila Mella Rahmawati Mukminin Mellyisa Mochamad Nurul Lail Mufida, Nisaul Muhammad Afwan Romdloni Muhammad Fadillah, Farchan Muhammad Taufiq Hidayat Mukarramah, Imraatul Mukhtar Adi Nugroho Nadzarillah, Najmatul Jannah Najwa Asnani, Abidah Dyah Nanik Handayani Novera Herdiani, Novera Nur Lailatul Qodriyah Nur Zalsabila Isnaini Nuzula, Fina Firdausi Pratiwi, Viera Nuriza Prayekti, Endah Raden Joko Kuncoroningrat Susilo Rahmawati Fitri Awalia Rahmawati, Lili Susan Risthanti, Reine Risa Rizki Nurmalya Kardina Rohmah, Wardah Rosda Rodhiyana S. P. Edijanto Penulis Safinah Izzatunnisa Salim, Hotimah Masdan Sari, Herliani Rahmania Suprapto Maat Suryandaru, Suryandaru Syafira, Nanda Syafiuddin, Achmad Syinta Nur Isnaini Ulan Sari, Della Citra Uswatun Hasanah Wardah Rohmah Wardany, Nadya Ika Widya Novita Sari Widya Novitasari Wilujeng, Putri Shinta Wulansari, Devyani Wulansari, Devyani Diah Wulansari, Devyani Diah Wuryaningsih, Lucia Endang Yusron Suryonegoro Mushawwir Zain, R.A Wafiqah Aulia