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Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 21 Documents
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Search results for , issue "Vol 22, No 1 (2025)" : 21 Documents clear
Effectiveness of Nano Spray From Extract of Kelubut Leaf (Passiflora foetida L.) as Antibiofilm on catheters of Patients with Urinary Tract Infection Hamzah, Hasyrul; Astriani, Nur Atika; Farida, Norma Feti; Kamilah, Lila Zulfa; Azizah, Aryantinur; Rahman, Fathur
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008198

Abstract

Catheter-associated urinary tract infections (CAUTI) have increased significantly every year. Approximately 70-80% of these infections involve biofilms. This study aims to determine the effectiveness of nano spray formula of kelubut leaf extract in inhibiting and eradicating biofilm formation on catheters. Kelubut (Passiflora foetida L.) leaf extract was obtained through maceration process to obtain useful compounds. Antibiofilm activity was assessed using microbroth dilution, with scanning electron microscopy for visualization. The nano spray formulation activity of kelubut (Passiflora foetida L.) leaf extract was able to inhibit biofilm growth by (77.74% ± 0.01), while ciprofloxacin was slightly more effective with a value of (80.22% ± 0.01). SEM analysis confirmed the ability of the kelubut leaf extract nanospray formulation to inhibit and damage Escherichia coli biofilms. The nano spray formulation of kelubut leaf extract (Passiflora foetida L.) coded NS1 is able to inhibit biofilm formation activity on catheters and has the potential to be developed as an antibiofilm candidate against bacteria that cause urinary tract infections.
Hematology Toxicities in Paclitaxel-Carboplatin Cancer Regiment Meitasari, Annisa Diyan; Ermawati, Dian Eka; Rohmani, Sholichah; Sasongko, Heru; Zulpadly, Muhammad Fiqri; Utami, Diyah Tri; Susanto, Nindita Clourisa Amaris; Untari, Meta Kartika; Darojati, Ulfa Afrinurfadhilah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007064

Abstract

Chemotherapy is one of therapy for patients with cancer. Treatment carboplatin paclitaxel regimen is usually use for cervix, breast, and ovarium cancer. But the data of ADRs in hematology toxicity caused paclitaxel-carboplatin regiment is minimal, so it is required to do research. The aim of this research is can give information about the hematology toxicity, incident, severity, relationship between risk factor due incident of myelosuppression, and relationship between pre post chemotherapy due the myelosuppression. The severity ADRs use CTCAE 5.0. The ADRs were evaluated by severity, descriptive statistics, and some bivariate analysis. Anemia (66.46%) has a highest incident and followed by leukopenia (18.18%), neutropenia (13.22%), and thrombocytopenia (9.09%). Type of cancer associate with incident of anemia, leukopenia, and thrombocytopenia. The number of cycle chemotherapy use carboplatin paclitaxel regiments affects significant with the incidence of anemia. Patients who use paclitaxel-carboplatin as a regimen chemotherapy confirmed decrease in hematologic data such as hemoglobin, leukocyte, and thrombocyte.
A Decade of Research about Honey as an Antioxidant in the Scopus Database: Bibliometric Analysis Setyawan, Eka Indra; Putra, Komang Dian Aditya; Ishfahan, Izzul; Lingling, Gek Niken Tasya
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007378

Abstract

Honeybees transform flowers' delicious, aromatic, and viscous nectar into the naturally occurring, antioxidant-rich honey. A growing scientific study increasingly supports honey's use in complementary and alternative medicine. No bibliometric analysis of published data on honey antioxidants has been conducted to ascertain the state of the research. Using VOSviewer and RStudio, we conducted a bibliometric analysis of the scholarly articles about honey's antioxidants in the Scopus database. Honey's antioxidant properties were covered in 765 papers between 2013 and 2023. Most publications (309 articles) are attributed to Malaysian researchers, with Universiti Sains Malaysia being the most productive, with 53 articles produced. Food Chemistry is the most productive source, with an average of 64.8 citations per article and 24 documents. Having the highest H-index of 10, Battino M significantly influenced the honey's antioxidant properties studies. "Honey" and "antioxidant activity" were the most frequent keywords. We can learn about the novelty of honey as an antioxidant research from this results.
Evaluation of the Level of Knowledge, Attitudes, and Behavior of High School Students in the City of Pekanbaru in the Use of Antibiotics Lubis, Nursyafni; Rahmawati, Ayu; Indriani, Lusi; Afandi, Ayu Indah Lestari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007268

Abstract

The high use of antibiotics in the community will lead to resistance. According to the results of studies in Indonesia, the problem of antibiotic resistance is very complex and will continue to increase every year. Infectious diseases account for more than 13 million deaths per year in developing countries. Wise and rational use of antibiotics can reduce the disease burden, especially infectious diseases. Conversely, the widespread use of antibiotics that do not match the indications significantly increases antibiotic resistance. Students must know the proper use of antibiotics so as not to develop antibiotic resistance. They do not know much or fully understand antibiotics during the transition from childhood to adulthood. This study aims to determine the relationship between knowledge, attitudes, and behavior of SMAN Se-Kota Pekanbaru students in the use of antibiotics. This research uses a descriptive survey method with 360 respondents. Data analysis was done using a chi-square test with a significance level of p 0.05. The results of this study showed that there were students with good knowledge (67%), with some who showed a positive attitude (75%), and less behavior in the use of antibiotics (74%). The chi-square test showed a significant relationship between attitudes and antibiotic use behavior with a p-value of 0.001 (p 0.005). While the level of knowledge and attitude had a p-value of 0.605 (p 0.05) and the level of knowledge and behavior had a p-value of 0.118 (p 0.05), indicating there was no significant relationship. From the results of this study, it can be concluded that there is no significant relationship between students' knowledge with attitudes and behavior in the use of antibiotics, and there is a significant relationship between attitudes and student behavior in the use of antibiotics.
Acute and Sub-Acute Oral Toxicity Assessment of Marchantia paleacea Bertol. Liverwort Herb Extract in Mice on Liver and Kidney Function Purkon, Dicki Bakhtiar; Nainggolan, Aurelya Veny Kurnia; Ningsih, Padmasari Diah Ayu Kumala; Kusmiyati, Mimin; Sudaryat, Yayat; Srinati, Ine; Fadhlillah, Faizah Min; Sufa, Hafizah Ilmi; Hotimah, Alni Khusnul
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008218

Abstract

Herbaceous liverwort Marchantia paleacea Bertol. has been known as a potential source that has bioactive compounds with various pharmacological benefits, such as: antimicroorganism, antifungal, antioxidant, immunomodulator, hepatoprotector, antipyretic, diuretic, cardiotonic, and vasorelactan. However, information regarding oral acute and sub-acute toxicity data from ethanol extracts of Marchantia paleacea Bertol. liverwort herb is still very limited. Therefore, this study aimed to evaluate the acute and sub-acute toxicity of liverwort herb ethanol extract in female mice of ddY strains. The acute toxicity test method was carried out by giving ethanol extract of the liverwort herb Marchantia paleacea Bertol. (EEMP) in single doses at doses of 250, 500, 1000, and 2000 mg/kg bw orally for 14 days, while sub-acute toxicity tests were performed by administering EEMP test extracts at doses of 125, 250, 500, 1000, and 2000 mg/kg bw orally for 28 days in accordance with testing standards from BPOM (2022), Thompson-Weil, and OECD. Parameters observed include clinical symptoms (including: mortality), profile of body weight changes, biochemical analysis of serum, and histopathological analysis of vital organs (liver and kidney). Results from acute toxicity testing showed that a single dose of EEMP at the tested level did not cause significant clinical symptoms and histopathological disorders, and there were no deaths in test animals classified as mild toxic substances based on BPOM criteria ( 2000 mg/kg bw). And sub-acute toxicity tests from the 125, 250, and 2000 mg/kg bw test groups revealed a significant increase in average SGOT levels compared to the normal control group on the 28th test day (p0.05) but still within the normal range. Most other test parameter profiles show no significant changes. Some of the observed changes, particularly in the biochemical and histological parameters of the organs that occur are assumed to be transient reaction effects and are not a sign of toxicity. These findings suggest the need for further study of the potential toxic effects of the liverwort herb Marchantia paleacea Bertol. This study provides important insights in the understanding of the potential uses of the liverwort herb Marchantia paleacea Bertol. as a product of herbal ingredients (nutraseutics, supplements, and traditional medicine), and reinforces the need to understand the potential toxicity risks associated with it. 
Development of an Information System with an Herbal Database of East Java Suppliers and Distributors Yunita, Oeke; Savitri, Melania Dwi; Dinata, Hendra; Krisnawan, Alfian Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008086

Abstract

The production and marketing operations of small traditional medicine businesses (UKOT) in Indonesia heavily depend on the availability and choice of distributors of herbal products as well as suppliers of raw materials. The guarantee of accuracy and convenience of access to supplier and distributor data at UKOT PT X in Surabaya, East Java, can be supported by an internal information system that includes a database of East Java suppliers and distributors. Data was gathered via an interview with the Responsible Pharmacist (APJ) and documentation on PT X's records. Subsequently, the completed data generated from the chosen documentation is entered into the database that is a component of PT X's internal information system. The analysis was conducted on PT X's internal database, with an emphasis on its completeness, correctness, and accessibility. This result was obtained by 80% of data completeness evaluation ranges. All respondents properly answered questions about data about finished product suppliers and distributors from PT X's internal information system database. Ninety-three percent of respondents agree that the database in PT X's information system is very easy to access in terms of data display, language, and search feature functions.
The Relationship of Medication Adherence to Controlled HbA1c and ASCVD Risk in Type II Diabetes Mellitus Patients in Minggir Primary Health Care Dewita, Aquina Nino Rama Dhanti; Hendra, Phebe; Virginia, Dita Maria
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007464

Abstract

Type II diabetes mellitus (DM) therapy can be evaluated from the controlled HbA1c. Another aspect that needs to be controlled in patients with DM is lipid levels. Lipid levels should be controlled in a patient with type II DM to prevent atherosclerotic cardiovascular disease (ASCVD). The study was conducted to determine the relationship between medication adherence with controlled HbA1c and ASCVD risk in patients with type II DM. The study was an analytical observational study with a cross-sectional research design used to examine the relationship between medication adherence with controlled HbA1c and ASCVD risk. Our respondents were patients following a chronic disease management program at Minggir Primary Health Care. The level of medication adherence was measured using the Medication Adherence Report questionnaires. The ASCVD risk was measured using the American College of Cardiology/American Heart Association tools. The chi-squared test was applied to determine the relationship between medication adherence with HbA1c values and ASCVD risk in patients with type II DM. Most patients with type II DM had high medication adherence (60%), controlled HbA1c values (56.4%), and high ASCVD risk (70.9%). There was no significant relationship between medication adherence in type II DM patients with controlled HbA1c values and ASCVD risk.
Comparison of GPU-accelerated Molecular Dynamics Simulation Efficiency for the Acetylcholinesterase-Huprine X Complex using YASARA, GROMACS, and AMBER Wiranata, Bonifacius Ivan; Istyastono, Enade Perdana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009061

Abstract

Molecular dynamics simulations are a valuable tool in identifying potential acetylcholinesterase inhibitors for Alzheimer's disease therapy. Recent advancements in hardware and software, particularly the implementation of graphics processing units (GPUs), have significantly improved the efficiency of MD simulations. This study aims to compare GPU-accelerated molecular dynamics (MD) simulations of the acetylcholinesterase-Huprine X complex using YASARA, GROMACS, and AMBER. The complex was obtained from Protein Data bank with code 1E66 and was prepared with same conditions. MD simulations were performed for 50 ns with three replicates per software. GROMACS exhibited the shortest average simulation duration (45,104 seconds), followed by AMBER (48,884 seconds) and YASARA (649,208 seconds). RMSD analysis of protein backbone and ligand movement indicated stable simulations across all platforms. Interaction analysis at 25 ns and 35 ns of YASARA’s run revealed that Huprine X maintained key aromatic interactions within the AChE binding pocket, despite undergoing a 180° rotation. YASARA proved more efficient in MD preparation and produced more precise results, while GROMACS was most efficient in simulation runtime. The study highlights the trade-offs between ease of use, simulation speed, and result consistency among these software packages for AChE-HUX MD simulations.
Antihypertensive Effects of Fig Leaves (Ficus carica L.) Ethanolic Extract: An In Vitro and In Silico Study Kurniawan, Muhammad Fariez; Apriliyanti, Suci
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006449

Abstract

Pathological conditions of hypertension can occur due to contractions of blood vessels. Vascular contraction response occurs when epinephrine successfully binds to adrenergic receptors. Objective: This study aims to determine the antagonistic activity of giving ethanolic extracts of fig leaves (Ficus carica L. Folium) in β-adrenergic receptors of isolated aortic organs and to determine the value of the affinity of one of the compounds present in fig leaf extract, which has a strong potential as a vasodilator agent to treat hypertension. This study uses in silico and in vitro methods. The in silico method test used molecular docking, and the in vitro method test used an organ bath on a guinea pig's aortic organs. An in silico docking test was conducted on compounds suspected to have a vasodilator effect, namely Quercetin and β-adrenergic receptor test with native ligand timolol (PDB ID: 6PS6). The in vitro testing of foliar ethanolic extracts was done by administering 0.5 mg of extracts at 100 µL and 200 µL. The resulting data included a percent of aortic contraction data on administering epinephrine concentration series, which was transformed into a pD2 value. The result from the in silico method showed that quercetin binding affinity value (-7.8 kcal/mol) was better than timolol as a comparison (-6.4 kcal/mol). The result from the in vitro method showed that the fig leaf's ethanolic extract could shift the percentage curve of contraction response to the administration of epinephrine series by decreasing the pD2 value. A dose of 0.5 mg volume 200 µL is effective because it gives a significant difference to the control group but does not show a significant difference in the comparison group. Conclusively, the ethanolic extract of fig leaves can be developed as a vasodilator agent. 
W/O/W Emulsions Formula of Bacteriophages ϕPT1b As a Fruit Wash to Inhibit Pathogenic Escherichia coli Contamination Khairunnisa, Icha; Narulita, Erlia; Winarti, Lina; Febrianti, Riska Ayu; Kuswati, Kuswati; Yulian, Ria
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007143

Abstract

Pathogenic Escherichia coli infect fruit through irrigation contaminated water. Bacteriophage ϕPT1b has ability to infect E. coli and act as food security. Bacteriophage formulations as emulsion preparations increase the efficiency of application and the stability of long-term storage, one of it is W/O/W emulsions. The objective of this study was to examine the effect of cremophor RH 40, span 80 and their interaction on viscosity, droplet size and inhibition of bacteriophage ϕPT1b W/O/W emulsions against pathogenic E. coli. Factorial design method was used to get the optimum formula. The results showed that the cremophor RH 40, span 80, and their interactions increased the viscosity response, decreased the emulsion droplet size, and increased the inhibition against E. coli. FB is the optimum formula for ϕPT1b W/O/W emulsions which has 1% cremophor RH 40 and 4.5% span 80. The formula produced a viscosity of 29 dPas, an average emulsion droplet diameter size of 10.483, and an inhibition against E. coli of 8.65 m. The desirability index value of 0.905 indicates that FB meets 90.5% of the specified criteria.

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