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Yan Hendrika
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JOPS (Journal Of Pharmacy and Science)
Published by Universitas Abdurrab
ISSN : 26229919     EISSN : 26151006     DOI : https://doi.org/10.36341/jops
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JOPS is Journal Of Pharmacy and Science with Scopes of Science : 1) Pharmacy 2) Food Chemistry 3) Biotechnology 4) Pharmacology 5) Microbiology 6) Food Analysis JOPS adalah Jurnal Farmasi dan Sains dengan Ruang Lingkup keilmuan : 1) Farmasi 2) Kimia makanan 3) Bioteknologi 4) Farmakologi 5) Mikrobiologi 6) Analisa Makanan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 220 Documents
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Characterization of Functional Groups and Sunscreen Activity of Ethanol Extract of Breadfruit Leaves (Artocarpus altilis) Gharsina Yumni; Elda Septiana
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7778

Abstract

Breadfruit leaves (Artocarpus altilis) contain phenolic and flavonoid compounds with potential as sunscreens. This study aimed to characterize functional groups and determine the in vitro sunscreen activity of the 96% ethanol extract of breadfruit leaves from Tengaran. The extract was obtained by maceration using 96% ethanol. Functional group analysis was performed using FTIR spectroscopy. Sunscreen activity was tested at concentrations of 200, 400, 600, 800, and 1000 ppm using UV-Vis spectrophotometry (290-320 nm), and SPF values were calculated using the Mansur equation. FTIR results indicated the presence of phenolic and flavonoid compounds characterized by functional groups O-H, C-H aliphatic, C=O, C=C aromatic, C=C alkene, NO₂, and C-O. The SPF values obtained were 24.096; 29.474; 32.449; 38.301; and 40.008, respectively, all falling into the ultra-protection category (>15). In conclusion, the extract contains phenolic and flavonoid functional groups and exhibits potent sunscreen activity with ultra protection.
Uji Efektifitas Antijamur Sediaan Nanogel Mengandung Zink Oxide Ekstrak Air Kulit Jengkol (Pithecellobium lobatum Benth) monica valerie; Vera Estefania Kaban
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7786

Abstract

Introduction: The skin of jengkol fruit contains metabolites such as saponins, tannins, flavonoids, and phenolic compounds that can inhibit microbial growth. Fungal infections caused by Candida albicans remain a health problem, necessitating the development of effective and safe antifungal preparations based on natural ingredients. Objective: This study aims to prove that nanogel preparations containing nanoparticles from water extracts of jengkol skin (Pithecellobium lobatum Benth.) have activity against Candida albicans fungi. Methods: The study was conducted experimentally using nanogels with concentrations of 2.5%, 5%, and 10%. Particle size was analyzed using a Particle Size Analyzer (PSA), while antifungal activity was tested using the well diffusion method on Potato Dextrose Agar (PDA) medium. Ketoconazole 2% was used as a positive control and the nanogel base as a negative control. The tests were conducted in triplicate. Results: The PSA test results showed that the nanogel particle size was in the nanometer scale, namely 38.86 nm; 38.80 nm; and 43.10 nm. The antifungal test results showed that the average inhibition zone diameter was 9.73 mm; 10.70 mm; and 11.76 mm, respectively, while the negative control did not show an inhibition zone. Statistical analysis showed significant differences between treatments (p<0.05). Conclusion: It can be concluded that the nanogel preparation has nanometer-sized particles and antifungal activity against Candida albicans
Aktivitas Antijamur Nanopartikel Zinc Oxide (ZnO) yang Disintesis Menggunakan Ekstrak Kulit Buah Duku (Lansium domesticum) Mutiara Ihsani; Vera Estefania Kaban; Razoki Lubis
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7800

Abstract

This study evaluated zinc oxide (ZnO) nanoparticles biosynthesized using an aqueous extract of duku (Lansium domesticum Corr Corr.) fruit peel for their antifungal activity against Candida albicans, given the rising incidence of candidiasis and the growing resistance to conventional antifungal drugs. The synthesized ZnO nanoparticles were characterized by particle size analysis, showing a Z-average diameter of 89 nm and a polydispersity index of 0.243, confirming their nanoscale dimension and reasonably uniform size distribution. Antifungal activity was assessed using the agar well diffusion method at concentrations of 25-500%. ZnO nanoparticles inhibited Candida albicans growth at every concentration tested, with inhibition zone diameters increasing proportionally with concentration, from 9.65 ± 0.28 mm (moderate category) at 25% to 15.33 ± 0.11 mm (strong category) at 500%, compared with 31.86 mm for the ketoconazole positive control. One-way ANOVA confirmed significant differences among treatment concentrations (F = 397.795; p < 0.001). These findings indicate that green-synthesized ZnO nanoparticles from duku peel extract exhibit concentration-dependent antifungal activity against Candida albicans , supporting their potential as an environmentally friendly alternative antifungal agent.
Effect of Educational Videos on Osteoporosis Knowledge Among Menopausal Women in Semidang Alas Village, Pagar Alam City Reza Rahmawati; Delvia Novalisya; Delia Komalasari; Rizki Oktarini; Muthia Nurhidayah; Dian Handayani
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7810

Abstract

Osteoporosis is a bone-loss disease caused by decreased estrogen levels, predominantly affecting menopausal women. Limited access to health information in rural areas remains a major barrier to early prevention efforts. This study aimed to determine the effect of educational videos on osteoporosis knowledge levels among menopausal women in Semidang Alas Village, Pagar Alam City. A pre-experimental design with a one group pre-test–post-test approach was employed, involving 83 respondents selected through total sampling. Prior to the intervention, 61 respondents (73.50%) demonstrated poor knowledge. Following the educational video intervention, a significant improvement was observed, with 76 respondents (91.60%) achieving good knowledge levels. The paired t-test results indicated a p-value of 0.000, confirming a statistically significant effect of the educational video on osteoporosis knowledge. It is concluded that audiovisual media is an effective health education strategy, particularly for rural communities with limited access to health information.
Antibacterial Activity of Graded Extract of Sikkam Stem Bark (Bischofia javanica Blume) Against Staphylococcus aureus Shintjia Dewi Agustan; Vera Estefania Kaban; Astriani Natalia Br Ginting; Roy Indrianto Bangar
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7819

Abstract

Antibiotic resistance in represents a serious global health challenge, driving the search for alternative antibacterial agents from natural sources. The stem bark of the sikkam tree (Bischofia javanica Blume) has bioactive potential, yet systematic evaluation of its antibacterial activity based on solvent polarity remains limited. This study aimed to investigate the antibacterial potential of graded extracts of Sikkam stem bark against Staphylococcus aureus. Extraction was performed by graded maceration and antibacterial activity was assessed using the disc diffusion method, with amoxicillin and dimethyl sulfoxide serving as positive and negative controls, respectively. Phytochemical screening revealed the presence of phenolics, flavonoids, alkaloids, tannins, saponins, steroids/terpenoids, and quinones. Among the tested extracts, the ethyl acetate extract showed the highest yield (44.65%) and exhibited the strongest antibacterial activity, producing an inhibition zone of 13.75 ± 0.09 mm at concentration 500 mg/mL The ethanol extract also demonstrated strong and consistent inhibition zone of 12.90 ± 0.13 mm, while the n-hexane extract showed the lowest activity, with an inhibition zone of 10.86 ± 0.20 mm. This study indicates that ethyl acetate and ethanol extracts of sikkam stem bark have potential as natural antibacterial agents against Staphylococcus aureus.
Optimalisasi Terapi Antidiabetik Oral pada Diabetes Mellitus Tipe 2: Studi Komparatif Monoterapi dan Kombinasi terhadap Outcome Glikemik Optimalisasi Terapi Antidiabetik Oral pada Diabetes Mellitus Tipe 2: Studi Komparatif Monoterapi dan Kombinasi terhadap Outcome Glikemik Kiki Rawitri; Sri Wahyuni; Syilvi Rinda Sari; Ziza Putri Aisyia Fauzi; Ferina Septiani Damanik; Cut Intan Annisa Puteri; Anggitha Ningtias
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7854

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease with a high prevalence in primary healthcare settings; however, real-world evidence regarding the effectiveness of oral antidiabetic therapies remains limited. This study aimed to compare the effectiveness of oral antidiabetic monotherapy and combination therapy in patients with T2DM at the Teladan Community Health Center (Puskesmas) in Medan. A non-experimental observational study with a cross-sectional design was conducted on 78 patients selected via systematic random sampling, utilizing medical records and data from the "referral-back" program covering the period from September to November 2025. Effectiveness was assessed using random blood glucose (RBG) levels and analyzed with the Kruskal–Wallis test. The results indicated that the combination of glimepiride and metformin was the most frequently used regimen (64.10%), followed by metformin monotherapy (26.92%) and glimepiride monotherapy (8.97%). The lowest mean RBG level was observed in the metformin monotherapy group (147.80±47.27 mg/dl), followed by the metformin-glimepiride combination group (168.72 ± 60.56 mg/dl) and the glimepiride monotherapy group (178±61.31 mg/dL); however, no statistically significant difference was found among the treatment groups (p=0.322). The study concludes that there is no significant difference in effectiveness between monotherapy and combination therapy regarding glycemic control, although metformin showed a trend toward better outcomes. These findings underscore the importance of an individualized approach to therapy for T2DM patients in primary healthcare facilities.
Evaluasi Penggunaan Obat Antituberkulosis pada Pasien Tuberkulosis Dewasa di Dua Puskesmas Kota Pekanbaru Novtafia Endri; Nurul Adzkia Ghearizky; Winda Sri Wahyuni
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7928

Abstract

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB) and remains a major health problem in Indonesia. This study aims to evaluate the appropriateness of antituberculosis drug (OAT) use, including the appropriateness of the drug, dosage, and duration of treatment, and to analyze the relationship between the appropriateness of the duration of treatment and treatment outcomes. This study is an observational, descriptive-analytical study using retrospective medical record data from July 2024 to June 2025. A purposive sampling method was used, with a sample 259 patients who met the inclusion criteria. Data analysis was performed univariately to describe the distribution of study variables and bivariately to examine relationships between variables. The results of the univariate analysis showed that the appropriateness of drug use included 100% drug accuracy, 100% dose accuracy, and 81.1% treatment duration accuracy. The results of the bivariate analysis showed a significant relationship between the appropriateness of treatment duration and treatment outcomes (p-value < 0.001). Patients with appropriate treatment durations had a significantly greater chance of recovery than those with inappropriate treatment durations (OR = 9870). These findings indicate that the treatment process for adult tuberculosis (TB) patients at two community health centers in Pekanbaru City met the 2020 National Guidelines for Tuberculosis Management.
Profil GC-MS Ekstrak Mitragyna speciosa Korth. asal Kalimantan Selatan Hayatun Izma; Normaidah
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7972

Abstract

Mitragyna speciosa Korth. (kratom) has attracted attention due to its alkaloid content, biological activity, and potential for misuse. This study aimed to characterize the secondary metabolite profile of M. speciosa extract using Gas Chromatography–Mass Spectrometry (GC-MS) to identify major marker compounds and establish a chemical fingerprint for sample verification. The sample used was an ethanolic extract of kratom leaves collected from Hulu Sungai Selatan, South Kalimantan, and analyzed using GC-MS. The results showed three major compounds, with mitragynine (25.14%), Corynan-16-carboxylic acid, 16,17-didehydro-9,17-dimethoxy-, methyl ester (3β,16-E) (25.38%), and rhynchophylline (18.89%) as the dominant constituents. These compounds are associated with various biological activities, particularly in the nervous and cardiovascular systems. The findings provide an overview of the chemical compounds in South Kalimantan kratom by GC-MS and may serve as a scientific basis for sample identification, evidence-based kratom monitoring, and further studies related to its potential applications and safety.
Hubungan Antara Obat Yang Digunakan Terhadap Kejadian Kausalitas Adverse Drug Reactions (ADRs) dengan Menggunakan Skala WHO UMC Pada Pasien Congestive Heart Failure Annis Rahmawaty; Rifda Naufa Lina; Gunawan Firmansyah
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.8015

Abstract

Patients with Congestive Heart Failure (CHF) are often prescribed combination therapy, which may lead to Adverse Drug Reactions (ADRs). ADRs assessment can be performed using the WHO-UMC scale by considering the clinical pharmacological aspects of the case history, as well as the quality of documentation and patient observation. This study aimed to determine the relationship between the number of drugs used and the causality of ADRs based on the WHO-UMC scale in patients with Congestive Heart Failure. Data were collected prospectively during June 2025 from 58 patients with a duration of CHF of more than one year at RSI Sunan Kudus. The sampling technique used was total sampling. Data were analyzed descriptively using an observational approach, while the correlation analysis was conducted using the Chi-square test and Fisher’s Exact Test. The results showed that the majority of patients were aged 45–59 years, accounting for 29 patients (50%). ADRs were more frequently observed in male patients, with 36 cases (62.1%), compared to female patients, with 22 cases (37.9%). there are 49 comorbid diseases in patients. The most frequently reported ADR was dizziness, occurring in 17 cases (24.6%), while the most common causality category based on the WHO-UMC scale was “possible,” found in 36 cases. Most patients received more than five medications, with 44 cases reported. In conclusion, there was a significant relationship between the number of medications used and the causality of ADRs based on the WHO-UMC scale in patients with Congestive Heart Failure. The greater the number of medications administered, the higher the risk of ADRs.
Characteristics And Regimen Modifications In Drug-Sensitive Tuberculosis Patients With Drug-Induced Liver Injury: A Retrospective Study umi fatma wati; Fahmi Dimas Abdul Aziz; Rasyidin Rumulus; Indah Tripujiati
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.8021

Abstract

Drug-induced liver injury (DILI) is a serious side effect of first-line anti-tuberculosis drugs (isoniazid, rifampicin, pyrazinamide, ethambutol) in drug-sensitive tuberculosis (TB SO) patients, which can lead to treatment interruption and drug resistance. This retrospective observational study aims to analyze the usage patterns in TB SO patients with DILI using patient medical records from January 1 to December 31, 2024. The variables analyzed include demographic characteristics and the ATT regimen. Out of 100 patients, the majority were male (61%), aged 18-59 years (58%), and had a BMI <18.5 kg/m² (68%). All patients (100%) suffered from pulmonary TB; 74% were new cases and 26% had a history of previous treatment. DILI most often occurs in the first month of the intensive phase (74%). Comorbidities were found in 66% of patients (diabetes mellitus 48%, hypertension 18%). A history of smoking was reported in 51% of patients. Management of DILI: 61% underwent modification of the RHZE regimen, 39% experienced temporary cessation followed by reintroduction. The most common non-hepatotoxic regimen was streptomycin-levofloxacin-ethambutol (SLE) in 83% of modified cases. Severe DILI was found in 53% of patients and very severe DILI in 47% of patients. DILI remains a significant challenge in the treatment of SO TB, especially in patients with malnutrition, diabetes mellitus, and a history of smoking. Modification of the regimen and strict monitoring of liver function are crucial to improving clinical outcomes. Keywords: DILI, drug-sensitive tuberculosis, hepatotoxicity, anti-tuberculosis drugs

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