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Muhammadiyah Medical Journal
Published by Universitas Muhammadiyah Jakarta
ISSN : -     EISSN : 2721317X     DOI : 10.24853
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Muhammadiyah Medical Journal (MMJ) Faculty of Medicine and Health is an international journal based on scientific research. The journal is published 2 (two) times in 1 year, March and September. Muhammadiyah Medical Journal Faculty of Medicine and Health invites the lecturers, practitioners and observers as well as S1/S2/S3 students to submit their scientific articles about the progress of science in the field of Medicine. Article will be reviewed with blind-peer review process. The result of review will be announce in Open Journal System.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 72 Documents
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Endoscopy Gastrointestinal Esophagogastroduodenoscopy (EGD) Profile at Primaya Bekasi Timur Hospital Period October 2021 - October 2022 Sismanto, Bayu Aji; Fauji, Achmad; Rahmah, Nur Miladiyah
Muhammadiyah Medical Journal Vol 5, No 1 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.1.59-68

Abstract

Introduction: Esophagogastroduodenoscopy or gastroscopy is one of the types of endoscopies; the examination includes the esophagus, gastric, and duodenum. Endoscopy is a non-surgical attempt to visualize organs with abnormalities or disorders. It can also be used to obtain tissue (biopsy), remove foreign bodies in the gastrointestinal tract, and observe organs in the body. This study aims to determine the profile of gastrointestinal endoscopy in patients examined at the endoscopy unit of Primaya Hospital, East Bekasi. Methods: The type of research conducted was descriptive retrospective using secondary data in the Medical Record Installation of Primaya Hospital, East Bekasi, from October 2021 to October 2022, totaling 103 patients. Results: The results of this study showed that 51 patients (49.5%) were male, 52 patients (50.5%) were female, and the majority of the patients were aged 41-60 years as many as 44 patients, 42.7%). The most common pre-action diagnosis was dyspepsia (43 patients, 42%), and the most common post-action diagnosis (21 patients, 20.6%) was erosive gastroduodenitis. The most common location of findings in the corpus was 33 patients (32.1%), and the most common finding was mucosal erosion in 36 patients (35.0%). Biopsy was performed in 30 patients (29.1%), and anatomical pathology revealed Helicobacter pylori in 5 patients, chronic duodenitis in 4 patients, chronic gastritis in 19 patients, chronic gastroduodenitis in 1 patient, and polyp putz jeers in 1 patient. And with the most prolonged duration of action being 10-30 minutes, namely 91 patients (88.3%). Conclusion: The results of this study indicate that chronic gastritis accompanied by H.pylori infection is a diagnosis that is more commonly found through esophagogastroduodenoscopic examination and the results of anatomical pathology examination of biopsy tissue compared to other diagnoses.
Antibiotic Susceptibility Profile in Urinary Tract Infection Patients at Tarakan Regional Hospital Dharmawan, Ade; Wijaya, Pande I Gede Indra; Septiana, Yorisye; Pasaribu, Donna Mesina Rosadini; Tan, Henny Tannady; Simanjuntak, Lasma Susi F.
Muhammadiyah Medical Journal Vol 5, No 1 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.1.28-35

Abstract

Background: Urinary tract infections (UTIs) are common in the community and hospital. In Indonesia, the incidence of UTI reaches 180,000 new cases per year. The most common pathogenic bacteria causing UTIs are dominated by Escherichia coli. Early empirical treatment of UTI cases can reduce morbidity. Knowing the pathogenic bacteria involved in urinary tract infections and their antimicrobial susceptibility patterns is necessary to provide appropriate empirical therapy. Purposes: Describe bacterial patterns and susceptibility profiles in urinary tract infection patients. Methods: A retrospective UTI dataset between 2019-2021whom admitted to Tarakan Regional General Hospital with a diagnosis of UTI. Resistance marker data for ESBL were obtained from the results of identification and resistance using the BD PhoenixTM Automated Microbiology System (Becton Dickinson, USA). The data was analyzed descriptively. Results: As many as 40 isolates were analyzed. Consist of E.coli (37.5%), Enterococcus faecium (20%) and Klebsiella pneumoniae (17.5%). The ESBL-producing E.coli bacteria rate reached 60%, while ESBL-producing K. pneumoniae reached 100%. Conclusion: E. coli was the most common pathogen, with the highest antibiotic sensitivity being imipenem, meropenem, and amikacin.
Uncovering the Enolase Gene (eno) and Its Role in Biofilm Formation in Clinical Isolates of Staphylococcus aureus Setiabudy, Marta; Widhidewi, Ni Wayan; Wijaya, Putu Austin Widyasari; Santoso, Putu Nia Calista; Suryawan, Kadek
Muhammadiyah Medical Journal Vol 5, No 2 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.2.97-106

Abstract

Background: Enolase is an enzyme potentially possessed by Staphylococcus aureus (S.aureus) bacteria, which holds essential virulence factors in human infections. The eno gene that encodes enolase is important in attachment to host cells, leading to biofilm formation, evasion of host immune response, and bacterial central metabolism. This biofilm formation might complicate the therapy. Purposes: This study aimed to assess the prevalence of the enolase gene, namely eno, in clinical isolates of S.aureus and its association with biofilm production. Methods: The research was conducted from December 1, 2023, to February 29, 2024, at the Faculty of Medicine and Health Science Research Laboratory, Warmadewa University. This study employed an analytical approach with a cross-sectional design. Result: The collected samples comprised 18 isolates of S.aureus, 66.6% of which produced biofilm. Most of the S.aureus clinical isolates 17 (94.4%) were detected to have the eno gene. Six samples (33.3%) formed weak biofilm followed by strong and moderate, with the same number of 3 isolates each (16.7%). No correlation between the enolase gene and biofilm production in this study suggested phenotypic heterogeneity, environment and time forming biofilm in vivo differences, and various other genes that influence biofilm formation. Conclusion: The high prevalence of the enolase gene in these clinical isolates indicates the potential for more severe infections in patients related to its adherence, which leads to biofilm and resistance problems and metabolic function.
Correlation between Interleukin-6 with D-dimer and C-reactive protein Levels in Patients with Confirmed COVID-19 Severe Criteria Gemintang, Ghea Setia; Wiratmoko, Raden Mirsyam Ratri; Tubarad, Gladys Dwiani Tinovella
Muhammadiyah Medical Journal Vol 5, No 2 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.2.69-75

Abstract

Background: In Coronavirus Disease 2019 (COVID-19) severe criteria, cytokine storm conditions are often found, and there will be an increase in Interleukin-6 as a cytokine and CRP as an acute phase protein induced by IL-6. In COVID-19 patients with severe criteria, coagulation disorders can also be found, characterized by an increase in the D-dimer value. Purpose: To determine the correlation between IL-6, D-dimer, and CRP levels in patients with confirmed COVID-19 severe criteria at Bunda Margonda General Hospital in 2021. Methods: This research was an analytical observation study with a cross-sectional approach, using secondary data from medical records of patients with confirmed COVID-19 severe criteria at Bunda Margonda General Hospital in 2021. Results: The number of patients with confirmed COVID-19 severe criteria was primarily male (59%), aged 46-55 years (33%), with degree of severity with severe criteria in 100 patients, increased IL-6 (91%), increased D-dimer levels (90%), increased CRP levels (95%). There was a correlation between increased IL-6 with D-dimer levels (p-value 0,005) and a correlation between increased IL-6 with CRP levels (p-value of 0,000). A simultaneous and significant relationship was found between IL-6, D-dimer, and CRP levels in severe COVID-19 criteria. COVID-19 patients with severe criteria were more commonly found in males in the 46-55-year age group with increased IL-6, D-dimer, and CRP values. Conclusion: There was a correlation between increased IL-6 and D-dimer and CRP levels in COVID-19 patients with severe criteria at Bunda Margonda General Hospital in 2021.
Preliminary Study of Cinnamomum burmannii Extracts to Reduce Fasting Blood Glucose Level and Body Weight in Type-2-DM-Induced Rats Claudia, Regita Almira; Sari, Shinta Dewi Permata; Safitri, Yolanda
Muhammadiyah Medical Journal Vol 5, No 2 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.2.107-115

Abstract

Background: Diabetes mellitus prevalence in Indonesia tends to be elevated based on glucose measurement. Antidiabetic oral has some serious side effects for long-term use. Several studies explored various types of Cinnamomum extract's effects on antidiabetic activity and potentially became an alternative therapy in Diabetes mellitus patients. Purposes: This study aimed to determine Cinnamomum burmannii extract’s effect on body weight and fasting blood glucose level in rats induced Type-2 DM. Methods: This study was conducted at the Laboratory of the Faculty of Pharmacy and Science, University Muhammadiyah of Prof. DR. Hamka. This study design was a true experimental method by administering Cinnamon extract at 30mg/kg, 60mg/kg, 120mg/kg, and 200mg/kg to animal tests. The statistical analysis used a T-test to compare the different results in parameters before and after the administration of Cinnamon extract. Results: This study shows a difference in blood sugar level and body weight before and after the cinnamon extract group administration. The body weight results presented no significant differences between before and after administering Cinnamon extracts at doses of 30mg/kg, 60mg/kg, 120mg/kg, and 200mg/kg. In contrast, the blood sugar level showed significant differences between before and after administration of Cinnamon extract at group doses (p0.05). Metformin was still more influential in reducing fasting blood sugar than Cinnamomum burmannii extract at 30mg/kg. Conclusion: This study concluded that Cinnamomum burmannii extract with various doses could reduce fasting blood glucose levels and body weight. The highest dose showed a significant difference in fasting blood glucose levels before and after the administration of extracts.
Prevalence of Regional Wall Motion Abnormalities in Patients Coronary Artery Disease at Tangerang District Hospital Hasni, Hasni; Nauli, Siti Elkana; Budiman, Muhamad Arif
Muhammadiyah Medical Journal Vol 5, No 2 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.2.76-82

Abstract

Background: Coronary artery disease (CAD) is when the coronary blood vessels cannot supply blood to the heart due to a pile of atherosclerotic plaque in the coronary arteries, so blood flow to the myocardium is disrupted. This blood flow disturbance will cause myocardial contractile dysfunction and Regional Wall Motion Abnormalities (RWMA). Purposes: This study aims to determine the prevalence of Regional Wall Motion Abnormalities in CAD patients based on a single-center study at Tangerang District Hospital in January - May 2024. Methods: Our study used a descriptive approach in 130 CAD patients grouped based on gender, age, hypertension, and diabetes mellitus. In addition, the determination of RWMA severity cases in CAD was measured by only the Wall Motion Score Index (WMSI) and Wall Motion Score Index (WMSI) followed by the Bull's-eye plot parameters. Results: The prevalence of CAD patients with RWMA using the WMSI method was found to be 41 patients (32%) who were predominantly male (76%) and occurred at the mean of age 61,14 years, 27% hypertension, and 17% diabetes mellitus. Conclusion: WMSI parameters followed by the Bull's-eye plot could identify 14.6% more RWMA cases than only WMSI.
A Patient with Suspect Chronic Myeloid Leukemia: A Case Report Dharmawaiswari, Anak Agung Ayu Ratih; Tedja, I Gusti Ayu Wiradari; Prianggandanni, Made Ayu Vita; Dharmawati, I Gusti Agung Ayu; Bekti, Heri Setiyo
Muhammadiyah Medical Journal Vol 5, No 2 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.2.116-121

Abstract

Chronic myeloid leukemia (CML) is a type of cancer that starts in the blood-forming cells of the bone marrow. In contrast to other types of leukemia, chronic myeloid leukemia (CML) progresses slowly. This report covers a 52-year-old male patient who came to the emergency room at Wangaya Regional Hospital with weakness, nausea, and pallor. His weight had drastically decreased over the last few months. The clinical condition of the patient was that both eyes appeared anemic, and the abdominal examination revealed hepatomegaly. Complete blood count examination results showed the following results: leukocytes 222.73x103/µl, hemoglobin 7.3 g/dL, platelets 679x103/µl, neutrophil 87.5%, neutrophil/lymphocyte ratio 16.66%. The results of peripheral blood smear analysis showed that hyperleukocytosis, with the maturation stage of myelocyte cells with a percentage of myeloblasts 6%, promyelocytes 7%, myelocytes 6%, metamyelocytes 8%, neutrophils 10%, neutrophil segments 60%, other cells 3%. These examination results suggest chronic myeloid leukemia. However, to confirm the diagnosis, the BCR-ABL fusion protein must be expressed, which can be used to identify the presence or absence of the Philadelphia chromosome in patients diagnosed with chronic myeloid leukemia (CML).
Correlation between Gender and Occupation with Severity of Stress, Depression, and Anxiety during the COVID-19 Pandemic Apsari, Putu Indah Budi; ATWN, Anak Agung Sagung; Suryanditha, Putu Arya; Widhidewi, Ni Wayan; Wijaya, Made Indra
Muhammadiyah Medical Journal Vol 5, No 2 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.2.83-88

Abstract

Background: Mental health was a severe problem among tourism workers during the COVID-19 pandemic. Purposes: This study aimed to determine the correlation of gender and occupation with the level of depression, anxiety, and stress during the COVID-19 pandemic. Methods: This research used a cross-sectional analytic study to recruit subjects grouped into tourism and non-tourism workers. This research took place in Bali province during the July-August 2023 period. Level of depression, anxiety, and stress score was assessed using Depression, Anxiety, Stress Score (DASS) questionnaires by the Google form sheet and analyzed by Chi-square test with SPSS version 27. Result: A total of 138 subjects consisting of 32 (23.2%) males and 106 (76.8%) females, 127 (92.0%) tourism workers, and 11 (8.0%) non-tourism workers. There was a positive correlation between occupation and level of depression, anxiety, and stress, while there was no significant correlation found in gender. Conclusion: Occupation in the tourism sector correlated with the severity of stress, depression, and anxiety during the COVID-19 pandemic.
Drug Alternative Approach Through Comparative Study of Antibacterial Effect of Curcumin and Andrographolide Against Salmonella enterica serovar Typhimurium Kirani, Elisa Safa; Sari, Shinta Dewi Permata; Kurnia, Achdi; Rahmadi, Agus
Muhammadiyah Medical Journal Vol 5, No 2 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.2.122-129

Abstract

Background: Salmonella typhimurium is a pathogen that causes gastroenteritis with a broad host range. Several studies reported antimicrobial resistance against S. Typhimurium. The inappropriate use of antibiotics exacerbates the issue of drug resistance. Indonesian natural products, curcumin, a polyphenol derived from turmeric, and andrographolide from Andrographis paniculata, have shown antibacterial activity due to their various health benefits. These natural products are potential candidates for alternative therapy in S. Typhimurium infection to evade antibiotic resistance. Purposes: This study aims to compare the effectiveness of the antibacterial activity of curcumin and andrographolide against S. Typhimurium. Methods: This study design was true experimental. The curcumin (500 μg/mL, 1000 μg/mL, 5000 μg/mL) and andrographolide (10 μg/mL, 100 μg/mL, 1000 μg/mL) were tested for their antibacterial effects against S. Typhimurium using the Kirby-Bauer diffusion method. Chloramphenicol was used as a positive control, and DMSO was used as a negative control. Inhibition zone bacteria with curcumin treatment compared to andrographolide treatment to assess the effectiveness of the antibacterial activity. Results: Various concentrations of curcumin and andrographolide inhibit the growth of S. Typhimurium bacteria. The highest average of S. Typhimurium inhibition zone was 9 mm and 9.67 mm, with doses of 500 μg/mL curcumin and 1000 μg/mL andrographolide. The andrographolide inhibition zone is larger than curcumin at 1000 µg/mL. These findings showed the potential of andrographolide as a natural antibacterial agent against S. Typhimurium. However, chloramphenicol inhibition zone is still highest between andrographolide and curcumin group doses. Conclusion: Andrographolide has a more effective antibacterial effect against S. Typhimurium than curcumin at 1000 µg/mL based on inhibition zone diameter results. However, chloramphenicol is still more effective as an antibacterial agent against S. Typhimurium.
Comparison of GeneXpert Results of Adult Pulmonary Tuberculosis (TB) Patients with Human Immunodeficiency Virus (HIV) without HIV Infection at three private hospitals in Jakarta Fachri, Muhmmad; Pramesti, Salsabila Widya; Akaputra, Risky; Yanti, Fitri
Muhammadiyah Medical Journal Vol 5, No 2 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.2.89-96

Abstract

Background: Tuberculosis (TB) is a bacterial infection caused by Mycobacterium TB. According to the International Standard for TB Care (ISTC), Human Immunodeficiency Virus (HIV) is one of the main comorbidities in TB. Purposes: To compare the positivity rate of GeneXpert in diagnosing TB to suspected TB adult patients with and without HIV infection at three private hospitals in Jakarta. Methods: This study uses a cross-sectional approach; the data comes from medical records. The sampling technique in this research uses the cluster sampling formula. The inclusion criteria in this study were adult pulmonary TB patients more than 18 years of age, patients with pulmonary TB, and patients who had complete medical record data, and the exclusion criteria were patients who did not have GeneXpert examination results and adult pulmonary TB patients who did not have laboratory results of HIV Rapid test results. Statistical analysis using the Chi-Square statistical test. Results: A total of 24 adult pulmonary TB patients with HIV and positive GeneXpert were identified, whereas 13 adult TB patients with HIV and positive GeneXpert were identified, and pulmonary TB patients without HIV and positive GeneXpert numbered 59, while those with positive GeneXpert numbered 15. There is a tendency for fewer positive GeneXpert values in Adult Pulmonary TB patients with HIV compared to those without HIV Infection. Statistically not significant (p 0.05) Conclusion: Adult pulmonary TB patients without HIV tend to have higher positive GeneXpert test results than adult pulmonary TB patients with HIV, and there is no statistically significant relationship.

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