cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
mkb.fkunpad@gmail.com
Editorial Address
Gedung Rumah Sakit Pendidikan Unpad/Pamitran Unpad (Teaching Hospital Building) Faculty of Medicine Unpad, 3rd Floor Jl. Prof. Eyckman No. 38 Bandung, 40161, Indonesia
Location
Kota bandung,
Jawa barat
INDONESIA
Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
Arjuna Subject : -
Articles 12 Documents
 1   2 
Search results for , issue "Vol 56, No 3 (2024)" : 12 Documents clear
Effectiveness of Short-Term Use Denosumab and Risedronate Using β-Crosslaps and Histopathology as a Parameter in Osteoporotic Rat Model Siwendro, Afrisya Bimo; Ramdan, Ahmad; Ismiarto, Yoyos Dias; Yantisetiasti, Anglita; fachri, Dliyauddin
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3016

Abstract

Osteoporosis is a condition of decreased bone mass density. Pharmacological management uses drugs that decrease bone resorption or increase bone formation. The most commonly used drugs are bisphosphonates. Risedronate is one of these bisphosphonates. It inhibits osteoclasts, resulting in osteoclast apoptosis. Denosumab is a human monoclonal antibody that inhibits receptor activator kappa-B ligand, inhibiting osteoclast activation. Both drugs are widely used. Research on the efficacy of these two mechanisms has yet to obtain conclusive results. β-cross-laps is a parameter that can be used to evaluate the effectiveness of therapy through monitoring the bone resorption process. This experimental study used female rats >9 weeks old and was conducted at the Pharmacology and Therapeutic Laboratory, Universitas Padjadjaran Bandung, Indonesia, from  June to September 2021. This study utilized a simple random sampling to allocate 24 experimental animals into three groups: control, risedronate, and denosumab. β-Crosslaps expression values before ovariectomy, post ovariectomy before receiving medication, and post ovariectomy and receiving medication was recorded and statistically analyzed using the SPSS version 24.0. The analysis of 24 samples revealed a statistically significant decrease in the median value of β-Crosslaps after ovariectomy in the denosumab group (p=0.036) when compared to the control group, whereas the decrease in the risedronate group was not significant (p=0.687). Administration of denosumab in rat models is more effective in reducing bone resorption compared to risedronate.
Unusual Lifespan of Edwards' Syndrome in COVID-19 Era Suryaningrat, Filla Reviyani; Hudayari, Devatri; Amalda Ediwan, Natasha; Rita Mardhiya, Wan; Aprilia Kadi, Fiva; Primadi, Aris; Yuniati, Tetty
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3230

Abstract

Edwards' syndrome is caused by an extra chromosome on the 18th chromosome. Patients with this diagnosis have median survival of only 3-14.5 days, with the majority of infants with full trisomy 18 type die before or shortly after they are born. There is only supportive treatment available for Edwards’ syndrome. During the COVID-19 pandemic, providing health services was challenging, leading to less than optimum treatments added by patients’ reluctance to visit healthcare facilities due to the fear of COVID-19 transmission. This case study presented an infant with Edwards’ syndrome with major malformation. The patient had several organ problems, was admitted to the NICU, and continued with home care for monitoring for 6 months. Patient then died at 9 months of age. Maintaining the best quality of life for this patient was very challenging for parents and healthcare providers. Since the management for this type of sydnome is more palliative, good education, information, and psychosocial supports for the parents are needed to prepare them with the worst conditions, which was especially more challenging during the COVID-19 pandemic.
Antioxidant and Antiaging Properties of Ethanolic Ripe Sesoot Fruit Extract Utami, Sri; Sosiawan, Insan; Nurul, Dewi; Purnamasari, Endah; Batubara, Lilian; Sachrowardi, Qomariyah Romadhiyani; Damayanti, Ndaru Andri; Aryenti, Aryenti; Dewi, Intan Keumala; Nafik, Said; Arrahmani, Betharie Cendera; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Utomo, Herry S
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3472

Abstract

Skin aging can be characterized by changes in skin, such as the appearance of wrinkles and loss of skin moisture. Some elements that might lead to cell damages and aging are free radicals through the increase of the activities of hyaluronidase and tyrosinase. Bioactive compounds found in sesoot (Garcinia picrorhiza Miq.) are known for their antioxidant properties, which may reduce excessive amounts of free radicals in the body and act as an antiaging agent by inhibiting hyaluronidase and tyrosinase activities. This study aimed to examine the antioxidant, anti-hyaluronidase, and anti-tyrosinase properties found in Ethanolic Extract Ripe Sesoot (EERS). The ethanol extract of ripe sesoot fruit obtained from LIPI, Bogor Botanical Garden was used for the antioxidant and antiaging assays conducted at PT Aretha Medika Utama in December 2016. The activity of antioxidants was measured as the Ferric Reducing Antioxidant Power (FRAP) of the EERS, while the antiaging assays were performed through the inhibition activity of hyaluronidase and tyrosinase. Results indicated that the EERS has a higher FRAP activity (17.58 μM Fe (II)/μg) than xanthone (2.54 μM Fe (II)/μg) at the highest concentration of sample of 5,000 µg/mL. The anti-hyaluronidase of the EERS exhibited lower activity (IC50 of 619.21±12.15 µg/mL) than xanthone (IC50 of 365.55±25.10 µg/mL) and the tyrosinase inhibitory assay demonstrated a lower activity of EERS (IC50 of 1060.68±12.81 µg/mL) compared to xanthone (IC50 of 218.33±9.73 µg/mL). To conclude, EERS shows antioxidant and antiaging properties.
Patient’s Quality of Life After 3-and 6-Months Cataract Surgery Juanarta, Pieter; Karfiati, Feti; Budiman, Budiman
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3137

Abstract

Cataract surgery is the most common elective procedure and has been shown to increase patients' visual acuity. However, visual acuity alone cannot adequately represent their quality of life. Quality of life can be measured with a standardized questionnaire, such as the National Eye Institute Refractive Error Quality of Life Instrument. Patients with better quality of life pre-operatively will benefit less from cataract surgery. This study aimed to describe patients' quality of life after long-term cataract surgery in the National Eye Center Cicendo Eye Hospital. This cross-sectional descriptive study used primary data collected using a questionnaire  from March to May 2022. The subjects were 33 people with cataracts who underwent uncomplicated cataract surgery at Cicendo National Eye Hospital over the past three and six months of the study. Patients who met the inclusion criteria were given the NEI-RQL 42 questionnaire. In visual clarity, patient expectations, near vision, far vision, daily fluctuations, activity limitations, suboptimal correction, and satisfaction with correction variables, an increase in value at three months was observed, yet slightly decreased at 6 months. There was decreased glare complaints, symptoms, and dependence on correction at preoperative, 3 months, and 6 months. An increase in the level of concern and appearance from preoperative, 3 months, and 6 months post-operative was observed. Thus, an improvement in the patient's quality of life is observed three months after surgery, yet decreases slightly in six months after surgery.
Correlation between Kupffer Cell Infiltration and Liver Parenchymal Cell Damages in Immunosuppressed Drugs-Induced Rats Pargaputri, Agni Febrina; Wahjuningsih, Endah; Andriani, Dwi
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3569

Abstract

The liver is the largest organ in the body, composed of both parenchymal and non-parenchymal cells. Chemical substances and various drugs can induce liver injury and involve Kupffer cells which are non-parenchymal cells that release biologically active substances, promoting pathological processes. This study aimed to evaluate the correlation between the number of Kupffer cells and liver parenchymal cell damages in immunosuppressed, drug-induced rats. The study was conducted from July to December 2019 at the Oral Biology Laboratory of the Faculty of Dentistry and the Biochemical Laboratory of the Faculty of Medicine at Universitas Hang Tuah Surabaya. Twelve healthy male Wistar rats were divided into two groups: Healthy (H) and Immunosuppressed Drug-Induced (ID) groups. Immunosuppression was induced using dexamethasone (0.5 mg/day/rat), administered orally for 14 days, combined with tetracycline (1%/day/rat). Liver samples from all rats were examined for Kupffer cell count and parenchymal cell damages were assessed using a light microscope with 400x magnification. Results revealed a significant difference in the number of Kupffer cells and liver parenchymal cell damages between the H and ID groups (p<0.05). Pearson correlation analysis indicated a significant correlation between Kupffer cell number and parenchymal cell damages (p=0.000). Continuous administration of immunosuppressive drugs may activate Kupffer cells, leading to damage of liver parenchymal cells. In conclusion, the infiltration of Kupffer cells is associated with liver parenchymal cell damages, mediated by various factors in the immunosuppressed drug-induced rat model.
Awareness and Knowledge of Celiac Disease Among the General Population in Saudi Arabia AlHussaini, Khalid I.; Alhusaini, Bassam Abdulaziz; Alzmamy, Saad Abdullah; Alfozan, Omar Abdulaziz; Alnayil, Abdulaziz Mohammed; Algannas, Turki Sulaiman; Alassaf, Turki Yazeed; Hakami, Osamah A.
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3674

Abstract

Celiac disease (CD) is an immune-mediated systemic disorder affecting nutrient absorption triggered by both environmental (gluten) and genetic factors. This study aimed to determine the level of awareness and knowledge of CD among the general population of Saudi Arabia. A community-based online cross-sectional study was conducted between August and October 2022 to examine the awareness regarding signs, symptoms, complications, and treatment of celiac disease. Data were collected and analyzed from 1,675 participants distributed across the five regions in Saudi Arabia. Analysis shows that 65.1% of the participants were familiar with the symptoms of celiac disease, and 49.6% confirmed that symptoms, blood tests, and endoscopy are the best way to diagnose celiac disease. The mean awareness score for the study participants was 71.8 (SD 13.9), with 5.2% of the participants needed a better level of awareness. Having a family history of celiac disease was an important predictor of having a higher level of awareness of celiac disease (p<0.001). The general public in Saudi Arabia demonstrates a moderate to high level of awareness of CD, emphasizing the need for extensive efforts to maintain high awareness of CD among the general public.
Prostate Specific Antigen Level and Gleason Score in Indonesian Prostate Cancer Patients Herawan, Muhammad Imam Al Kautsar; Adriansjah, Ricky
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3571

Abstract

In Indonesia, the number of prostate cancer continues to increase and even becomes the most common malignancy in men in 2015. Delayed early detection of prostate cancer is a significant concern. Prostate-specific antigen (PSA) level is found to be elevated in various conditions of prostate tissue damage, including prostate cancer. The extent of tissue damage in prostate cancer, represented by the Gleason score, is suspected to be related to the increase in the PSA level in the bloodstream. To investigate the relationship between the PSA level and Gleason scores in prostate cancer patients, a cross-sectional observational study was conducted. The study population consisted of 83 prostate cancer patients treated in Dr. Hasan Sadikin General Hospital Bandung, Indonesia, from 2017 to 2021. Data collected were analyzed using Spearman correlation test was used with an alpha value of 5%. Results indicated that 37.3% patients had a PSA level above 200 ng/dL, and 25.3% had a PSA level between 10-50 ng/dL. The majority of patients (48.1%) had a Gleason score of 9-10 (ISUP 5), while 24.1% had a score of 8 (ISUP 4). Bivariate analysis showed no significant relationship between the PSA level and Gleason score (p-value=0.445). Further studies are needed to determine the sensitivity and specificity of PSA in diagnosing prostate cancer.
Effect of Saline Nasal Irrigation in Patients with Sinonasal Symptoms Widuri, Asti; Fakhriani, Rizka; Daniswara, Deoni
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3621

Abstract

Nasal irrigation with saline is frequently used as an alternative therapy for sinonasal diseases since it effectively reduces sinonasal symptoms and improves the quality of life when measured by various subjective instruments. The mechanisms of action of saline irrigation remain unclear, but some hypotheses attribute the direct physical cleansing of thick mucus, allergens, and pollutants. This study aimed to determine the effect of nasal saline irrigation on the nasal mucosa using the modified Lund-Kennedy endoscopic score as the objective evaluation. This pre-post-experimental study was conducted at PKU Muhammadiyah Gamping Hospital Yogyakarta, Indonesia, from May to June 2023. The study included 18 individuals presenting with sinonasal symptoms. Participants meeting the inclusion and exclusion criteria who provided informed consent were trained in nasal saline irrigation. Patients were assessed at baseline and one week after nasal saline irrigation using endoscopy, TNSS, and MCC time. Results revealed that the mean of endoscopic scores before and after saline irrigation were 6.89±1.1 and 5.33±1.4, respectively (p-value 0.006),  while the mean of TNSS scores before and after saline irrigation was 6.17±2.3 and 4.28±2.6, respectively (p-value 0.006). Thus, nasal saline irrigation significantly improves the endoscopy and TNSS scores, but not the MCC time.
Microbial Diversity and Antimicrobial Susceptibility from Wound Dehiscence Isolates in an Indonesian Tertiary Referral Hospital Aviana, Felicia; Fatmawati, Ni Nengah Dwi
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3422

Abstract

Healthcare-associated infections (HAIs) remain a critical issue for public health in Indonesia, with wound dehiscence associated with surgical site infections (SSIs) being one of them. Globally, SSIs are known as the most common postoperative complications with a heightened prevalence, particularly in low to middle-income countries. With its retrospective and descriptive design, this study aimed to illustrate the microbial patterns identified in Prof. Dr. I.G.N.G. Ngoerah General Hospital from 12 January 2020 to 12 December 2022. The study includes all patients who underwent surgery and were subsequently diagnosed with wound dehiscence and SSIs. Specimens were collected from patients and submitted to the Microbiology Laboratory at the hospital above. Bacterial identification and susceptibility testing to antimicrobials were performed using the Vitek 2 Compact System (bioMerieux, Marcy l'Etoile, France). Patient information was sourced from medical records. Out of 172 samples, 151 (87.8%) yielded positive cultures. Among these, 151 (87.8%) were found to be positive. Gram-negative bacteria were found to be most prevalent, with Escherichia coli (20.2%) and Pseudomonas aeruginosa (19.6%) being the most frequently isolated bacteria. The bacteria isolated were mostly susceptible to amikacin (72.1%), followed closely by meropenem (71.4%). This information could contribute to the development of an empirical antibiotic therapy protocol for wound dehiscence or SSI cases in this local context.
Comparison of Different Cycloplegic Refraction Regimens for Children Irfani, Irawati; Gunawan, Fany; Satari, Karmelita; Sari, Maya; Oktarima, Primawita; Caesarya, Sesy; Karfiati, Feti
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3311

Abstract

In the process of a pediatric eye exam, cycloplegic refraction is a crucial step. Since no single cycloplegic drug is ideal, a combination regimen is employed. This study compares the ocular (refractive power and pupil diameter) and systemic (blood pressure and heart rate) effects of administering a combination of 1% cyclopentolate and 2.5% phenylephrine, with or without 1% tropicamide, to children with refractive errors. This study aimed to discover a more feasible regimen for children. This was a single-blind study, a randomized clinical trial conducted from November–December 2020 in children with mild to moderate refractive errors. Group A received 1% cyclopentolate, 2.5% phenylephrine, and 1% tropicamide (SFT), whereas group B received 1% cyclopentolate and 2.5% phenylephrine (SF). The outcomes were measured using an auto refractometer and IOL Master® 700. Before and 60 minutes after medication was administered, blood pressure and heart rate were measured. There were 54 participants (108 eyes) with an average age of 12.85± 2.84 years. Although the SFT group's refractive power and pupil width were greater than those of the SF group, the differences were not statistically significant (p=0.271 and p=0.088). Heart rate (p=0.521) and blood pressure (systolic p=0.201; diastolic p=0.950) did not significantly differ between the two groups. Despite mydriasis manifested more rapidly in the SFT group, there was no discernible difference in the cycloplegic effects between those groups. SF might be a more feasible regimen for cycloplegic refraction in children with refractive errors.

Page 1 of 2 | Total Record : 12

 1   2 

Filter by Year

2024 2024


Reset
Filter By Issues
All Issue Vol 57, No 3 (2025) Vol 57, No 2 (2025) Vol 57, No 1 (2025) Vol 56, No 4 (2024) Vol 56, No 3 (2024) Vol 56, No 2 (2024) Vol 56, No 1 (2024) Vol 55, No 4 (2023) Vol 55, No 3 (2023) Vol 55, No 2 (2023) Vol 55, No 1 (2023) Vol 54, No 4 (2022) Vol 54, No 3 (2022) Vol 54, No 2 (2022) Vol 54, No 1 (2022) Vol 53, No 4 (2021) Vol 53, No 3 (2021) Vol 53, No 2 (2021) Vol 53, No 1 (2021) Vol 52, No 4 (2020) Vol 52, No 3 (2020) Vol 52, No 2 (2020) Vol 52, No 1 (2020) Vol 51, No 4 (2019) Vol 51, No 3 (2019) Vol 51, No 2 (2019) Vol 51, No 1 (2019) Vol 50, No 4 (2018) Vol 50, No 3 (2018) Vol 50, No 2 (2018) Vol 50, No 1 (2018) Vol 49, No 4 (2017) Vol 49, No 3 (2017) Vol 49, No 2 (2017) Vol 49, No 1 (2017) Vol 48, No 4 (2016) Vol 48, No 3 (2016) Vol 48, No 2 (2016) Vol 48, No 1 (2016) Vol 47, No 4 (2015) Vol 47, No 3 (2015) Vol 47, No 2 (2015) Vol 47, No 1 (2015) Vol 46, No 4 (2014) Vol 46, No 3 (2014) Vol 46, No 2 (2014) Vol 46, No 1 (2014) Vol 45, No 4 (2013) Vol 45, No 3 (2013) Vol 45, No 2 (2013) Vol 45, No 1 (2013) Vol 42, No 3 Vol 44, No 4 (2012) Vol 44, No 3 (2012) Vol 44, No 2 (2012) Vol 44, No 1 (2012) Vol 43, No 4 Vol 43, No 3 Vol 43, No 2 Vol 43, No 1 Vol 42, No 4 Vol 42, No 2 Vol 42, No 1 Vol 41, No 4 Vol 41, No 3 Vol 41, No 2 Vol 41, No 1 More Issue