cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Risti Graharti
Contact Email
risti.graharti@gmail.com
Phone
+6281369730011
Journal Mail Official
medulla.fkunila@gmail.com
Editorial Address
-
Location
Kota bandar lampung,
Lampung
INDONESIA
Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 972 Documents
 73   74   75   76   77 
Skrining Fitokimia Kualitatif Ekstrak Etanol 96% dan H-Heksana Kulit Batang Bakau Lindur (Bruguiera gymnorrhiza) Ismunanto, Aziza Regina Kinasih; Kurniawati, Evi; Putri, Giska Tri; Susianti, Susianti
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1253

Abstract

Lindur mangrove plants (Bruguiera gymnorrhiza) are known to contain secondary metabolite compounds which function as antibacterials. These secondary metabolite compounds include alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids. The design of this research was experimental, carried out to determine and compare the phytochemical components contained in 96% ethanol extract and n-hexane of Bruguiera gymnorrhiza mangrove bark. Bruguiera gymnorrhiza mangrove bark was taken at KPH Gunung Balak, East Lampung, then 4.5 kg of wet mangrove bark was obtained and dried for 7 days, then the extract was made using the maceration method for 3x24 hours using 2 types of solvents, namely 96% ethanol and n-hexane with a ratio of 1:10 between simplicia and solvent. Thick extracts were obtained from the two types of solvents which were then carried out qualitative phytochemical tests.  The results of this study showed that 96% ethanol extract and n-hexane of Bruguiera gymnorrhiza mangrove bark positively contained secondary metabolite compounds. The 96% ethanol extract of Bruguiera gymnorrhiza mangrove bark contains all types of secondary metabolite compounds, namely alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids, while the n-hexane extract contains secondary metabolite compounds, namely alkaloids, flavonoids, tannins, phenols, terpenoids, steroid but does not contain saponins. The conclusion of this research is that the 96% ethanol extract of Bruguiera gymnorrhiza mangrove bark contains more secondary metabolite compounds than the n-hexane extract of Bruguiera gymnorrhiza mangrove bark.
Infeksi Cryptosporidium pada Manusia: Patogenesis, Diagnosis dan Terapi Hatimi, Fahmi Ilham; Mutiara, Hanna; Islami, Suryadi; Sukohar, Asep
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1261

Abstract

Cryptosporidium is a zoonotic protozoan parasite capable of infecting humans and animals, primarily transmitted through contaminated water or food. This infection is a leading cause of moderate to severe diarrhea, particularly in children from low-income regions and immunocompromised individuals, contributing to significant global morbidity and mortality. The pathogenesis of Cryptosporidium involves the invasion of intestinal epithelial cells, resulting in mucosal damage, villous atrophy, and increased intestinal permeability, leading to watery diarrhea. Local inflammatory responses exacerbate symptoms, while immunocompromised individuals often experience chronic infections with serious complications. Diagnosis relies on microscopy, immunofluorescence, and molecular techniques such as PCR, which offer high sensitivity and specificity. Supportive care is the mainstay of treatment, with nitazoxanide being the preferred therapeutic option for selected patients. For immunocompromised individuals, management is more complex and may involve immune restoration therapies, such as antiretroviral treatment for HIV/AIDS patients. However, resistance to conventional treatments remains a significant challenge, necessitating further research into novel therapeutic agents, such as KDU731, which has shown promising efficacy in preliminary studies. This review provides a comprehensive analysis of the pathogenesis, diagnostic methods, and therapeutic strategies for Cryptosporidium infections. Additionally, it highlights the importance of prevention measures, including improved access to clean water and public health education. Enhanced control efforts are crucial to mitigating the global health impact of this infection, particularly among vulnerable populations such as children and immunocompromised individuals.
Keberadaan Bakteri Coliform dan Escherichia coli dalam Sumber Air Bersih Sebagai Penyebab Diare pada Rumah Tangga: Literature Review Fathia, Nauriel; Utama, Winda Trijayanthi; Marcellia, Selvi; Carolia, Novita
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1293

Abstract

Water is an essential necessity for humans on Earth. Its role is crucial for daily activities, including household needs, industry, offices, and food production. In Indonesia, each person is estimated to require approximately 30–60 liters of water per day, whereas in developed countries, the demand per person ranges between 60–120 liters per day. The feasibility of water usage is regulated based on quality characteristics, referred to as water quality. One of the key indicators related to household water quality is biological parameters, particularly concerning the presence of coliform bacteria and Escherichia coli. These bacteria have a fecal-oral entry route, meaning that if consumed in excessive amounts, they can cause gastrointestinal diseases, primarily diarrhea. This study aims to examine the impact of coliform and Escherichia coli contamination in household water sources, leading to diarrhea cases. The research method used is a literature review and analysis. The findings indicate that the presence of Escherichia coli in household water sources, especially in areas with poor sanitation, poses a high health risk, particularly increasing the likelihood of diarrhea. Several factors contribute to this contamination, including the proximity of wells to pollution sources, inadequate waste management, and improper well construction that does not meet safety standards. These conditions suggest that environmental sanitation and the distance between water sources and potential contaminants play a significant role in water quality and public health. Through this study, it is expected that the community will be more aware of the importance of maintaining clean water used for household needs to prevent diarrhea-related diseases.
- Cut-Off Point Kadar Feritin sebagai Prediktor Kadar NLR pada Pasien Talasemia Beta Mayor: - Tsaqihrafa, Nasyaira; -, -; -, Terza Aflika Happy; -, Dyah Wulan Sumekar Rengganis Wardani
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1370

Abstract

Thalassemia is a hereditary disease that has a high prevalence, both in Indonesia and the world. Thalassemia with the most severe symptoms is the classification of beta thalassemia major. Severe symptoms have an impact on poor body conditions, one of which can occur iron accumulation and inflammation. Thus, in patients with beta thalassemia major, ferritin and neutrophil lymphocyte ratio (NLR) examinations can be carried out. The cutoff point for ferritin levels as a predictor of NLR levels in patients with beta thalassemia major can also be found out. This study used a cross-sectional design, then the data results were processed with a data processing application on a computer. The cutoff value for ferritin levels was 2907.145 ng/mL which can predict NLR levels. The ferritin level used as a predictor was obtained through the cutoff point by analyzing the receiver operating characteristic (ROC) curve in the data processing application and changing its coordinates in the form of a graph. The result was 2907.145 ng/mL where the ferritin level above that can increase the risk of increasing NLR levels in patients with beta thalassemia major.
Analysis of Malathion Insecticide Resistance in Aedes aegypti Mosquitoes Using the CDC Bottle Bioassay Method Kirche, Agnes Angelina; Kurniawan, Betta; Putri, Giska Tri; Mutiara, Hanna
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1376

Abstract

Dengue is an infectious disease transmitted by the Aedes aegypti mosquito, which breeds rapidly in Indonesia's tropical environment, increasing the risk of spreading this disease. Vector control using malathion insecticide can be effective, but repeated use and inappropriate dosage can cause resistance in mosquitoes which ultimately increases the risk of dengue infection. CDC Bottle Bioassay is a test method for evaluating mosquito resistance to insecticides with a standardized procedure and is carried out using bottles containing insecticides with different diagnostic doses. Research using this method shows that Aedes aegypti mosquitoes in various locations show resistance to malathion at certain doses and tolerance at other doses. Several studies have also shown that mosquitoes exposed to malathion show categories of resistance or tolerance based on the mortality rate recorded during the test. Malathion, which is a class of organophosphorus insecticides, works by irreversibly binding to acetylcholinesterase and effectively kills mosquitoes, but repeated use can trigger resistance. Factors influencing resistance include biological factors such as migration, operational factors such as insecticide dosage and application, as well as genetic factors associated with the resistant allele. If mosquitoes carrying resistant alleles move or interbreed, this can increase the resistance status in an area, which is seen in Aedes aegypti populations in several regions of the world.
Review Article: Pharmacological Activities of Red Spinach (Amaranthus tricolor) Hasyimi, Meifia; Iqbal, Muhammad; Andrifianie, Femmy; Triyandi, Ramadhan
Medula Vol 15 No 2 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i2.1381

Abstract

  Red spinach (Amaranthus tricolor) is a leafy vegetable known for its distinctive red or purplish leaves. This plant is widely cultivated as its leaves are edible and packed with essential nutrients beneficial to the body. Red spinach is rich in antioxidants such as beta-carotene and vitamin C, along with vital minerals like iron, calcium, magnesium, phosphorus, and potassium, which support overall health. Regular consumption of red spinach is believed to improve blood circulation, boost immunity, prevent anemia, accelerate wound healing, and promote bone health due to its comprehensive nutritional content. This article aims to review the pharmacological activities of red spinach based on literature from credible sources such as Google Scholar, Garuda, Neliti, and Sinta, focusing on publications within the past five years. The review findings reveal that red spinach possesses various potential pharmacological properties. These include antioxidant activity, anemia treatment, reduction of liver enzymes such as SGOT and SGPT, improvement of liver function, and enhancement of metabolic processes. Additionally, red spinach is recognized for its benefits in maintaining facial skin health, suggesting its potential as a natural ingredient in skincare products. Therefore, red spinach is not only a nutritious vegetable but also holds promise as a natural herbal remedy with therapeutic potential for the future.
Glasgow Coma Scale: Tinjauan terhadap Kegunaan, Keterbatasan, dan Perkembangannya Aquila Graham; Setiorini, Anggi; Septiani, Linda; Perdani, Roro Rukmi Windi
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1396

Abstract

The Glasgow Coma Scale (GCS) is a widely used neurological assessment tool for evaluating the level of consciousness in patients with brain injury. Introduced in 1974 by Teasdale and Jennett, it has become a standard in emergency departments, intensive care units, and neurosurgical wards worldwide. The GCS assesses patient responses in three domains: eye opening, verbal response, and motor response, with scores ranging from 3 (deep coma) to 15 (fully conscious). The GCS score is used to classify the severity of Traumatic Brain Injury (TBI) and predict clinical outcomes. However, several studies have highlighted limitations of the GCS, particularly in predicting patient outcomes and its application in specific populations. This article provides a critical review of the GCS, including its utility, limitations, and ongoing modifications and developments.
Tinjauan Pustaka : Kebiasaan Merokok dan Paparan Ultraviolet Sebagai Faktor Risiko Katarak Senilis Ghaitsa Lulua; Himayani, Rani; Septiani, Linda; Berawi, Khairunnisa
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1419

Abstract

Cataract ranks second as the most common visual impairment and first as a cause of blindness, as the lens hardens and causes a decrease in sharp vision. Based on age, cataracts are divided into several types: congenital cataract, juvenile cataract and senile cataract. Senile cataract is a cataract that often occurs in older people. The classification of senile cataracts is based on the progression of the cataract's opacity, namely, incipient, immature, mature, and hypermature. Some of the risk factors for senile cataracts include a history of diabetes mellitus, family history, smoking, and exposure to ultraviolet light. Smokers have a higher risk of developing senile cataracts than non-smokers. Ingredients in cigarettes such as cyanate, nicotine and tar can cause changes and denaturation of proteins in the lens of the eye. Meanwhile, sunlight absorbed by the eye produces free radicals and affects the tissues in the lens of the eye, triggering oxidative reactions, causing changes in amino acid reactions and leading to senile cataracts.
Potensi Ekstrak Kulit Nanas (Ananas comosus) Sebagai Antimikroba Sinaga, Herman Fransiskus; Apriliana, Ety; Septiani, Linda; Kurniati, Intanri
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1427

Abstract

Pineapple is one of the traditional plants that may be used as an alternative treatment to reduce pathogenic microbes. Its content is rich in chlorine, iodine, phenol and the enzyme bromelain which functions to stop microbial growth. This research aims to determine the potential of pineapple peel extract (Ananas comosus) as antimicrobe agents. This research uses a literature review study method, namely by using research articles obtained through a literature search process related to the potential use of pineapple peel extract on microbe from 2015 to 2025. Pineapple peel extract contains the main compounds, namely flavonoids, polyphenols, bromelain and saponins. This content causes pineapple skin extract (Ananas comosus) to have an effect on microbes.
INFEKSI SALURAN KEMIH AKIBAT PENGGUNAAN KATETER PADA PASIEN RAWAT INAP DI RUMAH SAKIT Ananta, Yoga; Mustofa, Syazili; Septiani, Linda; Busman, Hendri
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1436

Abstract

Urinary tract infection (UTI) is a disorder caused by microorganisms that multiply in the urinary tract, which is normally sterile from bacteria. Risk factors for UTI include age, gender, medical procedures such as catheterization, hygiene, and duration of catheter use. Catheter-related UTI is the most common type of nosocomial infection, with a prevalence of up to 80% in patients who use catheters. The main cause of UTI is gram-negative bacteria, such as Escherichia coli (48.44%) and Klebsiella pneumoniae. In women, the risk is higher because the urethra is shorter and closer to the anus. UTI is divided into lower and upper urinary tract infections, where symptoms vary from pain during urination to serious complications such as pyelonephritis and urosepsis. The pathophysiology of UTI often involves the colonization of microorganisms on the catheter or urinary tract. The risk of infection increases with the duration of catheter placement, reaching 5–10% per day. Diagnosis of UTI involves history taking, physical examination, and urine culture, although modern methods such as flow cytometry are increasingly used for efficiency. Prevention involves personal hygiene, aseptic technique during catheter insertion, and prophylactic antibiotic use in selected cases. Treatment of UTI includes empiric antibiotics such as trimethoprim-sulfamethoxazole, fluoroquinolones, or nitrofurantoin, depending on the severity and causal pathogen. Appropriate preventive and treatment approaches can reduce the incidence of UTI, improve patient quality of life, and decrease the rate of complications. Keywords: Trigger Factors, Urinary Tract Infection (UTI), Catheter

Page 75 of 98 | Total Record : 972

 73   74   75   76   77 

Filter by Year

2019 2026


Reset
Filter By Issues
All Issue Vol 16 No 3 (2026): Medula Vol 16 No 2 (2026): Medula Vol 16 No 1 (2026): Medula Vol 14 No 10 (2025): Medula Vol 15 No 4 (2025): Medula Vol 15 No 3 (2025): Medula Vol 15 No 2 (2025): Medula Vol 15 No 1 (2025): Medula Vol 14 No 12 (2024): Medula Vol 14 No 11 (2024): Medula Vol 14 No 9 (2024): Medula Vol 14 No 8 (2024): Medula Vol 14 No 7 (2024): Medula Vol 14 No 6 (2024): Medula Vol 14 No 5 (2024): Medula Vol 14 No 4 (2024): Medula Vol 14 No 3 (2024): Medula Vol 14 No 2 (2024): Medula Vol 14 No 1 (2024): Medula Vol 13 No 4.1 (2023): Medula - Edisi Spesial (Special Sense) Vol 13 No 7 (2023): Medula Vol 13 No 6 (2023): Medula Vol 13 No 5 (2023): Medula Vol 13 No 4 (2023): Medula Vol 13 No 3 (2023): Medula Vol 13 No 2 (2023): Medula Vol 13 No 1 (2023): Medula Vol 12 No 4 (2022): Medula Vol 12 No 3 (2022): Medula Vol 12 No 2 (2022): Medula Vol 12 No 1 (2022): Medula Vol 11 No 4 (2021): Medula Vol 11 No 3 (2021): Medula Vol 11 No 2 (2021): Medula Vol 11 No 1 (2021): Medula Vol 10 No 4 (2021): Medula Vol 10 No 3 (2020): Medula Vol 10 No 2 (2020): Medula Vol 10 No 1 (2020): Medula Vol 9 No 4 (2020): Medula Vol 9 No 3 (2019): Medula Vol 9 No 2 (2019): Medula More Issue